Gene AqueK583 (A.queenslandica)

AqueK583

Species: A.queenslandica
Alias: AqueK583
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK583.AA Protein None 650 None Fasta, JSON
AqueK583.kin_dom Protein Kinase Domain None 156 None Fasta, JSON

Protein domain

Protein domains of AqueK583.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kelch_1 AqueK583.AA Kelch_1 11-67 15 1.088526 6.24 Pfam 1-45 (45) Show / Hide 
Range on Protein: 11-67
Range on HMM: 1-45/45
Sequence Identity: 15% (9 aa)

KRAAHRTVSVGDSLYVWAGDQDDLPEAHDSEEKRRITSNIQHFTPSTGQWITRDTTG
.|. |  ..... .||  |  .            ......  . |.|.||    . .
PRCGHGVCVHNGKIYVIGGCDG------------QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK583.AA Kelch_2 11-29 31 1.649369 6.06 Pfam 1-19 (51) Show / Hide 
Range on Protein: 11-29
Range on HMM: 1-19/51
Sequence Identity: 31% (6 aa)

KRAAHRTVSVGDSLYVWAG
 |. | ....|. .||. |
PRYCHASCVPGGKIYVFGG
Kelch_2 AqueK583.AA Kelch_2 72-119 19 0.000392 19.83 Pfam 1-51 (51) Show / Hide 
Range on Protein: 72-119
Range on HMM: 1-51/51
Sequence Identity: 19% (10 aa)

GVRAYCCTAINDQLYYFGGY---CGHDDCYHNSITQLDTISLQWRELEPTD
.     .. .....| ||||    ...||....|  .|. . .|... . .
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK583.AA Kelch_1 72-119 25 0.00059 17.95 Pfam 1-45 (45) Show / Hide 
Range on Protein: 72-119
Range on HMM: 1-45/45
Sequence Identity: 25% (12 aa)

GVRAYCCTAINDQLYYFGGYCGHDDCYHNSITQLDTISLQWRELEPTD
  . ......|...| .||..|    | ||.  .|. . ||... |  
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK583.AA Kelch_2 276-309 18 1.552389 6.16 Pfam 14-51 (51) Show / Hide 
Range on Protein: 276-309
Range on HMM: 14-51/51
Sequence Identity: 18% (7 aa)

LVISGGE----DKNEDTLDDCWIFNITQHSWIKLDVPH
....||     . | . . | |...   |.| .. ...
IYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK583.AA Kelch_1 276-305 16 2.94527 4.69 Pfam 14-41 (45) Show / Hide 
Range on Protein: 276-305
Range on HMM: 14-41/45
Sequence Identity: 16% (5 aa)

LVISGGEDKNEDTLDDCWIFNITQHSWIKL
. . || |     |....... . ..| ..
IYVIGGCDG--QYLNSVECYDPETNQWTRC
Kinase AqueK583.AA TKL 497-642 24 4.6e-33 116.18 In-house 1-205 (364) Show / Hide 
Range on Protein: 497-642
Range on HMM: 1-205/364
Sequence Identity: 24% (51 aa)

LGKGSYGFVTVGIFRG----------LSVAVKSLHT-------------------------IIISDYNRGLFSREMSIASRVRHPNLVQFIGATK-----
.|.|..| |  |..||            |||| ...                            .  .|  . .|. . || ||||.|||.|. .     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------VGNPLVLTELM-STSLYKKLQETKLTNQQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNVLLKPCTG---------AAGYEAKV
          |..   .|..   ||.  |.      .|....|.|.|.|.||||  .|      ||||||  |.|.|..             .| . .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

ADYGTAKVVQ
.|.|......
CDFGLSRFMS
Kinase AqueK583.AA MLK 491-639 26 4.4e-27 91.07 In-house 1-181 (291) Show / Hide 
Range on Protein: 491-639
Range on HMM: 1-181/291
Sequence Identity: 26% (48 aa)

TLTKEELGKGSYGFVTVGIFRGLS-----VAVKSLHTIIISDYNR-----GLFSREMSIASRVRHPN----LVQFIGA-TKVGN-PLVLTELMST-SLYK
 ...| .|.||.| |  | .|.       ||||  .. |. |  .       | .|  ......|||     .|| |. .. ..  ....| ..  ||| 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

KLQETK---------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKP-CTGAAGYEAKVADYGTAK
 | . .                . ......| ..| |..|||  .|.||||||  |.|.|.   |   ..  .|..| ||..
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase AqueK583.AA TKL-Unique 493-649 30 2.2e-26 90.17 In-house 1-175 (290) Show / Hide 
Range on Protein: 493-649
Range on HMM: 1-175/290
Sequence Identity: 30% (54 aa)

TKEELGKGSYGFVTVGIFRGLSVAVKSLHT-IIISDYNRGLFSREMSIASRVR-HPNLVQFIGATK---VGNP--LVLTELMST-SLYKKLQ--------
  . .| |.|| |  |..|| .||.|..|    .|   .  |..| .. .. . |||.|...|...   | .|     .| ..  |||. |.        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

---ETKLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVADYGTAKVVQAENTGTV
   ..||..||....|.|.|.|..|||  .|  |||||  |.|.|.      | . .|..| |..|.   .|..|.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTN
Kinase AqueK583.AA CZAK 492-619 35 5.9e-23 80.29 In-house 1-142 (279) Show / Hide 
Range on Protein: 492-619
Range on HMM: 1-142/279
Sequence Identity: 35% (50 aa)

LTKE-ELGKGSYGFVTVGIFRGLSVAVKSLHTIIISDYNR----GLFSREMSIASRVRHPNLVQFIGATKVGN---PLVLTELMS-TSLYKKLQETKLTN
|. . . |.| .| |  .  || .||.| .| .   .         | .| || |  .||| |||.||   ..     . .| |   || . | .     
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH

QQ----ILSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLL
.|     ...| |.| | ||||  .|| ||.||| || |.||
KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
Kinase AqueK583.AA Dicty4 493-611 34 1.6e-20 65.32 In-house 3-139 (277) Show / Hide 
Range on Protein: 493-611
Range on HMM: 3-139/277
Sequence Identity: 34% (47 aa)

TKEELGKGSYGFVTVGIFRGLSVAVKSL--HTIIISDYNRGLFSREMSIASRVRHPNLVQFIGA-T----KVGNPLVLTELM-STSLYKKLQE------T
. ...||||.| |  |. ||  |||| |  | .  . .    | .| .| .  ||||...| || |    . | ..  ||.| ...||. |         
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

KLTNQ--QILS---IAQDVALGLNYLHLFKPQPIIHRD
. . .   |..   .| |.|.|.|.||   |  |||||
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD
Kinase AqueK583.AA TK 491-636 15 5.5e-20 63.0 In-house 1-296 (486) Show / Hide 
Range on Protein: 491-636
Range on HMM: 1-296/486
Sequence Identity: 15% (45 aa)

TLTKEELGKGSYG---FVTVGIFRGL---------------------------SVAVKSLHTIIISDYNRGL---------------FSREMSIAS--RV
    ..||.| .|    |  |. ||.                            |||| |.    .. .. .               . .||.. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNLVQFIG-ATKVGN------------PLVLTELMS-TS----LYKKLQETK----------------------------------------------
.|||.|...|  |....            .....|.|.  .    | . |.. .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTNQQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLLKPCTGAA------GYEAKVADYG
                               || .| | .....| |. |||  .    | ..|||.   |.|.      .      |. .|.||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG
Kinase AqueK583.AA STE 492-639 18 5.1e-19 63.89 In-house 1-195 (359) Show / Hide 
Range on Protein: 492-639
Range on HMM: 1-195/359
Sequence Identity: 18% (39 aa)

LTK-EELGKGSYGFVTVGIFR-----------------GLSVAVKSLH---------------TIIISDYNRGLFSREMSIASRVR--HPNLVQFIGATK
... |..|||..| |  .. .                 |  .|.| ..               . .. . ..  . .|..| .. .  ||| |...|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG--------NPLVLTELMS-TSLYKKLQ---ETKLT------------NQQILSIAQDVALG-LNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAK
..        .  .  |.|.  || . ..   ... .             .||  |....  | |.|||  .   |||||. . |.||          .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------VK

VADYGTAK
 .| |...
LCDFGVCG
Kinase AqueK583.AA LRRK 491-637 23 9.5e-19 62.94 In-house 1-224 (351) Show / Hide 
Range on Protein: 491-637
Range on HMM: 1-224/351
Sequence Identity: 23% (53 aa)

TLTKEELGKGSYG-FVTVGIFRG----------------------------LSVAVKSLHTI----------------------------------IISD
    |..|.|..| ||  ...||                             .||.|.....                                   .  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

YNRGLFSREMSIASRVRHPNLVQFIGATKVGNPLVL-TELMST-SLYKKLQETK----------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSP
..  .| .|..| |. .|||.|. .| .   .|| . .|...  .||. |...|          .. . .| || ..| |..||| ..| ||||||  ||
FR--EFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSP

NVLL-KPCTGA------AGYEAKVADYGT
|.|| .  ..       | . ||.||.|.
NILLWSSPQNHSPNYPNAHVCAKIADFGI
Kinase AqueK583.AA HH498 493-636 32 2e-18 54.65 In-house 3-169 (284) Show / Hide 
Range on Protein: 493-636
Range on HMM: 3-169/284
Sequence Identity: 32% (57 aa)

TKEELGKGSYGFVTVGIFRGLSVAVKSLHTIII---SD---YNRGLFSREMSIASRVRHPNLVQFIGATKVGNP---LVLTELMST-SLYKKL-------
..|  | ||.| |  | .|.  ||||      .   ||   . .  | || || .|  ||. |||..|. .  |   .. |.  .  ||.  |       
FHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYAC-CDDPSQFAIVTQYCDNGSLFSILNTIPIGG

-------QETK-----LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVADYG
        . |     .  | .. |. ||| | ||||   ..||||||  | |.|.     . |  |.|||.|
AGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH----EDGH-AVVADFG
Pkinase_Tyr AqueK583.AA Pkinase_Tyr 490-636 26 8.5e-18 60.9 Pfam 1-156 (270) Show / Hide 
Range on Protein: 490-636
Range on HMM: 1-156/270
Sequence Identity: 26% (44 aa)

VTLTKEELGKGSYGFVTVGIFR------GLSVAVKSLHTIIISDYN--RGLFSREMSIASRV-RHPNLVQFIGATK-VGNP---LVLTELMST-SLYKKL
.|.  ..||.|..| |  |. .      .. ||||.|     .. .  |  | ||..| .   .|||.|...|.    | |   .. .|.|   .|.. |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QET-----KLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVADYG
..      .|| ...|......| |..||.  .   .||||.   |.|..      .  .|..| |
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE-----NNVVKICDFG
Kinase AqueK583.AA Pkinase 491-612 20 6.3e-12 43.26 Pfam 1-134 (293) Show / Hide 
Range on Protein: 491-612
Range on HMM: 1-134/293
Sequence Identity: 20% (28 aa)

TLTKEELGKGSYGFVTVGIFRGLS--VAVKSLHTIIISD-YNRGLFS-REMSIASRVRHPNLVQFIGATK-VGNPLVLTELMST-----SLYKKLQ---E
  ... .|.||.| |  .. .| .  |||| .    ...  .. ..  .| .|  |..||| |.....    ... . .|..       .|.  ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TKL--TNQQILSIAQDVALGLNYLHLFKPQPIIHRDV
...  . ... ...  .. ||.|.|      |||||.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDL
Kinase AqueK583.AA LISK 496-554 34 6.4e-12 34.82 In-house 1-64 (296) Show / Hide 
Range on Protein: 496-554
Range on HMM: 1-64/296
Sequence Identity: 34% (22 aa)

ELGKGSYGFVTVGIFR--GLSVAVKSLHT---IIISDYNRGLFSREMSIASRVRHPNLVQFIGA
|.|||..| |  |  |  |  .|.| .|.     . . ..  . ||. .  . |||| |||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV
Kinase AqueK583.AA S_TKc 491-649 13 2.6e-08 -55.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 491-649
Range on HMM: 1-231/231
Sequence Identity: 13% (33 aa)

TLTKEELGKGSYGFVTVGIFRG--LSVAVKSLHTIIISDYNRGLFSREMSIASRVRHPNLVQFIGATKVGNPLVLTELMST---SLYKKLQETK------
    ...|||..| |  .. ..    ||.| ..           . ||..| .. .|||.|.....   ..  . .|....   .|.. ... .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVADYGTAKVV-------------------------------------
 ..  .. .... ....|.|.|  .   |||||.   |.||         . |..| | |...                                     
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCG

-------------------------------------QAEN-------TGTV
                                     .| .          .
YPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK583.AA TyrKc 491-649 15 2.2e-07 -103.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 491-649
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

TLTKEELGKGSYGFVTVGIFRGLSVAVKSLHTIIISDYNRGLFSREMSIASRV--RHPNLVQFIGATKV--------GNPLVLTELMST-SLYKKLQETK
   ...|| | .| |  |. . . ||||.|.        |  | ||..| ...  .|||.|...|.           . .....|.|.  .| . |....
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCT------------GAAG---------YEAK---VAD-------------------
  |.... ||.. ..| | .|||     ..||||    |.|..               .  .         | .|    ..                   
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

----------------------YGT------------AKVVQA------EN----------------------------------TGTV
                      |              ..| |       .|                                      
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK583.AA LISK 586-645 38 1e-06 17.25 In-house 104-159 (296) Show / Hide 
Range on Protein: 586-645
Range on HMM: 104-159/296
Sequence Identity: 38% (23 aa)

LSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVADYGTAKVVQAEN
..|| |.|.|. |||    . |||||  | |.|..   .  ....||.| | |.... ||
VKIALDIACGMSYLHS---MNIIHRDLKSKNCLVREN-DNNQWRIKVCDFGFARMMDCEN