Gene AqueK545 (A.queenslandica)

AqueK545

Species: A.queenslandica
Alias: AqueK545
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK545.AA Protein None 231 None Fasta, JSON
AqueK545.kin_dom Protein Kinase Domain None 129 None Fasta, JSON

Protein domain

Protein domains of AqueK545.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK545.AA TKL 99-221 23 1.1e-25 89.4 In-house 1-173 (364) Show / Hide 
Range on Protein: 99-221
Range on HMM: 1-173/364
Sequence Identity: 23% (41 aa)

LGKGGWGEVKVADFCG----------LKVAAKCLYEIIISPHNI-------------------------MKFSREMNIASKICHPNLLQFIGATTEGN--
.|.|| |||  . . |            || | . .   . ...                          .. .|... |...|||..||.|. ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PIILTELM-PTSLRKELETGGLAYHAVLNISLDIACALNYLHLFKP-----HPILHRDISSANVLL
            . | .|..   ||.  |       |  ....||||...||||  .|      ||.|||. |.|.|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILV
Kinase AqueK545.AA CZAK 96-221 40 2.7e-22 77.87 In-house 4-142 (279) Show / Hide 
Range on Protein: 96-221
Range on HMM: 4-142/279
Sequence Identity: 40% (56 aa)

GVVLGKGGWGEVKVADFCGLKVAAKCLYEIIISPHNI----MKFSREMNIASKICHPNLLQFIGATTEGN---PIILTELMP-TSLRKELETGGLAYHAV
| . |.|  |||. |   |  || | .. .             | .|  | || |||| .||.|| .|..     | .| |   |||. | |    ||  
GQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLL-TDHYFYHKQ

-----LNISLDIACALNYLHL-FKPHPILHRDISSANVLL
     .|. .|||   ||||  .|| |||||| || |.||
NPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
Kinase AqueK545.AA MLK 134-221 25 2.1e-15 50.04 In-house 51-160 (291) Show / Hide 
Range on Protein: 134-221
Range on HMM: 51-160/291
Sequence Identity: 25% (28 aa)

KFSREMNIASKICHPN----LLQFIGATTE-GN-PIILTELMPT-SLRKELETG---------------GLAYHAVLNISLDIACALNYLHLFKPHPILH
.| .| .......|||      || |. .. ..   |..| ..  ||   | ..                   . ..|..|..| ...|||  .|.|| |
DFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIH

RDISSANVLL
||. | |.|.
RDLKSHNILI
Kinase AqueK545.AA TKL-Unique 95-221 27 6.5e-14 45.61 In-house 1-145 (290) Show / Hide 
Range on Protein: 95-221
Range on HMM: 1-145/290
Sequence Identity: 27% (41 aa)

TGVVLGKGGWGEVKVADFCGLKVAAKCLYEIIISPHNI-MK-FSREMNIASKIC-HPNLLQFIGATT-----EGNPIILTELMPT-SLRKELE-------
 . ..| || |.|. . . | .|| | . .   ...|. |. |..| |. .|.  |||.....|...     ..| .| .| .|  ||.. |        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

----TGGLAYHAVLNISLDIACALNYLHLFKPHPILHRDISSANVLL
       | .  .... .||| ...|||  .|  |.|||. | |.|.
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLV
Kinase AqueK545.AA TK 134-221 15 8.6e-12 35.03 In-house 84-273 (486) Show / Hide 
Range on Protein: 134-221
Range on HMM: 84-273/486
Sequence Identity: 15% (30 aa)

KFSREMNIASKIC-----HPNLLQFIGATTEGN-------------PIILTELMP-TS----LRKELETGG-----------------------------
.| .|...... |     |||.....|. |.|              ..|..|.||  .    ||. | .                               
DFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGD

------------------------------------------------LAYHAVLNISLDIACALNYLHLFKPHPI----LHRDISSANVLL
                                                |  |  | ....|||.. |||  .         |||.   |.|.
ITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLV
Kinase AqueK545.AA Pkinase_Tyr 114-221 26 4e-11 38.29 Pfam 28-144 (270) Show / Hide 
Range on Protein: 114-221
Range on HMM: 28-144/270
Sequence Identity: 26% (32 aa)

GLKVAAKCLYEIIISPHN--IMKFSREMNIASKI-CHPNLLQFIGATT-EGNP---IILTELMPT-SLRKELETG-----GLAYHAVLNISLDIACALNY
...|| |.|     ....  . .| ||..| ...  |||.....|. | .| |   .| .|.||  .|.. | .       |  .  |.....||....|
KIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEY

LHLFKPHPILHRDISSANVLL
|.  .   . |||.   |.|.
LESKN---CIHRDLAARNCLV
Kinase AqueK545.AA DRK 94-220 33 1.3e-10 32.19 In-house 2-132 (258) Show / Hide 
Range on Protein: 94-220
Range on HMM: 2-132/258
Sequence Identity: 33% (44 aa)

MTGVVLGKGGWGEVKVADFCGLKVAAKCLYEIIISPHNIMK-FSREMNIASKICHPNLLQFIGATTE-GNPIILTELMPT-SLRKEL--ETGGLAYHAVL
  |.  |.|..|||      | .|| | |    |   |... | || |. ..  |||  ||.|. ..   . | .| ||  || . |  |   .    ..
KIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMK

NISLDIACALNYLHLFKPHPILHRDISSANVL
 . .|.|  ..|||   |  |.|||  | | |
QMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLL
Kinase AqueK545.AA TK-Unique 92-223 20 4.1e-10 31.18 In-house 1-168 (294) Show / Hide 
Range on Protein: 92-223
Range on HMM: 1-168/294
Sequence Identity: 20% (35 aa)

ITMTGVVLGKGGWGEVKVADFCGLK-------VAAKCLYEIIISPHNIMKFSREMNIASKIC-HPNLLQFIGATT-EG-NPIILTELMPTS-LRKELETG
... | |.|.|  |.|  ....|..       ..|  . ..  ...  ..| .| .. ...  |||..|..|..|  . .. |. | .| . |.. | | 
LEV-GDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

G---------------------------LAYHAVLNISLDIACALNYLHLFKPHPILHRDISSANVLLQG
.                           . .. ....  .|||...||.   .. | |||... ||||..
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLCARNVLLTE
Kinase AqueK545.AA Pkinase 137-225 19 8.4e-10 35.74 Pfam 47-145 (293) Show / Hide 
Range on Protein: 137-225
Range on HMM: 47-145/293
Sequence Identity: 19% (20 aa)

R--EMNIASKICHPNLLQFIGAT-TEGNPIILTELMPT-----SLRKELE---TGGL--AYHAVLNISLDIACALNYLHLFKPHPILHRDISSANVLLQG
|  |  |  ...||| ......  ..... . .|...      .|   ..    |..   .. . .. . |...|.|.|      |.|||. ..|.|.  
RLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDN

TG
.|
NG
Kinase AqueK545.AA HH498 188-225 47 5.3e-09 24.26 In-house 124-161 (284) Show / Hide 
Range on Protein: 188-225
Range on HMM: 124-161/284
Sequence Identity: 47% (18 aa)

LNISLDIACALNYLHLFKPHPILHRDISSANVLLQGTG
. ||.|.|   ||||   .||| |||  | |.|.   |
MTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDG
Kinase AqueK545.AA IRAK 188-221 45 5e-08 24.72 In-house 112-146 (317) Show / Hide 
Range on Protein: 188-221
Range on HMM: 112-146/317
Sequence Identity: 45% (16 aa)

LNISLDIACALNYLHLFKPH-PILHRDISSANVLL
. |.. .||....|| . |  || |.||.|||.||
CSICWGTACGIQFLHQNHPCTPIIHGDIKSANILL
Kinase AqueK545.AA LISK 98-156 26 1e-06 17.18 In-house 1-64 (296) Show / Hide 
Range on Protein: 98-156
Range on HMM: 1-64/296
Sequence Identity: 26% (17 aa)

VLGKGGWGEVKVADFC--GLKVAAKCLY---EIIISPHNIMKFSREMNIASKICHPNLLQFIGA
..|||. |.|        |  .| | .    .  . | .. .. ||. .  .. ||| .||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV
Kinase AqueK545.AA LISK 188-221 47 6.3e-05 11.73 In-house 104-134 (296) Show / Hide 
Range on Protein: 188-221
Range on HMM: 104-134/296
Sequence Identity: 47% (16 aa)

LNISLDIACALNYLHLFKPHPILHRDISSANVLL
..|.|||||.. |||  .   |.|||  | |.|.
VKIALDIACGMSYLHSMN---IIHRDLKSKNCLV
Kinase AqueK545.AA S_TKc 93-226 13 7.4e-05 -105.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 93-226
Range on HMM: 1-231/231
Sequence Identity: 13% (33 aa)

TMTGVVLGKGGWGEVKVADFCG--LKVAAKCLYEIIISPHNIMKFSREMNIASKICHPNLLQFIGATTEGNPIILTELMPT---SLRKELETGG------
   . ..|||. |.|. .   .   .|| |..           .. ||..| .|  |||. .....  ...  . .|....   .|.. ..  |      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LAYHAVLNISLDIACALNYLHLFKPHPILHRDISSANVLLQ-------------------------------GT-------------------------
 .    .  .   |.|||.|.|  .   |.|||.  .|.||                                |.                         
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQM

---------------------------------G----------F
                                            |
QMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK545.AA TyrKc 93-230 15 0.000179 -150.29 SMART 1-265 (280) Show / Hide 
Range on Protein: 93-230
Range on HMM: 1-265/280
Sequence Identity: 15% (43 aa)

TMTGVVLGKGGWGEVKVADFCGLKVAAKCLYEIIISPHNIMKFSREMNIASKI--CHPNLLQFIGATTE--------GNPIILTELMPT-SLRKELETGG
   | .|| |  |||  .    ..|| |.| |       .. | ||..| .|.   |||.....|. |.        . . |..|.||  .|.. |   .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LAYHAVLNISLDIACALNYLHLFKPHPILHRDISSANVLLQGTG------------------------------------------------------
  |     |.....|||  .|||    ... |||.   |.|.   .                                                      
PKLCMKDLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

-----------------------FG----------------------------------------------WRA
                        |                                              |..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE
Kinase AqueK545.AA IRAK 95-155 20 0.029525 4.0 In-house 3-70 (317) Show / Hide 
Range on Protein: 95-155
Range on HMM: 3-70/317
Sequence Identity: 20% (14 aa)

TGVVLGKGGWGEVKVADFCGLK--VAAK-CLYEIIISPHNIMK-FSR---EMNIASKICHPNLLQFIG
 . ..|.|| |.|  ... ..   .| |    .  .|.  ... |     |. . ....|||.. . |
KDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYG
Kinase AqueK545.AA HH498 134-157 37 0.053241 1.68 In-house 48-71 (284) Show / Hide 
Range on Protein: 134-157
Range on HMM: 48-71/284
Sequence Identity: 37% (9 aa)

KFSREMNIASKICHPNLLQFIGAT
.| ||  | ..  ||.  ||..|.
MFCREVSIMCRLNHPCVVQFVYAC