Gene AqueK521 (A.queenslandica)

AqueK521

Species: A.queenslandica
Alias: AqueK521
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a2

Sequence

Name Sequence Type Origin Length Description Download
AqueK521.AA Protein None 242 None Fasta, JSON
AqueK521.kin_dom Protein Kinase Domain None 208 None Fasta, JSON

Protein domain

Protein domains of AqueK521.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK521.AA TKL 24-226 21 4.1e-31 109.29 In-house 1-289 (364) Show / Hide 
Range on Protein: 24-226
Range on HMM: 1-289/364
Sequence Identity: 21% (63 aa)

LGKGKWGRVSVGTFRR----------CSVAVKQMHQE----------------------IITQQHIWRMDREIYILSQLH---HPNIIKFIGAVFDMSF-
.|.|  | |  |..|             ||||.....                      .. .   | ...|.. . ...   ||||..|.|.... .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------NRMIITEIMDI-SLLNAYENQELTPDLSCRPAILSIMCDIAQGLNYLHC--L----PDPVIHHDIDSDNVLLKSVGG----------RK
           . .|..| ..  |||. .            . ..... |||.|.||||        . |.|| |. |.|.|... .             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

WKAKISDFGSANFVRLSYNPY----------------------PGAIAYSAPETERGL--YEQLY--------KKQTPKIDSFSYGILLCEAITCQFPE
|..||.||| . |.  | |                         | ... |||  ||   |.. .        .. ..|.| .|.||.|.| .|.. |.
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY
Kinase AqueK521.AA MLK 18-225 24 1.7e-23 78.48 In-house 1-235 (291) Show / Hide 
Range on Protein: 18-225
Range on HMM: 1-235/291
Sequence Identity: 24% (60 aa)

VLSNVELGKGKWGRVSVGTFRRCS-----VAVKQMHQEI----ITQQHIWRMDREIYILSQLHHPN----IIKFIGAVFDMSFNRMIITEIMDISLLNAY
 .    .|.|  | |  |..|        ||||. ...|    .|   .| ...|...|. | |||    ||.| |.  .   .  |..| .. . |. .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

ENQE----------------LTPDLSCRPAILSIMCDIAQGLNYLHC-LPDPVIHHDIDSDNVLLKS-----VGGRKWKAKISDFGSANFVRLS---YNP
 . .                 ..|.     ..... ..|.|..|||. .|.|.||.|. | |.|.        .|   ..||.||| . ..  .      
LHGARSKWMDANHNQKNDRVYDHDH-----AMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHG---TLKICDFGTSRDWHQMCTNMMS

YPGAIAYSAPET-ERGLYEQLYKKQTPKIDSFSYGILLCEAITCQFP
 .|  |. |||  .. . .. | .   | | .|.|..| | .|.. |
NAGTYAWMAPEVIQQ-FRCEKYSE---KCDVWSWGVVLWEMLTREVP
Kinase AqueK521.AA TKL-Unique 23-221 27 2.7e-20 68.41 In-house 4-223 (290) Show / Hide 
Range on Protein: 23-221
Range on HMM: 4-223/290
Sequence Identity: 27% (63 aa)

ELGKGKWGRVSVGTFRRCSVAVKQMH-QEIITQQHIWRMDREIYILSQLH-HPNIIKFIGAVFD---MSFNRMIITEIMDI-SLLNAYE---------NQ
 .| |. |.|  |..|. .||.|| | .| .  . .    .|. ... || |||| ...|. .|      |. |..| ..  || .            |.
KIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNN

ELTPDLSCRPAILSIMCDIAQGLNYLHCLPDPVIHHDIDSDNVLLKSV-GGRKWKAKISDFGSANFVR-LSYNPYP-----------GAIAYSAPETERG
....... |   ...  |||||..||| .  |.|| |. | |.|. .     .|..||.||| . |    . ...            | . ..|||  |.
NCKLNMQQR---VKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

LYEQLYKKQTPKIDSFSYGILLCEAIT
.     .. . |.| .|.|| | | .|
NF----CQYSEKSDVYSFGIVLWEIAT
Kinase AqueK521.AA STE 19-170 22 5.4e-20 67.38 In-house 1-194 (359) Show / Hide 
Range on Protein: 19-170
Range on HMM: 1-194/359
Sequence Identity: 22% (46 aa)

LSN-VELGKGKWGRVSVGTFRRCS-----------------VAVKQMH---------------QEIITQQHIWRMDREIYILSQLH--HPNIIKFIGAVF
. .  ..|||  | |  .  .  .                 .|.|||.                |.. .. . .  .|| |.....  ||||.|..|. |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DMS------FNRMIITEIMD-ISLLNAYE-NQELTPDLSCR---------PAILSIMCDIAQG-LNYLHCLPDPVIHHDIDSDNVLLKSVGGRKWKAKIS
. .       .  |. | ||  ||   .. . .   .|.           . |  | ..| .| |.||| .   .|| || ..|.||         .|..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL---------VKLC

DFGSA
||| .
DFGVC
Kinase AqueK521.AA TK 18-218 15 4.7e-19 59.81 In-house 1-386 (486) Show / Hide 
Range on Protein: 18-218
Range on HMM: 1-386/486
Sequence Identity: 15% (60 aa)

VLSNVELGKGK---WGRVSVGTFRR---------------------------CSVAVKQMHQEIITQQHIWRM---------------DREIYILSQ--L
.    .||.|    .|.|  |. |.                           . ||||... .  ..|   ..                .|. ....  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPNIIKFIGAVFDMSFN-----------RMIITEIMDI-----SLLNAYENQE----------------------------------------------
|||||....|....   .            ||..| |.      ||..   .                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------LTPDLSCRPAILS-------------------IMCDIAQGLNYLHCLPD----PVIHHDIDSDNVLLKSVGGRKWK-------AKISDFGSAN-
      . |.  .    |.                   ....||.|. ||| ..      ..| |.   |.|. . . .||.       .||.||| .  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----FVRLSYN--PY------------------------------PGAIAYSAPETER-GLYEQL--YKKQTPKIDSFSYGILLCE
      |  |.   |                                 | . |||. . . . .   |.| |.| | .|.|.|. |
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWE
Kinase AqueK521.AA DRK 18-168 32 1.3e-18 59.64 In-house 1-145 (258) Show / Hide 
Range on Protein: 18-168
Range on HMM: 1-145/258
Sequence Identity: 32% (49 aa)

VLSNVELGKGKWGRVSVGTFRRCSVAVKQMHQEIIT-QQHIWRMDREIYILSQLHHPNIIKFIGAVFDMSFNRMIITEIMDI-SLLNAYENQELTPDLSC
.   .  |.| .| |  || |   |||| .    |     .  . ||| ...|| ||||. |.|.    .    |..| |   || |   .. .  | . 
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPP-DICICMEYMPRGSLYNILHDESIEMDWPL

RPAILSIMCDIAQGLNYLHCLPDPVIHHDIDSDNVLLKSVGGRKWKAKISDFG
.   ...| |.| |..||||    .|| |  |.| |        |. |..|||
M---KQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDE----HWQVKVADFG
Kinase AqueK521.AA Dicty4 18-168 29 2.2e-18 58.05 In-house 1-159 (277) Show / Hide 
Range on Protein: 18-168
Range on HMM: 1-159/277
Sequence Identity: 29% (48 aa)

VLSNVELGKGKWGRVSVGTFRRCSVAVKQM--HQEIITQQHIWRMDREIYILSQLHHPNIIKFIGAVF---DMSFNRMIITEIM-DISLLNAYEN-----
    ...|||  | |  || |   |||| .  |..   .  .    .|. |.... ||||..| ||       .   .| || |   .|..   .     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-QELTPDLSCRPAILSIMCDIAQGLNYLHC-LPDPVIHHDIDSDNVLLKSVGGRKWKAKISDFG
 |. ..|.. . . . .. |.|.|.|.|||  |. .|| |. |.| |        |..|..|||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLV----DKNWRVKVCDFG
Kinase AqueK521.AA HH498 18-174 29 1.9e-17 51.49 In-house 1-175 (284) Show / Hide 
Range on Protein: 18-174
Range on HMM: 1-175/284
Sequence Identity: 29% (54 aa)

VLSNVELGKGKWGRVSVGTFRRCSVAVKQMHQEIITQQHI---WRMD---REIYILSQLHHPNIIKFIGAVFDMSFNRMIITEIMD----ISLL------
.      | |  | |  |..|   ||||    . .        |  |   ||. |...| ||. ..|..|  |      |.|.  |     |.|      
IEFHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIG

-----NAYENQE---LTPDLSCRPAILSIMCDIAQGLNYLHC-LPDPVIHHDIDSDNVLLKSVGGRKWKAKISDFGSANFVR
     |   ||       ||   . .. |  |.|.| ||||  |. |.|| |  | |.|.   |    .|.. |||   ||.
GAGANNNNHNQKNNYRIMDL---QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDG----HAVVADFGESRFVC
Kinase AqueK521.AA Pkinase 18-225 22 8.5e-16 56.93 Pfam 1-211 (293) Show / Hide 
Range on Protein: 18-225
Range on HMM: 1-211/293
Sequence Identity: 22% (51 aa)

VLSNVELGKGKWGRVSVGTFRRCS--VAVKQMHQEIITQ----QHIWRMDREIYILSQLHHPNIIKFIGAVFDMSFNRMIITEIMDIS----LLN----A
      .|.|  |.|  .. .  .  ||||..  . .      .|...  .||.|.  |.||||....... | . .  ...| ..       |     .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST

YENQEL--TPDLSCRPAILSIMCDIAQGLNYLHCLPDPVIHHDIDSDNVLLKSVGGRKWKAKISDFGSA----NFVRLSYNPYPGAIAYSAPETERGLYE
 ..  .  ...      . ..|  |..||.|.|     .|| |. ..|.|... |  . . ||.|||.|    .     .. . | . | |||       
WRHGCFYFSEWE-----CKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV------

QL-YKKQTPKIDSFSYGILLCEAITCQFP
 . ... .||.| .|.|..| | .. ..|
IRGGQYYGPKVDMWSCGCILYEMLCGRPP
Pkinase_Tyr AqueK521.AA Pkinase_Tyr 17-94 29 1.7e-12 42.98 Pfam 1-87 (270) Show / Hide 
Range on Protein: 17-94
Range on HMM: 1-87/270
Sequence Identity: 29% (26 aa)

VVLSNVELGKGKWGRVSVGTFR------RCSVAVKQMHQEIITQQH--IWRMDREIYILSQL-HHPNIIKFIGAVFDMSFN--RMIITE
...  . ||.|  |.|  || .      .. |||| .  |  ....  .  . ||. |..|| |||||....|.. | .     .|..|
ITFGKK-LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVME
Kinase AqueK521.AA S_TKc 18-242 21 3.8e-12 1.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-242
Range on HMM: 1-231/231
Sequence Identity: 21% (57 aa)

VLSNVELGKGKWGRVSVGTFRR--CSVAVKQMHQEIITQQHIWRMDREIYILSQLHHPNIIKFIGAVFDMSFNRMIITEIMDI---SLLNAYENQE----
     ..|||  |.|  .. ..    ||.|...          .. ||| ||.. |||||.|....  |   .  ...| .|    .|.   ...     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTPDLSCRPAILSIMCDIAQGLNYLHCLPDPVIHHDIDSDNVLLKSVGGRKWKAKISDFGSANFVRLSYNPYPGAIAYSAPETERGLYEQLYKKQTP
   ...       . ..|. |...|.|.| .   .|| |.  .|.|| .        ||.|||.| ..    . . |   | |||           . ..
RFPFPE-H-----ARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL---------GYGK

-KIDSFSYGILLCEAITCQFPEP---------------TLFQSLLQK----------VQ-------LSSV
 |.|  | |..| | .. . | |                . . .|||           |          .
CKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK521.AA STE-Unique 126-171 44 1.3e-11 36.98 In-house 412-458 (616) Show / Hide 
Range on Protein: 126-171
Range on HMM: 412-458/616
Sequence Identity: 44% (21 aa)

IAQGLNYLHCLPDPVIHHDIDSDNVLLKSVG-GRKWKAKISDFGSAN
|. ||.|||   .|.||.|. ..|... . | ||  |.||.||| |.
ILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHAT
Kinase AqueK521.AA TyrKc 18-237 21 1.6e-11 -36.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-237
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

VLSNVELGKGKWGRVSVGTFRRCSVAVKQMHQEIITQQHIWRMDREIYILSQL--HHPNIIKFIGAVFDMS------FNRMIITEIMD-ISLLNAYENQE
.  . .|| |  |.|  || .   |||| .. .      .  . ||. |...|  |||||....|.. . .         ||..| |.  .|..   . .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

LTPDLSCRPAILSIMCDIAQGLNYLHCLPDPVIHHDIDSDNVLLKSVGGRKWKAKISDFGSANFVRLS--------YNP------YP--GAIAYSAPETE
 .    | .  ||.. .||.| .|||    ..|| |.   |.|... .     .|||||| . ..           |              |   |||. 
PK---LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

RGLYEQLYKKQTPKIDSFSYGILLCEAIT-CQFPEPT-------------------------L------------------------------FQSLLQK
       |.| |.| | .|.|... |  | .| | |                                                         |. . ..
------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

V
 
F
Kinase AqueK521.AA CZAK 120-168 35 3.7e-09 29.58 In-house 108-167 (279) Show / Hide 
Range on Protein: 120-168
Range on HMM: 108-167/279
Sequence Identity: 35% (21 aa)

LSIMCDIAQGLNYLHC--LPDPVIHHDIDSDNVLLKSVGG---------RKWKAKISDFG
...  |||.| ||||    | |..| |  | |.|| .               ..||.|||
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFG
Kinase AqueK521.AA STE-Unique 19-84 23 5e-06 16.78 In-house 1-72 (616) Show / Hide 
Range on Protein: 19-84
Range on HMM: 1-72/616
Sequence Identity: 23% (17 aa)

LSNVELGKGKWGRVSVGT--FRRCSVAVKQMHQEIITQQH----IWRMDREIYILSQLHHPNIIKFIGAVFD
. .. .|.|  | |   .       .|.|  |... .       .  . .||.|.. |||.||.| .|....
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLW
Kinase AqueK521.AA CZAK 23-81 30 3.6e-05 14.92 In-house 6-68 (279) Show / Hide 
Range on Protein: 23-81
Range on HMM: 6-68/279
Sequence Identity: 30% (19 aa)

ELGKGKWGRVSVGTFRRCSVAVKQMHQEIITQQHI----WRMDREIYILSQLHHPNIIKFIGA
. |.|  | |  .  |  .||.| .| .              ..|. |.| | |||.. |.||
TIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGA
Kinase AqueK521.AA CZAK 182-225 36 0.001541 8.9 In-house 184-221 (279) Show / Hide 
Range on Protein: 182-225
Range on HMM: 184-221/279
Sequence Identity: 36% (16 aa)

GAIAYSAPETERGLYEQLYKKQTPKIDSFSYGILLCEAITCQFP
| ... |||   |    .|   |.| | .|.|..| . |||  |
GCLCWMAPECFKG---ENY---TEKVDVYSFGMILWCIITCDQP
Kinase AqueK521.AA Pkinase_Tyr 117-168 30 0.018658 8.94 Pfam 111-156 (270) Show / Hide 
Range on Protein: 117-168
Range on HMM: 111-156/270
Sequence Identity: 30% (16 aa)

PAILSIMCDIAQGLNYLHCLPDPVIHHDIDSDNVLLKSVGGRKWKAKISDFG
. .|..  .||.|..||.  .   || |.   |.|...    . ..||.|||
KDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE---NN-VVKICDFG