AqueK593

Species: A.queenslandica
Alias: AqueK593
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK593.AA Protein None 204 None Fasta, JSON
AqueK593.kin_dom Protein Kinase Domain None 195 None Fasta, JSON

Protein domain

Protein domains of AqueK593.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK593.AA TKL 1-199 21 7.1e-39 135.48 In-house 76-364 (364) Show / Hide
Range on Protein: 1-199
Range on HMM: 76-364/364
Sequence Identity: 21% (62 aa)

MSIASRVRHPNLVQFIGATK--------------VGNPLILTELM-STSLNHEIRRNRLSNEEILSIAQDVALGLNYLHLFKP-----EPIIHRDVSSPN
. . || ||||.|||.|. .               |.. | .|..   || | .       . ....|.|.|.|.||||  .|      ||||||  |.|
IMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN

VLLKRCSG---------AAGYEAKVADYGTAKVV-------------------QANSTSTGTVMPGNVAYAAREARDPE----------------QHSPA
.|...            .| . .|..|.|.....                   | |. .|     |. .. | |. . .                . |..
ILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEK

MDVYSYSVLLMEMNLRSQPEMTIAERARQ---------SGSV-----------------------SWSDMKSLIQRGLKADPRARPTMAQVVESL
.||||. ..| |.  | .|.  . .. ..         .. .                        . .||.|.|.  ..||..||.. .... |
CDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase AqueK593.AA MLK 3-149 26 9e-24 79.42 In-house 58-229 (291) Show / Hide
Range on Protein: 3-149
Range on HMM: 58-229/291
Sequence Identity: 26% (45 aa)

IASRVRHPN----LVQFIGA-TKVGN-PLILTELMST-SLNHEIRRNR---------------LSNEEILSIAQDVALGLNYLHLFKPEPIIHRDVSSPN
......|||     .|| |. .. ..  .|..| ..  ||.. .. .|                . . ....| ..| |..|||  .| ||||||  |.|
HLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHN

VLLKR-CSGAAGYEAKVADYGTAKVVQANSTSTGTVMPGNVAYAAREAR---DPEQHSPAMDVYSYSVLLMEM
.|. . |.  ..  .|..| ||.. .. .  .. . ..|..|. | |..     |. | . ||.|. |.| ||
ILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEM

Kinase AqueK593.AA TK 8-199 13 4e-20 63.47 In-house 101-486 (486) Show / Hide
Range on Protein: 8-199
Range on HMM: 101-486/486
Sequence Identity: 13% (54 aa)

RHPNLVQFIG-ATKVGN------------PLILTELMS-TS----LNHEIRRNR----------------------------------------------
.|||.|...|  |....            ..|..|.|.  .    | .  |..|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSNEEILSIAQDVALGLNYLHLFKPEPI----IHRDVSSPNVLLKRCSGAA------GYEAKVADYG--
                               |. .. | .....| |. |||  . |      .|||.   |.|. .    .      |. .|.||.|  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------TAKVVQANSTSTGTVMPGN-------------------------VAYAAREARD---------PEQHSPAMDVYSYSVLLMEMNL--RSQPE--
       |. .. ..  . .  .|                          . . | |. .            .... ||.|. ||. |.    . ..   
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

MTI------------------------------AERARQS--GSVS-W------------SDMKSLIQRGLKADPRARPTMAQVVESL
|.                                .| |.      . |             ..  |.|.  ..||. |||..|..| |
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase AqueK593.AA TKL-Unique 2-149 25 4.3e-20 67.69 In-house 47-221 (290) Show / Hide
Range on Protein: 2-149
Range on HMM: 47-221/290
Sequence Identity: 25% (45 aa)

SIASRVR-HPNLVQFIGATK---VGNP--LILTELMS----TSLNHE--------IRRNRLSNEEILSIAQDVALGLNYLHLFKPEPIIHRDVSSPNVLL
.. .. . |||.|...|...   | .|   | .| ..     .. |         .. . |... ....|.|.|.|..|||  .|  |||||  |.|.|.
NWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLV

KRCSGAAGYEAKVADYGTAKVVQANSTSTGT--------VMPGNVAYAAREARDP--EQHSPAMDVYSYSVLLMEM
 . |  | . .|..| |..|.   ....| .        .  |.  ..| |      .| |   ||||... | |.
DNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEI

Kinase AqueK593.AA CZAK 50-149 30 9.7e-16 53.77 In-house 108-215 (279) Show / Hide
Range on Protein: 50-149
Range on HMM: 108-215/279
Sequence Identity: 30% (34 aa)

LSIAQDVALGLNYLHL-FKPEPIIHRDVSSPNVLLKRCSG--------AAGYEAKVADYGTAKVVQANSTS-TGTVMPGNVAYAAREARDPEQHSPAMDV
...| |.| | ||||  .|| ||.||| || |.||                  .|..|.|  .      .  | |.  | ... | |    |  ..  ||
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTM--GCLCWMAPECFKGENYTEKVDV

YSYSVLLMEM
||.  .| ..
YSFGMILWCI

Kinase AqueK593.AA TK-Unique 8-149 22 1.3e-14 46.92 In-house 62-232 (294) Show / Hide
Range on Protein: 8-149
Range on HMM: 62-232/294
Sequence Identity: 22% (41 aa)

RHPNLVQFIGATK-VG-NPLILTELMSTS-LNHEIRRNR---------------------------LSNEEILSIAQDVALGLNYLHLFKPEPIIHRDVS
.|||.||..|..   . ...|. | .. . | | .|..|                           .| .  ...| ..| |..||.   .. |.|||..
DHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLC

SPNVLLKRCSGAAGYEAKVADYGTAK-----VVQANSTSTGTVMPGNVAYAAREARD--PEQH-SPAMDVYSYSVLLMEM
. |||| .     ....|..|.| |.      |.....| |...   ... | |.     ... ..  ||.|. ||. |.
ARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMCSQGRIP---IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEI

Kinase AqueK593.AA Dicty4 5-75 31 9.6e-14 42.39 In-house 53-139 (277) Show / Hide
Range on Protein: 5-75
Range on HMM: 53-139/277
Sequence Identity: 31% (28 aa)

SRVRHPNLVQFIGA-T----KVGNPLILTELM-STSLNHEIRR------NRLSNE--EILS---IAQDVALGLNYLHLFKPEPIIHRD
.  ||||...| || |    . | ..| ||.| ...|   ..        . . .   |..   .| |.|.|.|.||   |  |||||
CKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD

Kinase AqueK593.AA Dicty4-Unclassified 7-149 28 1.3e-13 42.91 In-house 55-201 (263) Show / Hide
Range on Protein: 7-149
Range on HMM: 55-201/263
Sequence Identity: 28% (45 aa)

VRHPNLVQFIGATKVGNP-------LILTELM-STSLNHEIR-----RNR-LSNEE--ILSIAQDVALGLNYLHLFKPEPIIHRDVSSPNVLLKRCSGAA
. |||||.  |.    ||        | .|.| .  |   |      ... .. ..  |. .| |.| |. .||      .||||. | |.|. .     
IQHPNLVKCYGYCI--NPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILMDKH----

GYEAKVADYGTAKVVQANSTSTGTVMPGNVAYAAREARDPEQHSPAMDVYSYSVLLMEM
 . .|.|| | . |.  | . | |.  | ..  . |    |    . ||||| ..| |.
-FNIKIADFGISRVIDFNFNMT-TIA-GTPKWESPECLMHESYNQKSDVYSYAMMLYEL

Kinase AqueK593.AA HH498 49-149 37 9.5e-13 36.34 In-house 123-219 (284) Show / Hide
Range on Protein: 49-149
Range on HMM: 123-219/284
Sequence Identity: 37% (38 aa)

ILSIAQDVALGLNYLHLFKPEPIIHRDVSSPNVLLKRCSGAAGYEAKVADYGTAKVVQANSTSTGTVMPGNVAYAAREARD-PEQHSPAMDVYSYSVLLM
.. |. ||| | ||||   . ||||||  | |.|. .     |  |.|||.|    |.     . |  |||  . | |      . |   ||.||   . 
KMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHE----DGH-AVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIW

EM
||
EM

Kinase AqueK593.AA Pkinase_Tyr 8-100 26 3.2e-12 42.03 Pfam 62-156 (270) Show / Hide
Range on Protein: 8-100
Range on HMM: 62-156/270
Sequence Identity: 26% (27 aa)

RHPNLVQFIGATK-VGNP---LILTELMST-SLNHEIRRN-----RLSNEEILSIAQDVALGLNYLHLFKPEPIIHRDVSSPNVLLKRCSGAAGYEAKVA
.|||.|...|.    | |   .| .|.|   .| .  |..     .|. ...|......| |..||.  .   .||||.   |.|...     .  .|..
HHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE-----NNVVKIC

DYG
| |
DFG

Kinase AqueK593.AA S_TKc 1-202 16 9.1e-12 -4.33 SMART 19-231 (231) Show / Hide
Range on Protein: 1-202
Range on HMM: 19-231/231
Sequence Identity: 16% (40 aa)

MSIA---------------------SRVRHPNLVQFIGATKVGNPLILTELMST---SLNHEIRRNR-------LSNEEILSIAQDVALGLNYLHLFKPE
  .                      .. .|||.|.....   ..  . .|....   .| . |....       ..  .. .... ....|.|.|  .  
RHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG--

PIIHRDVSSPNVLLKRCSGAAGYEAKVADYGTAKVVQANSTSTGTVMPGNVAYAAREARDPEQHSP-AMDVYSYSVLLMEMNLRSQ---PEMTIAERARQ
 |||||.   |.|| .       . |..| | |...        | . |   | | |     .... . |..|  ..| ||  .      .... .. . 
-IIHRDLKPENILLDE-------HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-

SGSVSWSDMKSLIQRGLKADPRARPTMAQVVE------SLKRM
      ...|..|.. |. ||. |||  .. .      .   .
-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK593.AA LRRK 52-114 34 1.9e-11 36.75 In-house 169-242 (351) Show / Hide
Range on Protein: 52-114
Range on HMM: 169-242/351
Sequence Identity: 34% (26 aa)

IAQDVALGLNYLHLFKPEPIIHRDVSSPNVLLKRCS-GA------AGYEAKVADYGTAK----VVQA-NSTSTGT
|| ..| |..||| ..| ||||||  |||.||.. . .       | . ||.||.|.      .  .  ....|.
IALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGN

Kinase AqueK593.AA TyrKc 1-199 15 3.7e-10 -58.4 SMART 1-280 (280) Show / Hide
Range on Protein: 1-199
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

MSIA----------------------------------------SRV--RHPNLVQFIGATKV--------GNPLILTELMST-SLNHEIRRNR--LSNE
 .                                          ...  .|||.|...|.           . ..|..|.|.  .|.. .|..|  |...
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

EILSIAQDVALGLNYLHLFKPEPIIHRDVSSPNVLLKRCSGAAGYEAKVADYGTAKVVQAN--------STST----GTVMPGNVAYAAREARDPEQHSP
. ||.. ..| | .|||     ..||||    |.|.     .... .|..| | .. .             ..    |. ..  .   | |. .    ..
DLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLV-----GENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

AMDVYSYSVLLME----------------MNLRSQPEMTIAERARQSGSV--------SWSDMKSLIQRGLKADPRARPTMAQVVESL
. ||.|. |.. |                |. .   |   . . .               ..| .....  ..||  |||.....| .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase AqueK593.AA Pkinase 6-149 23 2.5e-08 30.52 Pfam 56-205 (293) Show / Hide
Range on Protein: 6-149
Range on HMM: 56-205/293
Sequence Identity: 23% (38 aa)

RVRHPNLVQFIGATK-VGNPLILTELMST-----SLNHEIR---RNRL--SNEEILSIAQDVALGLNYLHLFKPEPIIHRDVSSPNVLLKRCSGAAGYEA
|..||| |.....    ... . .|..       .| . |.   ....  | .|. ...  .. ||.|.|      |||||. . |.|..   |  .   
RLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDACV

KVADYGTAKVVQANSTSTGTVMPGNVA---YAAREA-RDPEQHSPAMDVYSYSVLLMEM
|..| | ||...   .  .. | . .    |.| |  |. . ..|. |..|. ..| ||
KICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM

Kinase AqueK593.AA MLK 174-199 34 2.6e-07 21.56 In-house 266-291 (291) Show / Hide
Range on Protein: 174-199
Range on HMM: 266-291/291
Sequence Identity: 34% (9 aa)

MKSLIQRGLKADPRARPTMAQVVESL
.|.|...  ..||. ||...|.|. |
WKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase AqueK593.AA LRRK 171-201 35 6e-06 17.13 In-house 321-351 (351) Show / Hide
Range on Protein: 171-201
Range on HMM: 321-351/351
Sequence Identity: 35% (11 aa)

WSDMKSLIQRGLKADPRARPTMAQVVESLKR
| ....|||   ..||. ||.. |.|. |. 
WHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ

Kinase AqueK593.AA Dicty4-Unclassified 174-199 42 0.000139 11.58 In-house 238-263 (263) Show / Hide
Range on Protein: 174-199
Range on HMM: 238-263/263
Sequence Identity: 42% (11 aa)

MKSLIQRGLKADPRARPTMAQVVESL
.|.||   .  ||. |||| |... |
WKKLIKWCWHNDPNKRPTMNQIIQYL

Kinase AqueK593.AA CZAK 2-31 42 0.000228 11.95 In-house 52-84 (279) Show / Hide
Range on Protein: 2-31
Range on HMM: 52-84/279
Sequence Identity: 42% (14 aa)

SIASRVRHPNLVQFIGATKVGN---PLILTELM
|| |  .||| |||.||   ..     | .| |
SIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWM

Kinase AqueK593.AA Dicty4 175-201 31 0.000238 10.61 In-house 249-277 (277) Show / Hide
Range on Protein: 175-201
Range on HMM: 249-277/277
Sequence Identity: 31% (9 aa)

KSLIQRGLKADPRARPTMAQVVES--LKR
|.|||. .  ||  ||.......   |  
KHLIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase AqueK593.AA HH498 176-199 37 0.000265 9.11 In-house 261-284 (284) Show / Hide
Range on Protein: 176-199
Range on HMM: 261-284/284
Sequence Identity: 37% (9 aa)

SLIQRGLKADPRARPTMAQVVESL
.|||..  . |  ||. .|.|  |
NLIQMCWHPCPENRPDFDQIVTIL

Kinase AqueK593.AA TKL-Unique 177-199 34 0.000549 10.16 In-house 268-290 (290) Show / Hide
Range on Protein: 177-199
Range on HMM: 268-290/290
Sequence Identity: 34% (8 aa)

LIQRGLKADPRARPTMAQVVESL
|||.. . ||  ||.  .....|
LIQQCWHHDPSQRPSFDEIIHRL

Kinase AqueK593.AA TK-Unique 165-199 22 0.025535 3.95 In-house 260-294 (294) Show / Hide
Range on Protein: 165-199
Range on HMM: 260-294/294
Sequence Identity: 22% (8 aa)

QSGSVSWSDMKSLIQRGLKADPRARPTMAQVVESL
|  ...  .| .|... .. .|  ||. .|..  |
QPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL

Kinase AqueK593.AA Pkinase_Tyr 171-199 27 0.02749 8.37 Pfam 242-270 (270) Show / Hide
Range on Protein: 171-199
Range on HMM: 242-270/270
Sequence Identity: 27% (8 aa)

WSDMKSLIQRGLKADPRARPTMAQVVESL
. .. .|...  ..||  |||.....| |
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase AqueK593.AA Pkinase 168-199 22 0.115863 6.96 Pfam 244-293 (293) Show / Hide
Range on Protein: 168-199
Range on HMM: 244-293/293
Sequence Identity: 22% (11 aa)

SVSW----------------SDMKSLIQRGLKADPRARPTMAQVVES--L
|.|.                ...|..| . |. ||  ||| .|....  .
SISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase AqueK593.AA HH498 2-19 50 0.164467 0.1 In-house 54-71 (284) Show / Hide
Range on Protein: 2-19
Range on HMM: 54-71/284
Sequence Identity: 50% (9 aa)

SIASRVRHPNLVQFIGAT
|| .|  ||. |||..|.
SIMCRLNHPCVVQFVYAC

Kinase AqueK593.AA Pkinase_Tyr 138-149 50 7.917708 0.04 Pfam 196-207 (270) Show / Hide
Range on Protein: 138-149
Range on HMM: 196-207/270
Sequence Identity: 50% (6 aa)

DVYSYSVLLMEM
||.|. ||. |.
DVWSFGVLMWEI