Gene AqueK582 (A.queenslandica)

AqueK582

Species: A.queenslandica
Alias: AqueK582
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK582.AA Protein None 708 None Fasta, JSON
AqueK582.kin_dom Protein Kinase Domain None 149 None Fasta, JSON

Protein domain

Protein domains of AqueK582.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kelch_1 AqueK582.AA Kelch_1 9-65 17 0.040626 11.36 Pfam 1-45 (45) Show / Hide 
Range on Protein: 9-65
Range on HMM: 1-45/45
Sequence Identity: 17% (10 aa)

GRAFHCTVSVGDSLYVWGGAQDGLPGVHDSVEKRRITSNIRHFTPSTGQWITRGTTG
 |..|. ..... .|| ||  .            ......  . |.|.||    . .
PRCGHGVCVHNGKIYVIGGCDG------------QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK582.AA Kelch_2 9-65 19 1.263342 6.5 Pfam 1-51 (51) Show / Hide 
Range on Protein: 9-65
Range on HMM: 1-51/51
Sequence Identity: 19% (11 aa)

GRAFHCTVSVGDSLYVWGGAQDGLPGVHDSVEKRRITSNIRHFTPSTGQWITRGTTG
.|. | ....|. .||.||.        .. ..   .. |. . |.| .|      .
PRYCHASCVPGGKIYVFGGYC------RHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK582.AA Kelch_1 70-117 25 0.000219 19.49 Pfam 1-45 (45) Show / Hide 
Range on Protein: 70-117
Range on HMM: 1-45/45
Sequence Identity: 25% (12 aa)

GVRAYCCTAINDQLYYFGGYCGHGDCYHNSITQLDTVSLQWRELEPTD
  . ......|...| .||..|    | ||.  .|... ||... |  
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK582.AA Kelch_2 70-117 19 0.000347 20.03 Pfam 1-51 (51) Show / Hide 
Range on Protein: 70-117
Range on HMM: 1-51/51
Sequence Identity: 19% (10 aa)

GVRAYCCTAINDQLYYFGGY---CGHGDCYHNSITQLDTVSLQWRELEPTD
.     .. .....| ||||    ...||....|  .|. . .|... . .
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_2 AqueK582.AA Kelch_2 191-244 16 42.907002 0.68 Pfam 1-51 (51) Show / Hide 
Range on Protein: 191-244
Range on HMM: 1-51/51
Sequence Identity: 16% (9 aa)

QCIPPASSFVIEMINNTRAVLFGGV--ETDDDAKDTRTNNIYILEISISTVYIKKP
 . . ||. .     . . ..|||.  .|......... ... .|    |   . |
PRYCHASCVP-----GGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_2 AqueK582.AA Kelch_2 271-304 15 2.287857 5.52 Pfam 14-51 (51) Show / Hide 
Range on Protein: 271-304
Range on HMM: 14-51/51
Sequence Identity: 15% (6 aa)

LVISGGL----DKNADTLHDCWIFNITQYSWIKLAVPH
....||.    . |.. . | |...   ..| ......
IYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK582.AA Kelch_1 271-301 16 6.488245 3.46 Pfam 14-42 (45) Show / Hide 
Range on Protein: 271-301
Range on HMM: 14-42/45
Sequence Identity: 16% (5 aa)

LVISGGLDKNADTLHDCWIFNITQYSWIKLA
. . || |     | ...... .  .| ...
IYVIGGCDG--QYLNSVECYDPETNQWTRCP
Kinase AqueK582.AA TKL 493-635 24 5.8e-35 122.48 In-house 1-202 (364) Show / Hide 
Range on Protein: 493-635
Range on HMM: 1-202/364
Sequence Identity: 24% (50 aa)

LGRGSYGVVTVGIFRG----------LRVAVKSLHTLIISNYNR-------------------------GLFSREMSIASRVRHPNLVQFIGATKVGK--
.|.|..|.|  |..||            |||| ...   .. ..                           . .|. . || ||||.|||.|. . ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PLILTELM-RTSLYKRLQETELSTQQIVSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNVLLKPCTG---------AAGYEAKV
            . | .|.. . ||. .|.      .|....|.|.|.|.||||  .|      ||||||  |.|.|..             .| . .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

GDYGTAK
.|.|...
CDFGLSR
Kinase AqueK582.AA MLK 487-615 26 1.9e-29 99.39 In-house 1-160 (291) Show / Hide 
Range on Protein: 487-615
Range on HMM: 1-160/291
Sequence Identity: 26% (43 aa)

TLTEEELGRGSYGVVTVGIFRGLR-----VAVKSLHTLI----ISNYNRGLFSREMSIASRVRHPN----LVQFIGA-TKVGK-PLILTELMRT-SLYKR
 ...| .| ||.|.|  | .|. .     ||||  .. |    ..   .  | .|  ......|||     .|| |. .. ..  .|..| ..  |||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LQETE---------------LSTQQIVSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLL
| . .                . ......| ..| |..|||  .|.||||||  |.|.|.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILI
Kinase AqueK582.AA TKL-Unique 489-645 30 2.9e-27 93.3 In-house 1-175 (290) Show / Hide 
Range on Protein: 489-645
Range on HMM: 1-175/290
Sequence Identity: 30% (54 aa)

TEEELGRGSYGVVTVGIFRGLRVAVKSLHT-LIISNYNRGLFSREMSIASRVR-HPNLVQFIGATK---VGKP--LILTE-LMRTSLYKRLQ--------
  . .|.|.||.|  |..||  ||.|..|    .||  .  |..| .. .. . |||.|...|...   |  |   | .| . . |||. |.        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

---ETELSTQQIVSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVGDYGTAKLQQGTSTGSV
   ...|. ||.|..|.|.|.|..|||  .|  |||||  |.|.|.      | . .|. | |..|..   .....
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTN
Kinase AqueK582.AA Dicty4 489-607 35 5.2e-23 73.74 In-house 3-139 (277) Show / Hide 
Range on Protein: 489-607
Range on HMM: 3-139/277
Sequence Identity: 35% (49 aa)

TEEELGRGSYGVVTVGIFRGLRVAVKSL--HTLIISNYNRGLFSREMSIASRVRHPNLVQFIGA-T----KVGKPLILTELM-RTSLYKRLQE------T
.|...|.||.| |  |. ||  |||| |  |    . .    | .| .| .  ||||...| || |    . ||..| ||.| ...||. |         
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

ELSTQ--QIVS---IAQDVALGLNYLHLFKPQPIIHRD
. . .   | .   .| |.|.|.|.||   |  |||||
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD
Kinase AqueK582.AA TK 487-636 14 5e-21 66.55 In-house 1-305 (486) Show / Hide 
Range on Protein: 487-636
Range on HMM: 1-305/486
Sequence Identity: 14% (44 aa)

TLTEEELGRGSYG---VVTVGIFRGL---------------------------RVAVKSLHTLIISNYNRGL---------------FSREMSIAS--RV
   ...||.| .|   .|  |. ||.                           .|||| |.    .. .. .               . .||.. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNLVQFIG-ATKV------------GKPLILTELMR-TS----LYKRLQETE----------------------------------------------
.|||.|...|  |..            . ..|..|.|   .    | . |..                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSTQQIVSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLLKPCTGAA------GYEAKVGDYGTAK
                               |...| . .....| |. |||  .    | ..|||.   |.|.      .      |. .|..|.| ..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----L
     |
QGSGVL
Kinase AqueK582.AA CZAK 490-615 37 6.3e-21 72.83 In-house 4-142 (279) Show / Hide 
Range on Protein: 490-615
Range on HMM: 4-142/279
Sequence Identity: 37% (52 aa)

EEELGRGSYGVVTVGIFRGLRVAVKSLHTLIISNYNR----GLFSREMSIASRVRHPNLVQFIGA-TKVG--KPLILTELMR-TSLYKRLQETELSTQQ-
. . |.| .| |  .  ||  ||.| .|     |         | .| || |  .||| |||.|| .  |     | .| |   || . | .     .| 
GQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQN

---IVSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLL
     ..| |.| | ||||  .|| ||.||| || |.||
PHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
Kinase AqueK582.AA LRRK 487-645 22 4.4e-20 67.74 In-house 1-240 (351) Show / Hide 
Range on Protein: 487-645
Range on HMM: 1-240/351
Sequence Identity: 22% (55 aa)

TLTEEELGRGSYG-VVTVGIFRG----------------------------LRVAVKSLHTL----------------------------------IISN
   ||..|||..| .|  ...||                              ||.|....                                    . .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

YNRGLFSREMSIASRVRHPNLVQFIGATKVGKPLIL-TELMRT-SLYKRLQETE----------LSTQQIVSIAQDVALGLNYLHLFKPQPIIHRDVSSP
..  .| .|..| |. .|||.|. .| .   .||.. .|...  .||..|....          .| . .  || ..| |..||| ..| ||||||  ||
FR--EFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSP

NVLL-KPCTGA------AGYEAKVGDYGTAK----LQQGTSTGSV
|.|| .  ..       | . ||..|.|.      .. |   |.|
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV
Pkinase_Tyr AqueK582.AA Pkinase_Tyr 486-616 26 4.5e-19 65.22 Pfam 1-145 (270) Show / Hide 
Range on Protein: 486-616
Range on HMM: 1-145/270
Sequence Identity: 26% (40 aa)

VTLTEEELGRGSYGVVTVGIFR------GLRVAVKSLHTLIISNYN--RGLFSREMSIASRV-RHPNLVQFIGATK-VGKP---LILTELMRT-SLYKRL
.|.  ..||.|..|.|  |. .      .. ||||.|     .  .  |  | ||..| .   .|||.|...|.    |.|   .| .|.|   .|.. |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QET-----ELSTQQIVSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLK
..       |............| |..||.  .   .||||.   |.|..
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVT
Kinase AqueK582.AA STE 488-635 19 1.2e-18 62.58 In-house 1-195 (359) Show / Hide 
Range on Protein: 488-635
Range on HMM: 1-195/359
Sequence Identity: 19% (40 aa)

LTE-EELGRGSYGVVTVGIFR-----------------GLRVAVKSLH---------------TLIISNYNRGLFSREMSIASRVR--HPNLVQFIGATK
..  |..|.|..|.|  .. .                 | ..|.| ..               . .. . ..  . .|..| .. .  ||| |...|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG--------KPLILTELMR-TSLYKRLQET-----ELS----------TQQIVSIAQDVALG-LNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAK
..        .  |  |.|   || . ....     .|.           .||  |....  | |.|||  .   |||||. . |.||          .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------VK

VGDYGTAK
  | |...
LCDFGVCG
Kinase AqueK582.AA LISK 492-658 28 1.4e-18 56.81 In-house 1-187 (296) Show / Hide 
Range on Protein: 492-658
Range on HMM: 1-187/296
Sequence Identity: 28% (54 aa)

ELGRGSYGVVTVGIFR--GLRVAVKSLHTL---IISNYNRGLFSREMSIASRVRHPNLVQFIGATKV-GKPL-ILTELMRT-SLYKRLQET-----ELST
|.|.|..| |  |  |  |  .|.| .|..    . . ..  . ||. .  . |||| |||.|. .   . | |.||..    |  .|  .      |. 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

QQIVSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVGDYGTAKLQQGTSTGSV-----------APNAMAIQRRGRS
.| |.|| |.|.|. |||    . |||||  | |.|..   .  ....||.| | |.. . .. ..            ..|.|   |....
PQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVREN-DNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPK
Kinase AqueK582.AA Shk 489-607 37 5.5e-17 57.59 In-house 3-128 (269) Show / Hide 
Range on Protein: 489-607
Range on HMM: 3-128/269
Sequence Identity: 37% (48 aa)

TEEELGRGSYGVVTVGIFRGLRVAVKSLHTLIISNYNRGLFSREMSIASRVRHPNLVQFIGA-T-KVGKPLILTELM-RTSLYK--RLQETELS--TQQI
.|. || ||.| |  |. ||  |||| .|    . .    |  | .| |...|||.. | || | . ||  | |||| ...| |  . |....   . . 
REDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILYKR

-VSIAQDVALGLNYLHLFKPQPIIHRD
   .. | ||| | ||   .  |||||
AMRMCRDAALGMNWLHGSNCN-IIHRD
Kinase AqueK582.AA Pkinase 487-608 21 1.7e-15 55.85 Pfam 1-134 (293) Show / Hide 
Range on Protein: 487-608
Range on HMM: 1-134/293
Sequence Identity: 21% (30 aa)

TLTEEELGRGSYGVVTVGIFRGLR--VAVKSLHT-LIISNYNRGLFS-REMSIASRVRHPNLVQFIGATK-VGKPLILTELMRT-----SLYKRLQ---E
  ... .|.||.|.|  .. .| .  |||| .    . |. .. ..  .| .|  |..||| |.....    ... . .|...      .|. ...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TEL--STQQIVSIAQDVALGLNYLHLFKPQPIIHRDV
. .  | ... ...  .. ||.|.|      |||||.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDL
Kinase AqueK582.AA S_TKc 487-708 16 3.6e-12 1.49 SMART 1-220 (231) Show / Hide 
Range on Protein: 487-708
Range on HMM: 1-220/231
Sequence Identity: 16% (41 aa)

TLTEEELGRGSYGVVTVGIFRG--LRVAVKSLHTLIISNYNRGLFSREMSIASRVRHPNLVQFIGATKVGKPLILTELMRT---SLYKRLQETE------
    ...|.|..|.|  .. ..   .||.| ..           . ||..| .. .|||.|.....   ..  . .|.. .   .|......        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSTQQIVSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVGDYGTAKLQQGTSTGS---VAPNAMAIQRRGRSRGYTE--------
 ..  .. .... ....|.|.|  .   |||||.   |.||         . |..| | |..   |  |.   .||  .         ||.         
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQL-TTFCGTPWYMAPEVL---------GYGKCKCDWWSC

-----SLLS---PLEAGTIPKNATFRLRPESSRCNLFSKG---EYIRRIESISSIR
      .|.   | .    ..    ...  .. ... .|    .  .|.      .
GCILYEMLCGYPPFP---QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase AqueK582.AA TyrKc 487-701 17 2.5e-11 -39.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 487-701
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

TLTEEELGRGSYGVVTVGIFRGLRVAVKSLHTLIISNYNRGLFSREMSIASRV--RHPNLVQFIGATKV--------GKPLILTELMRT-SLYKRLQETE
   ...||.| .|.|  |. . . ||||.|.        |  | ||..| ...  .|||.|...|.           . ..|..|.|   .| ..|....
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LSTQQIVSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVGDYGTAKLQQGT-------STGSVA--PNAM-----------AIQ
  |.... .|.. ..| | .|||     ..||||    |.|..         .|..| | ..            .. ...   ..            .|.
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

RR---------------------GRSRGYTESL--LSPLEAGTIPKNATFRLRPES-----------------SRCNLF------SKGEYIRRI
 .                     | .  . . .  .|. |.    |.   . .|..                 ..|  .      .  | ....
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF