Gene AqueK554 (A.queenslandica)

AqueK554

Species: A.queenslandica
Alias: AqueK554
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK554.AA Protein None 197 None Fasta, JSON
AqueK554.kin_dom Protein Kinase Domain None 189 None Fasta, JSON

Protein domain

Protein domains of AqueK554.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK554.AA TKL 1-193 19 2.6e-35 123.64 In-house 76-364 (364) Show / Hide 
Range on Protein: 1-193
Range on HMM: 76-364/364
Sequence Identity: 19% (56 aa)

MNIASEIRHPNLLQFIGATTEGN--------------PIILTELM-PTSLRKELETGGLAYPAILSISLDVAYALNYLHLFKP-----HPILHRDISSAN
... | .||||..||.|. ....              . | .|..   ||.  |       . .....||.| ..||||  .|      ||.|||. |.|
IMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN

VLLQ-PMV----------GVWKAKVSDYGTVSFQPLAK---------------------TCNPG-NPVYSAPES-----PYPI-----------QHSPAM
.|.   .             |..|..|.|.  |    .                     |.... .| . |||      .|.            . |...
ILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKC

DVFSYGVLLIEMVLCQFPEEDKSMR------------EAQIKAIKRLTLK--------------------NLIERCLIENYRHRPTMSDIIKEI
||.|.|..| |.. .. |..|  ..            .  ..  .|....                    .|...|  .. . ||....|.|..
DVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK554.AA MLK 2-193 22 1.8e-22 74.84 In-house 57-291 (291) Show / Hide 
Range on Protein: 2-193
Range on HMM: 57-291/291
Sequence Identity: 22% (54 aa)

NIASEIRHPN----LLQFIGATTE-GN-PIILTELMPT-SLRKELETG---------------GLAYPAILSISLDVAYALNYLHLFKPHPILHRDISSA
.... ..|||      || |. .. ..   |..| ..  ||   | ..                     .....|..| ...|||  .|.|| |||. | 
RHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSH

NVLLQP---MVGVWKAKVSDYGTVS-FQPL-A-KTCNPGNPVYSAPESP---YPIQHSPAMDVFSYGVLLIEMVLCQFP--EEDKSMREAQIKAIKRLT-
|.|.       .  ..|..| ||.  ..   . ...|.|.. . |||        . | . ||.|.||.| ||. .. |  .....|. |   | ..|. 
NILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRP

---------LKNLIERCLIENYRHRPTMSDIIKEI
         .|.|...|  .. . ||... |... 
PIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK554.AA TK 8-193 12 1.5e-19 61.52 In-house 101-486 (486) Show / Hide 
Range on Protein: 8-193
Range on HMM: 101-486/486
Sequence Identity: 12% (47 aa)

RHPNLLQFIGATTEGN-------------PIILTELMP-TS----LRKELETGG----------------------------------------------
.|||.....|. |.|              ..|..|.||  .    ||. | .                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LAYPAILSISLDVAYALNYLHLFKPHPI----LHRDISSANVLLQ-PMVGVWK-------AKVSDYG--
                               |  .  | .....| .. |||  .         |||.   |.|.   .|  |.       .|..|.|  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------TVSFQPLAKTCNPGNPVY-----------------------------SAPESPY---------PIQHSPAMDVFSYGVLLIEMV-LC-QFPEED
           .  .     .. .                              |||.              .... ||.|.|||. |.. .. . . ..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

KSM--------REAQIKAIKR---------------LTLK------------------------NLIERCLIENYRHRPTMSDIIKEI
 |          .  .. ..|               . ..                         |. .|  .. ..|||.|.. ...
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK554.AA CZAK 3-152 30 1.7e-19 67.57 In-house 53-224 (279) Show / Hide 
Range on Protein: 3-152
Range on HMM: 53-224/279
Sequence Identity: 30% (53 aa)

IASEIRHPNLLQFIGATTEGN---PIILTELMP-TSLRKEL-ETGGLAYP---AILSISLDVAYALNYLHL-FKPHPILHRDISSANVLLQPMVG-----
| |  .||| .||.|| .|..     | .| |   |||. | .   .  .     ... .|.|   ||||  .|| |||||| || |.||   .      
IMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPV

-----VWKAKVSDYGTV---SFQPLAKTCNPGNPVYSAPESPYPIQHSPAMDVFSYGVLLIEMVLCQFPEED
       ..|..|.|       ||   |   |   . |||       ..  ||.|.| .| ... |  |  .
VSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVYSFGMILWCIITCDQPYQN
Kinase AqueK554.AA TKL-Unique 2-144 25 4.7e-17 56.84 In-house 47-222 (290) Show / Hide 
Range on Protein: 2-144
Range on HMM: 47-222/290
Sequence Identity: 25% (45 aa)

NIASEIR-HPNLLQFIGATT-----EGNPIILTELMPT-SLRKELE-----------TGGLAYPAILSISLDVAYALNYLHLFKPHPILHRDISSANVLL
|. . .. |||.....|...     ..| .| .| .|  ||.. |               | .  .... .|.| ...|||  .|  |.|||. | |.|.
NWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLV

QPM--VGVWKAKVSDYGTVSFQP--LAKTCN----------PGNPVYSAPESPYP--IQHSPAMDVFSYGVLLIEMV
        |..|..| |.. |.   ...| |           |.. ..|||       | |   ||.|.|. |.|..
DNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIA
Kinase AqueK554.AA STE 1-191 18 2.2e-13 43.71 In-house 79-353 (359) Show / Hide 
Range on Protein: 1-191
Range on HMM: 79-353/359
Sequence Identity: 18% (53 aa)

MNIASEIR--HPNLLQFIGATT--------EGNPIILTELMP-TSLRKELE-TGGLA--------------YPAILSISLDVAYA-LNYLHLFKPHPILH
..| .. .  |||  ...|.          ...  |  |.|.  ||.. .. ..|                 . |  |  ..  . |.|||  .   | |
IKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIH

RDISSANVLLQPMVGVWKAKVSDYGTVS-FQP----------------LAKTC--NPGNPVYSAPESPYP------IQHSPAMDVFSYGVLLIEMVLCQF
||| .||.||        .| .| |. . ...                 .. .    | | . |||   .       ...   |. | | ..|||.  . 
RDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKP

PEED-KSMREAQIKAIKR-------------------------------------------LTLKNLIERCLIENYRHRPTMSDIIK
|  | . ||    ....                                              .|. |..||. ....||| |. .|
PWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLK
Kinase AqueK554.AA LRRK 52-120 36 3.2e-12 39.51 In-house 169-249 (351) Show / Hide 
Range on Protein: 52-120
Range on HMM: 169-249/351
Sequence Identity: 36% (30 aa)

ISLDVAYALNYLHLFKPHPILHRDISSANVLLQPMV---------GVWKAKVSDYGTVS----FQP-LAKTCNPGNPVYSAPE
|.|..| ...||| ..| ||.|||  | |.||. .             .||..|.|. .    |.. .||.|  |||.. |||
IALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV-GNPGWMAPE
Kinase AqueK554.AA S_TKc 1-197 18 2.2e-11 -10.07 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-197
Range on HMM: 19-231/231
Sequence Identity: 18% (43 aa)

MNIA---------------------SEIRHPNLLQFIGATTEGNPIILTELMPT---SLRKELETGG-------LAYPAILSISLDVAYALNYLHLFKPH
 ..                      .. .|||. .....  ...  . .|....   .|.. ..  |       .    . ..   .. ||.|.|  .  
RHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG--

PILHRDISSANVLLQPMVGVWKAKVSDYGTVSFQPLAKTCNPGNPVYSAPESPYPIQHSP-AMDVFSYGVLLIEMVLCQFPEEDKSMREAQIKAIKRLTL
 |.|||.  .|.||         |..| |   .     |   | | | |||     .... . |. | |..|.||.  . | .     .. .| |.   .
-IIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIGSPEA

KNLIERCLIENYRHRPTMSDIIKEI-----NESI
|..|..||  . ..|||  .. ..       . .
KDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK554.AA TK-Unique 8-144 21 3.1e-11 35.11 In-house 62-233 (294) Show / Hide 
Range on Protein: 8-144
Range on HMM: 62-233/294
Sequence Identity: 21% (38 aa)

RHPNLLQFIGATT-EG-NPIILTELMPTS-LRKELETGG---------------------------LAYPAILSISLDVAYALNYLHLFKPHPILHRDIS
.|||..|..|..|  . .. |. | .| . |.. | | .                           . .   ...  ..| ...||.   .. | |||..
DHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLC

SANVLLQPMVGVWKAKVSDYGTVS----FQPLAKTC--NPGNPVYSAPESPY--PIQH-SPAMDVFSYGVLLIEMV
. ||||.      ..|..|.|        ......|  ..    . ||||..    .. ..  || |.|||. |..
ARNVLLTE---DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIF
Kinase AqueK554.AA Pkinase_Tyr 5-83 25 2.9e-10 35.4 Pfam 58-144 (270) Show / Hide 
Range on Protein: 5-83
Range on HMM: 58-144/270
Sequence Identity: 25% (23 aa)

SEI-RHPNLLQFIGATT-EGNP---IILTELMPT-SLRKELETG-----GLAYPAILSISLDVAYALNYLHLFKPHPILHRDISSANVLL
... .|||.....|. | .| |   .| .|.||  .|.. | .       |  . .|......| ...||.  .   . |||.   |.|.
KQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV
Kinase AqueK554.AA TyrKc 3-193 17 2e-09 -70.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 3-193
Range on HMM: 1-280/280
Sequence Identity: 17% (52 aa)

IA------------------------------------------SEI--RHPNLLQFIGATTE--------GNPIILTELMPT-SLRKELETGG--LAYP
|                                           ...  .|||.....|. |.        . . |..|.||  .|.. |   .  |  .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

AILSISLDVAYALNYLHLFKPHPILHRDISSANVLLQPMVGVWKAKVSDYGTVSFQPLAKTCNPG------NPVYS----------------APESPYPI
  ||.....|   .|||    ... |||.   |.|.        .|.|| |      |..    .        .|.                |||.    
DLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH---TVKISDFG------LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--N

QH--SPAMDVFSYGVLLIEMV-LCQFPEED-----KSMRE--AQIKAIKRLTLKNL----------------IERCLIENYRHRPTMSDIIKEI
 .  ... ||.|.||.. |.  ..| | ..     .| .|  ...|. .|.                     ...|  |.   |||.|.|....
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK554.AA Dicty4 5-82 31 2.1e-09 27.7 In-house 53-146 (277) Show / Hide 
Range on Protein: 5-82
Range on HMM: 53-146/277
Sequence Identity: 31% (30 aa)

SEIRHPNLLQFIGATT-----EGNPIILTELM-PTSLRKELET------GGLAYP--AILS---ISLDVAYALNYLHLFKPHPILHRDISSANVL
. |||||...| || |      | . | ||.|  ..| . |             .   |..   . .|.|  .|.||   |  |.|||. |.| |
CKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLL
Kinase AqueK554.AA DRK 2-98 34 2.3e-09 27.92 In-house 49-145 (258) Show / Hide 
Range on Protein: 2-98
Range on HMM: 49-145/258
Sequence Identity: 34% (35 aa)

NIASEIRHPNLLQFIGATTE-GNPIILTELMPT-SLRKEL--ETGGLAYPAILSISLDVAYALNYLHLFKPHPILHRDISSANVLLQPMVGVWKAKVSDY
|. .  ||||  ||.|. ..   . | .| ||  || . |  |   .  | .... .|.|  ..|||   |  |.|||  | | |       |. ||.|.
NLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLLVDEH---WQVKVADF

G
|
G
Kinase AqueK554.AA Dicty4 168-195 30 1e-06 18.07 In-house 248-277 (277) Show / Hide 
Range on Protein: 168-195
Range on HMM: 248-277/277
Sequence Identity: 30% (9 aa)

LKNLIERCLIENYRHRPTMSDIIKE--INE
.| ||..|. ..  |||... ||..   ..
WKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK554.AA Pkinase 6-83 16 2e-06 24.08 Pfam 56-141 (293) Show / Hide 
Range on Protein: 6-83
Range on HMM: 56-141/293
Sequence Identity: 16% (15 aa)

EIRHPNLLQFIGAT-TEGNPIILTELMPT-----SLRKELE---TGGL--AYPAILSISLDVAYALNYLHLFKPHPILHRDISSANVLL
...||| ......  ..... . .|...      .|   ..    |..   .  . .. . .. .|.|.|      |.|||. ..|.|.
RLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILI
Kinase AqueK554.AA DRK 171-196 34 6e-05 12.73 In-house 234-258 (258) Show / Hide 
Range on Protein: 171-196
Range on HMM: 234-258/258
Sequence Identity: 34% (9 aa)

LIERCLIENYRHRPTMSDIIKEINES
|. .|. |.  |||.| ... |. |.
LMNDCWNEDPQHRPSMQECL-ERLEA
Kinase AqueK554.AA TKL-Unique 168-193 26 0.000203 11.7 In-house 265-290 (290) Show / Hide 
Range on Protein: 168-193
Range on HMM: 265-290/290
Sequence Identity: 26% (7 aa)

LKNLIERCLIENYRHRPTMSDIIKEI
...||..|   .   ||. ..||...
YRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK554.AA LRRK 168-195 28 0.000279 11.03 In-house 324-351 (351) Show / Hide 
Range on Protein: 168-195
Range on HMM: 324-351/351
Sequence Identity: 28% (8 aa)

LKNLIERCLIENYRHRPTMSDIIKEINE
...||. |  .. . ||..|.|.| . .
YQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK554.AA Pkinase 127-197 16 0.003245 12.45 Pfam 189-293 (293) Show / Hide 
Range on Protein: 127-197
Range on HMM: 189-293/293
Sequence Identity: 16% (18 aa)

HSPAMDVFSYGVLLIEMVLCQFPEEDK------SMREAQIKAIKR-------------------------------LTLKNLIERCLIENYRHRPTMSDI
..|. |..|.|..|.||.. ..|  ..      ....  |. |..                                ..| .|..||  .   |||    
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQM-ICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----

IKEINES--I
...| ..  .
AEQILQHPWF
Kinase AqueK554.AA TK-Unique 170-193 25 0.005151 6.38 In-house 271-294 (294) Show / Hide 
Range on Protein: 170-193
Range on HMM: 271-294/294
Sequence Identity: 25% (6 aa)

NLIERCLIENYRHRPTMSDIIKEI
||...|. ..  .||. ..|....
NLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK554.AA Pkinase_Tyr 168-193 26 0.062581 7.16 Pfam 245-270 (270) Show / Hide 
Range on Protein: 168-193
Range on HMM: 245-270/270
Sequence Identity: 26% (7 aa)

LKNLIERCLIENYRHRPTMSDIIKEI
. .|. .|  ..  .|||.|.|. ..
IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK554.AA Pkinase_Tyr 132-144 53 1.447269 2.54 Pfam 196-208 (270) Show / Hide 
Range on Protein: 132-144
Range on HMM: 196-208/270
Sequence Identity: 53% (7 aa)

DVFSYGVLLIEMV
|| |.|||. |..
DVWSFGVLMWEIF