Gene AqueK527 (A.queenslandica)

AqueK527

Species: A.queenslandica
Alias: AqueK527
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a2

Sequence

Name Sequence Type Origin Length Description Download
AqueK527.AA Protein None 1307 None Fasta, JSON
AqueK527.kin_dom Protein Kinase Domain None 248 None Fasta, JSON

Protein domain

Protein domains of AqueK527.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
UBQ AqueK527.AA UBQ 4-80 32 8.8e-18 66.32 SMART 1-72 (72) Show / Hide 
Range on Protein: 4-80
Range on HMM: 1-72/72
Sequence Identity: 32% (25 aa)

LEIFVNILSGTRGATVTLLVDELD-TVKDIKLKIQQEANIPVAKQKLLFDGRTLSEELNCTVTDCDIFEQATIFLVVL
..|||  . |  . |.|. |.. | ||...| .|... .||...|.|...|. | ..   |. |. | ...|| |.| 
MQIFVKWQNG--WKTFTFEVKPSDWTVSELKQHIEDKEGIPPEQQRLIYQGK-LEDD---TLADYNIQPGSTIHLMVR
UBQ AqueK527.AA UBQ 81-154 36 1.4e-17 65.68 SMART 1-72 (72) Show / Hide 
Range on Protein: 81-154
Range on HMM: 1-72/72
Sequence Identity: 36% (27 aa)

TIISIRFVTG-EIFSTDVNLVADTIETIKQSIEERNGVPLNQQCLIFKGKELNDDLSTLSDCKIEDGSVILFTIK
  | ..  .| . |  .|.  ..|....|| ||.. |.| .|| ||..|| |.||  ||.|..|..||.|   ..
MQIFVKWQNGWKTFTFEVKPSDWTVSELKQHIEDKEGIPPEQQRLIYQGK-LEDD--TLADYNIQPGSTIHLMVR
Ubiquitin AqueK527.AA ubiquitin 102-157 44 1.1e-16 64.17 Pfam 18-73 (73) Show / Hide 
Range on Protein: 102-157
Range on HMM: 18-73/73
Sequence Identity: 44% (25 aa)

DTIETIKQSIEERNGVPLNQQCLIFKGKELNDDLSTLSDCKIEDGSVILFTIKGAI
||.|..|| |... |.| .|| ||.|||.|..| .||||..|.|||....  .   
DTVEQLKQKIQQKQGIPPDQQRLIYKGKQLREDHRTLSDYNIQDGSFTIHMVLRQR
Ubiquitin AqueK527.AA ubiquitin 9-82 36 5.5e-13 50.69 Pfam 1-73 (73) Show / Hide 
Range on Protein: 9-82
Range on HMM: 1-73/73
Sequence Identity: 36% (27 aa)

NILSGTRGATVTLLVDELDTVKDIKLKIQQEANIPVAKQKLLFDGRTLSEELNCTVTDCDIFEQA-TIFLVVLTI
  |.|    |.|. ||. |||...| ||||. .||. .|.|...|. | .| ..|..|..| ... ||..|. . 
KTLDGKG-STFTFEVDPDDTVEQLKQKIQQKQGIPPDQQRLIYKGKQL-REDHRTLSDYNIQDGSFTIHMVLRQR
Rad60-SLD AqueK527.AA Rad60-SLD 102-149 30 0.001913 16.79 Pfam 22-69 (73) Show / Hide 
Range on Protein: 102-149
Range on HMM: 22-69/73
Sequence Identity: 30% (15 aa)

DTIETIKQSIEERNGVPL-NQQCLIFKGKELNDDLSTLSDCKIEDGSVI
.|......   ...|.|  .|. ||| |..|... .|. |  .|||..|
TTFSKLMNAYCKKRGIPEHQQVRLIFDGERLDPN-DTVEDYDMEDGDMI
Rad60-SLD AqueK527.AA Rad60-SLD 16-59 23 0.011895 13.8 Pfam 10-55 (73) Show / Hide 
Range on Protein: 16-59
Range on HMM: 10-55/73
Sequence Identity: 23% (11 aa)

GA-TVTLLVDELDTVKDIKLKIQQEANIPV-AKQKLLFDGRTLSEE
|  .|.. |.  .|..... . ... .||.  ...|.|||  |...
GKKEVFFKVKPTTTFSKLMNAYCKKRGIPEHQQVRLIFDGERLDPN
UBQ AqueK527.AA UBQ 159-235 35 1.4e-16 62.3 SMART 1-72 (72) Show / Hide 
Range on Protein: 159-235
Range on HMM: 1-72/72
Sequence Identity: 35% (28 aa)

FQISIKTLPIYSGKDHIKLIVKSTD-TIAHVKAMIVAKEGIPINKQCLIFNGKHIYADDATLADHKISSGDILHLLYP
.|| .|..     ...... ||..| |....|. | .||||| ..| ||..|| .  |  ||||..| .|...||   
MQIFVKWQNG---WKTFTFEVKPSDWTVSELKQHIEDKEGIPPEQQRLIYQGK-LEDD--TLADYNIQPGSTIHLMVR
Ubiquitin AqueK527.AA ubiquitin 167-232 33 1.4e-14 56.48 Pfam 1-68 (73) Show / Hide 
Range on Protein: 167-232
Range on HMM: 1-68/73
Sequence Identity: 33% (23 aa)

PIYSGK-DHIKLIVKSTDTIAHVKAMIVAKEGIPINKQCLIFNGKHIYADDATLADHKISSGD-ILHL
   .||  .. . |...||....|. | .|.|||...| ||..|| .  |. ||.|..| .|. ..|.
KTLDGKGSTFTFEVDPDDTVEQLKQKIQQKQGIPPDQQRLIYKGKQLREDHRTLSDYNIQDGSFTIHM
Rad60-SLD AqueK527.AA Rad60-SLD 170-234 23 0.001038 17.79 Pfam 8-73 (73) Show / Hide 
Range on Protein: 170-234
Range on HMM: 8-73/73
Sequence Identity: 23% (16 aa)

SGKD-HIKLIVKSTDTIAHVKAMIVAKEGIPI-NKQCLIFNGKHIYADDATLADHKISSGDILHLLY
.... .... || |.|......    |.|||  ... |||.|...  ...|..|  .  ||..... 
QDGKKEVFFKVKPTTTFSKLMNAYCKKRGIPEHQQVRLIFDGERL-DPNDTVEDYDMEDGDMIDVMI
CAP_GLY AqueK527.AA CAP_GLY 446-498 28 1.3e-09 35.71 Pfam 13-67 (72) Show / Hide 
Range on Protein: 446-498
Range on HMM: 13-67/72
Sequence Identity: 28% (16 aa)

MLQGKVMWIGKLPDTTE-VMAGIEL-NQSLEGCNDGTWRDQKYFSS-PPGRACFVP
.  | |...|..| .   . .|.|. ..   | |||..   .||.  ||... ||.
GRRGTVRYVGPTPGFKPGTWVGVEWDDEP-RGKNDGSVQGVRYFECRPPNHGIFVR
Kinase AqueK527.AA TKL 1055-1302 19 2.7e-44 153.5 In-house 1-364 (364) Show / Hide 
Range on Protein: 1055-1302
Range on HMM: 1-364/364
Sequence Identity: 19% (73 aa)

LGKGGWGEVVIGIFCE----------QRVAVKKLHD--VIVSDINL-----------------------ELIHREINTMAQLRHPNLLQFIGAIFDHP--
.|.|| |||  |..            . |||||..   .  ...|.                       . . .||. | .|||||..||.|. .. |  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------SGNPMIITEIM---D-VSLRKAYETKELTPDPQCRQIIFSIMRDVAVGLNYLHC--L----PDPIIHRDVSSANVLLESKGP---------
         .|...|..| .   .  ..                . ......|.| |.||||        . ||||||  |.|.|. ...          
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNP

-GKWKTKISDFGSAK----------------------IARSAFTKAAGAYVYSAPESLQSIIN----------IQKKLLTSKMDVFSYGVLLCEVINCQF
   |. ||.||| ..                        |..  .  | . . ||| |.  .|          ....  . |.||.|.|..|.|.. .. 
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR

PCSESFN-------------DLVEQVK------------------SSVSTLMYDLIIKCIEEEPTKRPTMKIVIQNI
| ..  .              .| . .                  ... . | .|. .| ...|.|||... ... .
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK527.AA TK 1049-1302 14 3.7e-33 107.93 In-house 1-486 (486) Show / Hide 
Range on Protein: 1049-1302
Range on HMM: 1-486/486
Sequence Identity: 14% (70 aa)

AITDELLGKGG---WGEVVIGIFCE---------------------------QRVAVKKLH---DVIVSDINLELIH---------REINTMAQLR----
 .  . ||.|    .|||  |.  .                           ..|||| |.   .    .  .| .|         .| . |....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLLQFIGAIFDHPS----------GNPMIITEIMD-VS----LRKAYETKE----------------------------------------------
 |||.....|..... .          . .||..| |.  .    ||.   ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------LTPDPQCRQIIFS-------------------IMRDVAVGLNYLHCLPD----PIIHRDVSSANVLLESKGPGKWK-------TKISDFGSAK-
      . |.| . .   .                   .....| |. ||| ..      ..|||.   |.|. .... ||.        ||.||| .. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----IARSAF-----TKAAGAYV---------------------------YSAPESLQS-IINIQ--KKLLTSKMDVFSYGVLLCEVIN---CQFPCSES
     ||        ... . ..                           . |||.|.. .   .  ..  |.| ||.|.|||. |.      ...   |
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

F---------NDLVEQVKS----------------------SVS--------------TLMYDLIIKCIEEEPTKRPTMKIVIQNI
           ...|....                        .              ...|||. .| ...| .|||.. . . .
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK527.AA MLK 1049-1252 25 2e-28 95.79 In-house 1-230 (291) Show / Hide 
Range on Protein: 1049-1252
Range on HMM: 1-230/291
Sequence Identity: 25% (59 aa)

AITDELLGKGGWGEVVIGIFCEQR-----VAVKKLH----DVIVSDINLELIHREINTMAQLRHPN----LLQFIGAIFDHPSGNPMIITEIMDV-SLRK
  . | .|.|. |.|  | .  ..     ||||. .    |. ...   . . .|..  . |.|||      || |.. ..|  .  |..| ..  ||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLYN

AYETKELTPD----------PQCRQIIFSIMRDVAVGLNYLHC-LPDPIIHRDVSSANVLLES--KGPGKWKTKISDFGSAK-IARS-A-FTKAAGAYVY
   ...  ..           .  . ..... ..| |..|||. .|.||||||  | |.|.    .  .. . ||.||| .. . .. .  ...|| | .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

SAPESLQSIINIQKKLLTSKMDVFSYGVLLCEVI
 ||| .|    ..    . | ||.|.||.| |..
MAPEVIQQ---FRCEKYSEKCDVWSWGVVLWEML
Kinase AqueK527.AA S_TKc 1049-1306 23 1.4e-27 98.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 1049-1306
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

AITDELLGKGGWGEVVIGIFCE--QRVAVKKLHDVIVSDINLELIHREINTMAQLRHPNLLQFIGAIFDHPSGNPMIITEIMDV---SLRKAYETKEL--
    ...|||. |.|  ..  .  ..||.|...         | | |||. . . .|||. ...... |   ..  ...| .|    .|..  . .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TPDPQCRQIIFSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKISDFGSAKIARSAFTKAAGAYVYSAPESLQSIINIQKKLLTS-KMD
.. |     . ..|. .. .|.|.| .   |||||.  .|.|| .        ||.|||.|..     |   |   | ||| |           .  | |
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL---------GYGKCKCD

VFSYGVLLCEVINCQFPCSESFNDLVEQVKSSVSTLMYDLIIKCIEEEPTKRPTMKIVIQ-----NIDKNF
. | |..| | .  . | .   . . ....   |  . |.| || . .|.||||   . |     ...  |
WWSCGCILYEMLCGYPPFP-QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK527.AA TKL-Unique 1053-1248 27 4.3e-24 81.97 In-house 3-218 (290) Show / Hide 
Range on Protein: 1053-1248
Range on HMM: 3-218/290
Sequence Identity: 27% (61 aa)

ELLGKGGWGEVVIGIFCEQRVAVKKLHDVIVSDINLELIH---REINTMAQLR-HPNLLQFIGAIFDHPSGNP--MIITEIMDV-SLRKAYE--------
...| || |.|  |..    ||.|..|    .|...|..    .|.|.|  |. |||.....|. .||   .|   |..| ..  ||..           
NKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-TKELTPDPQCRQIIFSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESK-GPGKWKTKISDFGSAKIARSAFTKAAG------------AYVYSAPES
  .......| |    .. .|.| |..||| .  ||||||  | |.|. ..    .|. ||.||| .|.. .  .. ..             . ..||| 
NNNNCKLNMQQR---VKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

LQSIINIQKKLLTSKMDVFSYGVLL
| .      .. . | ||.|.|. |
LRMNF----CQYSEKSDVYSFGIVL
Kinase AqueK527.AA Dicty4 1051-1248 29 1.3e-22 72.44 In-house 3-207 (277) Show / Hide 
Range on Protein: 1051-1248
Range on HMM: 3-207/277
Sequence Identity: 29% (64 aa)

TDELLGKGGWGEVVIGIFCEQRVAVKKL--HDVIVSDINLELIHREINTMAQLRHPNLLQFIGAIF--DHPSGNPMIITEIM-DVSLRKAYET------K
.....|||. |||  |.   . ||||||  | . ..   |.  ..|.. |...||||...| ||       .| ..| || |   .| .          .
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

ELTPD-PQCRQ-IIFSIMRDVAVGLNYLHC-LPDPIIHRDVSSANVLLESKGPGKWKTKISDFGSAK----IARSAF--TKAAGAYVYSAPESLQSIINI
. ..| |  .. .   ...|.| |.|.|||  |. |||||  |.| |        |. |..||| ..    .    .  . |.|   . ||| .      
SIKLDWPLIKRAM--RMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDK----NWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM------

QKKLLTSKMDVFSYGVLL
...  ..| ||.|.| .|
MHQPYNEKADVYSFGIVL
Kinase AqueK527.AA STE 1050-1296 18 2.1e-22 75.97 In-house 1-349 (359) Show / Hide 
Range on Protein: 1050-1296
Range on HMM: 1-349/359
Sequence Identity: 18% (67 aa)

ITD-ELLGKGGWGEVVIGIFC-----------------EQRVAVKKLH---------------DVIVSDINLELIHREINTMAQLR--HPNLLQFIGAIF
 .. | .|||. |.|. ..                    ...|.|...               . .. . ... | .||..| ...  |||  ...|. |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DH---PSG--NPMIITEIMDV-SLRKAYET--KELTPDPQCR--------QIIFSIMRDVAVG-LNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKIS
.     .   .  |. | ||  ||.. ...  . . |... |        ..|  | |..  | |.||| .   |||||. .||.||          |..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL---------VKLC

DFGSAKIARS-------------------AFTKAAGAYVYSAPESLQSIINIQKKL----LTSKMDVFSYGVLLCEVINCQFPCSE-SFN----------
||| ...  .                     .  .|   . |||    .|. ...      . | |. | | ...| .. . |... .            
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE----VIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNY

-------------DLVEQVKS-------------------SVSTLMYDLIIKCIEEEPTKRPTMK
             .   . ..                   ..|  . | | || . .| |||| .
HMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTAS
Kinase AqueK527.AA Pkinase 1049-1302 19 1.2e-19 70.58 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1049-1302
Range on HMM: 1-293/293
Sequence Identity: 19% (61 aa)

AITDELLGKGGWGEVVIGIFCEQR--VAVKKLHDVIVSDINLELIHR--EINTMAQLRHPNLLQFIGAIFDHPSGNPMIITEIMDV-----SLRKAYE--
  . . .|.|. |.| ...    .  ||||..  .  ..  ..   |  ||  |. |.||| ......  |  .... ...| ..      .|    .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

-TKEL--TPDPQCRQIIFSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKT----KISDFGSAK---IARSAFTKAAGAYVYSAPESLQSI
  . .  ...      . ..|. .. ||.|.|     |||||. ..|.|. ..|     .    ||.|||.||   . .. .|  .| . | ||| ..  
RHGCFYFSEW-----ECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNG----HIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIR--

INIQKKLLTSKMDVFSYGVLLCEVINCQFPCSES------------FNDLVEQVKSSVS-----------------------TLMYDLIIKCIEEEPTKR
     .  ..| |..|.|..| |... ..|....            ....  ..... .                         . |.| .|..  |.||
---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

PTMKIVIQN--I
|| . . |   .
PTAEQILQHPWF
Kinase AqueK527.AA TyrKc 1049-1302 23 3.8e-18 67.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 1049-1302
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

AITDELLGKGGWGEVVIGIFCEQRVAVKKLHDVIVSDINLELIHREINTMAQL--RHPNLLQFIGAIFDH-----PSGNPMIITEIMDV-SLRKAYETKE
   .. || |  |||. |.   . ||||.|..       .| ..||.. | .|  .|||.....|.. ..      .. .||..| |.  .|..    ..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

LTPDPQCRQIIFSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKISDFGSAKIARSA---------FTK-----AA--GAYVYSAPESL
 .    | .   |.. ..| | .|||    ..||||    |.|. ...      |||||| ..   .           .|     .     .   |||..
PK---LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

QSIINIQKKLLTSKMDVFSYGVLLCEVI-NCQFPCSE------SFNDLVEQVKSS----------------VSTLMYDLIIKCIEEEPTKRPTMKIVIQN
      ...  |.| ||.|.||.. |.  ..| | ..      |  ...|.||.                  .. ||... .| .|.| .|||.. ... 
------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

I
.
F
Kinase AqueK527.AA TK-Unique 1052-1248 25 1.3e-16 53.85 In-house 4-229 (294) Show / Hide 
Range on Protein: 1052-1248
Range on HMM: 4-229/294
Sequence Identity: 25% (60 aa)

DELLGKGGWGEVVIGIFCE--------QRVAVKKLHDVIVSDINLELIHREINTMAQLR-HPNLLQFIGAIFDHPSGNPMIITEIMDVS-----LRKAY-
....|.|  |.|  | ...        ..||||.|.|  ..|       .||. | .|  |||..|..|.  .   ...||| | .  .     ||. . 
GDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDN-ATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTCRP

ETKEL-------------TPDPQCRQII----FSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKISDFGSAK------IARSAFTKAA
....              ...|.   |     .... ..| |..||. ... |.|||... |||| .    . . ||.||| |.         .  ..  
AMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE----DKVCKICDFGMARDVYTNGVYSMMCSQGR

GAYVYSAPESLQSIINIQKKLL-TSKMDVFSYGVLL
  . . |||||.      ..   |.| || |.|||.
IPIRWMAPESLKCY----HGMYHTTKSDVWSFGVLM
Kinase AqueK527.AA CZAK 1150-1257 31 3.2e-14 48.16 In-house 106-221 (279) Show / Hide 
Range on Protein: 1150-1257
Range on HMM: 106-221/279
Sequence Identity: 31% (38 aa)

IIFSIMRDVAVGLNYLHC--LPDPIIHRDVSSANVLLESKGP---------GKWKTKISDFGSA---KIARSAFTKAAGAYVYSAPESLQSIINIQKKLL
.  .. .|.| | ||||    | ||.||| || |.||..               . ||.|||     .   .  | . |   . |||      .      
LQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENY------

TSKMDVFSYGVLLCEVINCQFP
| | ||.|.| .| ..| |  |
TEKVDVYSFGMILWCIITCDQP
Kinase AqueK527.AA DRK 1056-1128 44 6.5e-13 40.1 In-house 8-79 (258) Show / Hide 
Range on Protein: 1056-1128
Range on HMM: 8-79/258
Sequence Identity: 44% (33 aa)

GKGGWGEVVIGIFCEQRVAVKKLHDVIVSDIN-LELIHREINTMAQLRHPNLLQFIGAIFDHPSGNPMIITEIM
|.|..|||  |      ||||.|    . | | |   ||||| | ||||||  ||.|.    |.  . |..| |
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPD--ICICMEYM
Kinase AqueK527.AA Pkinase_Tyr 1049-1126 28 1.4e-12 43.22 Pfam 1-87 (270) Show / Hide 
Range on Protein: 1049-1126
Range on HMM: 1-87/270
Sequence Identity: 28% (25 aa)

AITDELLGKGGWGEVVIGIFC------EQRVAVKKLHDVIVSDIN--LELIHREINTMAQL-RHPNLLQFIGAIF--DHPSGNPMIITE
 . .. ||.|  |||. |.        .. ||||.| .   .. .  .|   ||...| || .|||.....|..   . |. ...|..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVME
Kinase AqueK527.AA STE-Unique 1151-1204 38 5e-10 31.23 In-house 405-459 (616) Show / Hide 
Range on Protein: 1151-1204
Range on HMM: 405-459/616
Sequence Identity: 38% (21 aa)

IFSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKW-KTKISDFGSAKI
.. . . .. ||.|||   .||||||. ..|... ..| |.  | ||.||| |..
VIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATC
Kinase AqueK527.AA DRK 1153-1252 32 3.3e-09 27.36 In-house 102-196 (258) Show / Hide 
Range on Protein: 1153-1252
Range on HMM: 102-196/258
Sequence Identity: 32% (34 aa)

SIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKISDFGSAK----IARSAFTK-AAGAYVYSAPESLQSIINIQKKLLTSKMDVFSYGVL
..| |.| |..||||    |||||  | | |        |. |..||| .     .    |.. . |     ||| | .         | | ||.|... 
QMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDE----HWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRN------QRYTEKADVYSFAIV

LCEVI
| |..
LWECV
Kinase AqueK527.AA STE-Unique 1050-1115 25 7.3e-08 23.41 In-house 1-72 (616) Show / Hide 
Range on Protein: 1050-1115
Range on HMM: 1-72/616
Sequence Identity: 25% (18 aa)

ITDELLGKGGWGEVVIGI--FCEQRVAVKKLHDVIVSDIN----LELIHREINTMAQLRHPNLLQFIGAIFD
.  . .|.|. |.|.  .      |.|.|..|  . .| |     . | .|| .|. |.|.|    .|....
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLW
Kinase AqueK527.AA CZAK 1052-1112 29 2e-06 19.61 In-house 4-68 (279) Show / Hide 
Range on Protein: 1052-1112
Range on HMM: 4-68/279
Sequence Identity: 29% (19 aa)

DELLGKGGWGEVVIGIFCEQRVAVKKLHDVIVSDINL----ELIHREINTMAQLRHPNLLQFIGA
    |.|  |||  .   .  ||.|..|     .       .   .|.  |  |.||| .||.||
GQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGA
Kinase AqueK527.AA Dicty4 1279-1304 28 5e-06 16.38 In-house 250-277 (277) Show / Hide 
Range on Protein: 1279-1304
Range on HMM: 250-277/277
Sequence Identity: 28% (8 aa)

DLIIKCIEEEPTKRPTMKIVIQN--IDK
.|| .| ...|..||... .||    . 
HLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK527.AA Pkinase_Tyr 1153-1200 31 4.5e-05 17.81 Pfam 115-156 (270) Show / Hide 
Range on Protein: 1153-1200
Range on HMM: 115-156/270
Sequence Identity: 31% (15 aa)

SIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKISDFG
.. ...| |..||.  .  .||||.   |.|...   .. . ||.|||
QMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE---NN-VVKICDFG
Kinase AqueK527.AA DRK 1280-1304 28 0.000109 11.84 In-house 234-258 (258) Show / Hide 
Range on Protein: 1280-1304
Range on HMM: 234-258/258
Sequence Identity: 28% (7 aa)

LIIKCIEEEPTKRPTMKIVIQNIDK
|.. | .|.|. ||.|  ... .. 
LMNDCWNEDPQHRPSMQECLERLEA
Kinase AqueK527.AA Pkinase_Tyr 1277-1302 30 0.000143 16.1 Pfam 245-270 (270) Show / Hide 
Range on Protein: 1277-1302
Range on HMM: 245-270/270
Sequence Identity: 30% (8 aa)

MYDLIIKCIEEEPTKRPTMKIVIQNI
.|||. .| ...| .|||.. ... .
IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK527.AA TK-Unique 1277-1302 30 0.000534 9.82 In-house 269-294 (294) Show / Hide 
Range on Protein: 1277-1302
Range on HMM: 269-294/294
Sequence Identity: 30% (8 aa)

MYDLIIKCIEEEPTKRPTMKIVIQNI
|| |.. |. .||..||.   ... .
MYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK527.AA STE-Unique 1263-1304 19 0.000933 8.56 In-house 575-616 (616) Show / Hide 
Range on Protein: 1263-1304
Range on HMM: 575-616/616
Sequence Identity: 19% (8 aa)

NDLVEQVKSSVSTLMYDLIIKCIEEEPTKRPTMKIVIQNIDK
. ..|   .. . .. ..|.||.| .|..||. .   .   .
QCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase AqueK527.AA MLK 1280-1302 30 0.002322 7.67 In-house 269-291 (291) Show / Hide 
Range on Protein: 1280-1302
Range on HMM: 269-291/291
Sequence Identity: 30% (7 aa)

LIIKCIEEEPTKRPTMKIVIQNI
|. .| ...| |||... ..|  
LMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK527.AA TKL-Unique 1279-1302 33 0.017055 4.83 In-house 267-290 (290) Show / Hide 
Range on Protein: 1279-1302
Range on HMM: 267-290/290
Sequence Identity: 33% (8 aa)

DLIIKCIEEEPTKRPTMKIVIQNI
||| .|   .|..||.   .|  .
DLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK527.AA CZAK 1280-1302 34 0.120393 1.94 In-house 257-279 (279) Show / Hide 
Range on Protein: 1280-1302
Range on HMM: 257-279/279
Sequence Identity: 34% (8 aa)

LIIKCIEEEPTKRPTMKIVIQNI
|| .| .  |  ||. | ..|  
LIEMCWNKNPDERPSFKQILQHL
Kinase AqueK527.AA Pkinase_Tyr 1220-1248 37 2.345161 1.83 Pfam 182-204 (270) Show / Hide 
Range on Protein: 1220-1248
Range on HMM: 182-204/270
Sequence Identity: 37% (11 aa)

APESLQSIINIQKKLLTSKMDVFSYGVLL
|||...  .       |.| || |.|||.
APECINYGK------FTTKSDVWSFGVLM