Gene AqueK547 (A.queenslandica)

AqueK547

Species: A.queenslandica
Alias: AqueK547
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK547.AA Protein None 162 None Fasta, JSON
AqueK547.kin_dom Protein Kinase Domain None 140 None Fasta, JSON

Protein domain

Protein domains of AqueK547.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

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Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK547.AA TKL 10-151 20 1e-23 82.29 In-house 85-290 (364) Show / Hide 
Range on Protein: 10-151
Range on HMM: 85-290/364
Sequence Identity: 20% (44 aa)

PNLLQFLGATTEGN--------------PIILTELM-PTSLRKELETGGLAYHAVLNISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQ-----
||..||.|. ....              . | .|..   ||.  |       |  ....||.|...||||  .|      ||.|||  |.|.|.      
PNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTN

------PMIGGWRAKVSDYG-RVSLQPLA--------------------RTCNPG-NPVYSAPEAVNPR----------------QHSPAMDVFSYGVCL
      . .  |..|..|.|   ....                      .|.... .| . |||. .                  . |...||.|.|..|
VSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL

IEMVLCQFPEE
 |.. .. |..
WEILTRCRPYY
Kinase AqueK547.AA MLK 2-144 24 4.2e-20 66.53 In-house 57-230 (291) Show / Hide 
Range on Protein: 2-144
Range on HMM: 57-230/291
Sequence Identity: 24% (42 aa)

NIASKICRPN----LLQFLGATTE-GN-PIILTELMPT-SLRKELETG---------------GLAYHAVLNISLDVACALNYLHLFKPHPILHRDVSSA
........||      ||.|. .. ..   |..| ..  ||   | ..                   . ..|..|..| ...|||  .|.|| |||  | 
RHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSH

NVLLQP---MIGGWRAKVSDYGRVS-LQPL-A-RTCNPGNPVYSAPEAV---NPRQHSPAMDVFSYGVCLIEMV
|.|.      ...  .|..| | .  ..   . ...|.|.. . |||.       . | . ||.|.||.| ||.
NILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase AqueK547.AA CZAK 3-149 34 2.7e-19 66.83 In-house 53-221 (279) Show / Hide 
Range on Protein: 3-149
Range on HMM: 53-221/279
Sequence Identity: 34% (59 aa)

IASKICRPNLLQFLGATTEGN---PIILTELMP-TSLRKELETGGLAYHAV-----LNISLDVACALNYLHL-FKPHPILHRDVSSANVLLQPMIG----
| || | || .||||| .|..     | .| |   |||. | |    ||       .|. .|.|   ||||  .|| |||||| || |.||   .     
IMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLL-TDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNP

------GWRAKVSDYGRV---SLQPLARTCNPGNPVYSAPEAVNPRQHSPAMDVFSYGVCLIEMVLCQFP
         .|..|.|       ||   |   |   . |||       ..  ||.|.|  | ... |  |
VVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVYSFGMILWCIITCDQP
Kinase AqueK547.AA TK 10-144 13 1.1e-15 48.34 In-house 103-388 (486) Show / Hide 
Range on Protein: 10-144
Range on HMM: 103-388/486
Sequence Identity: 13% (39 aa)

PNLLQFLGATTEGN-------------PIILTELMP-TS----LRKELETGG------------------------------------------------
||.....|. |.|              ..|..|.||  .    ||. | .                                                  
PNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDD

-----------------------------LAYHAVLNISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQ-PMIGGWR-------AKVSDYG----
                             |  |  | .....||.. |||  .         |||.   |.|.   ..  |        .|..|.|    
DLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----RVSLQPLARTCNPGNPVY-----------------------------SAPEAVN---------PRQHSPAMDVFSYGVCLIEMV
    .    .        .. .                              |||..|          . .... ||.|.||.. |..
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF
Kinase AqueK547.AA TKL-Unique 10-144 25 1.1e-14 48.37 In-house 56-222 (290) Show / Hide 
Range on Protein: 10-144
Range on HMM: 56-222/290
Sequence Identity: 25% (43 aa)

PNLLQFLGATT-----EGNPIILTELMPT-SLRKELE-----------TGGLAYHAVLNISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM--IGGW
||.... |...     ..| .| .| .|  ||.. |               | .  .... .|.| ...|||  .|  |.|||  | |.|.     |  |
PNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEW

RAKVSDYGRVSLQP--LARTCN----------PGNPVYSAPEAVNP--RQHSPAMDVFSYGVCLIEMV
..|..| | . ..   .. | |           |.. ..|||  .    | |   ||.|.|..|.|..
NIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIA
Kinase AqueK547.AA HH498 50-143 39 3.8e-14 40.84 In-house 124-219 (284) Show / Hide 
Range on Protein: 50-143
Range on HMM: 124-219/284
Sequence Identity: 39% (39 aa)

LNISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMIGGWRAKVSDYG----RVSLQPLARTCNPGNPVYSAPEAVN-PRQHSPAMDVFSYGVCLIEM
. ||.|||   ||||   .||| |||  | |.|.    |  .|.| |.|      ..     |  |||. . |||      . |   |||||. |. ||
MTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH-EDG--HAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEM
Kinase AqueK547.AA LRRK 52-138 29 9.1e-11 34.3 In-house 169-270 (351) Show / Hide 
Range on Protein: 52-138
Range on HMM: 169-270/351
Sequence Identity: 29% (31 aa)

ISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMI---------GGWRAKVSDYGRVS----LQP-LARTCNPGNPVYSAPEAVNPR---QHSPAMDVF
|.|..| ...||| ..| ||.|||  | |.||. .              ||..|.|  .    ... .|..|  |||.. ||| ..     . .   |..
IALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV-GNPGWMAPEIMRYNGEEEYTEKVDCY

SYGV
|.|.
SFGM
Kinase AqueK547.AA Dicty5 44-143 31 1.8e-10 32.22 In-house 101-196 (260) Show / Hide 
Range on Protein: 44-143
Range on HMM: 101-196/260
Sequence Identity: 31% (32 aa)

LAYHAVLNISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMIGGWRAKVSDYG--R-VSLQPLARTCNPGNPVYSAPEAVNPRQHSPAMDVFSYGVCL
.||   | . .|.| .. .||      | |||. | |.|.      | .|. |.|  | | .. .  | . | . . |.|  | .      ||.|.|. |
IAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMNFLITEN---WKIKIIDFGTSRFVDNR-YHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVL

IEM
 ||
WEM
Kinase AqueK547.AA TK-Unique 10-144 21 2.9e-10 31.74 In-house 64-233 (294) Show / Hide 
Range on Protein: 10-144
Range on HMM: 64-233/294
Sequence Identity: 21% (37 aa)

PNLLQFLGATT-EG-NPIILTELMPTS-LRKELETGG---------------------------LAYHAVLNISLDVACALNYLHLFKPHPILHRDVSSA
||..|.||..|  . .. |. | .| . |.. | | .                           . .. ....  ..||...||.   .. | |||... 
PNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLCAR

NVLLQPMIGGWRAKVSDYGRVS----LQPLARTC--NPGNPVYSAPEAVN--PRQH-SPAMDVFSYGVCLIEMV
||||.    . ..|..|.|.       ......|  ..    . |||.     ... ..  || |.|| . |..
NVLLTE---DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIF
Kinase AqueK547.AA IRAK 50-83 42 7.7e-08 24.04 In-house 112-146 (317) Show / Hide 
Range on Protein: 50-83
Range on HMM: 112-146/317
Sequence Identity: 42% (15 aa)

LNISLDVACALNYLHLFKPH-PILHRDVSSANVLL
. |..  ||....|| . |  || |.|..|||.||
CSICWGTACGIQFLHQNHPCTPIIHGDIKSANILL
Kinase AqueK547.AA Pkinase_Tyr 10-83 26 2.3e-07 25.54 Pfam 64-144 (270) Show / Hide 
Range on Protein: 10-83
Range on HMM: 64-144/270
Sequence Identity: 26% (22 aa)

PNLLQFLGATT-EGNP---IILTELMPT-SLRKELETG-----GLAYHAVLNISLDVACALNYLHLFKPHPILHRDVSSANVLL
||.....|. | .| |   .| .|.||  .|.. | .       |  .  |......|....||.  .   . |||.   |.|.
PNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV
S_TKc AqueK547.AA S_TKc 1-159 17 9.4e-07 -77.85 SMART 19-220 (231) Show / Hide 
Range on Protein: 1-159
Range on HMM: 19-220/231
Sequence Identity: 17% (38 aa)

MNIA---------------------SKICRPNLLQFLGATTEGNPIILTELMPT---SLRKELETGG-------LAYHAVLNISLDVACALNYLHLFKPH
 ..                      .|   ||. .....  ...  . .|....   .|.. ..  |       .    .  .   ..|||.|.|  .  
RHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG--

PILHRDVSSANVLLQPMIGGWRAKVSDYGRVSLQPLARTCNPGNPVYSAPEAVNPRQHSP-AMDVFSYGVCLIEMVL-----------------------
 |.|||.  .|.||       . |..| |   .     |   | | | ||| .   .... . |. | |..|.||.                        
-IIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDF

-----CQFPEERLRLKLLR
     .  ||.|.  ..|.
IRKCLQKDPEKRPTAEALQ
Kinase AqueK547.AA Pkinase 10-83 16 1e-05 21.4 Pfam 60-141 (293) Show / Hide 
Range on Protein: 10-83
Range on HMM: 60-141/293
Sequence Identity: 16% (14 aa)

PNLLQFLGAT-TEGNPIILTELMPT-----SLRKELE---TGGL--AYHAVLNISLDVACALNYLHLFKPHPILHRDVSSANVLL
|| ......  ..... . .|...      .|   ..    |..   .. . .. . ....|.|.|      |.|||. ..|.|.
PNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILI
TyrKc AqueK547.AA TyrKc 1-157 14 0.000228 -151.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-157
Range on HMM: 1-280/280
Sequence Identity: 14% (43 aa)

MNIASKI---------------------CR---------------------PNLLQFLGATTE--------GNPIILTELMPT-SLRKELETGG--LAYH
     |.                     ..                     ||.....|. |.        . . |..|.||  .|.. |   .  |   
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

AVLNISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMIGGWRAKVSDYGRVSLQPLARTCNPG------NPVYS----------------APEAVNPR
  |......||  .|||    ... |||    |.|.       ..|.|| |      |.|    .        .|.                |||. | .
DLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH---TVKISDFG------LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

QHSPAMDVFSYGVCLIEMV-LCQFPEER-----------------------------------------------------------LRLKL
  ... ||.|.|||. |.  ..| | .                                                            .. ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK547.AA Pkinase 114-149 35 0.001991 13.2 Pfam 175-211 (293) Show / Hide 
Range on Protein: 114-149
Range on HMM: 175-211/293
Sequence Identity: 35% (13 aa)

PVYSAPEAVN-PRQHSPAMDVFSYGVCLIEMVLCQFP
| | ||| ..  . ..|. |..|.|. |.||.. ..|
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPP
Kinase AqueK547.AA IRAK 118-142 33 0.022407 4.43 In-house 190-216 (317) Show / Hide 
Range on Protein: 118-142
Range on HMM: 190-216/317
Sequence Identity: 33% (9 aa)

APEAVN--PRQHSPAMDVFSYGVCLIE
.||. .   .| ..  ||.| |. | |
PPEFIRDPQGQLTKKTDVYSFGIVLLE
Kinase AqueK547.AA Pkinase_Tyr 132-144 46 1.81126 2.21 Pfam 196-208 (270) Show / Hide 
Range on Protein: 132-144
Range on HMM: 196-208/270
Sequence Identity: 46% (6 aa)

DVFSYGVCLIEMV
|| |.||.. |..
DVWSFGVLMWEIF