Gene AqueK579 (A.queenslandica)

AqueK579

Species: A.queenslandica
Alias: AqueK579
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK579.AA Protein None 451 None Fasta, JSON
AqueK579.kin_dom Protein Kinase Domain None 121 None Fasta, JSON

Protein domain

Protein domains of AqueK579.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK579.AA TKL 155-278 25 3.2e-30 106.0 In-house 1-174 (364) Show / Hide 
Range on Protein: 155-278
Range on HMM: 1-174/364
Sequence Identity: 25% (46 aa)

LGRGSYAVVTVGIFRG----------LRVAVKSLHTLIISNYNR-------------------------GLFSREMSIASRVRHPNLVQFIGATK-----
.|.|....|  |..||            |||| ...   .. ..                           . .|. . || ||||.|||.|. .     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------VGNPLILTELM-STSLYKKLQETELSNEQIVSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNVLLK
          |.. | .|..   ||.  |.      .|....|.|.|.|.||||  .|      ||||||  |.|.|..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVD
Kinase AqueK579.AA MLK 149-277 26 1.7e-25 85.5 In-house 1-160 (291) Show / Hide 
Range on Protein: 149-277
Range on HMM: 1-160/291
Sequence Identity: 26% (42 aa)

TLTKEELGRGSYAVVTVGIFRGLR-----VAVKSLHTLI----ISNYNRGLFSREMSIASRVRHPN----LVQFIGA-TKVGN-PLILTELMST-SLYKK
 ...| .| ||. .|  | .|. .     ||||  .. |    ..   .  | .|  ......|||     .|| |. .. ..  .|..| ..  |||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LQETE---------------LSNEQIVSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLL
| . .                . ......| ..| |..|||  .|.||||||  |.|.|.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILI
Kinase AqueK579.AA TKL-Unique 151-277 32 3e-25 86.11 In-house 1-145 (290) Show / Hide 
Range on Protein: 151-277
Range on HMM: 1-145/290
Sequence Identity: 32% (47 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSLHT-LIISNYNRGLFSREMSIASRVR-HPNLVQFIGATK---VGNP--LILTELMST-SLYKKLQ--------
  . .|.|.|..|  |..||  ||.|..|    .||  .  |..| .. .. . |||.|...|...   | .|   | .| ..  |||. |.        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

---ETELSNEQIVSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLL
   ...|...|.|..|.|.|.|..|||  .|  |||||  |.|.|.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLV
Kinase AqueK579.AA Dicty4 151-269 34 8.5e-21 66.24 In-house 3-139 (277) Show / Hide 
Range on Protein: 151-269
Range on HMM: 3-139/277
Sequence Identity: 34% (47 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSL--HTLIISNYNRGLFSREMSIASRVRHPNLVQFIGA-T----KVGNPLILTELM-STSLYKKLQE-------
. ...|.||.. |  |. ||  |||| |  |    . .    | .| .| .  ||||...| || |    . | ..| ||.| ...||. |         
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

-TELSNEQIVS---IAQDVALGLNYLHLFKPQPIIHRD
 ..|. . | .   .| |.|.|.|.||   |  |||||
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD
Kinase AqueK579.AA CZAK 150-277 35 2.2e-19 67.13 In-house 1-142 (279) Show / Hide 
Range on Protein: 150-277
Range on HMM: 1-142/279
Sequence Identity: 35% (51 aa)

LTKE-ELGRGSYAVVTVGIFRGLRVAVKSLHTLIISNYNR----GLFSREMSIASRVRHPNLVQFIGATKVGN---PLILTELMS-TSLYKKLQETELSN
|. . . |.| .  |  .  ||  ||.| .|     |         | .| || |  .||| |||.||   ..     | .| |   || . | .     
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH

EQ----IVSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLL
.|      ..| |.| | ||||  .|| ||.||| || |.||
KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
Kinase AqueK579.AA STE 150-290 18 5.5e-19 63.76 In-house 1-188 (359) Show / Hide 
Range on Protein: 150-290
Range on HMM: 1-188/359
Sequence Identity: 18% (38 aa)

LTK-EELGRGSYAVVTVGIFR-----------------GLRVAVKSLH---------------TLIISNYNRGLFSREMSIASRVR--HPNLVQFIGATK
... |..|.|.. .|  .. .                 | ..|.| ..               . .. . ..  . .|..| .. .  ||| |...|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG--------NPLILTELMS-TSLYKKLQET-----ELS----------NEQIVSIAQDVALG-LNYLHLFKPQPIIHRDVSSPNVLLKPCTGAASYEAK
..        .  |  |.|.  || . ....     .|.           .||  |....  | |.|||  .   |||||. . |.||          .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------VK

L
|
L
Kinase AqueK579.AA DRK 156-276 37 5.3e-17 54.15 In-house 8-132 (258) Show / Hide 
Range on Protein: 156-276
Range on HMM: 8-132/258
Sequence Identity: 37% (48 aa)

GRGSYAVVTVGIFRGLRVAVKSLHTLIISNYN-RGL---FSREMSIASRVRHPNLVQFIGA-TKVGNPLILTELMST-SLYKKL--QETELSNEQIVSIA
|||.|. |  |  ||  |||| |  .   | |   .   | ||  . .. |||| .||.|. .    ..| .| |.  |||. |  .  |..   . ...
GRGNYGEVFRGTWRGTQVAVKMLFNH---NINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMM

QDVALGLNYLHLFKPQPIIHRDVSSPNVL
 |.| |..|||   |  |||||  | | |
FDCAKGMIYLHCCNPI-IIHRDLKSHNLL
Kinase AqueK579.AA TK 149-277 13 8.7e-17 52.07 In-house 1-273 (486) Show / Hide 
Range on Protein: 149-277
Range on HMM: 1-273/486
Sequence Identity: 13% (38 aa)

TLTKEELGRGSYA---VVTVGIFRGL---------------------------RVAVKSLHTLIISNYNRGL---------------FSREMSIAS--RV
    ..||.| .    .|  |. ||.                           .|||| |.    .. .. .               . .||.. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNLVQFIG-ATKVGN------------PLILTELMS-TS----LYKKLQETE----------------------------------------------
.|||.|...|  |....            ..|..|.|.  .    | . |..                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSNEQIVSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLL
                               |. .| . .....| |. |||  .    | ..|||.   |.|.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLV
Pkinase_Tyr AqueK579.AA Pkinase_Tyr 148-278 26 1.4e-16 56.8 Pfam 1-145 (270) Show / Hide 
Range on Protein: 148-278
Range on HMM: 1-145/270
Sequence Identity: 26% (39 aa)

VTLTKEELGRGSYAVVTVGIFR------GLRVAVKSLHTLIISNYN--RGLFSREMSIASRV-RHPNLVQFIGATK-VGNP---LILTELMST-SLYKKL
.|.  ..||.|.. .|  |. .      .. ||||.|     .  .  |  | ||..| .   .|||.|...|.    | |   .| .|.|   .|.. |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QET-----ELSNEQIVSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLK
..       |. ..........| |..||.  .   .||||.   |.|..
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVT
Kinase AqueK579.AA LISK 154-278 32 8.9e-15 44.25 In-house 1-135 (296) Show / Hide 
Range on Protein: 154-278
Range on HMM: 1-135/296
Sequence Identity: 32% (45 aa)

ELGRGSYAVVTVGIFR--GLRVAVKSLHTL---IISNYNRGLFSREMSIASRVRHPNLVQFIGATKV-GNPL-ILTELMST-SLYKKLQET-----ELSN
|.|.|... |  |  |  |  .|.| .|..    . . ..  . ||. .  . |||| |||.|. .     | |.||...   |   |  .      |. 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

EQIVSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLK
.| |.|| |.|.|. |||    . |||||  | |.|..
PQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVR
Kinase AqueK579.AA Pkinase 149-270 21 3.7e-14 51.16 Pfam 1-134 (293) Show / Hide 
Range on Protein: 149-270
Range on HMM: 1-134/293
Sequence Identity: 21% (29 aa)

TLTKEELGRGSYAVVTVGIFRGLR--VAVKSLHT-LIISNYNRGLFS-REMSIASRVRHPNLVQFIGATK-VGNPLILTELMST-----SLYKKLQ---E
  ... .|.||...|  .. .| .  |||| .    . |. .. ..  .| .|  |..||| |.....    ... . .|..       .|.  ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TEL--SNEQIVSIAQDVALGLNYLHLFKPQPIIHRDV
. .  | ... ...  .. ||.|.|      |||||.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDL
Kinase AqueK579.AA LRRK 149-277 22 5.5e-14 45.84 In-house 1-199 (351) Show / Hide 
Range on Protein: 149-277
Range on HMM: 1-199/351
Sequence Identity: 22% (45 aa)

TLTKEELGRGSYA-VVTVGIFRG----------------------------LRVAVKSLHTL----------------------------------IISN
    |..|||... .|  ...||                              ||.|....                                    . .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

YNRGLFSREMSIASRVRHPNLVQFIGATKVGNPLIL-TELMST-SLYKKLQETE----------LSNEQIVSIAQDVALGLNYLHLFKPQPIIHRDVSSP
..  .| .|..| |. .|||.|. .| .   .||.. .|...  .||. |....          .|   .  || ..| |..||| ..| ||||||  ||
FR--EFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSP

NVLL
|.||
NILL
Kinase AqueK579.AA S_TKc 149-451 11 5.1e-11 -15.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 149-451
Range on HMM: 1-231/231
Sequence Identity: 11% (39 aa)

TLTKEELGRGSYAVVTVGIFRG--LRVAVKSLHTLIISNYNRGLFSREMSIASRVRHPNLVQFIGATKVGNPLILTELMST---SLYKKLQETE------
    ...|.|....|  .. ..   .||.| ..           . ||..| .. .|||.|.....   ..  . .|....   .|.. ...        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSNEQIVSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCT------GAASYEAKLDVPHSVSKRWSHSLSVFIMSPHCVWIITAGG-YVDW----
 ..  .. .... ....|.|.|  .   |||||.   |.||   .      | |                .   . . |.|  .     |.  .||    
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

--IGTLVT-----NPNIVMITELVTNSKGEWTVGDTLDTNGMNNEEYKKKYQQQLQTVRRIWLEEYQKPRKGDTADIEQTIQTLMKSLEEKEREAQVYHQ
  .  ...       .. |. ...                                                                            
CILYEMLCGYPPFP-QMQMMFKKIG---------------------------------------------------------------------------

QLEQKEREEAEKEQEIRRYCHQLQEKDRE----------------HQVV
             .| .    .. .|| |                |. .
------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK579.AA TyrKc 149-355 17 1.2e-08 -83.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 149-355
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

TLTKEELGRGSYAVVTVGIFRGLRVAVKSLHTLIISNYNRGLFSREMSIASRV--RHPNLVQFIGATKV--------GNPLILTELMST-SLYKKLQETE
   ...||.| . .|  |. . . ||||.|.        |  | ||..| ...  .|||.|...|.           . ..|..|.|.  .| . |....
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LSNEQIVSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGA---------ASYEA-------KLDVPHS--VSK-----RW----SHSLSVF-
  |.... .|.. ..| | .|||     ..||||    |.|..    .         . |.        .  .. .   .|     ||    .   ..| 
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

-------------------------I----MSPHCVWIITAGGYVDWIGTLV-------TNPNIVMITELVTNSKGE-----WTVGDTL
                         .    ||.  |      ||   .   .         . . .| .   . . |     ... . .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF