Gene AqueK587 (A.queenslandica)

AqueK587

Species: A.queenslandica
Alias: AqueK587
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK587.AA Protein None 549 None Fasta, JSON
AqueK587.kin_dom Protein Kinase Domain None 192 None Fasta, JSON

Protein domain

Protein domains of AqueK587.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SIR2 AqueK587.AA SIR2 7-124 35 2.3e-28 105.33 Pfam 63-195 (213) Show / Hide 
Range on Protein: 7-124
Range on HMM: 63-195/213
Sequence Identity: 35% (49 aa)

KVHPTLCHYFIRLLEANGLLLRCYTENIDTLERRAGITDEHLVKVHGALDTAHCITCGKGYSYEFVKAQAGNI--------PFCTSFGC-------AYEP
...|. |||||...|..| |||||| |||.|.||||..|||.|  || . .|.|..|.. |..| ...   |         | |  .|        .   
QFQPNPCHYFIKMWEDKGKLLRCYTQNIDNLHRRAGSKDEHVVECHGSFAKARCVSCHWKYDGEWLYEMIRNHCVPFKFDIPHCCQCGGKREYFRVG---

KVDSGTYK-----GIVKPDVVFVGEDPP-RKFTVLANEE
  ..   .     ||.|||.|. ||. | .||  . .|.
--MTEH-PQLNHFGIMKPDIVWFGEMLPQDKFHRCMEED
Kinase AqueK587.AA TKL 303-492 20 7.7e-39 135.36 In-house 83-364 (364) Show / Hide 
Range on Protein: 303-492
Range on HMM: 83-364/364
Sequence Identity: 20% (60 aa)

RHPNLVQFIGATKVDN--------------PLILTELM-STSLYKKLQETKLTNQQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNVLLKPCT
||||.|||.|. .  .              . | .|..   ||.  |.      .|....|.|.|.|.||||  .|      ||||||  |.|.|..   
RHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENW

G---------AAGYEAKVSDYGAAKLQQGTS--------------------TGTVMPGNPAYAAPEAPIPD----------------QHSPAMDVYSYSV
          .| . .|..|.| ..  ....                    |     |.|.. |||.   .                . |...||||. .
TNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI

LLMEMNLCCKPEMMTAEREVQ---------SRGV-----------------------SWSDMKSLIQRGLNANPRARPTMAQALLQL
.| |.  .|.|.    .....         .  .                        . .||.|.|.  ...|..||.. . | .|
VLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK587.AA MLK 303-442 27 5.8e-25 83.62 In-house 63-229 (291) Show / Hide 
Range on Protein: 303-442
Range on HMM: 63-229/291
Sequence Identity: 27% (46 aa)

RHPN----LVQFIGATKVD-N-PLILTELMST-SLYKKLQETK---------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKP
.|||     .|| |. . . .  .|..| ..  |||  | . .                . ......| ..| |..|||  .|.||||||  |.|.|.  
SHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE

-CTGAAGYEAKVSDYGAAK-LQQGTSTGTVMPGNPAYAAPEAP---IPDQHSPAMDVYSYSVLLMEM
 |   ..  .|..| |... ..| ... . ..|..|. |||.      .. | . ||.|. |.| ||
ICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEM
Kinase AqueK587.AA TKL-Unique 299-442 29 1.5e-24 83.63 In-house 49-221 (290) Show / Hide 
Range on Protein: 299-442
Range on HMM: 49-221/290
Sequence Identity: 29% (51 aa)

SITSR-HPNLVQFIGATK---VDNP--LILTELMST-SLYKKLQ-----------ETKLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKP
. . . |||.|...|...   |..|   | .| ..  |||. |.           ..||..||....|.|.|.|..|||  .|  |||||  |.|.|.  
MKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDN

CTGAAGYEAKVSDYGAAKLQQGTSTGTVM----------PGNPAYAAPEAPIP--DQHSPAMDVYSYSVLLMEM
    | . .|..| | .|..   ...|.            |.. ..|||      .| |   ||||... | |.
NSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEI
Kinase AqueK587.AA CZAK 303-442 31 1.2e-21 75.55 In-house 58-215 (279) Show / Hide 
Range on Protein: 303-442
Range on HMM: 58-215/279
Sequence Identity: 31% (51 aa)

RHPNLVQFIGATKVDN---PLILTELMS-TSLYKKLQETKLTNQQ----ILSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLLKPCTG--------AA
.||| |||.||   |.     | .| |   || . | .     .|     ...| |.| | ||||  .|| ||.||| || |.||               
CHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQ

GYEAKVSDYGAA--KLQQGTS-TGTVMPGNPAYAAPEAPIPDQHSPAMDVYSYSVLLMEM
   .|..|.|    .  |..  | |.  |  .. |||  . .  ..  ||||.  .| ..
DIICKINDFGLSREMMEQPFEMTQTM--GCLCWMAPECFKGENYTEKVDVYSFGMILWCI
Kinase AqueK587.AA TK 303-492 13 5.7e-20 62.93 In-house 101-486 (486) Show / Hide 
Range on Protein: 303-492
Range on HMM: 101-486/486
Sequence Identity: 13% (54 aa)

RHPNLVQFIG-ATKVDN------------PLILTELMS-TS----LYKKLQETK----------------------------------------------
.|||.|...|  |....            ..|..|.|.  .    | . |.. .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTNQQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLLKPCTGAA------GYEAKVSDYG---
                               || .| | .....| |. |||  .    | ..|||.   |.|.      .      |. .|..|.|   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----AAKLQQGTSTGTVMPGNPA---------------------------YAAPEAPI---------PDQHSPAMDVYSYSVLLMEMNLCCK-------
      |.  .  .  ... .  .                           . |||.              .... ||.|. ||. |.   ..       
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

-----------PEMMTAERE------------------VQSRGVS-W------------SDMKSLIQRGLNANPRARPTMAQALLQL
            |.|   |.                   |  . . |             ..  |.|.  ...|. |||..| . ||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK587.AA Dicty4 303-442 29 1.1e-15 49.0 In-house 56-210 (277) Show / Hide 
Range on Protein: 303-442
Range on HMM: 56-210/277
Sequence Identity: 29% (47 aa)

RHPNLVQFIGA-T----KVDNPLILTELM-STSLYKKLQE------TKLTNQ--QILS---IAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAA
||||...| || |    .   ..| ||.| ...||. |         . . .   |..   .| |.|.|.|.||   |  |||||  | | |       .
RHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLV-----DK

GYEAKVSDYGAAK-LQQGTSTGT---VMPGNPAYAAPEAPIPDQHSPAMDVYSYSVLLMEM
 . .||.| | ..  . ... ..    . | |.. |||    .    . ||||.. .| |.
NWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEI
Kinase AqueK587.AA STE 302-419 21 1.5e-15 51.49 In-house 85-232 (359) Show / Hide 
Range on Protein: 302-419
Range on HMM: 85-232/359
Sequence Identity: 21% (35 aa)

SR--HPNLVQFIGATKVD--------NPLILTELMS-TSLYKKLQ---ETKLT------------NQQILSIAQDVALG-LNYLHLFKPQPIIHRDVSSP
..  ||| |...|.  ..        .  |  |.|.  || . ..   ... .             .||  |....  | |.|||  .   |||||. . 
CNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPA

NVLLKPCTGAAGYEAKVSDYGAAKLQQG---------------TSTGT--VMPGNPAYAAPE
|.||          .| .| | ..  .                |. .    . | | . |||
NILL----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
S_TKc AqueK587.AA S_TKc 279-500 19 1.6e-15 50.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 279-500
Range on HMM: 1-231/231
Sequence Identity: 19% (50 aa)

TLTKEELGRGGYAVVKGNEYSI----------------------TSRHPNLVQFIGATKVDNPLILTELMST---SLYKKLQETK-------LTNQQILS
    ...|.|....|.                              .|||.|.....   |.  . .|....   .|.. ... .       ..  .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

IAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVSDYGAAKLQQGTSTGTVMPGNPAYAAPEAPIPDQHSP-AMDVYSYSVLLMEMNLC
... ....|.|.|  .   |||||.   |.||         . |..| | |..       | . | | | |||     .... . |..|  ..| || ||
YMYQICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM-LC

CKP---EMMTAEREVQSRGVSWSDMKSLIQRGLNANPRARPTMAQALL-QLPNLTMIYL
 .|   .|..  . .       ...|..|.. |. .|. |||  .||  ..    . ..
GYPPFPQMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK587.AA TK-Unique 303-442 21 2e-15 49.72 In-house 62-232 (294) Show / Hide 
Range on Protein: 303-442
Range on HMM: 62-232/294
Sequence Identity: 21% (39 aa)

RHPNLVQFIGATK-VD-NPLILTELMSTS-LYKKLQETK---------------------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVS
.|||.||..|..   | ...|. | .. . | . |....                           .. .. ...| ..| |..||.   .. |.|||..
DHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLC

SPNVLLKPCTGAAGYEAKVSDYGAAK-------LQQGTSTGTVMPGNPAYAAPEAPI--PDQH-SPAMDVYSYSVLLMEM
. ||||       ....|..|.| |.       ..  .| |...    .. |||..     .. ..  ||.|. ||. |.
ARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMCSQGRIP---IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEI
Kinase AqueK587.AA HH498 304-442 31 6.7e-14 40.07 In-house 61-219 (284) Show / Hide 
Range on Protein: 304-442
Range on HMM: 61-219/284
Sequence Identity: 31% (52 aa)

HPNLVQFIGATKVDNP---LILTELMST-SLYKKL--------------QETK-----LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKP
||. |||..|. .| |   .| |.  .  ||.  |               . |     .  | .. |. ||| | ||||   ..||||||  | |.|.  
HPCVVQFVYAC-CDDPSQFAIVTQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH-

CTGAAGYEAKVSDYGAA--KLQQGTSTGTVMPGNPAYAAPEAPI-PDQHSPAMDVYSYSVLLMEM
   . |  |.| |.|    . . .  . |  |||. . |||      . |   ||.||   . ||
---EDGH-AVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEM
Kinase AqueK587.AA LRRK 303-419 31 8.5e-14 45.18 In-house 115-249 (351) Show / Hide 
Range on Protein: 303-419
Range on HMM: 115-249/351
Sequence Identity: 31% (44 aa)

RHPNLVQFIGATKVDNPLIL-TELMST-SLYKKLQETK----------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLL-KPCTGA-----
.|||.|. .| .   .||.. .|...  .||. |...|          .. . .| || ..| |..||| ..| ||||||  |||.|| .  ..      
NHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYP

-AGYEAKVSDYGAAK----LQQG-TSTGTVMPGNPAYAAPE
 | . ||..|.|       .. | ... .   ||| . |||
NAHVCAKIADFGISRMFQCFHMGVAKGCV---GNPGWMAPE
Kinase AqueK587.AA Pkinase 303-442 24 1.2e-13 49.28 Pfam 58-205 (293) Show / Hide 
Range on Protein: 303-442
Range on HMM: 58-205/293
Sequence Identity: 24% (38 aa)

RHPNLVQFIGATK-VDNPLILTELMST-----SLYKKLQ---ETKL--TNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKV
.||| |.....    |.. . .|..       .|.  ..   ....  . ... ...  .. ||.|.|      |||||. . |.|..  .|  .   |.
NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDACVKI

SDYGAAKL--QQGTSTGTVMPGNPAYAAPEAPI-PDQHSPAMDVYSYSVLLMEM
.| | ||.      |  |.  | | |.|||       ..|. |..|. ..| ||
CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase AqueK587.AA Pkinase_Tyr 303-395 26 3.9e-12 41.73 Pfam 62-156 (270) Show / Hide 
Range on Protein: 303-395
Range on HMM: 62-156/270
Sequence Identity: 26% (27 aa)

RHPNLVQFIGATK-VDNP---LILTELMST-SLYKKLQET-----KLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVS
.|||.|...|.    . |   .| .|.|   .|.. |..      .|| ...|......| |..||.  .   .||||.   |.|..      .  .|..
HHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE-----NNVVKIC

DYG
| |
DFG
TyrKc AqueK587.AA TyrKc 279-492 16 7.3e-11 -46.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 279-492
Range on HMM: 1-280/280
Sequence Identity: 16% (49 aa)

TLTKEELGRGGYAVVKGNEYSITS--------------------------RHPNLVQFIGATKV--------DNPLILTELMST-SLYKKLQETK--LTN
   ...||.| . .|   ... .                           .|||.|...|.           . ..|..|.|.  .| . |....  |..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

QQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVSDYGAAKLQQGT-------STGTVM---PGNP----AYAAPEAPIPDQHS
.. ||.. ..| | .|||     ..||||    |.|..         .|.|| | ..            .. ...    |.        |||.      .
KDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

PAMDVYSYSVLLMEM-NLCCKPE----------------MMTAEREVQSRGV-------SWSDMKSLIQRGLNANPRARPTMAQALLQL
.. ||.|. |.. |.  .. .|                  .. .|  |   .         ..| .....  ...|  |||...   ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK587.AA MLK 467-492 30 3e-06 18.06 In-house 266-291 (291) Show / Hide 
Range on Protein: 467-492
Range on HMM: 266-291/291
Sequence Identity: 30% (8 aa)

MKSLIQRGLNANPRARPTMAQALLQL
.|.|...  |..|. ||...| . .|
WKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK587.AA HH498 469-492 33 0.000305 8.91 In-house 261-284 (284) Show / Hide 
Range on Protein: 469-492
Range on HMM: 261-284/284
Sequence Identity: 33% (8 aa)

SLIQRGLNANPRARPTMAQALLQL
.|||.. ...|  ||. .| .  |
NLIQMCWHPCPENRPDFDQIVTIL
Kinase AqueK587.AA Dicty4 468-494 27 0.001621 7.79 In-house 249-277 (277) Show / Hide 
Range on Protein: 468-494
Range on HMM: 249-277/277
Sequence Identity: 27% (8 aa)

KSLIQRGLNANPRARPTMAQALLQ--LPN
|.|||. .. .|  ||.... . .  |  
KHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK587.AA LRRK 464-494 29 0.005079 6.51 In-house 321-351 (351) Show / Hide 
Range on Protein: 464-494
Range on HMM: 321-351/351
Sequence Identity: 29% (9 aa)

WSDMKSLIQRGLNANPRARPTMAQALLQLPN
| ....|||   ...|. ||.. | . .|  
WHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK587.AA TKL-Unique 470-492 30 0.018787 4.68 In-house 268-290 (290) Show / Hide 
Range on Protein: 470-492
Range on HMM: 268-290/290
Sequence Identity: 30% (7 aa)

LIQRGLNANPRARPTMAQALLQL
|||.. . .|  ||.  . .  |
LIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK587.AA STE 280-295 27 0.100944 2.01 In-house 1-18 (359) Show / Hide 
Range on Protein: 280-295
Range on HMM: 1-18/359
Sequence Identity: 27% (5 aa)

LTK-EELGRGGYA-VVKG
... |..|.|..  |.|.
WEGIEKIGKGAFGTVYKA
Kinase AqueK587.AA STE 465-495 33 0.224198 0.77 In-house 328-359 (359) Show / Hide 
Range on Protein: 465-495
Range on HMM: 328-359/359
Sequence Identity: 33% (11 aa)

SDMKSLIQRGLNANPRARPTMAQALLQ--LPNL
...|  |.. |. .|. |||  | ||.   | .
PEFKDFINKCLQKDPNKRPTASQ-LLKSEHPFI
Kinase AqueK587.AA TK-Unique 466-492 25 0.282706 0.3 In-house 268-294 (294) Show / Hide 
Range on Protein: 466-492
Range on HMM: 268-294/294
Sequence Identity: 25% (7 aa)

DMKSLIQRGLNANPRARPTMAQALLQL
.| .|... .. .|  ||. .| . .|
EMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK587.AA Pkinase 465-492 30 0.638151 4.34 Pfam 264-293 (293) Show / Hide 
Range on Protein: 465-492
Range on HMM: 264-293/293
Sequence Identity: 30% (9 aa)

SDMKSLIQRGLNANPRARPTMAQALLQ--L
...|..| . |. .|  ||| .|.|    .
EECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK587.AA Pkinase_Tyr 431-442 50 7.917708 0.04 Pfam 196-207 (270) Show / Hide 
Range on Protein: 431-442
Range on HMM: 196-207/270
Sequence Identity: 50% (6 aa)

DVYSYSVLLMEM
||.|. ||. |.
DVWSFGVLMWEI