Gene AqueK635 (A.queenslandica)

AqueK635

Species: A.queenslandica
Alias: AqueK635
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH498

Sequence

Name Sequence Type Origin Length Description Download
AqueK635.AA Protein None 424 None Fasta, JSON
AqueK635.kin_dom Protein Kinase Domain None 187 None Fasta, JSON

Protein domain

Protein domains of AqueK635.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK635.AA TKL 28-220 23 1.8e-34 120.88 In-house 1-289 (364) Show / Hide 
Range on Protein: 28-220
Range on HMM: 1-289/364
Sequence Identity: 23% (68 aa)

LGRGAYGVVLEVKVSG----------FSCAGKKLH----DAIAG---------------------EFLVKSFVNECVNHSHLRHPNIVQLMG-VYFPPD-
.|.|..|.|   |  |             | ||..    |                         ... . ...| . .| ||||||||.|| .  ||. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------STIPILVMERL-QVS-LAQCLIEATLPLKLKYSILLDIANGLNYFHHRT------PPIIHRDLTAQNVLLTKSFT--------------AK
         .. . .|||     | | . .      . .. .. |||| |.|| | ..      ||||||||. .|.|. . .|              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IADLGVSRIIDPGRPRSHTD------------------VPGNPAVMPPEAFDDQ----------------PYDYKLDVFSYGCLIIHTFNQEWPF
|.|.| || ...    ..|                   . |.|. |.||....|                .|. | ||.|.| ..   .  ..|.
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY
Kinase AqueK635.AA HH498 116-220 41 1.3e-27 84.26 In-house 120-226 (284) Show / Hide 
Range on Protein: 116-220
Range on HMM: 120-226/284
Sequence Identity: 41% (44 aa)

LKLKYSILLDIANGLNYFHH-RTPPIIHRDLTAQNVLLTKSFTAKIADLGVSRIIDPGRPRSHTDVPGNPAVMPPEAFD-DQPYDYKLDVFSYGCLIIHT
|  |  | .|.|.| || |   ..|||||||. .|.|. .   |..|| | || .        |  |||.  | || |   | |. | |||||.  |   
LQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEM

FNQEWPF
.  | ||
HTREVPF
Kinase AqueK635.AA MLK 22-207 26 6.2e-25 83.51 In-house 1-223 (291) Show / Hide 
Range on Protein: 22-207
Range on HMM: 1-223/291
Sequence Identity: 26% (60 aa)

ELTGEELGRGAYGVVLEVKVSGFS-----CAGKKLHDAIAGEFLV-----KSFVNECVNHSHLRHPN----IVQLMGVYFPPDSTIPILVMERLQV-SLA
 .. | .| |..|.|   .  .        | |. .  |  .  .     . |  ||   ..|.|||    |.|..||   |      .||| ..  ||.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLY

QCLIEAT---------------LPLKLKYSILLDIANGLNYFHHRTP-PIIHRDLTAQNVLLT------KSFTAKIADLGVSRIIDPGRPRSHTDVPGNP
  | .|.                .. .. .. |..|.|..|.|   | |||||||  .|.|..      .  |.||.| |.|| .       ... .|..
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTY

AVMPPEAF---DDQPYDYKLDVFSYG
| | ||..     ..|. | ||.|.|
AWMAPEVIQQFRCEKYSEKCDVWSWG
Kinase AqueK635.AA TKL-Unique 24-207 28 6.1e-24 81.42 In-house 1-215 (290) Show / Hide 
Range on Protein: 24-207
Range on HMM: 1-215/290
Sequence Identity: 28% (61 aa)

TGEELGRGAYGVVLEVKVSGFSCAGKKLH-DAIAGEFLVKSFVNECVNHSHLR-HPNIVQLMGVYFPPDSTIP--ILVMERLQV-SLAQCLI--------
 .. .|.|.||.|  .|  | . | |..|  .     ... | ||    . |. |||||..||. .    ..|  ..||| ..  ||   |         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

---EATLPLKLKYSILLDIANGLNYFHHRTPPIIHRDLTAQNVLLTKS-----FTAKIADLGVSRIIDPGRPRSHT--------DVPGNPAVMPPEAFDD
   . .|........ .||| |..| ||. ||||||||. .|.|..       . .||.| | |.. .     . .        .. |..  |.|| . .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--QPYDYKLDVFSYG
    |. | ||.|.|
NFCQYSEKSDVYSFG
Kinase AqueK635.AA Dicty4 24-207 29 1.7e-23 75.39 In-house 3-204 (277) Show / Hide 
Range on Protein: 24-207
Range on HMM: 3-204/277
Sequence Identity: 29% (62 aa)

TGEELGRGAYGVVLEVKVSGFSCAGKKL--HDAIAGEFLVKSFVNECVNHSHLRHPNIVQLMGVYFPPDST----IP---ILVMERL-QVSLAQCLIE--
.....|.|..| |.  .. |   | |||  |   . |.. ..| .|    . .|||||...||      .|    .|     |.| . . .|.  |    
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGA-----CTAPRSHPGKMCIVTEYMPKGNLYSLLHDKP

------ATLPLKLKYS---ILLDIANGLNYFHHRTPPIIHRDLTAQNVLLTKSFTAKIADLGVSRIIDPGRPRSHTD----VPGNPAVMPPEAFDDQPYD
       .|.. |  .   . .|.| |.|. | ..| |||||| . | |  |....|..|.| |... ..   .|.|    . | |. | ||    |||.
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHE--DHKDNQMTACGTPCWMAPEVMMHQPYN

YKLDVFSYG
 | ||.|.|
EKADVYSFG
Kinase AqueK635.AA TK 22-210 14 2.5e-23 74.39 In-house 1-384 (486) Show / Hide 
Range on Protein: 22-210
Range on HMM: 1-384/486
Sequence Identity: 14% (57 aa)

ELTGEELGRGAYG---VVLEVKVSGF---------------------------SCAGKKLHDAIAGEFL-VKS--------------FVNECVNHSH--L
   |..||.|..|   .| . .. |                             .| | |..  | .    .               ...|    .|  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNIVQLMGVYFPPDS----------TIPILVMERLQ-VS----LAQCLIEAT----------------------------------------------
.|||||.| || . ...            ...|||  .  .    | . | .                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LPLKLKYSILLDIANGLNYFHHRTP----PIIHRDLTAQNVLLTKSFT-----------AKIADLG---
                               |... .  . ..||.|. | | .       ..|||| | |.|.... .           .|||| |   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----VSRIIDPG---RPRSHTDVPGNPAV-----------------------MPPEAFDDQP---------YDYKLDVFSYGCLI
      .| |...   . .|  ......                         |.||...|.          .  | ||.|.|.|.
QGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
Kinase AqueK635.AA Pkinase 22-221 25 1.7e-22 80.66 Pfam 1-213 (293) Show / Hide 
Range on Protein: 22-221
Range on HMM: 1-213/293
Sequence Identity: 25% (56 aa)

ELTGEELGRGAYGVVLEVKVSGFS--CAGKKLHDAIAGEFLVKSFVN--ECVNHSHLRHPNIVQLMGVYFPPDSTIPILVMERLQV-----SLAQCLI--
  .|. .|.|..|.| . .  | .   | |..    . .   .. ..  |.  . .|.|||||.| ...  .|.    .||| ..      .|.  .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY--MVMEYCEGGLYVMDLFDYISTW

-EATL--PLKLKYSILLDIANGLNYFHHRTPPIIHRDLTAQNVLLTKSFTA----KIADLGVSRIIDPGRPRSHTDVPGNPAVMPPEAFD-DQPYDYKLD
 . ..  . .   .... |. ||.| | .   ||||||  .|.|. .  .     ||.| |... .|   . | |.. | |  |.||    .|.|..| |
RHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVD

VFSYGCLIIHTFNQEWPFP
..|.||...  .. . |||
MWSCGCILYEMLCGRPPFP
Kinase AqueK635.AA LISK 114-207 27 2.4e-22 69.22 In-house 98-226 (296) Show / Hide 
Range on Protein: 114-207
Range on HMM: 98-226/296
Sequence Identity: 27% (36 aa)

LPLKLKYSILLDIANGLNYFHHRTPPIIHRDLTAQNVLLTKS----FTAKIADLGVSRIIDPGR---------------------------------PRS
|| ... .| |||| |. | | .   ||||||...|.|. ..    ...|..|.|  |..|  .                                 ...
LPWPQRVKIALDIACGMSYLHSMN--IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKR

HTDVPGNPAVMPPEAFDDQPYDYKLDVFSYG
.  . |.|  |.||   .| ||.. ||||.|
RMTICGTPYWMAPEMLLGQSYDESCDVFSFG
Kinase AqueK635.AA LRRK 22-207 25 6.7e-21 70.67 In-house 1-269 (351) Show / Hide 
Range on Protein: 22-207
Range on HMM: 1-269/351
Sequence Identity: 25% (71 aa)

ELTGEELGRGAYG-VVLEVKVSG----------------------------FSCAGKKLHDA-----------------------------IAGEFLVKS
   .|..|||..| .|   |. |                            .. | ||..                               . .|.. ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FV---NECVNHSHLRHPNIVQLMGVYFPPDSTIPILVMERLQV-SLAQCLI---EAT-------LPLKLKYSILLDIANGLNYFHHRTPPIIHRDLTAQN
|    .|..  |||.|||||.|.|. . |    ...||| ..  .| . |    .         ..  ||. | |.|| |..| | ..||||||||.  |
FREFRHEVWIMSHLNHPNIVSLKGFCIHP----LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPN

VLLTKS------------FTAKIADLGVSR---IIDPG-RPRSHTDVPGNPAVMPPEAFDDQ---PYDYKLDVFSYG
.|| .|             .||||| | ||   .. .| ....     |||  | ||   .     |. | |..|.|
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV----GNPGWMAPEIMRYNGEEEYTEKVDCYSFG
Pkinase_Tyr AqueK635.AA Pkinase_Tyr 21-210 27 2.9e-19 65.88 Pfam 1-204 (270) Show / Hide 
Range on Protein: 21-210
Range on HMM: 1-204/270
Sequence Identity: 27% (57 aa)

VELTGEELGRGAYGVVLEVKVS------GFSCAGKKLHDAIAGEFL--VKSFVNECVNHSHL-RHPNIVQLMGVYFPPDST-IPILVMERLQV-SLAQCL
...  ..||.||.|.| . .        .  .| |.|    | .     ..| .|    ..| .|||||.|.||  . .    ...|||  .  .|   |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

IEA-----TLPLKLKYSILLDIANGLNYFHHRTPPIIHRDLTAQNVLLTKSFTAKIADLGVSRII-DPGRP-RSHTDVPGNPAVMPPEAFDDQPYDYKLD
 .       |..| . .. ..||.|..| . .   .||||| | |.|.|.....||.| | .| | . .   |.... .     |.||.. .  .  | |
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD

VFSYGCLI
| |.| |.
VWSFGVLM
Kinase AqueK635.AA S_TKc 22-290 20 3.4e-18 67.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-290
Range on HMM: 1-231/231
Sequence Identity: 20% (60 aa)

ELTGEELGRGAYGVVLEVKV--SGFSCAGKKLHDAIAGEFLVKSFVNECVNHSHLRHPNIVQLMGVYFPPDSTIPILVMERLQV---SLAQCLIEAT---
   ....|.||.|.|  ..   .|  .| |...         ... .|   ... .|||||.| .|.     .   .||| .     .| . . .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LPLKLKYSILLDIANGLNYFHHRTPPIIHRDLTAQNVLLTKSFTAKIADLGVSRIIDPGRPRSHTDVPGNPAVMPPEAFDDQPYDY-KLDVFSYGC
    .|     ...  |...|.| | .   ||||||  .|.||..  . ||.| |..|..        | . | |  |.|| .   .|.. | |. | ||
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

LIIHTFNQEWPFPVSQLSIDPLNNLPDDGTRVGDLGHLYDMIISKKEQKSEYEMSQRLHHDVWSSAVRSSAVRSKSGKALS----------F
...  .  . |||                    ..  ....|            |. . . .    ..  . |    .||           |
ILYEMLCGYPPFP--------------------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK635.AA STE-Unique 122-212 23 1.4e-16 54.94 In-house 408-545 (616) Show / Hide 
Range on Protein: 122-212
Range on HMM: 408-545/616
Sequence Identity: 23% (32 aa)

ILLDIANGLNYFHHRTPPIIHRDLTAQNVLLTKSF-----TAKIADLGVSRIIDPGRP-------------------------------------RSHTD
... |. ||.| | .  ||||||| . |......       .||.| | . .  |. .                                     .. ..
YTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKY

VPGNPAVMPPEAFDDQ-----PYDYKLDVFSYGCLIIH
 .|.|  | ||    .     ||| | |..| ||...|
CCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFH
Kinase AqueK635.AA STE 122-212 29 3.8e-16 53.63 In-house 156-260 (359) Show / Hide 
Range on Protein: 122-212
Range on HMM: 156-260/359
Sequence Identity: 29% (33 aa)

ILLDIANGLNYFHHRTPPIIHRDLTAQNVLLTKSFTAKIADLGVSRIIDPGRP---------------RSHTDVPGNPAVMPPEAFD------DQPYDYK
|. .|  || |..|.   |||||. ..|.||     .|..| ||. ....  .                  . . | |  | ||  .      |..||.|
ICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTK

LDVFSYGCLIIH
 |. | ||.||.
CDIWSLGCTIIE
Kinase AqueK635.AA TyrKc 22-266 23 2.6e-13 -7.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-266
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

ELTGEELGRGAYGVVLEVKVSGFSCAGKKLHDAIAGEFLVKSFVNECVNHSHL--RHPNIVQLMGVYFPP-----DSTIPILVME--RLQVSLAQCLIEA
   |..||.||.|.| . . .   .| |.|..       .. | .|    ..|  .|||||.| ||   .      .  . .|||   .  .| . | . 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH

T--LPLKLKYSILLDIANGLNYFHHRTPPIIHRDLTAQNVLLTKSFTAKIADLGVSRIIDPG----------RPRS--HTD--VPGNPAV--MPPEAFDD
   |..| . |. ..||.| .| |..  ..||||| | |.|... .|.||.| | || |. .          |...  ...  .|    .  |.||....
RPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP----IRWMAPECINY

QPYDYKLDVFSYGCLI--IHTFNQEWPFPVSQ--LSIDPLNNLPDDGTRVGDLGH------------LYDMIISKKEQKSE-----YEMSQRL
  .  | ||.|.| ..  | |. |. .  . |  .| . . .. ..| |     .            .|... .  . . |      |  ...
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK635.AA STE 23-87 19 9.6e-10 30.71 In-house 1-100 (359) Show / Hide 
Range on Protein: 23-87
Range on HMM: 1-100/359
Sequence Identity: 19% (19 aa)

LTG-EELGRGAYG-VVLEVKV----------------SGFSCAGKKLH---------------DAIAGEFLVKSFVNECVNHSHLR--HPNIVQLMGVYF
..| |..|.||.| |.. ...                .|. .| |...               . .  .  .... .|   .....  |||||.  | ||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
Kinase AqueK635.AA STE-Unique 23-87 28 1.6e-08 25.81 In-house 1-71 (616) Show / Hide 
Range on Protein: 23-87
Range on HMM: 1-71/616
Sequence Identity: 28% (20 aa)

LTGEELGRGAYGVVLEVK--VSGFSCAGKKLHDAIAGEF----LVKSFVNECVNHSHLRHPNIVQLMGVYF
.  . .|||. |.|   .  . .| || |..|  .   |    ||. ...| . .. |.|.||| . | ..
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWL
Kinase AqueK635.AA LISK 74-86 84 0.006749 5.02 In-house 53-65 (296) Show / Hide 
Range on Protein: 74-86
Range on HMM: 53-65/296
Sequence Identity: 84% (11 aa)

LRHPNIVQLMGVY
|||||||| |||.
LRHPNIVQFMGVC
SH2 AqueK635.AA SH2 325-413 31 1.8e-17 65.29 SMART 1-87 (87) Show / Hide 
Range on Protein: 325-413
Range on HMM: 1-87/87
Sequence Identity: 31% (29 aa)

HEWYYHKISNATAEVILLERERKNGNFIVHS--NSNGEYYLLVCFEQKAIHMRIFKDMNEKFFLDGLYCNNKKSFDGLDELVNYYREIPLV
..||. .|| . || .|. .. ..| |.|    ...|.| | |....|  | ||... . |...|..   ....|. | ||||.|.  ||.
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDET---WRRKFPSL-ELVNHYQHNPLG
SH2 AqueK635.AA SH2 327-407 32 1.2e-11 36.02 Pfam 1-81 (81) Show / Hide 
Range on Protein: 327-407
Range on HMM: 1-81/81
Sequence Identity: 32% (28 aa)

WYYHKISNATAEVILLERERKNGNFIV-HSN-SNGEYYLLVCFEQ---KAIHMRIFKDMNEKFFLDGLYCNNKKSFDGLDELVNYY
||. ||| . || .|.... ..| |.|  |  . |.| | |...    .  | || .. |.     |.|.  .. |. | |||..|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNG-----GYYITGRHKFCSLQELVEHY