Gene AqueK543 (A.queenslandica)

AqueK543

Species: A.queenslandica
Alias: AqueK543
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK543.AA Protein None 426 None Fasta, JSON
AqueK543.kin_dom Protein Kinase Domain None 115 None Fasta, JSON

Protein domain

Protein domains of AqueK543.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CAP_GLY AqueK543.AA CAP_GLY 70-140 31 1.5e-18 66.36 Pfam 1-72 (72) Show / Hide 
Range on Protein: 70-140
Range on HMM: 1-72/72
Sequence Identity: 31% (23 aa)

IGSMVRIDTVKGDPLYGVVKWIGPVPDYPG-TIAGVEM-EKPLRDCTDGTWRGIRFFTC-PPGRGYFCPLNTLK
.|. ...    |.  .|.|...||.|  .. | .|||.  .| |   ||.. |.| |.| ||..| |.. ....
VGDRCEV-WDGGGGRRGTVRYVGPTPGFKPGTWVGVEWDDEP-RGKNDGSVQGVRYFECRPPNHGIFVRPSKVE
Kinase AqueK543.AA TKL 313-421 21 1.4e-20 70.84 In-house 1-147 (364) Show / Hide 
Range on Protein: 313-421
Range on HMM: 1-147/364
Sequence Identity: 21% (33 aa)

LGRGGWGVIWMGEFRG----------QRVAVKQMHD--VIKSEDNM-----------------------DLLHREINTMSQLRHPNLLQFIGAVLDDDDD
.|.|| |... |..||          . ||||...   . ....|.                       . . .||. ||.|||||..||.|.... ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PLIITELM-DTSLRKAYERKELTTDPGCRPVILSIMRDVAVGLNY
            . |..|..   ||.  .            ........|.| |.||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNY
Pkinase_Tyr AqueK543.AA Pkinase_Tyr 306-385 27 2.2e-18 62.9 Pfam 1-89 (270) Show / Hide 
Range on Protein: 306-385
Range on HMM: 1-89/270
Sequence Identity: 27% (25 aa)

ISLSRKELGRGGWGVIWMGEFR------GQRVAVKQMHDVIKSED--NMDLLHREINTMSQL-RHPNLLQFIGAVLDDDDD--PLIITELM
|..  |.||.|  |....|. .      .. |||| . .   .|.    |... |...|.|| .|||.....|...|...   ..|..|.|
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYM
Kinase AqueK543.AA Dicty4 310-389 30 3.1e-17 54.21 In-house 4-89 (277) Show / Hide 
Range on Protein: 310-389
Range on HMM: 4-89/277
Sequence Identity: 30% (26 aa)

RKELGRGGWGVIWMGEFRGQRVAVKQM--HDVIKSEDNMDLLHREINTMSQLRHPNLLQFIGAVL---DDDDDPLIITELM-DTSL
 ...|.|. |    |  ||. |||| .  | .  .|. .  ...|.. |...||||...| || .       ...| ||.|  ..|
EQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNL
Kinase AqueK543.AA LISK 312-386 32 2.2e-16 49.57 In-house 1-80 (296) Show / Hide 
Range on Protein: 312-386
Range on HMM: 1-80/296
Sequence Identity: 32% (26 aa)

ELGRGGWGVIWMGEFR--GQRVAVKQMH---DVIKSEDNMDLLHREINTMSQLRHPNLLQFIGAVLDDDDDPLIITELMD
|.|.|. | .  |. |  || .|.|. |   .. . ...   . ||. .|  ||||| .||.|.   .|.   |.||...
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYIN
Kinase AqueK543.AA DRK 314-385 42 4.6e-16 50.94 In-house 8-79 (258) Show / Hide 
Range on Protein: 314-385
Range on HMM: 8-79/258
Sequence Identity: 42% (31 aa)

GRGGWGVIWMGEFRGQRVAVKQMHDVIKS-EDNMDLLHREINTMSQLRHPNLLQFIGAVLDDDDDPLIITELM
|||..| .. |  ||  |||| .       |. .  .||||| |.||||||  ||.|. .    |..|..| |
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCN-NPPDICICMEYM
Kinase AqueK543.AA STE 308-396 22 3.2e-15 50.29 In-house 1-131 (359) Show / Hide 
Range on Protein: 308-396
Range on HMM: 1-131/359
Sequence Identity: 22% (29 aa)

LSR-KELGRGGWG-VIWM-----------GEF-----RGQRVAVKQMH---------------DVIKSEDNMDLLHREINTMSQLR--HPNLLQFIGAVL
. . ...|.|. | |              ||       |...|.|||.               . .| ...|. . .||..|....  |||  ...|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DD------DDDPLIITELMD-TSLRKAYERK
..      ||.  |. |.||  ||.. ...|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHK
Kinase AqueK543.AA TK 307-421 11 4.3e-14 42.87 In-house 1-249 (486) Show / Hide 
Range on Protein: 307-421
Range on HMM: 1-249/486
Sequence Identity: 11% (29 aa)

SLSRKELGRGG---WGVIWMGEFRG---------------------------QRVAVKQMHDVIKSEDNMDLL---------------HREINTMSQ--L
    |.||.|    .|....|| ||                           ..||||....   ..... ..                .|.  |..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNLLQFIGAVLDDDDD-----------PLIITELMD-TS----LRKAYERKE----------------------------------------------
.|||.....|......             ..|..|.|.  .    ||.   ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------LTTDPGCRPVILS-------------------IMRDVAVGLNY
      .  .| .    |.                   .....| |. |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEY
Kinase AqueK543.AA MLK 307-386 23 5.7e-14 44.97 In-house 1-93 (291) Show / Hide 
Range on Protein: 307-386
Range on HMM: 1-93/291
Sequence Identity: 23% (22 aa)

SLSRKELGRGGWGVIWMGEFRGQR-----VAVKQMH----DVIKSEDNMDLLHREINTMSQLRHPN----LLQFIGAVLDDDDDPLIITELMD
 .  . .| |. |. | |..|...     ||||. .    |. ...   . . .|..  . |.|||      || |. |..  . .|..| ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCE
Kinase AqueK543.AA Csk 306-385 34 1.4e-13 42.76 In-house 1-77 (251) Show / Hide 
Range on Protein: 306-385
Range on HMM: 1-77/251
Sequence Identity: 34% (28 aa)

ISLSRKELGRGGWGVIWMGEFRGQRVAVKQMHDVIKSE--DNMDLLHREINTMSQLRHPNLLQFIGAVLDDDDDPLIITELM
. | ... | |  | . .||.... ||||    .|| .     . .  |   | ||||||| |.|| .|.. .   |..| |
LHL-GECIGHGEFGDVMQGEYQNRKVAVK----CIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYM
Kinase AqueK543.AA TKL-Unique 311-421 25 3.8e-13 42.86 In-house 3-125 (290) Show / Hide 
Range on Protein: 311-421
Range on HMM: 3-125/290
Sequence Identity: 25% (32 aa)

KELGRGGWGVIWMGEFRGQRVAVKQMH-DVIKSEDNMDLLHREINTMSQLR-HPNLLQFIGAVLDDDDDPL---IITELMDT-SLRKAYE---------R
. .|.|| |..  |..||  ||.|| |    .| . |. ...|.|.|. |. |||.....|.  |.  .|    |..| ..  ||..            .
NKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

KELTTDPGCRPVILSIMRDVAVGLNY
.... ..    ..... .|.| |..|
NNCKLNMQ---QRVKMAIDIAQGMYY
Kinase AqueK543.AA Src 306-385 37 2.1e-12 38.38 In-house 1-76 (255) Show / Hide 
Range on Protein: 306-385
Range on HMM: 1-76/255
Sequence Identity: 37% (30 aa)

ISLSRKELGRGGWGVIWMGEFRG-QRVAVKQMHDVIKSEDNMDLLHREINTMSQLRHPNLLQFIGAVLDDDDDPLIITELM
| | || ||.|  |  ||| ..|   |||| .       .. ..| .|...| .|||..|.|   || ....  .|.||.|
IKLCRK-LGQGQFGEVWMGYWNGNTKVAVKTLKPGT--MSPEAFL-QEAQIMKKLRHEKLVQLY-AVCSQEEPIYIVTEYM
Kinase AqueK543.AA Pkinase 307-389 22 5.3e-08 29.38 Pfam 1-91 (293) Show / Hide 
Range on Protein: 307-389
Range on HMM: 1-91/293
Sequence Identity: 22% (21 aa)

SLSRKELGRGGWGVIWMGEFRGQR--VAVKQMH-DVIKSEDNMDLLH-REINTMSQLRHPNLLQFIGAVLDDDDDPLIITELMDT-----SL
    . .|.|. |. . .  .| .  ||||..  . .||. .. ... .||  |  |.||| ....... | .|.. ...|...      .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDL
Kinase AqueK543.AA TyrKc 306-419 10 0.000269 -153.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 306-419
Range on HMM: 1-280/280
Sequence Identity: 10% (30 aa)

ISLSRKELGRGGWGVIWMGEFRGQRVAVKQMHDVIKSEDNMDLLHREINTMSQL--RHPNLLQFIGAVLDD------DDDPLIITELM------------
|.| .| ||.|  |... |. . . |||| ...       .  ..||.. |..|  .|||.....|.....      .. ..|..|.|            
ITLGKK-LGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

----------------------------------------DTSL----------RKAYER-------KELT------TD---------------------
                                        .  .          |. |.        .  .      ..                     
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

---------------------PG----------------------------------CRPVILSIMR--------------DVAVGL
                     ||                                  | . . .||.              ..   .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK543.AA S_TKc 307-417 9 0.000382 -116.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 307-417
Range on HMM: 1-231/231
Sequence Identity: 9% (22 aa)

SLSRKELGRGGWGVIWMGEFRG--QRVAVKQMHDVIKSEDNMDLLHREINTMSQLRHPNLLQFIGAVLDDDDDPLIITELMDT---SLRKAYERKE----
    ...|.|. |. . .  ..  ..||.|...         . . |||. ... .|||. .....  |  |.  ...|..|.   .|..  ...     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

----------------------------------------------------------------------------------------------------
                                                                                                    
RFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQMQM

-----------------LTTDPGCRPVILSIMR-------DVAV
                 |. ||  || .  ...       .  .
MFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF