Gene AqueK519 (A.queenslandica)

AqueK519

Species: A.queenslandica
Alias: AqueK519
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a2

Sequence

Name Sequence Type Origin Length Description Download
AqueK519.AA Protein None 209 None Fasta, JSON
AqueK519.kin_dom Protein Kinase Domain None 156 None Fasta, JSON

Protein domain

Protein domains of AqueK519.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK519.AA TKL 1-152 21 1.3e-27 96.55 In-house 78-291 (364) Show / Hide 
Range on Protein: 1-152
Range on HMM: 78-291/364
Sequence Identity: 21% (47 aa)

MLAKVRHPNLLLFIAGVLDHPSGS-----------PIIITELL-DTSLRKAYTDYLISSDRVRISIMRDVAAALNYIHRQK------ESIIHRDVSSANV
|. . ||||...|.. ... |.|            . |..|.    ||.  ..        .|.....|.| ..|| | ..        |||||  |.|.
MMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI

LLESRGE----------GNWKAKLSDFGSANLVQFS----------------------TTVGPGAIPYAAPEV------PHN------------QTTKMD
|. . ..           .|..|..||| .  .. |                      |    | . . ||||        .             ..|.|
LVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCD

VYSYGVLLCEVMLSEFPFKE
|||.|..|.|..  . |...
VYSFGIVLWEILTRCRPYYD
Kinase AqueK519.AA TK 6-193 11 6e-20 62.87 In-house 101-486 (486) Show / Hide 
Range on Protein: 6-193
Range on HMM: 101-486/486
Sequence Identity: 11% (44 aa)

RHPNLLLFIAGVLDHPS----------GSPIIITEL---------LDTSLRKAYTDYLI-----------------------------------------
.|||.. ... .... .          . ..|..|.         |.. |||   .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------SSDRVRISIMRDVAAALNYIHRQKE----SIIHRDVSSANVLLESRGEGNWK-------AKLSDFGSA-
                                . . .. .....|... |.|...      ..|||.   |.|. ...   |.       .|..||| . 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

------------------------------------NLVQFSTTVGPGAIPYAAPEVPHN-----------QTTKMDVYSYGVLLCEVML--SEFPFK--
                                         ... |   | . |||.               ||| ||.|.|||. |..    | .    
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

-----------ERFPDMLQS----------------------LAGSW------------SLMHQLILSCTRHSVADRVDMMYVLDTF
           . . ..|..                      .. .|             ....|...| ..  .|| ..  ... .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK519.AA Pkinase 1-153 22 9.3e-20 70.94 Pfam 53-215 (293) Show / Hide 
Range on Protein: 1-153
Range on HMM: 53-215/293
Sequence Identity: 22% (39 aa)

MLAKVRHPNLLLFIAGVLDHPSGSPIIITELLDT-----SLR-----KAYTDYLISSDRVRISIMRDVAAALNYIHRQKESIIHRDVSSANVLLESRGEG
......||| . ..  . |  .... ...|...      .|      .... ..  |... ...|. .. .|.|.|..  .|||||. ..|.|. ..|. 
IMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHI

NWKAKLSDFGSA----NLVQFSTTVGPGAIPYAAPEV---PHNQTTKMDVYSYGVLLCEVMLSEFPFKER
. . |..|||.|    .  .  .|.  | ..|.||||       ..| |..|.|..| |... ..||...
DACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGH
Kinase AqueK519.AA TK-Unique 52-144 29 1e-16 54.31 In-house 134-233 (294) Show / Hide 
Range on Protein: 52-144
Range on HMM: 134-233/294
Sequence Identity: 29% (31 aa)

ISIMRDVAAALNYIHRQKESIIHRDVSSANVLLESRGEGNWKAKLSDFGSA------NLVQFSTTVGPGAIPYAAPEVPH----NQ-TTKMDVYSYGVLL
.... ..| ...|...|.. |.|||... |||| .    . ..|..||| |      . .. ... |.  | . |||..     .  ||| ||.|.|||.
YHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE----DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLM

CEVM
 |..
WEIF
Kinase AqueK519.AA CZAK 2-149 29 8.9e-16 53.9 In-house 54-221 (279) Show / Hide 
Range on Protein: 2-149
Range on HMM: 54-221/279
Sequence Identity: 29% (50 aa)

LAKVRHPNLLLFI-AGVLDHPSGSPIIITELLD-TSLRKAYTD--YLISS-DRVRISIMRDVAAALNYIHR-QKE-SIIHRDVSSANVLLESRGE-----
. | .||| . |. |  .| |     |..|     |||.  ||   ..     .. .. .|.|   || |   |.  |.||| || |.||..        
MSKLCHPNCVQFLGACSEDGP-NHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPV

----GNWKAKLSDFGSA---NLVQFSTTVGPGAIPYAAPEV--PHNQTTKMDVYSYGVLLCEVMLSEFP
       ..| .|||         |  |   | ... |||.    | | | ||||.| .| ..  .. |
VSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVYSFGMILWCIITCDQP
Kinase AqueK519.AA UTK 1-144 23 9.4e-16 50.38 In-house 62-234 (296) Show / Hide 
Range on Protein: 1-144
Range on HMM: 62-234/296
Sequence Identity: 23% (41 aa)

MLAKVR-HPNLLLFIAGVLDHPSGSPIIITEL-----LDTSLRKAYT----DYLISSDRVRISIMRDVAAALNYIHRQKESIIHRDVSSANVLLESRGEG
|..... |||.| ... ...     ..|.||.     |.. ||..      . .. ... |.. ..|.|....|.|...  ..|||.   |.|. . .  
MMKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCG--FVHRDLAARNCLVHMHRM-

NW----KAKLSDFG---SANLVQ---------FS-----TTVGPGAIPYAAPEVPHNQ---TTKMDVYSYGVLLCEVM
 |    ..|..|||    . .|.         .|     . ... .|   |||.  ..   ||| ||.|.||.. |..
MWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIW
Kinase AqueK519.AA MLK 50-165 26 1.8e-15 50.21 In-house 125-247 (291) Show / Hide 
Range on Protein: 50-165
Range on HMM: 125-247/291
Sequence Identity: 26% (34 aa)

VRISIMRDVAAALNYIHRQKE-SIIHRDVSSANVLLESRGE-----GNWKAKLSDFGSANLVQFS---TTVGPGAIPYAAPEV----PHNQ-TTKMDVYS
. .... ..| ...| | ..   |||||  | |.|.    |     .. ..| .||| .  .. .    .  .|   . ||||    .... . | ||.|
HAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILID---EICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWS

YGVLLCEVMLSEFPFKERFPDMLQSLAGSW
.||.| |..  | |.|    ... ..|  |
WGVVLWEMLTREVPYK----QHYDPMAIAW
Kinase AqueK519.AA TKL-Unique 2-152 23 4.4e-15 49.8 In-house 49-236 (290) Show / Hide 
Range on Protein: 2-152
Range on HMM: 49-236/290
Sequence Identity: 23% (44 aa)

LAKVR-HPNLLLFIAGVLDHPSGSP--IIITE-LLDTSLRKAYT----------DYLISSDRVRISIMRDVAAALNYIHRQKESIIHRDVSSANVLLESR
. | . |||.......  ||    |  .|..| .   ||..  .          . .  .  .|... .|.| ...|.|. .  |||||  | |.|. ..
MKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNN

-GEGNWKAKLSDFGSANLVQFS--TTVG----------PGAIPYAAPEVPHNQ----TTKMDVYSYGVLLCEVMLSEF------PFKE
  .  |..|..||| . .   .  .|..           | . ..||||  .     ..| ||||.|. | |   ..       |...
SNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQG
Kinase AqueK519.AA Ciliate-E2 42-150 19 1.3e-14 46.58 In-house 123-296 (365) Show / Hide 
Range on Protein: 42-150
Range on HMM: 123-296/365
Sequence Identity: 19% (35 aa)

DYLISS---------------DRVRISIMRDVAA---------------ALNYIHRQKESIIHRDVSSANVLLESRGEGNWKAKLSDFGSANLVQFS---
||....               .. .. ||. ..                ||.|.| ..  |||||    |.|.          |..||| .  .. .   
DYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF---------IKIIDFGLSKKYDDDNQN

-----------------TTVG--------------PGAIPYAAPEVPHNQT-----------TKMDVYSYGVLLCEVMLSEFPF
                 .| |               |  .| |||.  ..            .| |..| ||.| | .  ..||
RTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF
Kinase AqueK519.AA STE 27-155 22 6.9e-14 45.52 In-house 114-273 (359) Show / Hide 
Range on Protein: 27-155
Range on HMM: 114-273/359
Sequence Identity: 22% (39 aa)

IITELLD-TSLRKAYT-DYLISS-------------DRVRISIMRDVAAA-LNYIHRQKESIIHRDVSSANVLLESRGEGNWKAKLSDFGSANLVQF---
|. |..|  ||.. .   | .                 . . | |..  . |.|.|...  |||||. .||.||         .||.||| .  ..    
ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL---------VKLCDFGVCGQLTDSMA

----------------STTVGPGAIPYAAPEV--PHNQT------TKMDVYSYGVLLCEVMLSEFPFKERFP
                 ..   |   . ||||  . .|.      || |..| | ...|    . |. .  |
NIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHP
Kinase AqueK519.AA Ciliate-E2-Unclassified 47-151 23 2e-13 42.97 In-house 136-271 (352) Show / Hide 
Range on Protein: 47-151
Range on HMM: 136-271/352
Sequence Identity: 23% (33 aa)

SDRVRI-----SIMRDVAAALNYIHRQKESIIHRDVSSANVLLESRGEGNWKAKLSDFGSANLVQ--------------------FSTTVGPGAIP--YA
...  .      ... .  .|.|.|...  |||||    |.|. . |. | . |..|||..   |                    ..|..|       |.
TEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYT

APEVPHNQTTK------MDVYSYGVLLCEVMLSEFPFK
||||  .|          |..| ||.| | .  ..||.
APEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFY
Kinase AqueK519.AA S_TKc 1-198 18 5e-12 -0.51 SMART 16-231 (231) Show / Hide 
Range on Protein: 1-198
Range on HMM: 16-231/231
Sequence Identity: 18% (45 aa)

MLAKV-------------------------RHPNLLLFIAGVLDHPSGSPIIITELLDT---SLRKAYTDYLI------SSDRVRISIMRDVAAALNYIH
....                          .|||.  ..    |   ..  ...|..|.   .|..   ..         .  .  ..|. .. ||.|.|
YKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCH

RQKESIIHRDVSSANVLLESRGEGNWKAKLSDFGSANLVQFSTTVGPGAIPYAAPEVPHNQTT-KMDVYSYGVLLCEVMLSEFPFKERFPDMLQSLAGSW
..   |||||.  .|.|| .        |..|||.| ..    |   |   | ||||    .. | |..| |..| | .  . ||      |.. .    
SH--GIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--S

SLMHQLILSCTRHSVADRVDMMYVLD----TFNESFT
. . ..|  | .   ..|     .|       .  . 
PEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK519.AA Pkinase_Tyr 1-100 21 4.7e-10 34.67 Pfam 56-156 (270) Show / Hide 
Range on Protein: 1-100
Range on HMM: 56-156/270
Sequence Identity: 21% (23 aa)

MLAKV-RHPNLLLFIAGVL--DHPSGSPIIITEL-----LDTSLRKA-YTDYLISSDRVRISIMRDVAAALNYIHRQKESIIHRDVSSANVLLESRGEGN
.. .  .|||.. ... ..  . |. ...|..|.     |.. |||    .  ..  .  ... ...|....| ....  .||||.   |.|...   .|
IMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKD-LLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE---NN

WKAKLSDFG
 ..| .|||
-VVKICDFG
Kinase AqueK519.AA TyrKc 1-193 15 2.1e-07 -103.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-193
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

M------------------------------------------LAKV--RHPNLLLFIAGVLDH-----PSGSPIIITEL-----LDTSLRKAYTDYLIS
                                           . |.  .|||.. ... ....      .. . |..|.     |.  |||   .    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---L

SDRVRISIMRDVAAALNYIHRQKESIIHRDVSSANVLLESRGEGNWKAKLSDFGSANLVQFS--------TTV------GPGAIPYA--APEVPHNQ--T
. .  .|.. ..|.  .|.|..   .||||    |.|. ...     .| |||| .  .           . .      | . .|.   |||.      |
CMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

TKMDVYSYGVLLCEVMLSEFPFKER-----FPD-----------MLQSLAG--------SWSLMHQLILSCTRHSVADRVDMMYVLDTF
|| ||.|.||.. |..    .  .       ..           ..   .           . |.|....| ..  .||  .  . . |
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK519.AA TK-Unique 168-193 19 0.230497 0.61 In-house 269-294 (294) Show / Hide 
Range on Protein: 168-193
Range on HMM: 269-294/294
Sequence Identity: 19% (5 aa)

MHQLILSCTRHSVADRVDMMYVLDTF
|..|. ||....  .|..   ... .
MYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK519.AA Pkinase_Tyr 128-144 58 0.917762 3.21 Pfam 192-208 (270) Show / Hide 
Range on Protein: 128-144
Range on HMM: 192-208/270
Sequence Identity: 58% (10 aa)

TTKMDVYSYGVLLCEVM
||| ||.|.|||. |..
TTKSDVWSFGVLMWEIF