Gene AqueK581 (A.queenslandica)

AqueK581

Species: A.queenslandica
Alias: AqueK581
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK581.AA Protein None 1227 None Fasta, JSON
AqueK581.kin_dom Protein Kinase Domain None 149 None Fasta, JSON

Protein domain

Protein domains of AqueK581.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kelch_1 AqueK581.AA Kelch_1 222-251 16 1.481534 5.76 Pfam 14-41 (45) Show / Hide 
Range on Protein: 222-251
Range on HMM: 14-41/45
Sequence Identity: 16% (5 aa)

LVISGGEDDNYDILDDCWIFNITQHSWIKL
. . || |.   .|....... . ..| ..
IYVIGGCDG--QYLNSVECYDPETNQWTRC
Kelch_1 AqueK581.AA Kelch_1 520-576 15 0.248512 8.54 Pfam 1-45 (45) Show / Hide 
Range on Protein: 520-576
Range on HMM: 1-45/45
Sequence Identity: 15% (9 aa)

GRASHHTVSVGDSLYVWAGKQDGLPGVHDSEEKSRITSNIQHFTPSTGQWITRGTTG
 |..|  ..... .||  |  .            ......  . |.|.||    . .
PRCGHGVCVHNGKIYVIGGCDG------------QYLNSVECYDPETNQWTRCPPMP
Kelch_1 AqueK581.AA Kelch_1 581-628 25 0.001173 16.88 Pfam 1-45 (45) Show / Hide 
Range on Protein: 581-628
Range on HMM: 1-45/45
Sequence Identity: 25% (12 aa)

GVRAYCCTAINDQLYYFGGKCGHHGCYHNSITQLDTVSLQWRELEPTD
  . ......|...| .|| .|    | ||.  .|... ||... |  
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP
Kelch_1 AqueK581.AA Kelch_1 785-814 16 23.57419 1.45 Pfam 14-41 (45) Show / Hide 
Range on Protein: 785-814
Range on HMM: 14-41/45
Sequence Identity: 16% (5 aa)

LVISGGYDKNHDTLDDCWIFGITQHSWIKL
. . ||.|     |......  . ..| ..
IYVIGGCDG--QYLNSVECYDPETNQWTRC
Kinase AqueK581.AA TKL 1070-1227 21 1.2e-31 111.19 In-house 1-238 (364) Show / Hide 
Range on Protein: 1070-1227
Range on HMM: 1-238/364
Sequence Identity: 21% (53 aa)

LGRGSYAVVTVGIFRG----------LRVAVKSLHTLIISNYNR-------------------------GLFSREMSIASRVRHPNLVQFIGATK-----
.|.|....|  |..||            |||| ...   .. ..                           . .|. . || ||||.|||.|. .     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------VGNPLILTELM-STSLYKKLQETELSDEQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNVLLKPCTG---------AASYEAKV
          |.. | .|..   ||.  |.      .|....|.|.|.|.||||  .|      ||||||  |.|.|..             .| . .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

ADYGTAKLQQGTG---------------------STVMPGNPA
.|.|...  ...|                     .    |.|.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPR
Kinase AqueK581.AA TKL-Unique 1066-1214 30 1.1e-26 91.27 In-house 1-167 (290) Show / Hide 
Range on Protein: 1066-1214
Range on HMM: 1-167/290
Sequence Identity: 30% (51 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSLHT-LIISNYNRGLFSREMSIASRVR-HPNLVQFIGATK---VGNP--LILTELMST-SLYKKLQ--------
  . .|.|.|..|  |..||  ||.|..|    .||  .  |..| .. .. . |||.|...|...   | .|   | .| ..  |||. |.        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

---ETELSDEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAASYEAKVADYGTAKLQ
   ...|. .|....|.|.|.|..|||  .|  |||||  |.|.|.      | . .|..| |..|..
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFN
Kinase AqueK581.AA MLK 1064-1227 25 2.8e-26 88.23 In-house 1-198 (291) Show / Hide 
Range on Protein: 1064-1227
Range on HMM: 1-198/291
Sequence Identity: 25% (51 aa)

TLTKEELGRGSYAVVTVGIFRGLR-----VAVKSLHTLI----ISNYNRGLFSREMSIASRVRHPN----LVQFIGA-TKVGN-PLILTELMST-SLYKK
 ...| .| ||. .|  | .|. .     ||||  .. |    ..   .  | .|  ......|||     .|| |. .. ..  .|..| ..  |||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LQETE---------------LSDEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKP-CTGAASYEAKVADYGTAK-LQQG-TGSTVMPGNPA
| . .                . ......| ..| |..|||  .|.||||||  |.|.|.   |   .   .|..| ||.. ..|  |  . ..|..|
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYA
Kinase AqueK581.AA Dicty4 1066-1184 34 2.7e-21 67.95 In-house 3-139 (277) Show / Hide 
Range on Protein: 1066-1184
Range on HMM: 3-139/277
Sequence Identity: 34% (47 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSL--HTLIISNYNRGLFSREMSIASRVRHPNLVQFIGA-T----KVGNPLILTELM-STSLYKKLQE-------
. ...|.||.. |  |. ||  |||| |  |    . .    | .| .| .  ||||...| || |    . | ..| ||.| ...||. |         
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

-TELSDEQILS---IAQDVALGLNYLHLFKPQPIIHRD
 ..|. . |..   .| |.|.|.|.||   |  |||||
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD
Kinase AqueK581.AA STE 1065-1212 18 5.4e-21 70.95 In-house 1-195 (359) Show / Hide 
Range on Protein: 1065-1212
Range on HMM: 1-195/359
Sequence Identity: 18% (39 aa)

LTK-EELGRGSYAVVTVGIFR-----------------GLRVAVKSLH---------------TLIISNYNRGLFSREMSIASRVR--HPNLVQFIGATK
... |..|.|.. .|  .. .                 | ..|.| ..               . .. . ..  . .|..| .. .  ||| |...|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG--------NPLILTELMS-TSLYKKLQET-----ELS----------DEQILSIAQDVALG-LNYLHLFKPQPIIHRDVSSPNVLLKPCTGAASYEAK
..        .  |  |.|.  || . ....     .|.           .||  |....  | |.|||  .   |||||. . |.||          .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------VK

VADYGTAK
 .| |...
LCDFGVCG
Kinase AqueK581.AA CZAK 1065-1209 32 3.4e-20 70.16 In-house 1-167 (279) Show / Hide 
Range on Protein: 1065-1209
Range on HMM: 1-167/279
Sequence Identity: 32% (56 aa)

LTKE-ELGRGSYAVVTVGIFRGLRVAVKSLHTLIISNYNR----GLFSREMSIASRVRHPNLVQFIGATKVGN---PLILTELMS-TSLYKKLQETELSD
|. . . |.| .  |  .  ||  ||.| .|     |         | .| || |  .||| |||.||   ..     | .| |   || . | .     
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH

EQ----ILSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLLKPCTGAASYE-------------AKVADYG
.|     ...| |.| | ||||  .|| ||.||| || |.||       ||              .|..|.|
KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLD-----HSYTPKNPVVSSRQDIICKINDFG
Kinase AqueK581.AA TK 1064-1213 14 1.9e-18 57.76 In-house 1-305 (486) Show / Hide 
Range on Protein: 1064-1213
Range on HMM: 1-305/486
Sequence Identity: 14% (44 aa)

TLTKEELGRGSYA---VVTVGIFRGL---------------------------RVAVKSLHTLIISNYNRGL---------------FSREMSIAS--RV
    ..||.| .    .|  |. ||.                           .|||| |.    .. .. .               . .||.. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNLVQFIG-ATKVGN------------PLILTELMS-TS----LYKKLQETE----------------------------------------------
.|||.|...|  |....            ..|..|.|.  .    | . |..                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSDEQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLLKPCTGAA------SYEAKVADYGTAK
                               |. .| | .....| |. |||  .    | ..|||.   |.|.      .       . .|.||.| ..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----L
     |
QGSGVL
Kinase AqueK581.AA DRK 1071-1220 33 3.9e-18 58.04 In-house 8-161 (258) Show / Hide 
Range on Protein: 1071-1220
Range on HMM: 8-161/258
Sequence Identity: 33% (55 aa)

GRGSYAVVTVGIFRGLRVAVKSLHTLIISNYN-RGL---FSREMSIASRVRHPNLVQFIGA-TKVGNPLILTELMST-SLYKKL--QETELSDEQILSIA
|||.|. |  |  ||  |||| |  .   | |   .   | ||  . .. |||| .||.|. .    ..| .| |.  |||. |  .  |..   .....
GRGNYGEVFRGTWRGTQVAVKMLFNH---NINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMM

QDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAASYEAKVADYGTAK-----LQQGTGST
 |.| |..|||   |  |||||  | | |        ..  ||||.| .      .|...  |
FDCAKGMIYLHCCNPI-IIHRDLKSHNLLV-----DEHWQVKVADFGLSTRFKKHKQHKFAMT
Kinase AqueK581.AA LRRK 1064-1221 21 1.1e-17 59.1 In-house 1-239 (351) Show / Hide 
Range on Protein: 1064-1221
Range on HMM: 1-239/351
Sequence Identity: 21% (53 aa)

TLTKEELGRGSYA-VVTVGIFRG----------------------------LRVAVKSLHTL----------------------------------IISN
    |..|||... .|  ...||                              ||.|....                                    . .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

YNRGLFSREMSIASRVRHPNLVQFIGATKVGNPLIL-TELMST-SLYKKLQETE----------LSDEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSP
..  .| .|..| |. .|||.|. .| .   .||.. .|...  .||. |....          .|   .| || ..| |..||| ..| ||||||  ||
FR--EFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSP

NVLL-KPCTGA------ASYEAKVADYGTAK----LQQGTGSTV
|.|| .  ..       | . ||.||.|.      .. |  ...
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGC
Pkinase_Tyr AqueK581.AA Pkinase_Tyr 1063-1193 26 3.5e-16 55.42 Pfam 1-145 (270) Show / Hide 
Range on Protein: 1063-1193
Range on HMM: 1-145/270
Sequence Identity: 26% (40 aa)

VTLTKEELGRGSYAVVTVGIFR------GLRVAVKSLHTLIISNYN--RGLFSREMSIASRV-RHPNLVQFIGATK-VGNP---LILTELMST-SLYKKL
.|.  ..||.|.. .|  |. .      .. ||||.|     .  .  |  | ||..| .   .|||.|...|.    | |   .| .|.|   .|.. |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QET-----ELSDEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLK
..       |. ...|......| |..||.  .   .||||.   |.|..
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVT
Kinase AqueK581.AA HH498 1066-1209 30 5.3e-16 46.85 In-house 3-169 (284) Show / Hide 
Range on Protein: 1066-1209
Range on HMM: 3-169/284
Sequence Identity: 30% (52 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSLHTLIISNYNR------GLFSREMSIASRVRHPNLVQFIGATKVGNP---LILTELMST-SLYKKL-------
..|  | ||.  |  | .|.  ||||      ..            | || || .|  ||. |||..|. .  |   .| |.  .  ||.  |       
FHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYAC-CDDPSQFAIVTQYCDNGSLFSILNTIPIGG

-------QETE-----LSDEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAASYEAKVADYG
        .       ..   .. |. ||| | ||||   ..||||||  | |.|.      .   |.|||.|
AGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH-----EDGHAVVADFG
Kinase AqueK581.AA Pkinase 1064-1185 21 6.2e-15 53.89 Pfam 1-134 (293) Show / Hide 
Range on Protein: 1064-1185
Range on HMM: 1-134/293
Sequence Identity: 21% (29 aa)

TLTKEELGRGSYAVVTVGIFRGLR--VAVKSLHT-LIISNYNRGLFS-REMSIASRVRHPNLVQFIGATK-VGNPLILTELMST-----SLYKKLQ---E
  ... .|.||...|  .. .| .  |||| .    . |. .. ..  .| .|  |..||| |.....    ... . .|..       .|.  ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TEL--SDEQILSIAQDVALGLNYLHLFKPQPIIHRDV
. .  |.... ...  .. ||.|.|      |||||.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDL
Kinase AqueK581.AA S_TKc 1064-1222 12 1.5e-08 -51.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 1064-1222
Range on HMM: 1-231/231
Sequence Identity: 12% (32 aa)

TLTKEELGRGSYAVVTVGIFRG--LRVAVKSLHTLIISNYNRGLFSREMSIASRVRHPNLVQFIGATKVGNPLILTELMST---SLYKKLQETE------
    ...|.|....|  .. ..   .||.| ..           . ||..| .. .|||.|.....   ..  . .|....   .|.. ...        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSDEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAASYEAKVADYGTAK---------------------------------------
 ..  .. .... ....|.|.|  .   |||||.   |.||         . |..| | |.                                       
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCG

--------------------------LQ---------QGTG-------STVM
                          ||         .             .
YPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK581.AA TyrKc 1064-1227 16 2.2e-07 -103.28 SMART 1-268 (280) Show / Hide 
Range on Protein: 1064-1227
Range on HMM: 1-268/280
Sequence Identity: 16% (46 aa)

TLTKEELGRGSYAVVTVGIFRGLRVAVKSLHTLIISNYNRGLFSREMSIASRV--RHPNLVQFIGATKV--------GNPLILTELMST-SLYKKLQETE
   ...||.| . .|  |. . . ||||.|.        |  | ||..| ...  .|||.|...|.           . ..|..|.|.  .| . |....
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LSDEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCT-------------GAA--------SYEAK---VAD-------------------
  |. .. ||.. ..| | .|||     ..||||    |.|..                .           | .|    ..                   
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

----------------------YGT------------AKLQQGTGSTVMPG-----------------------NPA
                      |              ....||     .|                        .|.
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE