Gene AqueK575 (A.queenslandica)

AqueK575

Species: A.queenslandica
Alias: AqueK575
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK575.AA Protein None 140 None Fasta, JSON
AqueK575.kin_dom Protein Kinase Domain None 99 None Fasta, JSON

Protein domain

Protein domains of AqueK575.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK575.AA TKL 21-140 24 3.4e-21 73.05 In-house 1-170 (364) Show / Hide 
Range on Protein: 21-140
Range on HMM: 1-170/364
Sequence Identity: 24% (42 aa)

FRRRSFSVVTVGIFRG----------LRVAVKSLYDDVISDENV-------------------------ALFTREMSIVSRIRHPNLVQFFGATKVGS--
  . .|..|  |..||            |||| .  .  . ..                            . .|. . ||.||||.||| |. . ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PLIVTELM-STNLRKELPKTSLRKQQILSIAQDVALGLNYLHLFKP-----QPIIHRNVSSLN
            . ||.|..   .|.  |       .|....|.|.|.|.||||  .|      |||||.  | |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN
Kinase AqueK575.AA Dicty4 32-134 35 3.4e-20 64.21 In-house 18-138 (277) Show / Hide 
Range on Protein: 32-134
Range on HMM: 18-138/277
Sequence Identity: 35% (43 aa)

GIFRGLRVAVKSL--YDDVISDENVALFTREMSIVSRIRHPNLVQFFGA-T----KVGSPLIVTELM-STNLRKELPK------TSLRKQ--QILS---I
|. ||  |||| |    .. . .    | .| .| . |||||...| || |    . |...||||.| ..|| . | .       |  ..   |..   .
GTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRM

AQDVALGLNYLHLFKPQPIIHR
| |.|.|.|.||   |  ||||
AFDAARGMNWLHCCNPV-IIHR
Kinase AqueK575.AA CZAK 35-140 37 4.7e-17 58.59 In-house 21-139 (279) Show / Hide 
Range on Protein: 35-140
Range on HMM: 21-139/279
Sequence Identity: 37% (45 aa)

RGLRVAVKSLYDDVISDENV----ALFTREMSIVSRIRHPNLVQFFGA-TKVG--SPLIVTELMS-TNLRKELP-KTSLRKQ---QILSIAQDVALGLNY
||  ||.| .. .   .         | .| || |  .||| ||| || .  |     ||.| |    ||. |  . .. ||     ...| |.| | ||
RGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNY

LHL-FKPQPIIHRNVSSLN
||  .|| ||.||  || |
LHDNWKPNPILHRDLSSRN
Kinase AqueK575.AA TKL-Unique 25-140 29 9.7e-16 52.13 In-house 9-142 (290) Show / Hide 
Range on Protein: 25-140
Range on HMM: 9-142/290
Sequence Identity: 29% (40 aa)

SFSVVTVGIFRGLRVAVKSLY-DDVISDENVALFTREMSIVSRIR-HPNLVQFFGATK---VGSP--LIVTELMSTN-LRKELP-----------KTSLR
....|  |..||  ||.|..     .| | .  | .| .. .... |||.|...|...   |  |   ||.| .. . |.. |            .. | 
GYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLN

KQQILSIAQDVALGLNYLHLFKPQPIIHRNVSSLN
 ||....|.|.|.|..|||  .|  ||||.  |.|
MQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSN
Kinase AqueK575.AA Pkinase_Tyr 39-136 29 5.5e-14 47.98 Pfam 31-137 (270) Show / Hide 
Range on Protein: 39-136
Range on HMM: 31-137/270
Sequence Identity: 29% (33 aa)

VAVKSLYDDVISDEN--VALFTREMSIVSRI-RHPNLVQFFGATK-VGSP---LIVTELMST-NLRKELPKT-----SLRKQQILSIAQDVALGLNYLHL
||||.|  .  ..|.   . | ||..| . . .|||.|.. |.    | |   .||.|.|   .|.. | |      .|  ...|......| |..||. 
VAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES

FKPQPIIHRNV
 .   .||| .
KN---CIHRDL
Kinase AqueK575.AA TK 26-136 15 1.8e-13 40.79 In-house 12-266 (486) Show / Hide 
Range on Protein: 26-136
Range on HMM: 12-266/486
Sequence Identity: 15% (39 aa)

FS---VVTVGIFRGL---------------------------RVAVKSLYDD-VISDENVAL--------------FTREMSIVS--RIRHPNLVQFFG-
|    .|  |. ||.                           .|||| | ..   |.|   .              . .||.. .    .|||.|...| 
FGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGV

ATKV------------GSPLIVTELMS-TN----LRKELPKTS---------------------------------------------------------
 |..            . ..||.|.|.  .    ||. | | .                                                         
CTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPP

--------------------LRKQQILSIAQDVALGLNYLHLFKP---QPIIHRNV
                    |  .| | .....| |. |||  .    | ..||..
LTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDL
Kinase AqueK575.AA DRK 35-134 35 5.3e-13 40.4 In-house 21-124 (258) Show / Hide 
Range on Protein: 35-134
Range on HMM: 21-124/258
Sequence Identity: 35% (37 aa)

RGLRVAVKSLYDDVISDEN-VALFTREMSIVSRIRHPNLVQFFGA-TKVGSPLIVTELMST-NLRKEL--PKTSLRKQQILSIAQDVALGLNYLHLFKPQ
||  |||| |  . | ||| .  | ||  . .. |||| .|| |. .   ...|..| |.   | . |  .. ..    ..... |.| |..|||   | 
RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPI

PIIHR
 ||||
-IIHR
Kinase AqueK575.AA MLK 32-140 24 1.2e-12 40.33 In-house 18-157 (291) Show / Hide 
Range on Protein: 32-140
Range on HMM: 18-157/291
Sequence Identity: 24% (34 aa)

GIFRGLR-----VAVKSLY----DDVISDENVALFTREMSIVSRIRHPN----LVQFFGA-TKVGS-PLIVTELMS-----TNLRKELPKTS--------
| .|. .     ||||       | .....    | .|  ......|||     .|| |. .. ..  .||.| ..     . |. . .| .        
GRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKN

---LRKQQILSIAQDVALGLNYLHLFKPQPIIHRNVSSLN
      ......| ..| |..|||  .|.|||||   | |
DRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHN
Kinase AqueK575.AA LISK 20-124 31 2.7e-11 32.76 In-house 1-118 (296) Show / Hide 
Range on Protein: 20-124
Range on HMM: 1-118/296
Sequence Identity: 31% (37 aa)

EFRRRSFSVVTVGIFR--GLRVAVKSLY---DDVISDENVALFTREMSIVSRIRHPNLVQFFGATKV-GSPL-IVTELMST-NLRKELPKT-----SLRK
|. . .|. |  |  |  |  .|.| .    .|.. .|.   . ||. .  ..|||| |||.|. .   . | ||||...  .|.  | ..      |  
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

QQILSIAQDVALGLNYLH
.| ..|| |.|.|. |||
PQRVKIALDIACGMSYLH
Kinase AqueK575.AA Shk 32-124 37 2.9e-11 36.88 In-house 18-118 (269) Show / Hide 
Range on Protein: 32-124
Range on HMM: 18-118/269
Sequence Identity: 37% (38 aa)

GIFRGLRVAVKSLYDDVISDENVALFTREMSIVSRIRHPNLVQFFGA-T-KVGSPLIVTELM-STNLRKELPKTSLRKQ--QILS---IAQDVALGLNYL
|. ||  |||| .   . .      |  | .| |.|.|||.. | || | . |   ||||||  .|| | |      |    ..    .. | ||| | |
GRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILYKRAMRMCRDAALGMNWL

H
|
H
Kinase AqueK575.AA Dicty5 32-140 29 9.9e-11 33.16 In-house 18-134 (260) Show / Hide 
Range on Protein: 32-140
Range on HMM: 18-134/260
Sequence Identity: 29% (36 aa)

GIFRGLRVAVKSLYDDVISDENVALFTREMSIVSRIR--HPNLVQFFGATKVGSPL--IVTELMST-NLRKELPKTSLRK--------QQILSIAQDVAL
||..|  ||.| .  ..    .   | ||  |.| .   |||.. ..|| .       .|||. .   |.  |     ||         |.|..| |.| 
GIYKGMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYL--NDQRKTTGQPIAYFQQLHMAIDIAQ

GLNYLHLFKPQPIIHRNVSSLN
.. .||      |||| . |.|
SMRHLHSMN---IIHRDLKSMN
Kinase AqueK575.AA Pkinase 36-134 21 2.2e-07 27.17 Pfam 24-132 (293) Show / Hide 
Range on Protein: 36-134
Range on HMM: 24-132/293
Sequence Identity: 21% (24 aa)

GLRVAVKSLYDDVISDENVALFTR--EMSIVSRIRHPNLVQFFGATK-VGSPLIVTELMST-----NLRKELP---KTSL--RKQQILSIAQDVALGLNY
| .|||| .  . ....     .|  | .|  |..||| |.....    ... .|.|..        |   .    ....    ... ...  .. ||.|
GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEY

LHLFKPQPIIHR
.|      ||||
CHSM---GIIHR
TyrKc AqueK575.AA TyrKc 19-139 11 0.000532 -157.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-139
Range on HMM: 1-280/280
Sequence Identity: 11% (34 aa)

EEFRRR----SFSVVTVGIFRGLRVAVKSLYDDVISDENVALFTREMSIVSRI--RHPNLVQFFGATKV--------GSPLIVTELMST-NLRKELPKTS
 .. .      | .|  |. . . ||||.| .|      .. | ||..| ...  .|||.|...|.           . ..||.|.|.  .|.. | |. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LRKQQILSIAQDVALGLNYLH---------------LFKPQ-----------------------PII-------HR----------------------
  |  .. ||.. ..| | .|||               . ...                         .        .                      
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

-----------------------------------------------N----------------------------------VSSL
                                               |                                  .. .
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF