Gene AqueK574 (A.queenslandica)

AqueK574

Species: A.queenslandica
Alias: AqueK574
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK574.AA Protein None 469 None Fasta, JSON
AqueK574.kin_dom Protein Kinase Domain None 91 None Fasta, JSON

Protein domain

Protein domains of AqueK574.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK574.AA TKL 332-416 23 3.2e-17 58.57 In-house 145-282 (364) Show / Hide 
Range on Protein: 332-416
Range on HMM: 145-282/364
Sequence Identity: 23% (32 aa)

LNYLHLFKP-----QPIIHRDVSSPNVLLKPFGP----------AGYEAKVTDYGTA-------DLQETTCTIM---------------PGNAAYAAPEA
.||||  .|      ||||||  |.|.|..  .           | . .|..|.|..       . . |  |.|                |. .. |||.
MNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEV

RDPE----------------QHSPAMDVYSYSVLLMEM
 . .                . |...||||. ..| |.
LRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase AqueK574.AA MLK 332-416 33 6.3e-17 55.37 In-house 137-229 (291) Show / Hide 
Range on Protein: 332-416
Range on HMM: 137-229/291
Sequence Identity: 33% (32 aa)

LNYLHLFKPQPIIHRDVSSPNVLLK----PFGPAGYEAKVTDYGTAD-LQET-T-CTIMPGNAAYAAPEAR---DPEQHSPAMDVYSYSVLLMEM
..|||  .|.||||||  |.|.|.     ..  ..  .|..| ||.  .... |  . ..|..|. |||..     |. | . ||.|. |.| ||
MHYLHSMAPKPIIHRDLKSHNILIDEICHDM--HHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEM
Kinase AqueK574.AA Dicty4 265-327 36 4.7e-14 43.43 In-house 2-66 (277) Show / Hide 
Range on Protein: 265-327
Range on HMM: 2-66/277
Sequence Identity: 36% (24 aa)

VTGVELGRGSYATVNVGIFRGLRVAVKSL--HTIIISDYNLALFSREMSIASRVRHPNLVQFIGA
......|.||...|  |. ||  |||| |  | .  . . |  | .| .| .  ||||...| ||
NIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGA
Kinase AqueK574.AA DRK 265-327 43 1.6e-13 42.18 In-house 2-65 (258) Show / Hide 
Range on Protein: 265-327
Range on HMM: 2-65/258
Sequence Identity: 43% (28 aa)

VTGVELGRGSYATVNVGIFRGLRVAVKSLHTIIISDYN-LALFSREMSIASRVRHPNLVQFIGA
. |.  |||.|. |  |  ||  |||| |    | | | |  | ||  . .. |||| .||.|.
KIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGT
Kinase AqueK574.AA CZAK 333-416 31 3.7e-12 40.61 In-house 119-215 (279) Show / Hide 
Range on Protein: 333-416
Range on HMM: 119-215/279
Sequence Identity: 31% (32 aa)

NYLHL-FKPQPIIHRDVSSPNVLLKPFGPAGYE-------------AKVTDYGTA---DLQETTCTIMPGNAAYAAPEARDPEQHSPAMDVYSYSVLLME
||||  .|| ||.||| || |.||       |              .|. |.|       | .  |   |  .. |||    |  ..  ||||.  .| .
NYLHDNWKPNPILHRDLSSRNILLD----HSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVYSFGMILWC

M
.
I
Kinase AqueK574.AA HH498 333-416 37 1.2e-11 32.82 In-house 135-219 (284) Show / Hide 
Range on Protein: 333-416
Range on HMM: 135-219/284
Sequence Identity: 37% (33 aa)

NYLHLFKPQPIIHRDVSSPNVLLKPFGPAGYEAKVTDYG----TADLQETTCTIMPGNAAYAAPEARD-PEQHSPAMDVYSYSVLLMEM
||||   ..||||||  | |.|.  .|     |.| |.|      |. . . |  |||  . |||      . |   ||.||   . ||
NYLHNSLKHPIIHRDLNSHNILIHEDG----HAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEM
Kinase AqueK574.AA Gdt 270-335 28 2e-11 35.39 In-house 7-76 (289) Show / Hide 
Range on Protein: 270-335
Range on HMM: 7-76/289
Sequence Identity: 28% (21 aa)

LGRGSYATVNVGIFRGLRVAVKSLHTIIISDYN--------LALFSREMSIASRVRHPNLVQFIGATKVSLNYL
.. |.. .|. ||.|.. ||||    . ... |           . |||.| |...|.| | ||| . ......
CSQGTFGMVYKGIWRSSQVAVK---MFKHHYVNYTKTYSQSCDEIYREMDILSKIKHQNIVSFIGCV-HFSSHH
Kinase AqueK574.AA TKL 270-329 22 9.4e-11 34.95 In-house 1-95 (364) Show / Hide 
Range on Protein: 270-329
Range on HMM: 1-95/364
Sequence Identity: 22% (21 aa)

LGRGSYATVNVGIFRG----------LRVAVKSLHTIIISDYNL-------------------------ALFSREMSIASRVRHPNLVQFIGATK
.|.|....|  |..||            |||| ...   .  ..                           . .|. . || ||||.|||.|. .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCC
Kinase AqueK574.AA LISK 269-327 31 2.2e-10 29.71 In-house 1-64 (296) Show / Hide 
Range on Protein: 269-327
Range on HMM: 1-64/296
Sequence Identity: 31% (20 aa)

ELGRGSYATVNVGIFR--GLRVAVKSLHT---IIISDYNLALFSREMSIASRVRHPNLVQFIGA
|.|.|... |  |  |  |  .|.| .|.     . . ..  . ||. .  . |||| |||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV
Kinase AqueK574.AA S_TKc 264-459 16 2.1e-09 -39.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 264-459
Range on HMM: 1-231/231
Sequence Identity: 16% (42 aa)

TVTGVELGRGSYATVNVGIFRG--LRVAVKSLHTIIISDYNLALFSREMSIASRVRHPNLVQFIGATK----------VSL------NYLHLFKP-----
   . ..|.|....|  .. ..   .||.| ..           . ||..| .. .|||.|.....            ..        |..  ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

----------------------QPIIHRDVSSPNVLLKPFGPAGYEAKVTDYGTADLQETTCTIMPGNAAYAAPEARDPEQHSP-AMDVYSYSVLLMEMT
                      . |||||.   |.||        . |..| | | .     | . |   | |||     .... . |..|  ..| || 
PFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

LHLP---PEMTLAKREXXXXLLCQAMLLMLLLK-----LVILNDTV-------QQWM
   |    .... |.       .  ..  .| |     . .             .|.
CGYPPFPQMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK574.AA LRRK 332-413 30 6e-09 27.77 In-house 177-272 (351) Show / Hide 
Range on Protein: 332-413
Range on HMM: 177-272/351
Sequence Identity: 30% (30 aa)

LNYLHLFKPQPIIHRDVSSPNVLLKPFG-P-------AGYEAKVTDYGTAD----LQETTCTIMPGNAAYAAPEARD---PEQHSPAMDVYSYSVLL
..||| ..| ||||||  |||.||. .  .       | . ||. |.|.      ....    . ||  . ||| .     |. .   |.||. ..|
MEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMIL
Kinase AqueK574.AA TKL-Unique 266-329 27 1e-08 27.08 In-house 1-66 (290) Show / Hide 
Range on Protein: 266-329
Range on HMM: 1-66/290
Sequence Identity: 27% (19 aa)

TGVELGRGSYATVNVGIFRGLRVAVKSLHTIIISDYNLA---LFSREMSIASRVR-HPNLVQFIGATK
 .  .|.|.|..|  |..||  ||.|..|    .| ..     |..| .. .. . |||.|...|...
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCM
Kinase AqueK574.AA CZAK 267-327 35 1.2e-08 27.74 In-house 4-68 (279) Show / Hide 
Range on Protein: 267-327
Range on HMM: 4-68/279
Sequence Identity: 35% (23 aa)

GVELGRGSYATVNVGIFRGLRVAVKSLHTIIISDYNL----ALFSREMSIASRVRHPNLVQFIGA
| . |.| .  |  .  ||  ||.| .| .   .         | .| || |  .||| |||.||
GQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGA
Kinase AqueK574.AA TKL-Unique 332-416 28 1.5e-08 26.41 In-house 123-221 (290) Show / Hide 
Range on Protein: 332-416
Range on HMM: 123-221/290
Sequence Identity: 28% (28 aa)

LNYLHLFKPQPIIHRDVSSPNVLLKPF-GPAGYEAKVTDYGTADLQETT---CTIMP---------GNAAYAAPEARDP--EQHSPAMDVYSYSVLLMEM
..|||  .|  |||||  |.|.|.  .   | . .|. | |.. .. .     ....         |.. ..|||      .| |   ||||... | |.
MYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEI
Kinase AqueK574.AA TyrKc 264-459 14 5.9e-08 -93.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 264-459
Range on HMM: 1-280/280
Sequence Identity: 14% (41 aa)

TVTGVELGRGSYATVNVGIFRGLRVAVKSLHTIIISDYNLALFSREMSIASRV--RHPNLVQFIGATKVS----------------------LNYLHLFK
 . | .||.| . .|  |. . . ||||.|.        .. | ||..| ...  .|||.|...|.   .                      ..||.  .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

P-----------------------QPIIHRDVSSPNVLLKPFGPAGYEAKVTDYGTADLQETT----------------CTIMPGNAAYAAPEARDPEQH
|                       ...||||    |.|..  .     .|..| | .   .                  .. ..      |||. .    
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SPAMDVYSYSVLLMEMT-------LH-----LPPEMTLAKREXXXXLLCQAM-----------LLMLLLKLVILN--------DTVQQWM
... ||.|. |.. |.               ....  ... .    . . .             .  . |              .. . .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK574.AA LRRK 264-326 14 3e-06 18.22 In-house 1-124 (351) Show / Hide 
Range on Protein: 264-326
Range on HMM: 1-124/351
Sequence Identity: 14% (18 aa)

TVTGVELGRGSYA-TVNVGIFRG----------------------------LRVAVKSLHT--------------------------------IIISDYN
 . . ..|||... .|  ...||                              ||.|....                                .. .  .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LALFSREMSIASRVRHPNLVQFIG
. .| .|..| |. .|||.|. .|
FREFRHEVWIMSHLNHPNIVSLKG
Pkinase_Tyr AqueK574.AA Pkinase_Tyr 264-327 27 9e-06 20.11 Pfam 1-72 (270) Show / Hide 
Range on Protein: 264-327
Range on HMM: 1-72/270
Sequence Identity: 27% (20 aa)

TVTGVELGRGSYATVNVGIFR------GLRVAVKSLHTIIISDYN--LALFSREMSIASRV-RHPNLVQFIGA
 . | .||.|.. .|  |. .      .. ||||.|     .. .  .. | ||..| .   .|||.|...|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGV
Kinase AqueK574.AA MLK 264-327 25 0.000184 11.54 In-house 1-77 (291) Show / Hide 
Range on Protein: 264-327
Range on HMM: 1-77/291
Sequence Identity: 25% (20 aa)

TVTGVELGRGSYATVNVGIFRGLR-----VAVKSLHTIIISDYNLA-----LFSREMSIASRVRHPN----LVQFIGA
  .   .| ||.  |  | .|. .     ||||  .. |. |   .      | .|  ......|||     .|| |.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGV
Kinase AqueK574.AA Pkinase 264-327 26 0.000301 16.1 Pfam 1-68 (293) Show / Hide 
Range on Protein: 264-327
Range on HMM: 1-68/293
Sequence Identity: 26% (18 aa)

TVTGVELGRGSYATVNVGIFRGLR--VAVKSLHTIIISDYNLALFSR--EMSIASRVRHPNLVQFIGA
 ..|  .|.||...|  .. .| .  |||| .    ...  .    |  | .|  |..||| |.....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDW
Kinase AqueK574.AA LISK 343-371 41 0.000639 8.4 In-house 122-150 (296) Show / Hide 
Range on Protein: 343-371
Range on HMM: 122-150/296
Sequence Identity: 41% (12 aa)

IIHRDVSSPNVLLKPFGPAGYEAKVTDYG
|||||  | |.|.. ..  ....||.| |
IIHRDLKSKNCLVRENDNNQWRIKVCDFG
Kinase AqueK574.AA HH498 306-328 52 0.000767 7.62 In-house 49-71 (284) Show / Hide 
Range on Protein: 306-328
Range on HMM: 49-71/284
Sequence Identity: 52% (12 aa)

FSREMSIASRVRHPNLVQFIGAT
| || || .|  ||. |||..|.
FCREVSIMCRLNHPCVVQFVYAC
Kinase AqueK574.AA Pkinase 389-422 37 0.220767 5.97 Pfam 177-211 (293) Show / Hide 
Range on Protein: 389-422
Range on HMM: 177-211/293
Sequence Identity: 37% (13 aa)

YAAPEA-RDPEQHSPAMDVYSYSVLLMEMTLHLPP
|.|||  |. . ..|. |..|. ..| || .  ||
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPP
Kinase AqueK574.AA Pkinase_Tyr 405-416 50 7.917708 0.04 Pfam 196-207 (270) Show / Hide 
Range on Protein: 405-416
Range on HMM: 196-207/270
Sequence Identity: 50% (6 aa)

DVYSYSVLLMEM
||.|. ||. |.
DVWSFGVLMWEI