Gene AqueK663 (A.queenslandica)

AqueK663

Species: A.queenslandica
Alias: AqueK663
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
AqueK663.AA Protein None 502 None Fasta, JSON
AqueK663.kin_dom Protein Kinase Domain None 122 None Fasta, JSON

Protein domain

Protein domains of AqueK663.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK663.AA MLK 364-485 27 1.1e-25 86.1 In-house 1-153 (291) Show / Hide 
Range on Protein: 364-485
Range on HMM: 1-153/291
Sequence Identity: 27% (42 aa)

ILTKEELGRGSYGLVTVGTFRGLR-----VAVKSLHTLIISDYNQ-----GIFSREMSIASRVRHPN----LVQFIGA-TKVGN-PLILTELMST-SLNQ
|...| .| ||.| |  |..|. .     ||||  .. |. |  .       | .|  ......|||     .|| |. .. ..  .|..| ..  ||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ELRRNQ---------------LTNQQILSFAQDVALGLNYLHLFKPQPIIHRDL
 |. ..                . ......| ..| |..|||  .|.|||||||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDL
Kinase AqueK663.AA TKL 370-485 26 3.2e-25 87.75 In-house 1-166 (364) Show / Hide 
Range on Protein: 370-485
Range on HMM: 1-166/364
Sequence Identity: 26% (45 aa)

LGRGSYGLVTVGTFRG----------LRVAVKSLHTLIISDYNQ-------------------------GIFSREMSIASRVRHPNLVQFIGATK-----
.|.|..| |  |..||            |||| ...   .  .                            . .|. . || ||||.|||.|. .     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------VGNPLILTELM-STSLNQELRRNQLTNQQILSFAQDVALGLNYLHLFKP-----QPIIHRDL
          |.. | .|..   ||   |       .|....|.|.|.|.||||  .|      |||||||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDL
Kinase AqueK663.AA TK 364-485 16 9.1e-22 69.07 In-house 1-266 (486) Show / Hide 
Range on Protein: 364-485
Range on HMM: 1-266/486
Sequence Identity: 16% (43 aa)

ILTKEELGRGSYG---LVTVGTFRGL---------------------------RVAVKSLHTLIISDYNQGI---------------FSREMSIAS--RV
|   ..||.| .|    |  |. ||.                           .|||| |.    .. .. .               . .||.. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNLVQFIG-ATKVGN------------PLILTELMS-TS----LNQELRRN-----------------------------------------------
.|||.|...|  |....            ..|..|.|.  .    | . ||..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QLTNQQILSFAQDVALGLNYLHLFKP---QPIIHRDL
                              ||| .| | .....| |. |||  .    | ..||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDL
Kinase AqueK663.AA Dicty4 364-485 34 1.5e-21 68.82 In-house 1-140 (277) Show / Hide 
Range on Protein: 364-485
Range on HMM: 1-140/277
Sequence Identity: 34% (49 aa)

ILTKEELGRGSYGLVTVGTFRGLRVAVKSL--HTLIISDYNQGIFSREMSIASRVRHPNLVQFIGA-T----KVGNPLILTELM-STSLNQELRR-----
| . ...|.||.| |  || ||  |||| |  |    . .    | .| .| .  ||||...| || |    . | ..| ||.| ...|   |.      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-NQLTNQ--QILS---FAQDVALGLNYLHLFKPQPIIHRDL
    . .   |..    | |.|.|.|.||   |  ||||||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDL
Kinase AqueK663.AA TKL-Unique 366-485 31 1.2e-19 66.1 In-house 1-138 (290) Show / Hide 
Range on Protein: 366-485
Range on HMM: 1-138/290
Sequence Identity: 31% (44 aa)

TKEELGRGSYGLVTVGTFRGLRVAVKSLHT--LIISDYNQGIFSREMSIASRVR-HPNLVQFIGATK---VGNP--LILTELMST-SLNQELR-------
  . .|.|.|| |  |..||  ||.|..|   .. ..  |  |..| .. .. . |||.|...|...   | .|   | .| ..  ||.  |        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQE-FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

----RNQLTNQQILSFAQDVALGLNYLHLFKPQPIIHRDL
     . |..||....|.|.|.|..|||  .|  ||||||
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDL
Kinase AqueK663.AA CZAK 365-485 34 4.9e-19 65.87 In-house 1-135 (279) Show / Hide 
Range on Protein: 365-485
Range on HMM: 1-135/279
Sequence Identity: 34% (47 aa)

LTKE-ELGRGSYGLVTVGTFRGLRVAVKSLHTLIISDYNQ----GIFSREMSIASRVRHPNLVQFIGATKVGN---PLILTELMS-TSLNQELR-RNQLT
|. . . |.| .| |  .  ||  ||.| .|     .        .| .| || |  .||| |||.||   ..     | .| |   || . |  .  . 
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH

NQ---QILSFAQDVALGLNYLHL-FKPQPIIHRDL
 |     .. | |.| | ||||  .|| ||.||||
KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDL
Kinase AqueK663.AA Pkinase_Tyr 364-485 28 3.7e-18 62.14 Pfam 1-137 (270) Show / Hide 
Range on Protein: 364-485
Range on HMM: 1-137/270
Sequence Identity: 28% (40 aa)

ILTKEELGRGSYGLVTVGTFR------GLRVAVKSL-HTLIISD-YNQGIFSREMSIASRV-RHPNLVQFIGATK-VGNP---LILTELMST-SLNQELR
|   ..||.|..| |  || .      .. ||||.| ..   .. . .  .. |..| .   .|||.|...|.    | |   .| .|.|   .|   ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RN-----QLTNQQILSFAQDVALGLNYLHLFKPQPIIHRDL
..     .|| ...|......| |..||.  .   .|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDL
Kinase AqueK663.AA LISK 369-485 34 8.1e-18 54.29 In-house 1-127 (296) Show / Hide 
Range on Protein: 369-485
Range on HMM: 1-127/296
Sequence Identity: 34% (45 aa)

ELGRGSYGLVTVGTFR--GLRVAVKSLHTL---IISDYNQGIFSREMSIASRVRHPNLVQFIGATKV-GNPL-ILTELMST-SLNQELRRN-----QLTN
|.|.|..| |  || |  |  .|.| .|..    . . .|  . ||. .  . |||| |||.|. .     | |.||...   | | |...     .|. 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

QQILSFAQDVALGLNYLHLFKPQPIIHRDL
.| ...| |.|.|. |||    . ||||||
PQRVKIALDIACGMSYLHS---MNIIHRDL
Kinase AqueK663.AA DRK 364-485 37 1.3e-17 56.29 In-house 1-126 (258) Show / Hide 
Range on Protein: 364-485
Range on HMM: 1-126/258
Sequence Identity: 37% (48 aa)

ILTKEELGRGSYGLVTVGTFRGLRVAVKSLHTLIISDYNQ-GIFSREMSIASRVRHPNLVQFIGA-TKVGNPLILTELMST-SLNQELRRNQLTNQ--QI
|      |||.|| |  || ||  |||| |  . | | |    | ||  . .. |||| .||.|. .    ..| .| |.  || . |    .  .   .
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLM

LSFAQDVALGLNYLHLFKPQPIIHRDL
.. . |.| |..|||   |  ||||||
KQMMFDCAKGMIYLHCCNPI-IIHRDL
Kinase AqueK663.AA STE 365-485 18 5.3e-17 56.68 In-house 1-178 (359) Show / Hide 
Range on Protein: 365-485
Range on HMM: 1-178/359
Sequence Identity: 18% (33 aa)

LTK-EELGRGSYGLVTVGTFR-----------------GLRVAVKSLH---------------TLIISDYNQGIFSREMSIASRVR--HPNLVQFIGATK
... |..|.|..| |  .  .                 | ..|.| ..               . .. . ..  . .|..| .. .  ||| |...|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG--------NPLILTELMS-TSLNQELRRN-----QLT----------NQQILSFAQDVALG-LNYLHLFKPQPIIHRDL
..        .  |  |.|.  || . ....     .|.           .||  .....  | |.|||  .   |||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDI
Kinase AqueK663.AA Shk 364-485 36 5.6e-15 50.34 In-house 1-129 (269) Show / Hide 
Range on Protein: 364-485
Range on HMM: 1-129/269
Sequence Identity: 36% (47 aa)

ILTKEELGRGSYGLVTVGTFRGLRVAVKSLHTLIISDYNQGIFSREMSIASRVRHPNLVQFIGA-T-KVGNPLILTELM-STSLNQELRRNQLTNQ--QI
| . . || ||.| |  |. ||  |||| .|    . .    |  | .| |...|||.. | || | . |   | ||||  ..|   |.    .     .
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILY

LS---FAQDVALGLNYLHLFKPQPIIHRDL
.     . | ||| | ||   .  ||||||
KRAMRMCRDAALGMNWLHGSNCN-IIHRDL
Kinase AqueK663.AA Pkinase 364-485 21 6.3e-14 50.33 Pfam 1-134 (293) Show / Hide 
Range on Protein: 364-485
Range on HMM: 1-134/293
Sequence Identity: 21% (30 aa)

ILTKEELGRGSYGLVTVGTFRGLR--VAVKSLHTLIISDYNQGIFSR--EMSIASRVRHPNLVQFIGATK-VGNPLILTELMST-----SLNQELR---R
. ... .|.||.| |  .. .| .  |||| .    ...  . .  |  | .|  |..||| |.....    ... . .|..       .|   ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NQL--TNQQILSFAQDVALGLNYLHLFKPQPIIHRDL
. .  . ... ...  .. ||.|.|      ||||||
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDL
Kinase AqueK663.AA S_TKc 364-497 9 9e-07 -77.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 364-497
Range on HMM: 1-231/231
Sequence Identity: 9% (24 aa)

ILTKEELGRGSYGLVTVGTFRG--LRVAVKSLHTLIISDYNQGIFSREMSIASRVRHPNLVQFIGATKVGNPLILTELMST---SLNQELRRNQ------
    ...|.|..| |  .. ..   .||.| ..           . ||..| .. .|||.|.....   ..  . .|....   .| . .....      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LTNQQILSFAQDVALGLNYLH----------------------------------------------------------------------LFKPQPII
 ..  .. .... ....|.|.|                                                                      .|  |.  
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP-QMQM

---------HRDLFLFLFAFD------------------FDFF
          .|.   .. .|                    .|
MFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK663.AA TyrKc 364-502 13 1.3e-05 -131.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 364-502
Range on HMM: 1-280/280
Sequence Identity: 13% (40 aa)

ILTKEELGRGSYGLVTVGTFRGLRVAVKSLHTLIISDYNQGIFSREMSIASRV--RHPNLVQFIGATKV--------GNPLILTELMST-SLNQELRRNQ
|  ...||.| .| |  || . . ||||.|.        .  | ||..| ...  .|||.|...|.           . ..|..|.|.  .|.. ||...
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LTNQQILSFAQDVALGLNYLH----------------------------------------------------LFK----------------------
  |.... |||. ..| | .|||                                                      |                      
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

------------------PQP------IIHRDLFLFLFAFDFDFFVFH------------------------------------NI
                  | |      .  .... .. . .      .                                     .
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF