Gene AqueK540 (A.queenslandica)

AqueK540

Species: A.queenslandica
Alias: AqueK540
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a2

Sequence

Name Sequence Type Origin Length Description Download
AqueK540.AA Protein None 1056 None Fasta, JSON
AqueK540.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of AqueK540.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
UBQ AqueK540.AA UBQ 62-135 32 1.7e-13 52.11 SMART 1-72 (72) Show / Hide 
Range on Protein: 62-135
Range on HMM: 1-72/72
Sequence Identity: 32% (25 aa)

LNVFIKLGPNS-STVAIEVEPSD-TVKKVKKKIAEKESLLADKLQILTIDNKELQDSDVLQDHSIENEATVICTVS
...|.| ..|. .|...||.||| ||...|..|..||   ... | |. . | |.|   |.|. |....|. . |.
MQIFVK-WQNGWKTFTFEVKPSDWTVSELKQHIEDKEGIPPEQ-QRLIYQGK-LEDD-TLADYNIQPGSTIHLMVR
Ubiquitin AqueK540.AA ubiquitin 67-137 31 4.4e-11 43.76 Pfam 1-73 (73) Show / Hide 
Range on Protein: 67-137
Range on HMM: 1-73/73
Sequence Identity: 31% (23 aa)

KLGPNS-STVAIEVEPSDTVKKVKKKIAEKESLLADKLQILTIDNKEL-QDSDVLQDHSIENEA-TVICTVSQS
|   .. ||. .||.|.|||...|.||..|.   .   | |  . |.| .|   |.|. |. .. |... ..|.
KTLDGKGSTFTFEVDPDDTVEQLKQKIQQKQG-IPPDQQRLIYKGKQLREDHRTLSDYNIQDGSFTIHMVLRQR
Rad60-SLD AqueK540.AA Rad60-SLD 62-130 20 8.3e-05 21.93 Pfam 1-69 (73) Show / Hide 
Range on Protein: 62-130
Range on HMM: 1-69/73
Sequence Identity: 20% (14 aa)

LNVFIKLGPNSS-TVAIEVEPSDTVKKVKKKIAEKESLLADKLQILTIDNKELQDSDVLQDHSIENEATV
.|...| ...   .| ..|.|..|..|.... ..|... ... . |  | ..|.. |...|  .| . ..
INIKLK-CQDGKKEVFFKVKPTTTFSKLMNAYCKKRGIPEHQQVRLIFDGERLDPNDTVEDYDMEDGDMI
UBQ AqueK540.AA UBQ 227-298 36 3.8e-10 40.97 SMART 1-72 (72) Show / Hide 
Range on Protein: 227-298
Range on HMM: 1-72/72
Sequence Identity: 36% (27 aa)

IQIVVKTDSG-RTISLDVLPID-NVGRVKTIIEDKLAIPFKKQEVLFDGTLLEDNDTLFRCGINKGGQLQLHYL
.|| ||.  | .|. ..| | | .|  .|  ||||. ||  .| ....|  |||. ||  ..| .|  . |.  
MQIFVKWQNGWKTFTFEVKPSDWTVSELKQHIEDKEGIPPEQQRLIYQGK-LEDD-TLADYNIQPGSTIHLMVR
Ubiquitin AqueK540.AA ubiquitin 232-296 33 5.5e-09 36.15 Pfam 1-67 (73) Show / Hide 
Range on Protein: 232-296
Range on HMM: 1-67/73
Sequence Identity: 33% (23 aa)

KTDSGR--TISLDVLPIDNVGRVKTIIEDKLAIPFKKQEVLFDGTLL-EDNDTLFRCGINKGGQLQLH
|| .|.  |....| | | |  .|  |..|  ||  .| ....| .| ||. ||. ..| .|  ...|
KTLDGKGSTFTFEVDPDDTVEQLKQKIQQKQGIPPDQQRLIYKGKQLREDHRTLSDYNIQDGS-FTIH
Rad60-SLD AqueK540.AA Rad60-SLD 227-282 27 0.001703 16.98 Pfam 1-58 (73) Show / Hide 
Range on Protein: 227-282
Range on HMM: 1-58/73
Sequence Identity: 27% (16 aa)

IQIVVKTDSGR-TISLDVLPIDNVGRVKTIIEDKLAIPF-KKQEVLFDGTLLEDNDTL
|.|..|.  |  .... | | . .  .. .  .|. ||. ...  .|||  |..|||.
INIKLKCQDGKKEVFFKVKPTTTFSKLMNAYCKKRGIPEHQQVRLIFDGERLDPNDTV
UBQ AqueK540.AA UBQ 299-364 17 0.065568 0.14 SMART 1-72 (72) Show / Hide 
Range on Protein: 299-364
Range on HMM: 1-72/72
Sequence Identity: 17% (13 aa)

VTIHIKALTGANYPSLEMMTPV-SVEAIKENIQ-----PKD-QNLYFAGQLVRDGGIFFCEYEADEIVFQLSR
..|..| ..|...  .|.     .|. .|. |.     | . | |...|.  .|. .  .  . . ..    |
MQIFVKWQNGWKTFTFEVKPSDWTVSELKQHIEDKEGIPPEQQRLIYQGK-LEDDTLADYNIQPGSTIHLMVR
Ubiquitin AqueK540.AA ubiquitin 203-227 33 2.777493 4.45 Pfam 47-73 (73) Show / Hide 
Range on Protein: 203-227
Range on HMM: 47-73/73
Sequence Identity: 33% (9 aa)

L-DDLQSLSHYNIEYGA-TLRLEWSPI
| .| ..||.|||. |. |. .  .. 
LREDHRTLSDYNIQDGSFTIHMVLRQR
RING AqueK540.AA RING 376-417 23 0.000128 22.05 SMART 1-23 (23) Show / Hide 
Range on Protein: 376-417
Range on HMM: 1-23/23
Sequence Identity: 23% (10 aa)

CTQCNEAIEIGDGVVLANCSHLLCRLCMDKSVKIKDGECILC
|. | |       .|. .| |  |. |.          | .|
CPICLE-------PVVLPCGH-FCY-CI----------CPIC
Zf-C3HC4 AqueK540.AA zf-C3HC4 376-417 16 0.000575 12.52 Pfam 1-48 (48) Show / Hide 
Range on Protein: 376-417
Range on HMM: 1-48/48
Sequence Identity: 16% (8 aa)

CTQCNEAIEIGDGVVLANCSHL-----LCRLCMDKSVKIKDGE-CILC
|  | .  .      .  | |       |. |. . ....    | .|
CWICHCEWKDPNNPLIHPCGHRGSLKWFCHSCIKRWWNHSGNTQCPIC
Kinase AqueK540.AA TKL 756-1011 20 3e-49 169.93 In-house 1-364 (364) Show / Hide 
Range on Protein: 756-1011
Range on HMM: 1-364/364
Sequence Identity: 20% (75 aa)

LGRGAFGTVFVGKFRG----------QSVAVKQLHKV------------------------LQSPENINKMNREID-ILSQLRHPNIVQFIGAIFDHP--
.|.|.||.|. ||.||          . ||||....                          . .. ...  .|   ..|.|||||||||.|. .. |  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------DGDPLIITELM-DTSLREAYEGKKLTPNPSCRPVILSIMHDVAVGLNYLHTLPI-----DNIVHRDVSSANVLLESKGP----------GK
         .|.. |..|..   ||.. .            ........|.| |.||||.         .|.|||  |.|.|. ...             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

WKTKISDFGSAN----------------------IVRCAVSRAPGAEVYSAPECFQSVTNQYSA----------LQTPKMDVYSYGVLFCEALTCKFPDR
|. ||.||| .                         |.. ..  |   . |||...  .|  ..            ..|.||||.|....| ||.. | .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

-SSFQDML------QQVWSSTKSVGLITRS------------LHH-----ELIKSCTKDNPYKRPTMNEVIMDT
   . .|.      .  .   .     ..              .      .|.. | . .| |||...|..   
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK540.AA TK 750-1011 16 3.4e-36 118.31 In-house 1-486 (486) Show / Hide 
Range on Protein: 750-1011
Range on HMM: 1-486/486
Sequence Identity: 16% (78 aa)

TQSEKELGRGAFG---TVFVGKFRG---------------------------QSVAVKQLHKV-LQSPENINK--MN---------REIDILSQLR----
 . .|.||.|.||   .|. |. ||                           . ||||.|..   .|.|      |.         .|  ......    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVQFIGAIFDHPD----------GDPLIITELMD-TS----LREAYEGKK----------------------------------------------
 |||||...|.....            . ..|..|.|.  .    ||.    ..                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------LTPNPSCRPVILS-------------------IMHDVAVGLNYLHTLPI---DNIVHRDVSSANVLLESKGPGKWK-------TKISDFGSA--
      . |.| .    |.                   .....| |. ||| ...    |.||||.   |.|. .... ||.        ||.||| .  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

-------------NIVRCA-VSRAPGAEV----------------------YSAPECFQSVTNQYS---ALQTPKMDVYSYGVLFCEALT---CKFPDRS
             . .|    ... ..                        . ||||... .   .      |.| ||.|.|||  | .|     ..   
GSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SFQD-----MLQQVWSSTKSV-------------GLITR--------------------SLHHELIKSCTKDNPYKRPTMNEVIMDT
| ||      .|.|    ..              ..                        ....|...| . .| .|||. ..    
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
S_TKc AqueK540.AA S_TKc 750-1015 23 2.5e-35 124.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 750-1015
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

TQSEKELGRGAFGTVFVGKFRG--QSVAVKQLHKVLQSPENINKMNREIDILSQLRHPNIVQFIGAIFDHPDGDPLIITELMDT---SLREAYEGKKLTP
 .  ...|.||||.|. .. ..  . ||.|...         ... |||.||.. .|||||...... |   ..  ...|..|.   .|..  . ..  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

NP--SCRPVILSIMHDVAVGLNYLHTLPIDNIVHRDVSSANVLLESKGPGKWKTKISDFGSANIVRCAVSRAPGAEVYSAPECFQSVTNQYSALQTPKMD
..      .. ..|. .. .|.|.| .   .|.|||.  .|.|| .        ||.|||.| ..    .   |   | ||| .           ..| |
LRFPFPE-HARFYMYQICCALEYCHSH---GIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL--------GYGKCKCD

VYSYGVLFCEALTCKFPDRSSFQDMLQQVWSSTKSVGLITRSLHHELIKSCTKDNPYKRPTMNEVIMDT-----IPPV
..| |... | |. . | .   | |....          .... . .|. | . .| ||||  |.  |       | .
WWSCGCILYEMLCGYPPFP-QMQMMFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK540.AA MLK 750-959 25 5.5e-32 108.29 In-house 1-235 (291) Show / Hide 
Range on Protein: 750-959
Range on HMM: 1-235/291
Sequence Identity: 25% (62 aa)

TQSEKELGRGAFGTVFVGKFRGQS-----VAVKQLH----KVLQSPENINKMNREIDILSQLRHPN----IVQFIGAIFDHPDGDPLIITELMDT-SLRE
 | .. .| |.|| |. |..|..      ||||. .     . .. . . ....|. .|. |.|||    |.|| |.. ..|  . .|..| ..  || .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLYN

AYEGKKLTPNPSC----------RPVILSIMHDVAVGLNYLHTLPIDNIVHRDVSSANVLLES--KGPGKWKTKISDFGSANIVRCA---VSRAPGAEVY
   |..  ....             .........| |..||| .  . |.|||  | |.|.    .  .. . ||.||| .  . .       ..|   .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

SAPECFQ-SVTNQYSALQTPKMDVYSYGVLFCEALTCKFP
 ||| .| .  ..||     | ||.|.||.. | ||.. |
MAPEVIQQFRCEKYSE----KCDVWSWGVVLWEMLTREVP
Kinase AqueK540.AA Dicty4 751-902 31 1e-30 99.83 In-house 2-159 (277) Show / Hide 
Range on Protein: 751-902
Range on HMM: 2-159/277
Sequence Identity: 31% (54 aa)

QSEKELGRGAFGTVFVGKFRGQSVAVKQL--HKVLQSPENINKMNREIDILSQLRHPNIVQFIGAIF---DHPDGDPLIITELM-DTSLREAYEG-----
. |...|.|.||.|. |. ||. |||| |  |..  . . .|   .|..|....|||||..| ||      || |...| ||.|  ..| .         
NIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHP-GKMCIVTEYMPKGNLYSLLHDKPSEQ

-KKLTPNPSCRP--VILS---IMHDVAVGLNYLHT-LPIDNIVHRDVSSANVLLESKGPGKWKTKISDFG
 .. ..     .   |..   .. |.| |.|.||.  |.  |.|||  |.| |        |. |..|||
QQSIKL-----DWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDK----NWRVKVCDFG
Kinase AqueK540.AA STE 751-904 24 1.2e-30 105.49 In-house 1-194 (359) Show / Hide 
Range on Protein: 751-904
Range on HMM: 1-194/359
Sequence Identity: 24% (50 aa)

QSE-KELGRGAFGTVFVGKFR-----------------GQSVAVKQLHKVLQSP---------------ENINKMNREIDILSQLR--HPNIVQFIGAIF
.   ...|.||||||. .. .                 |. .|.||...  ...               |....  .||.|.....  |||||...|. |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DHP-----DGDPLIITELMD-TSLREAYEG--KKLTPNPSCR--------PVILSIMHDVAVG-LNYLHTLPIDNIVHRDVSSANVLLESKGPGKWKTKI
.       |..  |. |.||  ||.. ..   ... |... |        ..|  | ...  | |.||| .    |.|||. .||.||          |.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL---------VKL

SDFGSA
.||| .
CDFGVC
Kinase AqueK540.AA TKL-Unique 754-959 28 1.9e-30 104.65 In-house 3-233 (290) Show / Hide 
Range on Protein: 754-959
Range on HMM: 3-233/290
Sequence Identity: 28% (67 aa)

KELGRGAFGTVFVGKFRGQSVAVKQLHK-VLQSPENINKMNREIDILSQLR-HPNIVQFIGAIFDHPDGDP--LIITELMDT-SLREAYE---------G
. .|.|..|.|. ||.|| .||.||.|.  ..|.| . . ..|. ... |. |||||...|. .||    |   |..| ..  ||..             
NKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

KKLTPNPSCRPVILSIMHDVAVGLNYLHTLPIDNIVHRDVSSANVLLESK-GPGKWKTKISDFG----SANIVRCAVSRA-----PGAE---VYSAPECF
.....|..   ..... .|.| |..|||..    | |||  | |.|. ..    .|. ||.|||    ...| .  ...      .. .    ..||| .
NNCKLNMQ---QRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

QSVTNQYSALQTPKMDVYSYGVLFCEALTCKF------P
 .. .|||     | ||||.|.   | .| |       |
RMNFCQYSE----KSDVYSFGIVLWEIATRKITKTYKKP
Kinase AqueK540.AA CZAK 751-959 30 9e-28 98.0 In-house 2-221 (279) Show / Hide 
Range on Protein: 751-959
Range on HMM: 2-221/279
Sequence Identity: 30% (69 aa)

QSEKELGRGAFGTVFVGKFRGQSVAVKQLH----KVLQSPENINKMNREIDILSQLRHPNIVQFIGAIFDHPDGDPLIITELMD-TSLREAYEGKK--LT
. ... |.| || |  .  || .||.| .|    . . .    |   .|. |.| |.|||.|||.||     . .  |..| |   |||     .   . 
KFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHK

PNPSCRPVILSIMHDVAVGLNYLHT-LPIDNIVHRDVSSANVLLESKGP---------GKWKTKISDFGSA---NIVRCAVSRAPGAEVYSAPECFQSVT
.||. .   ...  |.| | ||||.      |.||| || |.||..               . ||.|||              . |   . |||||    
QNPHLQ---WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGEN

NQYSALQTPKMDVYSYGVLFCEALTCKFP
.      |.| ||||.| .  . .||  |
Y------TEKVDVYSFGMILWCIITCDQP
Kinase AqueK540.AA Pkinase_Tyr 750-902 29 2.3e-27 93.3 Pfam 1-156 (270) Show / Hide 
Range on Protein: 750-902
Range on HMM: 1-156/270
Sequence Identity: 29% (48 aa)

TQSEKELGRGAFGTVFVGKFR------GQSVAVKQLHKVLQSPEN--INKMNREIDILSQL-RHPNIVQFIGAIF--DHPDGDPLIITELMDT-SLREAY
 .  |.||.||||.|. |. .      .. |||| | |   ..|.  . .. ||. |..|| .|||||...|..   . |   ..|..|.|   .|..  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYL

EGKKLTPNPSCRPVILSIMHDVAVGLNYLHTLPIDNIVHRDVSSANVLLESKGPGKWKTKISDFG
  ..  ..| . . .|.. ...| |..||.  .   ..|||.   |.|...   .. . ||.|||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE---NN-VVKICDFG
Kinase AqueK540.AA Pkinase 750-959 23 1.1e-25 91.94 Pfam 1-211 (293) Show / Hide 
Range on Protein: 750-959
Range on HMM: 1-211/293
Sequence Identity: 23% (54 aa)

TQSEKELGRGAFGTVFVGKFRGQS--VAVKQLHKVLQSP-ENINKMN-REIDILSQLRHPNIVQFIGAIFDHPDGDPLIITELMDT-----SLREAYE--
 . .. .|.|.||.|. .. .| .  ||||.. |. ... ..... . .|| |.  |.|||||.....  |  .... ...|...      .| .  .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

-GKKL--TPNPSCRPVILSIMHDVAVGLNYLHTLPIDNIVHRDVSSANVLLESKGPGKWKT----KISDFGSA----NIVRCAVSRAPGAEVYSAPECFQ
 ....  ...     .. ..|  .. ||.|.|     .|.|||. ..|.|. ..|     .    ||.|||.|    .      .   |   | |||  .
RHGCFYFSEW-----ECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNG----HIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR

SVTNQYSALQTPKMDVYSYGVLFCEALTCKFP
      .   .|| |..|.|... | |. ..|
-----GGQYYGPKVDMWSCGCILYEMLCGRPP
Kinase AqueK540.AA LRRK 750-949 21 1.1e-23 80.62 In-house 1-271 (351) Show / Hide 
Range on Protein: 750-949
Range on HMM: 1-271/351
Sequence Identity: 21% (61 aa)

TQSEKELGRGAFG-TVFVGKFRG----------------------------QSVAVKQLHK--------------------------------VLQSPEN
  .|...|||.|| .|. .|.||                            |.||.|....                                   ....
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

INKMNREIDILSQLRHPNIVQFIGAIFDHPDGDPLIITELMDT-SLREAYEGKKLTPN----PS-CRPVILSIMHDVAVGLNYLHTLPIDN--IVHRDVS
 ..  .|. |.| |.|||||. .|  ...    . ...|...  .| .  . || ..     ..  . ..| |. ..| |..|||     |  |.|||  
FREFRHEVWIMSHLNHPNIVSLKGFCIHP----LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS---HNPPIIHRDLK

SANVLL-ESKGP-------GKWKTKISDFGSAN---IVRCA-VSRAPGAEVYSAPECFQSV-TNQYSALQTPKMDVYSYGVL
| |.|| .|. .          . ||.|||      ... . ...  | ... |||. .   . .|    | | |.||.|..
SPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEY----TEKVDCYSFGMI
Kinase AqueK540.AA LISK 755-813 43 1.1e-23 73.67 In-house 1-64 (296) Show / Hide 
Range on Protein: 755-813
Range on HMM: 1-64/296
Sequence Identity: 43% (28 aa)

ELGRGAFGTVFVGKFR--GQSVAVKQLHK---VLQSPENINKMNREIDILSQLRHPNIVQFIGA
|.|.|.|| |. |  |  || .|.|..|.   ..  ||.. .|.||. ..  |||||||||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV
Kinase AqueK540.AA DRK 757-829 47 4.6e-20 64.66 In-house 8-79 (258) Show / Hide 
Range on Protein: 757-829
Range on HMM: 8-79/258
Sequence Identity: 47% (35 aa)

GRGAFGTVFVGKFRGQSVAVKQLHKVLQSPENI-NKMNREIDILSQLRHPNIVQFIGAIFDHPDGDPLIITELM
||| .| || |  ||  |||| |       ||. | . |||....|||||||.||.|.    |  |..|..| |
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPP--DICICMEYM
Kinase AqueK540.AA TyrKc 750-1012 24 3.1e-17 56.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 750-1012
Range on HMM: 1-280/280
Sequence Identity: 24% (74 aa)

TQSEKELGRGAFGTVFVGKFRGQSVAVKQLHKVLQSPENINKMNREIDILSQL--RHPNIVQFIGAIFDH-----PDGDPLIITELMDT-SLREAYEGKK
 . .|.||.||||.|. |. . . |||| |..       .  . ||. |...|  .|||||...|.. ..      .. ..|..|.|.  .|..    ..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

LTPNPSCRPVILSIMHDVAVGLNYLHTLPIDNIVHRDVSSANVLLESKGPGKWKTKISDFGSANIVRCA--------VSRA---PGAE--V---YSAPEC
 .    | .  ||.....| | .|||     |..|||    |.|. ...      |||||| .  .           . |.    |.   .     ||||
PK---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

FQSVTNQYSALQTPKMDVYSYGVLFCEALTCKFPDRSS-FQ--DMLQQVWSSTKSVGLITRSLH-------------HELIKSCTKDNPYKRPTMNEVIM
.   .. .    |.| ||.|.||.  | .|   .  .   |     |.|    |. .   .  .             ....|.| . .| .|||..|.  
I--NYGKF----TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-H

DTI
. .
ECF
Kinase AqueK540.AA DRK 850-902 40 4.2e-07 20.15 In-house 98-145 (258) Show / Hide 
Range on Protein: 850-902
Range on HMM: 98-145/258
Sequence Identity: 40% (22 aa)

PVILSIMHDVAVGLNYLHTL-PIDNIVHRDVSSANVLLESKGPGKWKTKISDFG
| ....| |.| |..|||   ||  |.|||  | | |        |. |..|||
PLMKQMMFDCAKGMIYLHCCNPI--IIHRDLKSHNLLVDE----HWQVKVADFG
Kinase AqueK540.AA LISK 858-902 42 1.1e-05 14.28 In-house 109-150 (296) Show / Hide 
Range on Protein: 858-902
Range on HMM: 109-150/296
Sequence Identity: 42% (19 aa)

DVAVGLNYLHTLPIDNIVHRDVSSANVLLESKGPGKWKTKISDFG
|.| |. |||     ||.|||  | |.|.  .. . |. |. |||
DIACGMSYLHS---MNIIHRDLKSKNCLVRENDNNQWRIKVCDFG
Kinase AqueK540.AA LRRK 988-1008 33 0.000848 9.3 In-house 326-346 (351) Show / Hide 
Range on Protein: 988-1008
Range on HMM: 326-346/351
Sequence Identity: 33% (7 aa)

ELIKSCTKDNPYKRPTMNEVI
.||..| . .| |||......
DLIQHCWQHDPKKRPHFSQIV
Kinase AqueK540.AA Dicty4 988-1011 28 0.002794 6.99 In-house 250-277 (277) Show / Hide 
Range on Protein: 988-1011
Range on HMM: 250-277/277
Sequence Identity: 28% (8 aa)

ELIKSCTKDNPYKRPTMNEVI----MDT
.||. |   .| .||...|.|    ...
HLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK540.AA MLK 988-1011 29 0.007069 5.97 In-house 268-291 (291) Show / Hide 
Range on Protein: 988-1011
Range on HMM: 268-291/291
Sequence Identity: 29% (7 aa)

ELIKSCTKDNPYKRPTMNEVIMDT
.|.| | ...| |||.. ....  
KLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK540.AA TKL-Unique 988-1011 33 0.008723 5.87 In-house 267-290 (290) Show / Hide 
Range on Protein: 988-1011
Range on HMM: 267-290/290
Sequence Identity: 33% (8 aa)

ELIKSCTKDNPYKRPTMNEVIMDT
.||. | ...| .||. .|.|   
DLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK540.AA DRK 989-1011 28 0.01549 4.45 In-house 234-258 (258) Show / Hide 
Range on Protein: 989-1011
Range on HMM: 234-258/258
Sequence Identity: 28% (7 aa)

LIKSCTKDNPYKRPTMNEV--IMDT
|.. |   .|  ||.| |.  ... 
LMNDCWNEDPQHRPSMQECLERLEA
Kinase AqueK540.AA LISK 942-952 54 0.146167 0.61 In-house 221-231 (296) Show / Hide 
Range on Protein: 942-952
Range on HMM: 221-231/296
Sequence Identity: 54% (6 aa)

DVYSYGVLFCE
||.|.|.. ||
DVFSFGIVLCE
Kinase AqueK540.AA CZAK 988-1012 36 0.403043 0.01 In-house 256-279 (279) Show / Hide 
Range on Protein: 988-1012
Range on HMM: 256-279/279
Sequence Identity: 36% (9 aa)

ELIKSCTKDNPYKRPTMNEVIMDTI
|||  | . ||  ||.  . |..  
ELIEMCWNKNPDERPSFKQ-ILQHL