Gene AqueK591 (A.queenslandica)

AqueK591

Species: A.queenslandica
Alias: AqueK591
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK591.AA Protein None 849 None Fasta, JSON
AqueK591.kin_dom Protein Kinase Domain None 193 None Fasta, JSON

Protein domain

Protein domains of AqueK591.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kelch_1 AqueK591.AA Kelch_1 13-69 17 0.009516 13.62 Pfam 1-45 (45) Show / Hide 
Range on Protein: 13-69
Range on HMM: 1-45/45
Sequence Identity: 17% (10 aa)

GRAAHCTVSVSDSLYVWGGHQDGLPKVHDSEEKRRITSNIQHFTPSTGQWITRGTTG
 |. |. ... . .|| ||. .            ......  . |.|.||    . .
PRCGHGVCVHNGKIYVIGGCDG------------QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK591.AA Kelch_2 13-69 17 0.34123 8.66 Pfam 1-51 (51) Show / Hide 
Range on Protein: 13-69
Range on HMM: 1-51/51
Sequence Identity: 17% (10 aa)

GRAAHCTVSVSDSLYVWGGHQDGLPKVHDSEEKRRITSNIQHFTPSTGQWITRGTTG
.|. | .... . .||.||.        .. ..   .. |. . |.| .|      .
PRYCHASCVPGGKIYVFGGYC------RHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK591.AA Kelch_1 74-121 20 0.001121 16.95 Pfam 1-45 (45) Show / Hide 
Range on Protein: 74-121
Range on HMM: 1-45/45
Sequence Identity: 20% (10 aa)

GARSYSCTAINDLLYYFGGRCSHDGCYHNSITQLDTVSLQWRELEATD
  ........|...| .||...    | ||.  .|... ||...    
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK591.AA Kelch_2 74-121 15 0.002596 16.71 Pfam 1-51 (51) Show / Hide 
Range on Protein: 74-121
Range on HMM: 1-51/51
Sequence Identity: 15% (8 aa)

GARSYSCTAINDLLYYFGGR---CSHDGCYHNSITQLDTVSLQWRELEATD
.  . ... ... .| |||.     ...|....|  .|. . .|... . .
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK591.AA Kelch_1 278-307 16 0.591395 7.19 Pfam 14-41 (45) Show / Hide 
Range on Protein: 278-307
Range on HMM: 14-41/45
Sequence Identity: 16% (5 aa)

LVISGGLDKHNDTLDDCWIFNITQHSWIKL
. . || |     |....... . ..| ..
IYVIGGCDG--QYLNSVECYDPETNQWTRC
Kelch_2 AqueK591.AA Kelch_2 278-311 15 1.119143 6.7 Pfam 14-51 (51) Show / Hide 
Range on Protein: 278-311
Range on HMM: 14-51/51
Sequence Identity: 15% (6 aa)

LVISGGL----DKHNDTLDDCWIFNITQHSWIKLDVPH
....||.    .  .. . | |...   |.| .. ...
IYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kinase AqueK591.AA TKL 555-791 19 7.7e-46 158.61 In-house 1-364 (364) Show / Hide 
Range on Protein: 555-791
Range on HMM: 1-364/364
Sequence Identity: 19% (73 aa)

LGRGSYAVVTVGIFRGLG----------VAVKSLHTIIISDFNL-------------------------ALFSREMNIASQVRHPNLVQFIGATK-----
.|.|....|  |..|| |          |||| ...   . |..                           . .|... |. ||||.|||.|. .     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------VGNPLILTELM-STSLNQELRRKQLTNQQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNILLKPCTRP---------AGYEAKV
          |.. | .|..   ||   |       .|....|.|.|.|.||||  .|      ||||||  |.|||..   ..         | . .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

ADYGTAKLVQVDS--------------------TGTVMPGNPAYAAPEAPIPD----------------QHSPAMDVYSYSVLLMEMNLCSSPEMTTAER
.|.|... .. ..                    |     |.|.. |||.   .                . |...||||. ..| |.  .  |.    ..
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYM

EVQ---------SGSV-----------------------SWSDMKSLIQRGPNANPRARPTMAQVIESX
...         .. .                        . .||.|.|.  ...|..||.. ....  
PMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK591.AA MLK 549-741 26 8.6e-33 111.14 In-house 1-229 (291) Show / Hide 
Range on Protein: 549-741
Range on HMM: 1-229/291
Sequence Identity: 26% (61 aa)

TLTKEELGRGSYAVVTVGIFRGLG-----VAVKSLHTIIISDFNLA-----LFSREMNIASQVRHPN----LVQFIGA-TKVGN-PLILTELMST-SLNQ
 ...| .| ||. .|  | .|.       ||||  .. |. |   .      | .| .... ..|||     .|| |. .. ..  .|..| ..  ||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ELRRKQ---------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNILLKP-CTRPAGYEAKVADYGTAKLVQVD-STGTVMPGNPAY
 |. ..                . ......| ..| |..|||  .|.||||||  |.|||.   |   ..  .|..| ||.. ..   .. . ..|..|.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

AAPEAP---IPDQHSPAMDVYSYSVLLMEM
 |||.      .. | . ||.|. |.| ||
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEM
Kinase AqueK591.AA TKL-Unique 551-741 28 4.4e-29 99.78 In-house 1-221 (290) Show / Hide 
Range on Protein: 551-741
Range on HMM: 1-221/290
Sequence Identity: 28% (64 aa)

TKEELGRGSYAVVTVGIFRGLGVAVKSLHTIIISDFNLA---LFSREMNIASQVR-HPNLVQFIGATK---VGNP--LILTELMST-SLNQELR------
  . .|.|.|..|  |..||  ||.|..|    .|...     |..| |. .  . |||.|...|...   | .|   | .| ..  ||.  |       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-----RKQLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNILLKPCTRPAGYEAKVADYGTAKLVQVDSTGTVM----------PGNPAYAAPEA
      . |..||....|.|.|.|..|||  .|  |||||  |.|.|.      | . .|..| |..|.   ....|.            |.. ..||| 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

PIP--DQHSPAMDVYSYSVLLMEM
     .| |   ||||... | |.
LRMNFCQYSEKSDVYSFGIVLWEI
Kinase AqueK591.AA TK 549-741 14 1.5e-28 92.16 In-house 1-387 (486) Show / Hide 
Range on Protein: 549-741
Range on HMM: 1-387/486
Sequence Identity: 14% (58 aa)

TLTKEELGRGSYA---VVTVGIFRGLG---------------------------VAVKSLH---TIIISDFNLALFS---------REMNIASQVR----
    ..||.| .    .|  |. ||..                           |||| |.   .    .| .. .          .|...... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVQFIG-ATKVGN------------PLILTELMS-TS----LNQELRRK-----------------------------------------------
 |||.|...|  |....            ..|..|.|.  .    | . ||..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QLTNQQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNILLKPCTR------PAGYEAKVADYG---
                              ||| .| | .....| |. |||  .    | ..|||.   |.|.    .        |. .|.||.|   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----TAKLVQVDSTGTVMPGNPA---------------------------YAAPEAPI---------PDQHSPAMDVYSYSVLLMEM
      |. .. |.  ... .  .                           . |||.              .... ||.|. ||. |.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase AqueK591.AA Dicty4 551-741 29 4.6e-26 84.05 In-house 3-210 (277) Show / Hide 
Range on Protein: 551-741
Range on HMM: 3-210/277
Sequence Identity: 29% (64 aa)

TKEELGRGSYAVVTVGIFRGLGVAVKSL--HTIIISDFNLALFSREMNIASQVRHPNLVQFIGA-T----KVGNPLILTELM-STSLNQELRR------K
. ...|.||.. |  |. ||  |||| |  | .  . . |  | .| .| .. ||||...| || |    . | ..| ||.| ...|   |.       .
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

QLTNQ--QILS---IAQDVALGLNYLHLFKPQPIIHRDVSSPNILLKPCTRPAGYEAKVADYGTAKLVQVDSTGTV----MPGNPAYAAPEAPIPDQHSP
  . .   |..   .| |.|.|.|.||   |  |||||  | |.|       . . .||.| | ... . ... .     . | |.. |||    .    
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVD-----KNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNE

AMDVYSYSVLLMEM
. ||||.. .| |.
KADVYSFGIVLWEI
Kinase AqueK591.AA CZAK 550-741 29 1.9e-25 89.42 In-house 1-215 (279) Show / Hide 
Range on Protein: 550-741
Range on HMM: 1-215/279
Sequence Identity: 29% (63 aa)

LTKE-ELGRGSYAVVTVGIFRGLGVAVKSLHTIIISDFNL----ALFSREMNIASQVRHPNLVQFIGATKVGN---PLILTELMS-TSLNQELRRKQLTN
|. . . |.| .  |  .  ||  ||.| .| .   .         | .|  | |  .||| |||.||   ..     | .| |   || . |  .    
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH

QQ----ILSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNILLKPCTR--------PAGYEAKVADYGTAKLVQVDSTG-TVMPGNPAYAAPEAPIPDQHS
.|     ...| |.| | ||||  .|| ||.||| || ||||                  .|..|.|  ..     .  |   |  .. |||  . .  .
KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYT

PAMDVYSYSVLLMEM
.  ||||.  .| ..
EKVDVYSFGMILWCI
Kinase AqueK591.AA S_TKc 549-789 19 8.6e-24 86.28 SMART 1-220 (231) Show / Hide 
Range on Protein: 549-789
Range on HMM: 1-220/231
Sequence Identity: 19% (50 aa)

TLTKEELGRGSYAVVTVGIFRG--LGVAVKSLHTIIISDFNLALFSREMNIASQVRHPNLVQFIGATKVGNPLILTELMST---SLNQELRRKQ------
    ...|.|....|  .. ..    ||.| ..           . ||..| .. .|||.|.....   ..  . .|....   .| . .....      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNILLKPCTRPAGYEAKVADYGTAKLVQVDSTGTVMPGNPAYAAPEAPIPDQHSP-AMDVYSYS
 ..  .. .... ....|.|.|  .   |||||.   ||||         . |..| | |...      | . | | | |||     .... . |..|  
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

VLLMEMNLCSSPEMTTAEREVQSGSVSWSDMKSLIQRGPNANPRARPTMAQVIE
..| ||     |   . ..  .      ...|..|..  . .|. |||  .. .
CILYEMLCGYPPFP-QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase AqueK591.AA STE 550-718 18 3.5e-23 78.8 In-house 1-232 (359) Show / Hide 
Range on Protein: 550-718
Range on HMM: 1-232/359
Sequence Identity: 18% (46 aa)

LTK-EELGRGSYAVVTVGIFR-----------------GLGVAVKSLH---------------TIIISDFNLALFSREMNIASQVR--HPNLVQFIGATK
... |..|.|.. .|  .. .                 |  .|.| ..               . .. . ..  . .|..| .. .  ||| |...|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG--------NPLILTELMS-TSLNQELRRK-----QLT----------NQQILSIAQDVALG-LNYLHLFKPQPIIHRDVSSPNILLKPCTRPAGYEAK
..        .  |  |.|.  || . ...|     .|.           .||  |....  | |.|||  .   |||||. . ||||          .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------VK

VADYGTAKLVQ-----------------VDSTGTVMPGNPAYAAPE
 .| |... ..                  ..  . . | | . |||
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase AqueK591.AA LRRK 549-718 23 9.6e-21 70.1 In-house 1-249 (351) Show / Hide 
Range on Protein: 549-718
Range on HMM: 1-249/351
Sequence Identity: 23% (60 aa)

TLTKEELGRGSYA-VVTVGIFRG----------------------------LGVAVKSLHTI------------------------------IISDF--N
    |..|||... .|  ...||                              ||.|.....                              ...|.  .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LALFSREMNIASQVRHPNLVQFIGATKVGNPLIL-TELMST-SLNQELR---RKQ-------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNI
. .| .|. | |  .|||.|. .| .   .||.. .|...  .|.. |.   . .       .. . .| || ..| |..||| ..| ||||||  ||||
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNI

LLKPCTRP-------AGYEAKVADYGTAKLVQVDSTG--TVMPGNPAYAAPE
||.  . .       | . ||.||.|.  . |.. .|    . ||| . |||
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPE
Kinase AqueK591.AA Dicty4-Unclassified 552-741 26 2.6e-19 62.75 In-house 4-201 (263) Show / Hide 
Range on Protein: 552-741
Range on HMM: 4-201/263
Sequence Identity: 26% (56 aa)

KEELGRGSYAVVTVGIFRGLGVAVKSLHTIIISDFN---LALFSREMNIASQVRHPNLVQFIGATKVGNP-------LILTELMSTSLNQELRR------
  ..|.|  . |  |. .|  |||| .     . |    .  | .|  |   . |||||.  |.    ||        | .|.|      |.        
DQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFK-FREEMIQDFKKEVEILGSIQHPNLVKCYGYCI--NPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

-KQLTNQQ--ILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNILLKPCTRPAGYEAKVADYGTAKLVQVDSTGTVMPGNPAYAAPEAPIPDQHSPAMDVY
 . .      |. .| |.| |. .||      .||||. | |||.        . .|.|| | .  .    . |   | |.  .||         . |||
QQPIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILMD-----KHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVY

SYSVLLMEM
|| ..| |.
SYAMMLYEL
Pkinase_Tyr AqueK591.AA Pkinase_Tyr 548-710 26 2.8e-18 62.53 Pfam 1-173 (270) Show / Hide 
Range on Protein: 548-710
Range on HMM: 1-173/270
Sequence Identity: 26% (48 aa)

VTLTKEELGRGSYAVVTVGIFR------GLGVAVKSLHTIIISDFN--LALFSREMNIASQV-RHPNLVQFIGATK-VGNP---LILTELMST-SLNQEL
.|.  ..||.|.. .|  |. .      .. ||||.|     .. .  .. | ||..| .|  .|||.|...|.    | |   .| .|.|   .|   |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RRK-----QLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNILLKPCTRPAGYEAKVADYGTAKLVQVDSTG-TVMPG
|..     .|| ...|......| |..||.  .   .||||.   |.|..      .  .|..| | |.... |..  ..  |
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVT-----ENNVVKICDFGLARDIYNDDYYYRKRGG
Kinase AqueK591.AA Pkinase 549-741 24 4.6e-18 64.96 Pfam 1-205 (293) Show / Hide 
Range on Protein: 549-741
Range on HMM: 1-205/293
Sequence Identity: 24% (51 aa)

TLTKEELGRGSYAVVTVGIFRGLG--VAVKSLHTIIISDFNLALFSR--EMNIASQVRHPNLVQFIGATK-VGNPLILTELMST-----SLNQELR---R
  ... .|.||...|  .. .| |  |||| .    ...  .    |  |  |   ..||| |.....    ... . .|..       .|   ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KQL--TNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNILLK-PCTRPAGYEAKVADYGTAKL--VQVDSTGTVMPGNPAYAAPEAPI-PDQHSPAM
. .  . ... ...  .. ||.|.|      |||||. . |||..  .. .|    |..| | ||.     .|  |.  | | |.|||       ..|. 
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSYSVLLMEM
|..|. ..| ||
DMWSCGCILYEM
Kinase AqueK591.AA HH498 641-741 39 5.7e-16 46.75 In-house 121-219 (284) Show / Hide 
Range on Protein: 641-741
Range on HMM: 121-219/284
Sequence Identity: 39% (41 aa)

QQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNILLKPCTRPAGYEAKVADYGTAKLVQV--DSTGTVMPGNPAYAAPEAPI-PDQHSPAMDVYSYSVL
| .. |. ||| | ||||   ..||||||  | |||.    .     |.|||.|    |.   | . |  |||. . |||      . |   ||.||   
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGH-----AVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMC

LMEM
. ||
IWEM
Kinase AqueK591.AA TyrKc 549-791 21 9e-16 32.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 549-791
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

TLTKEELGRGSYAVVTVGIFRGLGVAVKSLHTIIISDFNLALFSREMNIASQV--RHPNLVQFIGATKV--------GNPLILTELMST-SLNQELRRKQ
   ...||.| . .|  |. . . ||||.|.        .. | ||..| ...  .|||.|...|.           . ..|..|.|.  .|.. ||...
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNILLKPCTRPAGYEAKVADYGTAKLVQVD-------STGTVM---PGNP----AYAAPEAPI
  |.... ||.. ..| | .|||     ..||||    |.|..         .|..| | .. .  |       .. ...    |.        |||.  
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

PDQHSPAMDVYSYSVLLMEM-NLCSSPE-------MTTAE--REVQSG------SV--------SWSDMKSLIQRGPNANPRARPTMAQVIESX
    ... ||.|. |.. |.  .. .|        |. .|  . |..|                  ..| .....  ...|  |||.....|  
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK591.AA MLK 766-791 26 0.000508 9.99 In-house 266-291 (291) Show / Hide 
Range on Protein: 766-791
Range on HMM: 266-291/291
Sequence Identity: 26% (7 aa)

MKSLIQRGPNANPRARPTMAQVIESX
.|.|...  |..|. ||...|...  
WKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK591.AA HH498 768-791 29 0.000794 7.57 In-house 261-284 (284) Show / Hide 
Range on Protein: 768-791
Range on HMM: 261-284/284
Sequence Identity: 29% (7 aa)

SLIQRGPNANPRARPTMAQVIESX
.|||.. ...|  ||. .|..   
NLIQMCWHPCPENRPDFDQIVTIL
Kinase AqueK591.AA HH498 551-613 30 0.00374 5.4 In-house 3-71 (284) Show / Hide 
Range on Protein: 551-613
Range on HMM: 3-71/284
Sequence Identity: 30% (21 aa)

TKEELGRGSYAVVTVGIFRGLGVAVKSLHTIIISDFNL------ALFSREMNIASQVRHPNLVQFIGAT
..|  | ||.  |  | .|.  ||||      ..            | ||  | ..  ||. |||..|.
FHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYAC
Kinase AqueK591.AA TK 775-791 35 0.101136 0.68 In-house 470-486 (486) Show / Hide 
Range on Protein: 775-791
Range on HMM: 470-486/486
Sequence Identity: 35% (6 aa)

NANPRARPTMAQVIESX
...|. |||..|. |  
HYDPEDRPTFSQLHEQL
Kinase AqueK591.AA Dicty4-Unclassified 766-791 38 0.185956 0.71 In-house 238-263 (263) Show / Hide 
Range on Protein: 766-791
Range on HMM: 238-263/263
Sequence Identity: 38% (10 aa)

MKSLIQRGPNANPRARPTMAQVIESX
.|.||       |. |||| |.|.  
WKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase AqueK591.AA Dicty4 767-789 34 0.211956 0.63 In-house 249-271 (277) Show / Hide 
Range on Protein: 767-789
Range on HMM: 249-271/277
Sequence Identity: 34% (8 aa)

KSLIQRGPNANPRARPTMAQVIE
|.|||.  . .|  ||.....|.
KHLIQWCWDHDPQHRPSFEEIIQ
Kinase AqueK591.AA LRRK 756-793 21 0.228231 0.58 In-house 314-351 (351) Show / Hide 
Range on Protein: 756-793
Range on HMM: 314-351/351
Sequence Identity: 21% (8 aa)

VQSGSVSWSDMKSLIQRGPNANPRARPTMAQVIESXXX
.. . . | ....|||   ...|. ||.. |...    
YCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK591.AA TKL-Unique 769-791 30 0.241308 0.72 In-house 268-290 (290) Show / Hide 
Range on Protein: 769-791
Range on HMM: 268-290/290
Sequence Identity: 30% (7 aa)

LIQRGPNANPRARPTMAQVIESX
|||.. . .|  ||.  ..|.. 
LIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK591.AA Pkinase_Tyr 730-741 50 7.917708 0.04 Pfam 196-207 (270) Show / Hide 
Range on Protein: 730-741
Range on HMM: 196-207/270
Sequence Identity: 50% (6 aa)

DVYSYSVLLMEM
||.|. ||. |.
DVWSFGVLMWEI
Kinase AqueK591.AA MLK 819-844 30 2.5e-07 21.63 In-house 266-291 (291) Show / Hide 
Range on Protein: 819-844
Range on HMM: 266-291/291
Sequence Identity: 30% (8 aa)

MKSLIQRGLNANPRARPTMAQVIESL
.|.|...  |..|. ||...|... |
WKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK591.AA TKL 816-844 27 3.5e-07 21.93 In-house 336-364 (364) Show / Hide 
Range on Protein: 816-844
Range on HMM: 336-364/364
Sequence Identity: 27% (8 aa)

WSDMKSLIQRGLNANPRARPTMAQVIESL
. .||.|.|.  ...|..||.. .... |
PPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK591.AA Dicty4 820-846 31 2.5e-05 13.92 In-house 249-277 (277) Show / Hide 
Range on Protein: 820-846
Range on HMM: 249-277/277
Sequence Identity: 31% (9 aa)

KSLIQRGLNANPRARPTMAQVIES--LKR
|.|||. .. .|  ||.....|.   |  
KHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK591.AA HH498 821-844 33 3.2e-05 12.07 In-house 261-284 (284) Show / Hide 
Range on Protein: 821-844
Range on HMM: 261-284/284
Sequence Identity: 33% (8 aa)

SLIQRGLNANPRARPTMAQVIESL
.|||.. ...|  ||. .|..  |
NLIQMCWHPCPENRPDFDQIVTIL
Kinase AqueK591.AA LRRK 809-846 23 3.4e-05 14.33 In-house 314-351 (351) Show / Hide 
Range on Protein: 809-846
Range on HMM: 314-351/351
Sequence Identity: 23% (9 aa)

VQSGSVSWSDMKSLIQRGLNANPRARPTMAQVIESLKR
.. . . | ....|||   ...|. ||.. |... |. 
YCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK591.AA TKL-Unique 822-844 34 0.000253 11.36 In-house 268-290 (290) Show / Hide 
Range on Protein: 822-844
Range on HMM: 268-290/290
Sequence Identity: 34% (8 aa)

LIQRGLNANPRARPTMAQVIESL
|||.. . .|  ||.  ..|..|
LIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK591.AA Dicty4-Unclassified 819-844 42 0.000307 10.38 In-house 238-263 (263) Show / Hide 
Range on Protein: 819-844
Range on HMM: 238-263/263
Sequence Identity: 42% (11 aa)

MKSLIQRGLNANPRARPTMAQVIESL
.|.||   .   |. |||| |.|. |
WKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase AqueK591.AA TK 816-844 24 0.001355 7.07 In-house 446-486 (486) Show / Hide 
Range on Protein: 816-844
Range on HMM: 446-486/486
Sequence Identity: 24% (10 aa)

W------------SDMKSLIQRGLNANPRARPTMAQVIESL
|             ..  |.|.  ...|. |||..|. | |
WMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK591.AA Pkinase_Tyr 816-844 24 0.078855 6.82 Pfam 242-270 (270) Show / Hide 
Range on Protein: 816-844
Range on HMM: 242-270/270
Sequence Identity: 24% (7 aa)

WSDMKSLIQRGLNANPRARPTMAQVIESL
. .. .|...  ...|  |||.....| |
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK591.AA CZAK 816-844 34 0.123447 1.9 In-house 251-279 (279) Show / Hide 
Range on Protein: 816-844
Range on HMM: 251-279/279
Sequence Identity: 34% (10 aa)

WSDMKSLIQRGLNANPRARPTMAQVIESL
| ..  || .  | ||  ||.  |... |
WKNLGELIEMCWNKNPDERPSFKQILQHL
Kinase AqueK591.AA Pkinase 813-844 20 0.469896 4.81 Pfam 244-293 (293) Show / Hide 
Range on Protein: 813-844
Range on HMM: 244-293/293
Sequence Identity: 20% (10 aa)

SVSW----------------SDMKSLIQRGLNANPRARPTMAQVIES--L
|.|.                ...|..| . |. .|  ||| .|. ..  .
SISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF