Gene AqueK522 (A.queenslandica)

AqueK522

Species: A.queenslandica
Alias: AqueK522
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a2

Sequence

Name Sequence Type Origin Length Description Download
AqueK522.AA Protein None 673 None Fasta, JSON
AqueK522.kin_dom Protein Kinase Domain None 208 None Fasta, JSON

Protein domain

Protein domains of AqueK522.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK522.AA TKL 448-649 22 1.1e-48 168.02 In-house 1-288 (364) Show / Hide 
Range on Protein: 448-649
Range on HMM: 1-288/364
Sequence Identity: 22% (68 aa)

LGRGGYGVVWVGQLR-------------VAVKKLHE-------------------------WIASQHNMETFHHEINIMSQLRHPNLLQFIGAVLDDPSG
.|.||.|.|. |..|             |||||...                         .  ........  ||..||.|||||..||.|.... |.|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

C-----------PMIVTEVM-DTSLREAYENKELTPDPDCRPVILSIMHDAAQGLKYLHC--L----PDPIIHRDVSSANVLLQSI---------AGTRK
|           ..||.| .   ||.. .            ........|.|.|. |||        . ||||||  |.|.|. .          .    
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

WKGKISDFGSAK----------------------LAENAVTEGPGAFAYSAPEAFQNMANPD---------PTKKQTTKMDVFSYGILFCEIMTCRFP
|. ||.||| ..                      . ...     | ... |||..... | .         . .. ..|.||.|.||...||.|.. |
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
Kinase AqueK522.AA TKL-Unique 444-645 28 6.1e-31 106.41 In-house 1-223 (290) Show / Hide 
Range on Protein: 444-645
Range on HMM: 1-223/290
Sequence Identity: 28% (66 aa)

LSKELGRGGYGVVWVGQL---RVAVKKLHEWIASQHNM--ETFHHEINIMSQLR-HPNLLQFIGAVLD---DPSGCPMIVTEVMDT-SLREAYE------
 .. .|.||||.|  |      ||.|..|.  ....|   ..|. |.|.|. |. |||.....|.  |   .|. .  ||.| ..  ||..         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNM-CIVMEYCPGGSLYDVLHQNNNNN

---NKELTPDPDCRPVILSIMHDAAQGLKYLHCLPDPIIHRDVSSANVLLQSIAGTRKWKGKISDFGSAKLAENA---VTEGP---------GAFAYSAP
   |.......    ..... .|.|||. ||| .  ||||||  | |.|. .     .|. ||.||| .|.. .     . ..         | | ..||
NNNNNNCKLNMQ---QRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAP

EAFQNMANPDPTKKQTTKMDVFSYGILFCEIMT
| . .       .. ..| ||.|.||   || |
EVLRMNF-----CQYSEKSDVYSFGIVLWEIAT
Kinase AqueK522.AA TK 442-645 16 5.4e-30 97.14 In-house 1-389 (486) Show / Hide 
Range on Protein: 442-645
Range on HMM: 1-389/486
Sequence Identity: 16% (66 aa)

VSLSKELGRGGYG---VVWVGQL------------------------------RVAVKKLHEWIASQHNMET---------------FHHEINIMSQ--L
. | |.||.| .|   .|. |..                              .|||| |.|  |.. ...                . .|. .|..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNLLQFIGAVLDDPS----------GCPMIVTEVMD-TS----LREAYENKE----------------------------------------------
.|||.....|..... .          . .|||.| |.  .    ||.   ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------LTPDPDCRPVILS-------------------IMHDAAQGLKYLHCLPD----PIIHRDVSSANVLLQSIAGTRKWK-------GKISDFGSAK
      . |.| .    |.                   .....|.|. ||| ..      ..|||.   |.|. .  ...||.        ||.||| ..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGE-NNVCKWHFDGCGPVCKIADFGLSR

-----LAENAVT--------------------------------EGPGAFAYSAPEAFQNMANPDP--TKKQTTKMDVFSYGILFCEIMT
     ||                                      |   . . |||...         ..| ||| ||.|.|.|  ||.|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase AqueK522.AA MLK 442-649 25 1.6e-29 99.67 In-house 1-235 (291) Show / Hide 
Range on Protein: 442-649
Range on HMM: 1-235/291
Sequence Identity: 25% (63 aa)

VSLSKELGRGGYGVVWVGQLR--------VAVKKLHEWI----ASQHNMETFHHEINIMSQLRHPN----LLQFIGAVLDDPSGCPMIVTEVMDT-SLRE
  ... .| |..|.|| |. |        ||||. .  |     .    . |  |... . |.|||      || |. |..|  .  ||.| ..  || .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLYN

AYENKELTPDPDC----------RPVILSIMHDAAQGLKYLHC-LPDPIIHRDVSSANVLLQS----IAGTRKWKGKISDFGSAK-LAEN-A-VTEGPGA
   ...  ...              ........ |.|. |||. .|.||||||  | |.|.      ....     ||.||| .. . .. .  .  .| 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTL---KICDFGTSRDWHQMCTNMMSNAGT

FAYSAPEAFQNMANPDPTKKQTTKMDVFSYGILFCEIMTCRFP
.|. |||..|      .  | . | ||.|.|... |..|.. |
YAWMAPEVIQQ----FRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase AqueK522.AA Dicty4 442-573 33 2e-29 95.46 In-house 1-146 (277) Show / Hide 
Range on Protein: 442-573
Range on HMM: 1-146/277
Sequence Identity: 33% (50 aa)

VSLSKELGRGGYGVVWVGQLR---VAVKKL--HEWIASQHNMETFHHEINIMSQLRHPNLLQFIGAVL--DDPSGCPMIVTEVM-DTSLREAYEN-----
    ...|.|..| |  |  |   ||||||  |   ...  .. |..|..||...||||...| || .     .| ..|||| |  ..| .   .     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-KELTPD-PDCRPVILS---IMHDAAQGLKYLHC-LPDPIIHRDVSSANVL
 .. ..| |.    |..   .. |||.|. .|||  |. |||||  |.| |
QQSIKLDWPL----IKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLL
Kinase AqueK522.AA UTK 442-645 25 7e-26 85.53 In-house 1-235 (296) Show / Hide 
Range on Protein: 442-645
Range on HMM: 1-235/296
Sequence Identity: 25% (63 aa)

VSLSKELGRGGYGVVWVGQL----------RVAVKKLHEWIASQHNME---TFHHEIN---IMSQLR-HPNLLQFIGAVLDDPSGCPMIVTEVMD-----
| |...||.| .|.| .. .          .||||.. .  ..|...|   .|  | .   .|.|.. |||.|...| ....    .||||| |      
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLR

TSLREAYENKELTPDPDCRP--VILSIMHDAAQGLKYLHCLPDPIIHRDVSSANVLLQSI--AGTRKWKGKISDFG---SAKLAE--------------N
. || . .. .  ..|.       |. . | | |. |||.    ..|||.   |.|. .    ... .. ||.|||    ....               .
SYLRRHRPTPP--ACPHWLTLHQRLCMAWDIARGMQYLHSC--GFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYM

AVTEGPGAFAYSAPEAFQNMANPDPTKKQTTKMDVFSYGILFCEIMT
|   .. ...  ||||. ...      . ||| ||.|.|..  ||.|
AQHQDRWPIRWMAPEALTHHT------RFTTKSDVWSFGVVCWEIWT
Kinase AqueK522.AA STE 442-649 20 1.4e-24 83.8 In-house 1-267 (359) Show / Hide 
Range on Protein: 442-649
Range on HMM: 1-267/359
Sequence Identity: 20% (58 aa)

VSLSKELGRGGYGVVWVGQLR--------------------VAVKKLH-----------EWIASQ------HNMETFHHEINIMSQLR--HPNLLQFIGA
  . ...|.|..|.|  .  .                    .|.|...           |    .       .|. . .||.||....  |||  ...|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

VLDD---PSG--CPMIVTEVMD-TSLREAYENKELTPDPDC----------RPVILSIMHDAAQG-LKYLHCLPDPIIHRDVSSANVLLQSIAGTRKWKG
 ...    .      |. | ||  ||.. ...|  ...|.            ..|  | ..  .| |.||| .   |||||. .||.||           
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL----------V

KISDFGSAKLAEN----------------------AVTEGPGAFAYSAPEAFQNMANPDPTKKQTTKMDVFSYGILFCEIMTCRFP
|..||| ..  ..                       ..  |    . |||  |.. ..   |. .|| |. | |.. .|  | . |
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP----WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPP
Kinase AqueK522.AA CZAK 442-649 30 4.9e-24 84.26 In-house 1-221 (279) Show / Hide 
Range on Protein: 442-649
Range on HMM: 1-221/279
Sequence Identity: 30% (71 aa)

VSLSKELGRGGYGVVWVGQLR---VAVKKLH--EWIASQHN--METFHHEINIMSQLRHPNLLQFIGA-VLDDPSGCPMIVTEVMD-TSLREAYENKE--
    .. |.| .| |  .  |   ||.|..|         |   . |  |. ||| |.||| .||.||  .| |     ||.| |   |||     .   
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGP-NHHCIVMEWMGGGSLRRLLTDHYFY

LTPDPDCRPVILSIMHDAAQGLKYLHC--LPDPIIHRDVSSANVLLQSIAG--------TRKWKGKISDFGSA---KLAENAVTEGPGAFAYSAPEAFQN
. . |  .   ...  | |.|  |||    | ||.||| || |.|| .               . ||.|||     .      |   |  .. ||| |  
HKQNPHLQ---WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKG

MANPDPTKKQTTKMDVFSYGILFCEIMTCRFP
  .       | | ||.|.|..  .| ||. |
ENY-------TEKVDVYSFGMILWCIITCDQP
Kinase AqueK522.AA DRK 442-591 37 6.9e-23 74.38 In-house 1-145 (258) Show / Hide 
Range on Protein: 442-591
Range on HMM: 1-145/258
Sequence Identity: 37% (58 aa)

VSLSKELGRGGYGVVWVGQLR---VAVKKLHEWIAS-QHNMETFHHEINIMSQLRHPNLLQFIGAVLDDPSGCPMIVTEVMDT-SLREAYENKELTPDPD
.      |||.|| |. |  |   ||||.|          .  || |||.|.||||||  ||.|. .  |. |  |..| |   ||     .  .  |  
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDIC--ICMEYMPRGSLYNILHDESIEMD--

CRPVILSIMHDAAQGLKYLHCLPDPIIHRDVSSANVLLQSIAGTRKWKGKISDFG
  | ....| |.| |. ||||    |||||  | | |         |. |..|||
-WPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDE-----HWQVKVADFG
Kinase AqueK522.AA Pkinase_Tyr 442-516 32 2.1e-21 73.14 Pfam 1-87 (270) Show / Hide 
Range on Protein: 442-516
Range on HMM: 1-87/270
Sequence Identity: 32% (29 aa)

VSLSKELGRGGYGVVWVGQLR---------VAVKKLHEWIASQHN--METFHHEINIMSQL-RHPNLLQFIGAVL--DDPSGCPMIVTE
... |.||.| .|.|. | ..         ||||.| |  |....  .| | .|..||.|| .|||.....|...  ..|.  ..||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVME
Kinase AqueK522.AA Dicty5 442-645 29 6.3e-21 68.75 In-house 1-198 (260) Show / Hide 
Range on Protein: 442-645
Range on HMM: 1-198/260
Sequence Identity: 29% (62 aa)

VSLSKELGRGGYGVVWVGQLR---VAVKKLHEWIASQHNMETFHHEINIMSQLR--HPNLLQFIGAVLDDPSGCPMIVTE-VMDTSLREAYENKEL-TPD
||. .    |  | |  |. .   ||.| .        ... |  |. |||     |||.  . ||   .    | .||| .   ||...   ..  |  
VSFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYN-DKYPFHVTEYCHNGSLFNYLNDQRKTTGQ

PDCRPVILSIMHDAAQGLKYLHCLPDPIIHRDVSSANVLLQSIAGTRKWKGKISDFGSAKLAENAVTEGP--GAFAYSAPEAFQNMANPDPTKKQTTKMD
|   . .|..  |.||....||     |||||. | |.|.     |  || || |||     .|.       |  .. |.| |.        .  . | |
PIAYFQQLHMAIDIAQSMRHLHSM--NIIHRDLKSMNFLI-----TENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFN-------GQPYHQKCD

VFSYGILFCEIMT
|.|.||   |..|
VYSFGIVLWEMFT
Kinase AqueK522.AA Pkinase 442-649 24 5.3e-16 57.67 Pfam 1-211 (293) Show / Hide 
Range on Protein: 442-649
Range on HMM: 1-211/293
Sequence Identity: 24% (55 aa)

VSLSKELGRGGYGVVWVGQLR-----VAVKKLH-EWIASQHNMETFH-HEINIMSQLRHPNLLQFIGAVLDDPSGCPMIVTEVMDT-----SLREAYE--
  . . .|.|..|.|. .. .     ||||..  . . |. ... ..  || ||  |.||| ....... |... .  .|.| ..      .| .  .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY--MVMEYCEGGLYVMDLFDYISTW

-NKEL--TPDPDCRPVILSIMHDAAQGLKYLHCLPDPIIHRDVSSANVLLQSIAGTRKWKGKISDFGSAK---LAENAVTEGPGAFAYSAPEAFQNMANP
 .. .  ...     .. ..|   ..||.|.|     |||||. ..|.|.    |. . . ||.|||.||   .  |  |   |   | |||  .     
RHGCFYFSEW-----ECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIR-----

DPTKKQTTKMDVFSYGILFCEIMTCRFP
   .. ..| |..|.|... | .. |.|
-GGQYYGPKVDMWSCGCILYEMLCGRPP
Kinase AqueK522.AA S_TKc 442-673 19 1.1e-15 53.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 442-673
Range on HMM: 1-231/231
Sequence Identity: 19% (53 aa)

VSLSKELGRGGYGVVWVGQLRV-----AVKKLHEWIASQHNMETFHHEINIMSQLRHPNLLQFIGAVLDDPSGCPMIVTEVMDT---SLREAYENKEL--
  . ...|.|..|.|. .. .      |.|...         |..  ||.|... .|||. .....  |   ..  .|.| .|.   .|..  ...    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TPDPDCRPVILSIMHDAAQGLKYLHCLPDPIIHRDVSSANVLLQSIAGTRKWKGKISDFGSAKLAENAVTEGPGAFAYSAPEAFQNMANPDPTKKQTT-K
.. |    .. ..|.  ...|.|.| .   |||||.  .|.|| .         ||.|||.|..     |   |   | ||| .          . .. |
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE-------HIKICDFGLARQL----TTFCGTPWYMAPEVL----------GYGKCK

MDVFSYGILFCEIMTCRFPDRVNFQDMLRQVHSISNRPSAC--------------------K----------L
 |. | |... | .. . | . . | |....      |.|.                    .          .
CDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK522.AA TyrKc 442-673 23 1.2e-14 14.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 442-673
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

VSLSKELGRGGYGVVWVGQLR--VAVKKLHEWIASQHNMETFHHEINIMSQL--RHPNLLQFIGAVLDD-----PSGCPMIVTEVMDT-SLREAYENKEL
..| |.||.| .|.|. |...  ||||.|.|       .| |..|..||..|  .|||.....|.....      .. .|||.| |.  .|..   ... 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

TPDPDCRPVILSIMHDAAQGLKYLHCLPDPIIHRDVSSANVLLQSIAGTRKWKGKISDFGSAKLAENA--------VT------EGP--GAFAYSAPEAF
.    | .  ||.....|.|  |||    ..||||    |.|. .         |||||| ..  ..         .        |         |||..
K---LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

QNMANPDPTKKQTTKMDVFSYGILFCEIMTC--RFPDR-----VNFQDMLRQVHSI------SN---------------------------RPS----AC
        ..| ||| ||.|.|..  ||.|     .       .. |.....| .        |                           ||.      
-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

KL
..
CF
Kinase AqueK522.AA Pkinase_Tyr 541-649 28 6.6e-05 17.24 Pfam 113-214 (270) Show / Hide 
Range on Protein: 541-649
Range on HMM: 113-214/270
Sequence Identity: 28% (33 aa)

ILSIMHDAAQGLKYLHCLPDPIIHRDVSSANVLLQSIAGTRKWKGKISDFGSAKLA-----E-NAVTEGPGAFAYSAPEAFQNMANPDPTKKQTTKMDVF
.|.. .. |.|. ||.  .  .||||.   |.|. .     . . ||.||| |..         . ..|.      |||.....         ||| || 
LLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE----NN-VVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-------FTTKSDVW

SYGILFCEIMT-CRFP
|.|.|  ||.| .. |
SFGVLMWEIFTYGEQP
Kinase AqueK522.AA DRK 628-645 44 0.055708 2.54 In-house 180-197 (258) Show / Hide 
Range on Protein: 628-645
Range on HMM: 180-197/258
Sequence Identity: 44% (8 aa)

TTKMDVFSYGILFCEIMT
| | ||.|..|   |..|
TEKADVYSFAIVLWECVT
Kinase AqueK522.AA Dicty4 628-646 47 0.09366 1.83 In-house 195-213 (277) Show / Hide 
Range on Protein: 628-646
Range on HMM: 195-213/277
Sequence Identity: 47% (9 aa)

TTKMDVFSYGILFCEIMTC
. | ||.|.||.  || |.
NEKADVYSFGIVLWEILTR