Gene AqueK586 (A.queenslandica)

AqueK586

Species: A.queenslandica
Alias: AqueK586
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK586.AA Protein None 201 None Fasta, JSON
AqueK586.kin_dom Protein Kinase Domain None 190 None Fasta, JSON

Protein domain

Protein domains of AqueK586.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK586.AA TKL 8-196 20 6.7e-41 142.19 In-house 83-364 (364) Show / Hide 
Range on Protein: 8-196
Range on HMM: 83-364/364
Sequence Identity: 20% (59 aa)

RHPNLVQFIGATK--------------VGNPLILTELM-STSICEELHRNRLTNQQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNVLLKPCT
||||.|||.|. .               |.. | .|..   | .. ||      .|....|.|.|.|.||||  .|      ||||||  |.|.|..   
RHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENW

G---------ATGYEAKVADYGTAKLHQGTG---------------------STVMPGNPAYAAPEARDPD----------------QHSPAMDVYSYSV
          .  . .|..|.|... ....|                     .    |.|.. |||. . .                . |...||||. .
TNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI

LLMEMNLHSQPEMTTTEREVQ---------SGSV-----------------------SWSDMKSLIQRGLNVDPRARPTMAQVIESL
.| |.    .|.    .....         .. .                        . .||.|.|.  . ||..||.. .... |
VLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK586.AA MLK 3-146 28 3.6e-26 87.84 In-house 58-229 (291) Show / Hide 
Range on Protein: 3-146
Range on HMM: 58-229/291
Sequence Identity: 28% (49 aa)

IASLVRHPN----LVQFIGA-TKVGN-PLILTELMST-SICEELHRNR---------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPN
... ..|||     .|| |. .. ..  .|..| ..  | .. || .|                . ......| ..| |..|||  .|.||||||  |.|
HLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHN

VLLKP-CTGATGYEAKVADYGTAK-LHQG-TGSTVMPGNPAYAAPEAR---DPDQHSPAMDVYSYSVLLMEM
.|.   |    .  .|..| ||.. .||  |  . ..|..|. |||..     .. | . ||.|. |.| ||
ILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEM
Kinase AqueK586.AA TK 1-146 13 1.3e-19 61.73 In-house 89-387 (486) Show / Hide 
Range on Protein: 1-146
Range on HMM: 89-387/486
Sequence Identity: 13% (41 aa)

MSIASLVR-----HPNLVQFIG-ATKVGN------------PLILTELMS-TS----ICEELHRNR----------------------------------
...... .     |||.|...|  |....            ..|..|.|.  .      . |...|                                  
AEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSH

-------------------------------------------LTNQQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLLKPCTG------ATG
                                           || .| | .....| |. |||  .    | ..|||.   |.|.            .|
ESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCG

YEAKVADYG--------TAKLHQGTGSTVMPGNPA----------------------------YAAPEARD---------PDQHSPAMDVYSYSVLLMEM
. .|.||.|         |. ..  .  .  ...                             . |||. .            .... ||.|. ||. |.
PVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase AqueK586.AA TKL-Unique 2-146 26 4.9e-19 63.89 In-house 47-221 (290) Show / Hide 
Range on Protein: 2-146
Range on HMM: 47-221/290
Sequence Identity: 26% (47 aa)

SIASLVR-HPNLVQFIGATK---VGNP--LILTELMST-SICEELH-----------RNRLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLL
.. .  . |||.|...|...   | .|   | .| ..  |  . ||            . |..||....|.|.|.|..|||  .|  |||||  |.|.|.
NWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLV

KPCTGATGYEAKVADYGTAKLHQ--GTGSTVMP---------GNPAYAAPEARDP--DQHSPAMDVYSYSVLLMEM
        . .|..| |..|.     .... ..         |.. ..|||      .| |   ||||... | |.
DNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEI
Kinase AqueK586.AA CZAK 50-146 31 9.8e-19 64.77 In-house 108-215 (279) Show / Hide 
Range on Protein: 50-146
Range on HMM: 108-215/279
Sequence Identity: 31% (34 aa)

LSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLLKPCTG--------ATGYEAKVADYGTA--KLHQGTGSTVMPGNPAYAAPEARDPDQHSPAMDVYS
...| |.| | ||||  .|| ||.||| || |.||                  .|..|.|    .  |..  |   |  .. |||    .  ..  ||||
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVYS

YSVLLMEM
.  .| ..
FGMILWCI
Kinase AqueK586.AA Dicty5 3-146 26 1.3e-15 50.26 In-house 49-196 (260) Show / Hide 
Range on Protein: 3-146
Range on HMM: 49-196/260
Sequence Identity: 26% (42 aa)

IASLVR--HPNLVQFIGATKVGNPL--ILTELMST-SICEEL--HRN----RLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGATG
| |..   |||.. . || .       ..||. .  |. . |   |.     .   |.|..| |.| .. .||      |||||. | |.|.        
IMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMNFLI-----TEN

YEAKVADYGTAK-LHQGTGSTVMPGNPAYAAPEARDPDQHSPAMDVYSYSVLLMEM
...|. |.||        . |.  | ... |.|           ||||. . | ||
WKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEM
Kinase AqueK586.AA HH498 47-146 37 4.4e-15 43.89 In-house 121-219 (284) Show / Hide 
Range on Protein: 47-146
Range on HMM: 121-219/284
Sequence Identity: 37% (39 aa)

QQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGATGYEAKVADYGTAKLHQGTGSTVM---PGNPAYAAPEARD-PDQHSPAMDVYSYSVL
| .. |. ||| | ||||   ..||||||  | |.|.     . |  |.|||.|     .  .   |   |||. . |||      . |   ||.||   
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH----EDGH-AVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMC

LMEM
. ||
IWEM
Kinase AqueK586.AA Dicty4 5-146 28 4.5e-15 46.87 In-house 53-210 (277) Show / Hide 
Range on Protein: 5-146
Range on HMM: 53-210/277
Sequence Identity: 28% (47 aa)

SLVRHPNLVQFIGA-T----KVGNPLILTELM-STSICEELHR------NRLTNQ--QILS---IAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCT
.  ||||...| || |    . | ..| ||.| ...  . ||        . . .   |..   .| |.|.|.|.||   |  |||||  | | |     
CKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLV----

GATGYEAKVADYGTAK-----LHQGTGSTVMPGNPAYAAPEARDPDQHSPAMDVYSYSVLLMEM
    . .||.| | ..       .... . . | |.. |||    .    . ||||.. .| |.
-DKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEI
Kinase AqueK586.AA STE 8-146 20 9.5e-15 48.61 In-house 86-261 (359) Show / Hide 
Range on Protein: 8-146
Range on HMM: 86-261/359
Sequence Identity: 20% (38 aa)

R--HPNLVQFIGATKVG--------NPLILTELMS-TSICEELHRN---------------RLTNQQILSIAQDVALG-LNYLHLFKPQPIIHRDVSSPN
.  ||| |...|.  ..        .  |  |.|.  |. . ....               |.  .||  |....  | |.|||  .   |||||. . |
NHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPAN

VLLKPCTGATGYEAKVADYGTAKLHQGT------------------GSTVMPGNPAYAAPEARDP------DQHSPAMDVYSYSVLLMEM
.||          .| .| |...  . .                   .. . | | . |||  ..      ....   |..|   ...||
ILL----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase AqueK586.AA LRRK 52-143 33 1.9e-14 47.51 In-house 169-272 (351) Show / Hide 
Range on Protein: 52-143
Range on HMM: 169-272/351
Sequence Identity: 33% (36 aa)

IAQDVALGLNYLHLFKPQPIIHRDVSSPNVLL-KPCTGA------TGYEAKVADYGTAK----LHQGTGSTVMPGNPAYAAPEARDPD---QHSPAMDVY
|| ..| |..||| ..| ||||||  |||.|| .  ..       . . ||.||.|.      .| |  ...  ||| . ||| .  .   . .   |.|
IALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV-GNPGWMAPEIMRYNGEEEYTEKVDCY

SYSVLL
|. ..|
SFGMIL
Kinase AqueK586.AA Pkinase 4-196 19 2.4e-14 51.81 Pfam 55-293 (293) Show / Hide 
Range on Protein: 4-196
Range on HMM: 55-293/293
Sequence Identity: 19% (48 aa)

ASLVRHPNLVQFIGATK-VGNPLILTELMST-----SICEELH---RNRL--TNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGATGY
..| .||| |.....    ... . .|..       . .. ..   ....  . ... ...  .. ||.|.|      |||||. . |.|..  .| .. 
KRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDA

EAKVADYGTAK---LHQGTGSTVMPGNPAYAAPEA-RDPDQHSPAMDVYSYSVLLMEMNLHSQPEMTT---------------TEREVQSGSVSW-----
  |..| | ||   .  ..  |.  | | |.|||  |.   ..|. |..|. ..| || .   |                    .... . .  |     
CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISY

----------------SDMKSLIQRGLNVDPRARPTMAQVIES--L
                ...|..| . |..||  ||| .|. ..  .
FFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK586.AA S_TKc 1-199 17 2.2e-12 4.69 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-199
Range on HMM: 19-231/231
Sequence Identity: 17% (41 aa)

MSIA---------------------SLVRHPNLVQFIGATKVGNPLILTELMST---SICEELHRNR-------LTNQQILSIAQDVALGLNYLHLFKPQ
  .                      .  .|||.|.....   ..  . .|....   .  . .....       ..  .. .... ....|.|.|  .  
RHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG--

PIIHRDVSSPNVLLKPCTGATGYEAKVADYGTAKLHQGTGSTVMPGNPAYAAPEARDPDQHSP-AMDVYSYSVLLMEMNLHSQPEMTTTEREVQSGSVSW
 |||||.   |.||         . |..| | |..      | . | | | |||     .... . |..|  ..| ||     |   . ..  .      
-IIHRDLKPENILLDE-------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--S

SDMKSLIQRGLNVDPRARPTMAQVIE------SLERM
...|..|.. |..||. |||  .. .      . . .
PEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK586.AA TyrKc 1-196 15 6.8e-10 -62.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-196
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

MSIASL----------------------------------------V--RHPNLVQFIGATKV--------GNPLILTELMSTSICEE-LHRNR--LTNQ
 .                                            .  .|||.|...|.           . ..|..|.|.   . . |...|  |...
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

QILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGATGYEAKVADYGTAKLHQGT------GSTVMP----GNP-----AYAAPEARDPDQHSP
. ||.. ..| | .|||     ..||||    |.|..         .|..| | .. .         ... ..    |          |||. .    ..
DLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

AMDVYSYSVLLMEM-----NLHSQ-----PEMTTTEREVQSG------SV--------SWSDMKSLIQRGLNVDPRARPTMAQVIESL
. ||.|. |.. |.       ..       . .   . |..|                  ..| .....  . ||  |||.....| .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK586.AA Pkinase_Tyr 8-100 26 1.7e-09 32.78 Pfam 62-156 (270) Show / Hide 
Range on Protein: 8-100
Range on HMM: 62-156/270
Sequence Identity: 26% (27 aa)

RHPNLVQFIGATK-VGNP---LILTELMST-SICEELHRN-----RLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGATGYEAKVA
.|||.|...|.    | |   .| .|.|   .  . |...     .|| ...|......| |..||.  .   .||||.   |.|..      .  .|..
HHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVT-----ENNVVKIC

DYG
| |
DFG
Kinase AqueK586.AA MLK 171-196 34 1e-06 19.03 In-house 266-291 (291) Show / Hide 
Range on Protein: 171-196
Range on HMM: 266-291/291
Sequence Identity: 34% (9 aa)

MKSLIQRGLNVDPRARPTMAQVIESL
.|.|...  | ||. ||...|... |
WKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK586.AA Dicty4 172-198 37 2e-06 18.04 In-house 249-277 (277) Show / Hide 
Range on Protein: 172-198
Range on HMM: 249-277/277
Sequence Identity: 37% (11 aa)

KSLIQRGLNVDPRARPTMAQVIES--LER
|.|||. .. ||  ||.....|.   || 
KHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK586.AA LRRK 161-198 26 0.000133 12.18 In-house 314-351 (351) Show / Hide 
Range on Protein: 161-198
Range on HMM: 314-351/351
Sequence Identity: 26% (10 aa)

VQSGSVSWSDMKSLIQRGLNVDPRARPTMAQVIESLER
.. . . | ....|||   . ||. ||.. |... |. 
YCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK586.AA TKL-Unique 174-196 39 0.000265 11.29 In-house 268-290 (290) Show / Hide 
Range on Protein: 174-196
Range on HMM: 268-290/290
Sequence Identity: 39% (9 aa)

LIQRGLNVDPRARPTMAQVIESL
|||.. . ||  ||.  ..|..|
LIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK586.AA CZAK 2-31 42 0.000515 10.65 In-house 52-84 (279) Show / Hide 
Range on Protein: 2-31
Range on HMM: 52-84/279
Sequence Identity: 42% (14 aa)

SIASLVRHPNLVQFIGATKVGN---PLILTELM
|| |  .||| |||.||   ..     | .| |
SIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWM
Kinase AqueK586.AA TK 168-196 26 0.00154 6.88 In-house 446-486 (486) Show / Hide 
Range on Protein: 168-196
Range on HMM: 446-486/486
Sequence Identity: 26% (11 aa)

W------------SDMKSLIQRGLNVDPRARPTMAQVIESL
|             ..  |.|.  . ||. |||..|. | |
WMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK586.AA HH498 173-196 33 0.001622 6.57 In-house 261-284 (284) Show / Hide 
Range on Protein: 173-196
Range on HMM: 261-284/284
Sequence Identity: 33% (8 aa)

SLIQRGLNVDPRARPTMAQVIESL
.|||.. .  |  ||. .|..  |
NLIQMCWHPCPENRPDFDQIVTIL
Kinase AqueK586.AA Pkinase_Tyr 168-196 27 0.152489 5.85 Pfam 242-270 (270) Show / Hide 
Range on Protein: 168-196
Range on HMM: 242-270/270
Sequence Identity: 27% (8 aa)

WSDMKSLIQRGLNVDPRARPTMAQVIESL
. .. .|...  . ||  |||.....| |
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK586.AA Pkinase_Tyr 135-146 50 7.917708 0.04 Pfam 196-207 (270) Show / Hide 
Range on Protein: 135-146
Range on HMM: 196-207/270
Sequence Identity: 50% (6 aa)

DVYSYSVLLMEM
||.|. ||. |.
DVWSFGVLMWEI