Gene AqueK652 (A.queenslandica)

AqueK652

Species: A.queenslandica
Alias: AqueK652
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: LZK

Sequence

Name Sequence Type Origin Length Description Download
AqueK652.AA Protein None 222 None Fasta, JSON
AqueK652.kin_dom Protein Kinase Domain None 159 None Fasta, JSON

Protein domain

Protein domains of AqueK652.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK652.AA ZAK 11-168 54 1e-89 304.37 In-house 1-173 (257) Show / Hide 
Range on Protein: 11-168
Range on HMM: 1-173/257
Sequence Identity: 54% (94 aa)

LEFYEKLGGGAAGSVYRAKWKSKD---KIVAVKKLLELEKEAEVLSSLSHRNVVQFFGAVITKPN-YCLVTEYAELGSLYEYL---RSNTID-------F
. |..  |.|  ||||||.| | |   . .||||.. .|||||.|| ..|||..||.| .   || |  ||||||.|||| |    ||  .|       .
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKVFKIEKEAEILSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRSQEMDSSSGGNSM

NQIRLWAKQIAMGMNYLHFEAPIPVIHRDLKSRNVVIAQDLTAKICDFGSSK-FHKHTTQMSLVGTFPWMAPE
. |  || ||| || |||..||  .||||||||||||. ..  |||||| |. || |.| ||.||||||||||
DHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVIDKNGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPE
Kinase AqueK652.AA MLK 11-168 37 1.6e-72 247.26 In-house 1-203 (291) Show / Hide 
Range on Protein: 11-168
Range on HMM: 1-203/291
Sequence Identity: 37% (77 aa)

LEFYEKLGGGAAGSVYRAKWKSKD---KIVAVKKLL--------------ELEKEAEVLSSLSHRN----VVQFFGAVITKPN-YCLVTEYAELGSLYEY
..| |..| |. |.|....|. ||   ||||||.                ..|.|.. |. |||.|    ..|| |. .  |. .|.|.||.| ||||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LRSNT---------------IDFNQIRLWAKQIAMGMNYLHFEAPIPVIHRDLKSRNVVIAQ------DLTAKICDFGSSK-FHKH-TTQMSLVGTFPWM
|....               .|. ..  ||.|.| ||.||| .|| |.|||||||.|..|..      ..|.|||||| |. .|.. |. ||  ||. ||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APE
|||
APE
Kinase AqueK652.AA TKL 17-168 29 1.9e-59 203.78 In-house 1-243 (364) Show / Hide 
Range on Protein: 17-168
Range on HMM: 1-243/364
Sequence Identity: 29% (72 aa)

LGGGAAGSVYRAKWKSKD--------KIVAVKKLLE-----------------------------------LEKEAEVLSSLSHRNVVQFFGAVITKPN-
.| |. | ||..||.  .        | |||||. .                                   .|.|. ..|.|.| |.||| |...  |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YCLVTEYAELGSLYEYLRSNTIDFNQIRLWAKQIAMGMNYLHFEAP-----IPVIHRDLKSRNVVIAQDLT--------------AKI
            .|.|.||.. |||..||      ..|.  ||..|| |||||| . |      |.|||||||.|. . ...|              .||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

CDFGSSKFHKHT---------------------TQMSLVGTFPWMAPE
|||| |.|....                     | |. .||. |||||
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPE
Kinase AqueK652.AA Pkinase 11-168 27 1.7e-47 168.88 Pfam 1-181 (293) Show / Hide 
Range on Protein: 11-168
Range on HMM: 1-181/293
Sequence Identity: 27% (52 aa)

LEFYEKLGGGAAGSVYRAKWKSKDKIVAVKKLLELEK------------EAEVLSSLSHRNVVQFFGAVITKPNYCLVTEYAELG----SLYEYLR---S
... .|.| |. |.||....|.  ||||||..   ..            |.... .|.| |.|...... .|.....|.||.| |    .|..|..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NTI--DFNQIRLWAKQIAMGMNYLHFEAPIPVIHRDLKSRNVVIAQDLTA----KICDFGSSK---FHKHTTQMSLVGTFPWMAPE
...  . .... ...||. |..|.| .    .||||||. |. | .. .     ||||||..|     . .  ....|| ..||||
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPE
Kinase AqueK652.AA TKL-Unique 13-168 31 6.6e-45 155.5 In-house 1-196 (290) Show / Hide 
Range on Protein: 13-168
Range on HMM: 1-196/290
Sequence Identity: 31% (63 aa)

FYEKLGGGAAGSVYRAKWKSKDKIVAVKKL---------LELEKEAEVLSSLS-HRNVVQFFGAVI----TKPNYCLVTEYAELGSLYEYLR--------
| .|.|.|..|.||..||..... . ....          |.|.|  ... |  | |.|...|. .    . ||.|.|.|| ..||||..|         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

---SNTIDFNQIRLWAKQIAMGMNYLHFEAPIPVIHRDLKSRNVVIAQD-----LTAKICDFGSSKFHKHTTQMSLV-----------GTFPWMAPE
   .......|.   |..|| ||.|||.. |  .|||||||.|. . ..     . .|||||| ||| .  ..|..            |.| |||||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE
Kinase AqueK652.AA Pkinase_Tyr 11-145 32 2.6e-43 147.33 Pfam 1-156 (270) Show / Hide 
Range on Protein: 11-145
Range on HMM: 1-156/270
Sequence Identity: 32% (51 aa)

LEFYEKLGGGAAGSVYRAKWK----SKDKIVAVKKL-----------LELEKEAEVLSSL-SHRNVVQFFGAVI-TKPN--YCLVTEYAELGSLYEYLRS
..| .||| || |.||...||    ...  ||||.|            .. .||.....| .| |.|.. |...  .    ...|.||...|.|..|||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N-----TIDFNQIRLWAKQIAMGMNYLHFEAPIPVIHRDLKSRNVVIAQDLTAKICDFG
.      ..  ..  .. |||.||.||.    .. |||||  ||. .. ....||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFG
Kinase AqueK652.AA LZK 8-168 42 6.3e-42 139.09 In-house 1-157 (241) Show / Hide 
Range on Protein: 8-168
Range on HMM: 1-157/241
Sequence Identity: 42% (71 aa)

FLDLEFYEKLGGGAAGSVYRAKWKSKDKIVAVKKLLELEKEAEV--LSSLSHRNVVQFFGAVITKPNYCLVTEYAELGSLYEYLRS-NTIDFNQIRLWAK
  .|.    || || | |.| ... .   |||||  .| || ..  |  | | |...| |     | || . ||   | ||| ||. .||  . .  | |
ISELQW---LGSGAQGAVFRGWFRNET--VAVKKVRDL-KETDIKHLRKLKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERRTITPQLMVDWSK

QIAMGMNYLHFEAPIPVIHRDLKSRNVVIAQDLTAKICDFGSSKFHKHT--TQMSLVGTFPWMAPE
||| ||.|||      .||||||| |. |...   |||||| |.  .    |.||  ||  |||||
QIAQGMHYLHQHK---IIHRDLKSPNILISHNDVVKICDFGTSHMWNEMDSTKMSFCGTVAWMAPE
Kinase AqueK652.AA Dicty4 11-168 33 6.6e-41 134.26 In-house 1-187 (277) Show / Hide 
Range on Protein: 11-168
Range on HMM: 1-187/277
Sequence Identity: 33% (64 aa)

LEFYEKLGGGAAGSVYRAKWKSKDKIVAVKKL------L------ELEKEAEVLSSLSHRNVVQFFGAVI----TKPNYCLVTEYAELGSLYEYLRS---
. . ...|.|. |.||...|. |.  ||||||      .      |. ||.. .....| |...| || .    ...  | ||||   |.||. |..   
INIEQRIGKGSFGEVYKGTWRGKE--VAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

-----NTIDFNQIRL---WAKQIAMGMNYLHFEAPIPVIHRDLKSRNVVIAQDLTAKICDFGSSK----FHKHTT-QMSLVGTFPWMAPE
      ..|.  |.     |. .| |||.||   |. .||||||| |  . .....|.|||| |.       |.. ||. .||  |||||
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPE
Kinase AqueK652.AA STE 11-168 21 5.6e-39 135.29 In-house 1-232 (359) Show / Hide 
Range on Protein: 11-168
Range on HMM: 1-232/359
Sequence Identity: 21% (52 aa)

LEFYEKLGGGAAGSVYRAKWK------SKDKI---------VAVKKLL-------------------------ELEKEAEVLSSLS--HRNVVQFFGAVI
.|. ||.| || |.||.|. .      .....         .|.|..                          ...|| .... ..  | |.|...|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TK-------PNYCLVTEYAELGSLYEYLRSN---------------TIDFNQIRLWAKQIAMG-MNYLHFEAPIPVIHRDLKSRNVVIAQDLTAKICDFG
 .        . ... || . ||| . ....               ... .||.  ..||  | ..|||      .||||.|. |. .     .|.||||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

SSKFHKH---------------TTQ-M--SLVGTFPWMAPE
 ..   .               |.| .  ..|||  |||||
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase AqueK652.AA MLK 11-168 34 5.8e-38 122.91 In-house 1-196 (280) Show / Hide 
Range on Protein: 11-168
Range on HMM: 1-196/280
Sequence Identity: 34% (68 aa)

LEFYEKLGGGAAGSVYRAKWKSKDKIV----------AVKK---LLELEKEAEVLSSLSHRNVVQFFGAVITKPNYCLVTEYAELGSLYEYLRSNTIDFN
|.  | .| |  | |||| || . . |          ...    . .. .||  .  |.| |...  |. . .|. ||| ||.. |||   ..   |  .
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGKRIPPH

QIRLWAKQIAMGMNYLHFEAPIPVIHRDLKSRNVVIAQDLT-------------------------AKICDFGSSKFHKHTTQMSLVGTFPWMAPE
 .  || ||| |||||| |||.|.||||||| |. | .                             || |||      .||.||  ||. |||||
VLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTTRMSAAGTYAWMAPE
Kinase AqueK652.AA TK 11-168 14 1.9e-36 119.19 In-house 1-355 (486) Show / Hide 
Range on Protein: 11-168
Range on HMM: 1-355/486
Sequence Identity: 14% (53 aa)

LEFYEKLGGGAAG---SVYRAKWKSKDK-------------------------IVAVKKLL----ELEK------------------EAEVLSSLS----
... .||| |. |    ||...|.....                          |||| |     . ..                  |||... ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNVVQFFGAVITK------------PNYCLVTEYAELGS----LYEYLRSNTIDFNQ-----------------------------------------
 | |.|...|..  .            . ...|.||...|.    | .|||..  .|..                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IRL----WAKQIAMGMNYLHFEAPI----PVIHRDLKSRNVVIAQDLT-----------AKICDFG---
                               . .    .. ||| || ||| . ..     ..||||  ||. ......           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLH-SKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----SSKFHKHTTQMSLVGTFP----------------------------WMAPE
      .. . . .    ...                              |||||
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPE
Kinase AqueK652.AA ARK 11-168 36 1.4e-33 117.92 In-house 1-174 (280) Show / Hide 
Range on Protein: 11-168
Range on HMM: 1-174/280
Sequence Identity: 36% (64 aa)

LEFYEKLGGGAAGSVYRAKWKSKDKIVAVKKLLELE----------KEAEVLSSLSHRNVVQFFGAVITKP----NYCLVTEYAELGSLYEYLRSNTIDF
||. .|.| |. . ||..|.  ..|.||.| |   .          || ...||..  .|| |.||.| .      .|.|.||   ||||  .. |..||
LEYTCKIGSGSSCKVYKGKY--RGKEVAIKVLKSIMTDSMQIEEFKKEFQIMSSIRSPHVVYFYGACIEPEPQKQKLCMVMEYCSRGSLYHIMNNNKMDF

--NQIRLWAKQIAMGMNYLHFEAPIPVIHRDLKSRNVVIAQDLTAKICDFGSSKFHKHTTQMSL---VGTFPWMAPE
  .    |. |.  | |.||   | ...|||||| |  .  . |.|.|||| |.|   ..| .|    |||   |||
GWDRFFKWMMQMVRGINCLHNWTP-QIVHRDLKSLNLLVNENWTCKVCDFGLSRFNTMSNQETLGKMRGTFAYCAPE
Kinase AqueK652.AA S_TKc 11-211 22 6.1e-24 86.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-211
Range on HMM: 1-231/231
Sequence Identity: 22% (56 aa)

LEFYEKLGGGAAGSVYRAKWKSKDKIVAVKKLL-ELEKEAEVLSSLSHRNVVQFFGAVITKPNYCLVTEYAEL--GSLYEYLRSNT-------IDFNQIR
 |. .|.| || |.||....|. ..|||.|..   ...| ..|..  | |.|.....  .  ....|.||..   |.|..|....        ..  ..|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

LWAKQIAMGMNYLHFEAPIPVIHRDLKSRNVVIAQDLTAKICDFGSSKFHKHTTQMSLVGTFPWMAPEHQPIPRYTP---------------TTGLTGLD
 ...||. ...|.|      .||||||  |. . .  . ||||||....      ....||  .||||      |..                .| .  .
FYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP

EDEDDDDDDD--------------------EDEKRWLNKTAGS--------PIF
      ...                     . |||.    |          | |
------QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK652.AA TyrKc 11-219 20 1.5e-17 61.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-219
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

LEFYEKLGGGAAGSVYRAKWKSKDKIVAVKKLL-----ELEKEAEVLSSL--SHRNVVQFFGAVITK-------PNYCLVTEYAELGSLYEYLRSNT--I
... .||| || | ||...||     ||||.|      .. .||.....|  .| |.|...|.....       . ...|.||...|.| .|||..   .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

DFNQIRLWAKQIAMGMNYLHFEAPIPVIHRDLKSRNVVIAQDLTAKICDFGSSKFHKHT-------TQMSL----VGT--FP--WMAPEHQPIPRYTPTT
   .   .. ||| ||.|||     ..|||||  ||. .. ..|.||.||| |.....           .      |   .|  |||||     ..|. .
CMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

-------------GLTGLDEDE-----DDDDD----DDEDEKRWLNKT--------AGSPIFEF----------------PLRQGL
              . .    .      ....     .. . .   .         . . ...                  ... .
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF