AqueK553

Species: A.queenslandica
Alias: AqueK553
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK553.AA Protein None 354 None Fasta, JSON
AqueK553.kin_dom Protein Kinase Domain None 189 None Fasta, JSON

Protein domain

Protein domains of AqueK553.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK553.AA TKL 169-354 20 1.7e-36 127.55 In-house 1-282 (364) Show / Hide
Range on Protein: 169-354
Range on HMM: 1-282/364
Sequence Identity: 20% (60 aa)

LGRGGWGEVRVARFHG----------LEVAVKVLHETIISEYNV-------------------------SLFSREMNIASKIRHPNLLQFIGATTEGN--
.|.|| |||  ....|           .||||.....  .| .                            . .|... |..||||..||.|. ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PIILTELM-PTSLRKELETGGLAYPAILSISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQPMGGGH---------GWRAKV
            . | .|..   ||.  |       . .....||.|...||||  .|      ||.|||  |.|.|.   .  .          |..|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

SDYGSANLQHLI---------------------IRSVNPGGPLYAAPEA--GNP--------------REHSPSMDVFSYGVLLLEM
.|.| .   .                        ..   | | . |||.  |..              .| |...||.|.|..| |.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI

Kinase AqueK553.AA MLK 163-354 24 1.6e-23 78.51 In-house 1-229 (291) Show / Hide
Range on Protein: 163-354
Range on HMM: 1-229/291
Sequence Identity: 24% (57 aa)

RMTERILGRGGWGEVRVARFHGLE-----VAVKVLHETIISEYNVS-----LFSREMNIASKIRHPN----LLQFIGATTE-GN-PIILTELMPT-SLRK
  .....| |. |.|  .|... .     ||||  . .|. .  ..      | .| .......|||      || |. .. ..   |..| ..  ||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ELETG---------------GLAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQ----PMGGGHGWRAKVSDYGSANLQHLI-I-RSVNPGG
 | ..                     .....|..| ...|||  .|.|| |||  | |.|.     .|..|.   .|..| | .   | .   .  |.| 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGT---LKICDFGTSRDWHQMCTNMMSNAGT

PLYAAPEA---GNPREHSPSMDVFSYGVLLLEM
. . |||.         | . ||.|.||.| ||
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEM

Kinase AqueK553.AA CZAK 166-291 35 2e-23 82.06 In-house 4-142 (279) Show / Hide
Range on Protein: 166-291
Range on HMM: 4-142/279
Sequence Identity: 35% (50 aa)

ERILGRGGWGEVRVARFHGLEVAVKVLHETIISEYNV----SLFSREMNIASKIRHPNLLQFIGATTEGN---PIILTELMP-TSLRKEL-ETGGLAYP-
..  |.|  |||. |.  |  ||.| .|     .         | .|  | || .||| .||.|| .|..     | .| |   |||. | .   .  . 
GQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQN

--AILSISLDVACALNYLHL-FKPHPILHRDVSSANVLL
    ... .|.|   ||||  .|| |||||| || |.||
PHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL

Kinase AqueK553.AA TK 166-354 15 5e-22 69.95 In-house 4-387 (486) Show / Hide
Range on Protein: 166-354
Range on HMM: 4-387/486
Sequence Identity: 15% (60 aa)

ERILGRGG---WGEVRVARFHGL---------------------------EVAVKVLHETIISEYN-VSL--------------FSREMNIAS--KIRHP
.. ||.|    .|||. .. .|.                           .||||.|.|.  .. .   .              . .|| . .  . .||
GKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHP

NLLQFIGATTEGN-------------PIILTELMP-TS----LRKELETGG-------------------------------------------------
|.....|. |.|              ..|..|.||  .    ||. | .                                                   
NIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDD

----------------------------LAYPAILSISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQPMGG------GHGWRAKVSDYGSAN--
                            |  .  | .....||.. |||  .         |||.   |.|.   .       | |  .|..|.| .   
LIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQG

---LQHLI------IRSVNPGGPL-------------------------YAAPEAGN---------PREHSPSMDVFSYGVLLLEM
   |   |       |. ..|...                         . |||. |          . ...  ||.|.|||. |.
SGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI

Kinase AqueK553.AA Pkinase 163-354 21 2.6e-20 72.9 Pfam 1-205 (293) Show / Hide
Range on Protein: 163-354
Range on HMM: 1-205/293
Sequence Identity: 21% (46 aa)

RMTERILGRGGWGEVRVARFHGLE--VAVKVLH-ETIISEYNVSLFS-REMNIASKIRHPNLLQFIGAT-TEGNPIILTELMPT-----SLRKELE---T
  ..|..|.|. |.|. .. .| .  ||||..  ... |. .....  .|  |  ...||| ......  ..... . .|...      .|   ..    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGL--AYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRAKVSDYGSAN---LQHLIIRSVNPGGPLYAAPEAGN-PREHSPSMD
|..   .  . .. . ....|.|.|      |.|||. ..|.|.    |  . . |..| |.|    . .    ..  | | |.|||  .  ....|. |
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VFSYGVLLLEM
..|.|..| ||
MWSCGCILYEM

Kinase AqueK553.AA Dicty4 165-308 33 1.2e-19 62.36 In-house 3-159 (277) Show / Hide
Range on Protein: 165-308
Range on HMM: 3-159/277
Sequence Identity: 33% (55 aa)

TERILGRGGWGEVRVARFHGLEVAVKVL--HETIISEYNVSLFSREMNIASKIRHPNLLQFIGATT-----EGNPIILTELM-PTSLRKELET------G
.| ..|.|. |||  ..  | |||||.|  | .  .|.  . | .| .| .||||||...| || |      | . | ||.|  ..| . |         
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

GLAYP--AILS---ISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRAKVSDYG
    .   |..   . .|.|  .|.||   |  |.|||  |.| |         ||.||.| |
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVD-----KNWRVKVCDFG

Kinase AqueK553.AA TKL-Unique 165-354 25 3.3e-19 64.53 In-house 1-221 (290) Show / Hide
Range on Protein: 165-354
Range on HMM: 1-221/290
Sequence Identity: 25% (57 aa)

TERILGRGGWGEVRVARFHGLEVAVKVLH-ETIISEYNVSLFSREMNIASKIR-HPNLLQFIGATT-----EGNPIILTELMPT-SLRKELE--------
    .|.|| |.|  . ..| .||.|..| .  .|   .  |..| |. .|.. |||.....|...     ..| .| .| .|  ||.. |         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

---TGGLAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRAKVSDYGSANLQHLIIRSVNP-----------GGPLYAAPEAGN
      | .  .... .|.| ...|||  .|  |.|||  | |.|.        |..|..| | . ..  |... |            | ....|||  .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

P--REHSPSMDVFSYGVLLLEM
      | . ||.|.|. | |.
MNFCQYSEKSDVYSFGIVLWEI

Kinase AqueK553.AA DRK 162-308 36 9.5e-19 60.15 In-house 1-145 (258) Show / Hide
Range on Protein: 162-308
Range on HMM: 1-145/258
Sequence Identity: 36% (55 aa)

IRMTERILGRGGWGEVRVARFHGLEVAVKVLHETIIS-EYNVSLFSREMNIASKIRHPNLLQFIGATTE-GNPIILTELMPT-SLRKEL--ETGGLAYPA
|    || |||..|||      | .|||| |    |  |  .. | || |. .. ||||  ||.|. ..   . | .| ||  || . |  |   .  | 
IKIGNRI-GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPL

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRAKVSDYG
.... .|.|  ..|||   |  |.|||  | | |         |. ||.|.|
MKQMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLLVD-----EHWQVKVADFG

Kinase AqueK553.AA Pkinase_Tyr 162-291 26 1.4e-17 60.14 Pfam 1-144 (270) Show / Hide
Range on Protein: 162-291
Range on HMM: 1-144/270
Sequence Identity: 26% (39 aa)

IRMTERILGRGGWGEVRVARFH------GLEVAVKVLHETIISEY--NVSLFSREMNIASKI-RHPNLLQFIGATT-EGNP---IILTELMPT-SLRKEL
|..  . ||.|  |||. .. .      ...||||.| |.  .|     .... |..| ... .|||.....|. | .| |   .| .|.||  .|.. |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

ETG-----GLAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
 .       |  . .|......|....||.  .   . |||.   |.|.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV

Kinase AqueK553.AA STE 164-354 18 4.1e-16 53.49 In-house 1-261 (359) Show / Hide
Range on Protein: 164-354
Range on HMM: 1-261/359
Sequence Identity: 18% (52 aa)

MTE-RILGRGGWGEVRVARFH-----------------GLEVAVKVLH----ETIISE------------YNVSLFSREMNIASKIR--HPNLLQFIGAT
 .  ...|.|. |.|  |. |                 |  .|.|...    .. . |             ..  . .|..| .| .  |||  ...|. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

T--------EGNPIILTELMP-TSLRKELE-TGGLA--------------YPAILSISLDVACA-LNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRA
         ...  |  |.|.  ||.. .. ..|                 . |  |  ..  . |.|||  .   | |||. .||.||          .
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------V

KVSDYGSAN-LQHLII-----------------RSVNPGGPLYAAPEAGNP------REHSPSMDVFSYGVLLLEM
| .| | .  |.. .                  |    | | . |||  ..       ... . |. | | ...||
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM

Kinase AqueK553.AA Shk 165-240 46 4.1e-16 54.42 In-house 3-80 (269) Show / Hide
Range on Protein: 165-240
Range on HMM: 3-80/269
Sequence Identity: 46% (36 aa)

TERILGRGGWGEVRVARFHGLEVAVKVLHETIISEYNVSLFSREMNIASKIRHPNLLQFIGATT--EGNPIILTELMP
.| .|| |  | |  .|  | ||||||.| .  .|.  . |  |  | |||.|||.. | || |   |   | |||||
REDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMP

Kinase AqueK553.AA LISK 168-226 26 8e-13 37.8 In-house 1-64 (296) Show / Hide
Range on Protein: 168-226
Range on HMM: 1-64/296
Sequence Identity: 26% (17 aa)

ILGRGGWGEVRVARFH--GLEVAVKVLH---ETIISEYNVSLFSREMNIASKIRHPNLLQFIGA
..|.|. |.|   .    | ..|.| .|   .. . . .   . ||. .  ..|||| .||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV

Kinase AqueK553.AA S_TKc 163-354 17 1e-11 -5.2 SMART 1-231 (231) Show / Hide
Range on Protein: 163-354
Range on HMM: 1-231/231
Sequence Identity: 17% (46 aa)

RMTERILGRGGWGEVRVARFHG--LEVAVKVLHETIISEYNVSLFSREMNIASKIRHPNLLQFIGATTEGNPIILTELMPT---SLRKELETGG------
    |..|.|. |.|. .| ..   .||.|...           . ||..| .| .|||. .....  ...  . .|....   .|.. ..  |      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRAKVSDYGSANLQHLIIRSVNPGGPLYAAPEAGNPREHSP-SMDVFSYGV
 .    . ..   ..|||.|.|  .   |.|||.  .|.||         . |..| |.| .      .   | | | |||      ... . |. | |.
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

LL---------------------------------------------LE----------M
.|                                             |.          .
ILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF

Kinase AqueK553.AA TyrKc 163-354 19 1.1e-09 -66.22 SMART 1-280 (280) Show / Hide
Range on Protein: 163-354
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

RMTERILGRGGWGEVRVARFHGLEVAVKVLHETIISEYNVSLFSREMNIASKI--RHPNLLQFIGATTE--------GNPIILTELMPT-SLRKELETGG
   ...||.|  |||. ..   ..||||.|.|       .  | ||..| .|.  .|||.....|. |.        . . |..|.||  .|.. |   .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRAKVSDYG-SANLQHL--------IIRS----VNPG-GPL-YAAPEAGN
  |  .  ||.....||  .|||    ... |||    |.|.   .     ..|.|| | | .. .          .|.       .  |.   |||. |
PKLCMKDLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

PREHSPSMDVFSYGVLL--------------------------------------L------------------------------------EM
 .. ..  ||.|.||..                                                                           ..
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase AqueK553.AA LISK 258-308 41 4.2e-05 12.32 In-house 104-150 (296) Show / Hide
Range on Protein: 258-308
Range on HMM: 104-150/296
Sequence Identity: 41% (21 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRAKVSDYG
..|.||.||.. |||  .   |.|||  | |.|.    .  .||.|| | |
VKIALDIACGMSYLHSMN---IIHRDLKSKNCLVREN-DNNQWRIKVCDFG

Kinase AqueK553.AA LISK 341-354 57 0.001507 7.17 In-house 219-232 (296) Show / Hide
Range on Protein: 341-354
Range on HMM: 219-232/296
Sequence Identity: 57% (8 aa)

SMDVFSYGVLLLEM
| ||||.|..|.|.
SCDVFSFGIVLCEI

Kinase AqueK553.AA Shk 323-354 37 0.046556 3.62 In-house 168-199 (269) Show / Hide
Range on Protein: 323-354
Range on HMM: 168-199/269
Sequence Identity: 37% (12 aa)

GGPLYAAPEAGNPREHSPSMDVFSYGVLLLEM
| ||. |||    ..   . ||.| | .| |.
GTPLWMAPEVMMNHPYNEKADVYSFGIILWEI