Gene AqueK555 (A.queenslandica)

AqueK555

Species: A.queenslandica
Alias: AqueK555
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK555.AA Protein None 197 None Fasta, JSON
AqueK555.kin_dom Protein Kinase Domain None 193 None Fasta, JSON

Protein domain

Protein domains of AqueK555.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK555.AA TKL 1-192 20 1.5e-37 131.12 In-house 76-364 (364) Show / Hide 
Range on Protein: 1-192
Range on HMM: 76-364/364
Sequence Identity: 20% (61 aa)

MNIASKIRHPNLLQFIGATTEGN--------------PMILTELM-PTSLRKELESGGVAYPAILSISLDVACALNYLHLFKP-----HPILHRDVSSAN
... |..||||..||.|. ....              ..| .|..   ||.  |       . .....||.|...||||  .|      ||.|||  |.|
IMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN

VLLQ-PMG----------GVWRAKVSDYGSANLQPLIG---------------------RTTNPGNPVYSAPEA--GNP--------------REHSPSM
.|.   .             |..|..|.| .      |                     . |  |.| . |||.  |..              .| |...
ILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKC

DVFSYGVLLLEMITRRIPLPEER--------------VGLIDGIRR--------------------ASFRSLVERCLIVEYRHRPTMNDIKTEL
||.|.|..| |..||..|  ..               .. .|  .|                     |...| ..|   . . ||....|. .|
DVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK555.AA MLK 2-150 25 3.2e-21 70.47 In-house 57-235 (291) Show / Hide 
Range on Protein: 2-150
Range on HMM: 57-235/291
Sequence Identity: 25% (46 aa)

NIASKIRHPN----LLQFIGATTE-GN-PMILTELMPT-SLRKELESG---------------GVAYPAILSISLDVACALNYLHLFKPHPILHRDVSSA
.......|||      || |. .. ..   |..| ..  ||   | ..                .    .....|..| ...|||  .|.|| |||  | 
RHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSH

NVLLQP-----MGGVWRAKVSDYGSAN-LQPL-IGRTTNPGNPVYSAPEA---GNPREHSPSMDVFSYGVLLLEMITRRIP
|.|.        .|.  .|..| | .  ..     .. |.|.. . |||.         | . ||.|.||.| ||.||..|
NILIDEICHDMHHGT--LKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase AqueK555.AA Pkinase 6-192 18 1.8e-19 69.93 Pfam 56-293 (293) Show / Hide 
Range on Protein: 6-192
Range on HMM: 56-293/293
Sequence Identity: 18% (46 aa)

KIRHPNLLQFIGAT-TEGNPMILTELMPT-----SLRKELE---SGGV--AYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGV-WRAK
...||| ......  ..... . .|...      .|   ..   .|..   .  . .. . ....|.|.|      |.|||. ..|.|.   | .  . |
RLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVK

VSDYGSAN---LQPLIGRTTNPGNPVYSAPEAGN-PREHSPSMDVFSYGVLLLEMITRRIPLPEE-------RVGLIDGIRR------------------
..| |.|    . .    ||  | | | |||  .  ....|. |..|.|..| ||...| | |..          .|. |..                  
ICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFF

-------------ASFRSLVERCLIVEYRHRPTMNDIKTE--L
              ........|| .    |||  .|.    .
RHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK555.AA TK 1-192 13 3.1e-19 60.43 In-house 89-486 (486) Show / Hide 
Range on Protein: 1-192
Range on HMM: 89-486/486
Sequence Identity: 13% (52 aa)

MNIASKIR-----HPNLLQFIGATTEGN-------------PMILTELMP-TS----LRKELESGG----------------------------------
...... .     |||.....|. |.|              .||..|.||  .    ||. | .                                    
AEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSH

-------------------------------------------VAYPAILSISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQ-PMGGVWR----
                                           .  .  | .....||.. |||  .         |||.   |.|.   .   |     
ESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGC

---AKVSDYGSAN-----LQPLIG------RTTNPGNPV-------------------------YSAPEAGN---------PREHSPSMDVFSYGVLLLE
   .|..|.| .      |   |.      |....| ..                         . |||. |          . ...  ||.|.|||. |
GPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWE

MIT--RRIPLP----------------------------------EERVGLI--DGIRR-------------ASFRSLVERCLIVEYRHRPTMNDIKTEL
. |  .  . .                                  ..|  .   ..                . .  |  .|   . ..|||. ... .|
IFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK555.AA HH498 47-150 38 2.1e-18 54.58 In-house 121-225 (284) Show / Hide 
Range on Protein: 47-150
Range on HMM: 121-225/284
Sequence Identity: 38% (42 aa)

PAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGVWRAKVSDYG-SANLQPLIGRT-TN-PGNPVYSAPEAGN-PREHSPSMDVFSYGVLLL
. .. ||.|||   ||||   .||| |||  | |.|.   |   .|.| |.| |  .. .   . |  |||. . |||        |   |||||.  . 
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDG---HAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIW

EMITRRIP
|| ||..|
EMHTREVP
Kinase AqueK555.AA Dicty4 5-194 26 5e-18 56.88 In-house 53-277 (277) Show / Hide 
Range on Protein: 5-194
Range on HMM: 53-277/277
Sequence Identity: 26% (60 aa)

SKIRHPNLLQFIGATT-----EGNPMILTELM-PTSLRKELES------GGVAYP--AILS---ISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMG
.||||||...| || |      | ..| ||.|  ..| . | .        .  .   |..   . .|.|  .|.||   |  |.|||  |.| |   . 
CKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLL---VD

GVWRAKVSDYGSAN-LQPLI----GRTTNPGNPVYSAPEAGNPREHSPSMDVFSYGVLLLEMITRRIPLP---EERVGLIDGIRR------------ASF
  ||.||.| | .   .. .    . .|  | | . |||    ..   . ||.|.| .| |. || .| .    . . ..... .            .|.
KNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSW

RSLVERCLIVEYRHRPTMNDIKTE--LND
..|...|.  .  |||... |  .  |. 
KHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK555.AA Dicty5 3-150 28 7.6e-18 58.01 In-house 49-202 (260) Show / Hide 
Range on Protein: 3-150
Range on HMM: 49-202/260
Sequence Identity: 28% (46 aa)

IASKIR--HPNLLQFIGATTEGNPM--ILTELMPT-SLRKELESGGV------AYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGVWR
| | .   |||.  . || .       ..||.    ||.  |           ||. .|.. .|.| .. .||      | |||. | |.|.      | 
IMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMNFLITEN---WK

AKVSDYG-SANLQPLIGRTTNPGNPVYSAPEAGNPREHSPSMDVFSYGVLLLEMITRRIP
.|. |.| | .     . |.. | . . |.|  | .      ||.|.|. | ||.||  |
IKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEP
Kinase AqueK555.AA CZAK 3-83 42 1e-16 57.32 In-house 53-142 (279) Show / Hide 
Range on Protein: 3-83
Range on HMM: 53-142/279
Sequence Identity: 42% (38 aa)

IASKIRHPNLLQFIGATTEGN---PMILTELMP-TSLRKELE--SGGVAY-PAI-LSISLDVACALNYLHL-FKPHPILHRDVSSANVLL
| || .||| .||.|| .|..     | .| |   |||. |   .  .   | . ... .|.|   ||||  .|| |||||| || |.||
IMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
Kinase AqueK555.AA TKL-Unique 2-150 25 1.1e-15 51.96 In-house 47-233 (290) Show / Hide 
Range on Protein: 2-150
Range on HMM: 47-233/290
Sequence Identity: 25% (48 aa)

NIASKIR-HPNLLQFIGATT-----EGNPMILTELMPT-SLRKELE-----------SGGVAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
|. .|.. |||.....|...     ..|  | .| .|  ||.. |            .    .  .... .|.| ...|||  .|  |.|||  | |.|.
NWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLV

QPM--GGVWRAKVSDYGSANLQPLIGRTTNP-----------GNPVYSAPEAGNP--REHSPSMDVFSYGVLLLEMITRRI------P
        |..|..| | . ..  | ..||            |.. ..|||  .      | . ||.|.|. | |..|| |      |
DNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase AqueK555.AA STE 1-187 17 1.2e-15 51.87 In-house 79-350 (359) Show / Hide 
Range on Protein: 1-187
Range on HMM: 79-350/359
Sequence Identity: 17% (50 aa)

MNIASKIR--HPNLLQFIGATT--------EGNPMILTELMP-TSLRKELESGGVAY---------------PAILSISLDVACA-LNYLHLFKPHPILH
..| .| .  |||  ...|.          ...  |  |.|.  ||.. ... .                  . |  |  ..  . |.|||  .   | |
IKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIH

RDVSSANVLLQPMGGVWRAKVSDYGSAN-LQPLIG-----------------RTTNPGNPVYSAPEAGNP------REHSPSMDVFSYGVLLLEMITRRI
||. .||.||        .| .| | .  |.. .                  |.|  | | . |||  ..       ... . |. | | ...||.| . 
RDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKP

PL---PEERVGLIDGIRR-------------------------------------------ASFRSLVERCLIVEYRHRPTMND
|.   .  |. .   .                                              .|.  ...||. ....||| ..
PWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase AqueK555.AA S_TKc 1-197 19 2.2e-13 19.22 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-197
Range on HMM: 19-231/231
Sequence Identity: 19% (45 aa)

MNIA---------------------SKIRHPNLLQFIGATTEGNPMILTELMPT---SLRKELESGG-------VAYPAILSISLDVACALNYLHLFKPH
 ..                      .| .|||. .....  ...  . .|....   .|.. ... |            . ..   ..|||.|.|  .  
RHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG--

PILHRDVSSANVLLQPMGGVWRAKVSDYGSANLQPLIGRTTNPGNPVYSAPEAGNPREHSP-SMDVFSYGVLLLEMITRRIPLPEERVGLIDGIRRASFR
 |.|||.  .|.||       . |..| |.| .      ||  | | | |||      ... . |. | |..| ||.... | | .   ... |.  ...
-IIHRDLKPENILLDE-----HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIGSPEAK

SLVERCLIVEYRHRPTMNDIKT----ELNDTVY
.....|| .. ..|||  .. .      ..   
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK555.AA Pkinase_Tyr 5-83 24 2.9e-11 38.75 Pfam 58-144 (270) Show / Hide 
Range on Protein: 5-83
Range on HMM: 58-144/270
Sequence Identity: 24% (22 aa)

SKI-RHPNLLQFIGATT-EGNP---MILTELMPT-SLRKELESG-----GVAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
... .|||.....|. | .| |   .| .|.||  .|.. | .       .  . .|......|....||.  .   . |||.   |.|.
KQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV
Kinase AqueK555.AA TyrKc 1-192 17 1.3e-09 -67.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-192
Range on HMM: 1-280/280
Sequence Identity: 17% (49 aa)

MNIASKI------------------------------------------RHPNLLQFIGATTE--------GNPMILTELMPT-SLRKELESGG--VAYP
     |.                                          .|||.....|. |.        . .||..|.||  .|.. | . .  .  .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

AILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGVWRAKVSDYGSANLQPLI------GRTTNP-----GN---PV-YSAPEAGNPREHSPSM
  ||.....||  .|||    ... |||    |.|.   .   ..|.|| | .            . .  .     |.   |.   |||. | .. ..  
DLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVFSYGVLLLEMITRRIPLPEE-----------RVGLIDGIRRASFRS---------------LVERCLIVEYRHRPTMNDIKTEL
||.|.||.. |. |.  . ...           .  . .| |.    .               . ..|   .   |||...|. ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK555.AA LISK-DD1 131-150 65 6.9e-08 24.84 In-house 211-230 (290) Show / Hide 
Range on Protein: 131-150
Range on HMM: 211-230/290
Sequence Identity: 65% (13 aa)

SMDVFSYGVLLLEMITRRIP
| ||||.|..|||.|||..|
SCDVFSFGMVLLELITRKKP
Kinase AqueK555.AA LISK-DD1 50-98 44 1e-05 16.89 In-house 126-172 (290) Show / Hide 
Range on Protein: 50-98
Range on HMM: 126-172/290
Sequence Identity: 44% (22 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM-GGVWRAKVSDYG
..|.||.|||  |||  .   |.|||  | | |.     . ||.|| | |
VKIALDIACAMAYLHSKN---IIHRDLKSKNILVDENGDSQWRIKVCDFG
Kinase AqueK555.AA LISK-DD1 7-31 30 0.000839 9.91 In-house 54-92 (290) Show / Hide 
Range on Protein: 7-31
Range on HMM: 54-92/290
Sequence Identity: 30% (12 aa)

IRHPNLLQFIGATTE--------------GNPMILTELM
|||||. ||||.  .              .  .|.||..
IRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFI
Kinase AqueK555.AA CZAK 117-150 32 0.019102 4.88 In-house 188-221 (279) Show / Hide 
Range on Protein: 117-150
Range on HMM: 188-221/279
Sequence Identity: 32% (11 aa)

YSAPEAGNPREHSPSMDVFSYGVLLLEMITRRIP
. |||       ..  ||.|.| .| ..|| . |
WMAPECFKGENYTEKVDVYSFGMILWCIITCDQP
Kinase AqueK555.AA Pkinase_Tyr 133-147 53 0.602102 3.83 Pfam 196-210 (270) Show / Hide 
Range on Protein: 133-147
Range on HMM: 196-210/270
Sequence Identity: 53% (8 aa)

DVFSYGVLLLEMITR
|| |.|||. |..|.
DVWSFGVLMWEIFTY