Gene AqueK544 (A.queenslandica)

AqueK544

Species: A.queenslandica
Alias: AqueK544
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK544.AA Protein None 184 None Fasta, JSON
AqueK544.kin_dom Protein Kinase Domain None 126 None Fasta, JSON

Protein domain

Protein domains of AqueK544.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK544.AA TKL 6-181 20 7.2e-34 118.85 In-house 1-275 (364) Show / Hide 
Range on Protein: 6-181
Range on HMM: 1-275/364
Sequence Identity: 20% (56 aa)

LGKGGWGEVKVAHFRG----------LKVAAKSLHEIIISPYNI-------------------------EIFSREMSILSKIRHPNCLQFIGATT-----
.|.|| |||  ...||            || | ...   .  ..                         . . .|. ..|..|||| .||.|. .     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------EGYPIILTELM-PTSLRKELESGGLAYPTILSISLDVACALNYLHLFKP-----HPLLHRDVSSANVLLQS-MT----------GVWRAKL
         .|.. | .|..   ||.  |       . .....||.|...||||  .|      |..|||  |.|.|. . .|            |..|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

SGYGSANFQHLT---------------------RTCNPG-NPVYSAPEAGNPE----------------EHSPAMDVFSM
. .| . | . .                     .|.... .| . |||. . .                | |...||.|.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSF
Kinase AqueK544.AA CZAK 3-130 37 4e-25 88.25 In-house 4-144 (279) Show / Hide 
Range on Protein: 3-130
Range on HMM: 4-144/279
Sequence Identity: 37% (53 aa)

EVVLGKGGWGEVKVAHFRGLKVAAKSLHEIIISPYNI----EIFSREMSILSKIRHPNCLQFIGATTEGY---PIILTELMP-TSLRKELE--SGGLAY-
. . |.|  |||. |  ||  || | .| .           ..| .| ||.|| .||||.||.|| .|.      | .| |   |||. |   .  .   
GQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQN

PTI-LSISLDVACALNYLHL-FKPHPLLHRDVSSANVLLQS
| . ... .|.|   ||||  .|| | |||| || |.|| .
PHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDH
Kinase AqueK544.AA MLK 2-166 21 6.1e-19 62.44 In-house 3-204 (291) Show / Hide 
Range on Protein: 2-166
Range on HMM: 3-204/291
Sequence Identity: 21% (45 aa)

TEVVLGKGGWGEVKVAHFRGLK-----VAAKSLH-EIIISPYN----IEIFSREMSILSKIRHPN----CLQFIGATTE-GY-PIILTELMPT-SLRKEL
.. ..|.|. |.|  . .|.       || |  . .|. .       .. | .|  .|....|||      || |. .. ..   |..| ..  ||   |
FHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVL

ESG---------------GLAYPTILSISLDVACALNYLHLFKPHPLLHRDVSSANVLLQS-----MTGVWRAKLSGYGSANFQHLT---RTCNPGNPVY
 ..                     .....|..| ...|||  .|.|. |||  | |.|.         |.  .| .  | . . | .   ...|.|.. .
HGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGT--LKICDFGTSRDWHQMCTNMMSNAGTYAW

SAPEA
 |||.
MAPEV
Kinase AqueK544.AA TKL-Unique 5-165 24 2.1e-17 58.1 In-house 4-196 (290) Show / Hide 
Range on Protein: 5-165
Range on HMM: 4-196/290
Sequence Identity: 24% (48 aa)

VLGKGGWGEVKVAHFRGLKVAAKSLH-EIIISPYNIEIFSREMSILSKIR-HPNCLQFIGATT-----EGYPIILTELMPT-SLRKELE-----------
..| || |.|. . .|| .|| |..| .  .|.  .. |..| ....|.. ||| ....|...     ... .| .| .|  ||.. |            
KIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNN

SGGLAYPTILSISLDVACALNYLHLFKPHPLLHRDVSSANVLLQSM--TGVWRAKLSGYGSANFQH--LTRTCN----------PGNPVYSAPE
.  | .  .... .|.| ...|||  .|   .|||  | |.|. .      |..|... | . |.   .. | |           |.. ..|||
NCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE
Kinase AqueK544.AA Dicty4 2-127 32 5.5e-16 49.98 In-house 3-146 (277) Show / Hide 
Range on Protein: 2-127
Range on HMM: 3-146/277
Sequence Identity: 32% (47 aa)

TEVVLGKGGWGEVKVAHFRGLKVAAKSL--HEIIISPYNIEIFSREMSILSKIRHPNCLQFIGATT-----EGYPIILTELM-PTSLRKELES------G
.|. .|||. |||  .  || .|| | |  | .  . . .. | .| .|..|||||| ..| || |      | . | ||.|  ..| . | .       
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

GLAYP--TILS---ISLDVACALNYLHLFKPHPLLHRDVSSANVL
    .  .|..   . .|.|  .|.||   |   .|||  |.| |
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLL
Kinase AqueK544.AA Pkinase_Tyr 5-128 25 1.3e-14 50.1 Pfam 6-144 (270) Show / Hide 
Range on Protein: 5-128
Range on HMM: 6-144/270
Sequence Identity: 25% (36 aa)

VLGKGGWGEVKVAHFR------GLKVAAKSLHEIIISPY--NIEIFSREMSILSKI-RHPNCLQFIGATT-EGYP---IILTELMPT-SLRKELESG---
.||.|  |||. .. .      ...|| |.| |   ..     . .. |..|.... .||| ....|. | .| |   .| .|.||  .|.. | .    
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRED

--GLAYPTILSISLDVACALNYLHLFKPHPLLHRDVSSANVLL
   |  ...|......|....||.  .   . |||.   |.|.
KQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV
Kinase AqueK544.AA TK 10-143 14 5.9e-14 42.41 In-house 13-296 (486) Show / Hide 
Range on Protein: 10-143
Range on HMM: 13-296/486
Sequence Identity: 14% (41 aa)

G-WGEVKVAHFRGL---------------------------KVAAKSLHEIIISPYNIEI---------------FSREMSILS--KIRHPNCLQFIGAT
| .|||  .  ||.                           .|| | |.|   .  . ..               . .||....  . .||| ....|. 
GSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVC

TEG-------------YPIILTELMP-TS----LRKELESGG----------------------------------------------------------
|.|              ..|..|.||  .    ||. | .                                                            
TQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPL

-------------------LAYPTILSISLDVACALNYLHLFKPHPL----LHRDVSSANVLLQS-MTGVWR-------AKLSGYG
                   |  .. | .....||.. |||  .   .     |||.   |.|. . ..  |        .|.. .|
TTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG
Kinase AqueK544.AA LRRK 1-165 21 3.6e-13 42.93 In-house 2-249 (351) Show / Hide 
Range on Protein: 1-165
Range on HMM: 2-249/351
Sequence Identity: 21% (53 aa)

MTEVVLGKGGWG-EVKVAHFRG----------------------------LKVAAKSLHEI-----------------------------IISPYNIEIF
. |  .|.|| | .|  | .||                             .||.|... .                             ...   ...|
KIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRAF

S---REMSILSKIRHPNCLQFIGATTEGYPIILTELMPT-SLRKELE---SGG-------LAYPTILSISLDVACALNYLHLFKPHPLLHRDVSSANVLL
.   .|..|.|. .||| .. .| . . . .. .|..|  .| . |.   . |       .   ..| |.|..| ...||| ..| |..|||  | |.||
REFRHEVWIMSHLNHPNIVSLKGFCIHPL-CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNILL

QSMT---------GVWRAKLSGYGSAN----FQH-LTRTCNPGNPVYSAPE
.|..             ||.. .|       |.. ....|  |||.. |||
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV-GNPGWMAPE
Kinase AqueK544.AA LISK 5-63 32 3.8e-13 38.87 In-house 1-64 (296) Show / Hide 
Range on Protein: 5-63
Range on HMM: 1-64/296
Sequence Identity: 32% (21 aa)

VLGKGGWGEV-KVAHF-RGLKVAAKSLH---EIIISPYNIEIFSREMSILSKIRHPNCLQFIGA
..|||. |.| |. |.  |  .| | .|   .  . | ..  . ||. .. ..|||| .||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV
Kinase AqueK544.AA DRK 1-127 33 1e-12 39.45 In-house 2-132 (258) Show / Hide 
Range on Protein: 1-127
Range on HMM: 2-132/258
Sequence Identity: 33% (44 aa)

MTEVVLGKGGWGEVKVAHFRGLKVAAKSLHEIIIS-PYNIEIFSREMSILSKIRHPNCLQFIGATTE-GYPIILTELMPT-SLRKEL--ESGGLAYPTIL
   .  |.|..|||     || .|| | |    |     .  | ||  .... ||||  ||.|. ..   . | .| ||  || . |  ||  .  | ..
KIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMK

SISLDVACALNYLHLFKPHPLLHRDVSSANVL
.. .|.|  ..|||   |   .|||  | | |
QMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLL
Kinase AqueK544.AA Dicty5 37-128 29 5.8e-12 37.47 In-house 38-137 (260) Show / Hide 
Range on Protein: 37-128
Range on HMM: 38-137/260
Sequence Identity: 29% (30 aa)

YNIEIFSREMSILSKIR--HPNCLQFIGATT--EGYPIILTELMPT-SLRKELESGGL------AYPTILSISLDVACALNYLHLFKPHPLLHRDVSSAN
.... | ||  |.| .   |||   . || .  . || ..||.    ||.  |           ||...|.. .|.| .. .||        |||. | |
FDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMN

VLL
.|.
FLI
Kinase AqueK544.AA Pkinase 2-128 17 9.4e-10 35.57 Pfam 3-141 (293) Show / Hide 
Range on Protein: 2-128
Range on HMM: 3-141/293
Sequence Identity: 17% (25 aa)

TEVVLGKGGWGEVKVAHFRGLK--VAAKSLHEIIISP-YNIEIFS-REMSILSKIRHPNCLQFIGAT-TEGYPIILTELMPT-----SLRKELE---SGG
.. ..|.|. |.|. .| .|    || | .    ...  ... .  .| .|. ...||| ......  ..... . .|...      .|   ..   .|.
IGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGC

L--AYPTILSISLDVACALNYLHLFKPHPLLHRDVSSANVLL
.   . .. .. . ....|.|.|       .|||. ..|.|.
FYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILI
Kinase AqueK544.AA S_TKc 1-184 18 2.1e-09 -39.05 SMART 2-220 (231) Show / Hide 
Range on Protein: 1-184
Range on HMM: 2-220/231
Sequence Identity: 18% (45 aa)

MTEVVLGKGGWGEVKVAHFRG--LKVAAKSLHEIIISPYNIEIFSREMSILSKIRHPNCLQFIGATTEGYPIILTELMPT---SLRKELESGG-------
    ..|||. |.|. .. ..   .|| | ..         | . ||..||.| .|||  .....  ...  . .|....   .|.. ... |       
EILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LAYPTILSISLDVACALNYLHLFKPHPLLHRDVSSANVLLQSMTGVWRAKLSGYGSANFQHLTRTCNPGNPVYSAPEAGNPEEHSP-AMDVFS-------
.   .. ..   ..|||.|.|  .    .|||.  .|.|| .     . |..  |.| .   |  |  | | | |||      ... . |. |       
FPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-----HIKICDFGLARQL--TTFC--GTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MVS-----------------------------------------S
|..                                          
MLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ
Kinase AqueK544.AA TyrKc 5-179 17 3.2e-08 -89.65 SMART 6-280 (280) Show / Hide 
Range on Protein: 5-179
Range on HMM: 6-280/280
Sequence Identity: 17% (51 aa)

VLGKGGWGEVKVAHFRGLKVAAKSLHEIIISPYNIEIFSREMSILSKI--RHPNCLQFIGATTE--------GYPIILTELMPT-SLRKELESGG--LAY
.|| |  |||  .. . ..|| |.|.|       .| | ||..|..|.  .||| ....|. |.        . . |..|.||  .|.. | . .  |  
KLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

PTILSISLDVACALNYLHLFKPHPLLHRDVSSANVLLQSMT-------GVWRAKLSG--------YGS------AN------------FQHL--------
.. ||.....||  .|||    ... |||    |.|. .         |  |.  ..        | .      ..            ...         
KDLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

-----------TRTCNPGNP----------VYSAPEAG----NPEE--------HSPAM----------------------DVF
           |.   |             |.   ..|     |..         ...|                      . |
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK544.AA LISK 95-139 36 8.6e-05 11.28 In-house 104-146 (296) Show / Hide 
Range on Protein: 95-139
Range on HMM: 104-146/296
Sequence Identity: 36% (17 aa)

LSISLDVACALNYLHLFKPHPLLHRDVSSANVLLQ-SMTGVWRAKL
..|.||.||.. |||  .    .|||  | |.|.  .  ..||.|.
VKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKV