Gene AqueK669 (A.queenslandica)

AqueK669

Species: A.queenslandica
Alias: AqueK669
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: TAK1

Sequence

Name Sequence Type Origin Length Description Download
AqueK669.AA Protein None 851 None Fasta, JSON
AqueK669.kin_dom Protein Kinase Domain None 190 None Fasta, JSON

Protein domain

Protein domains of AqueK669.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK669.AA TKL 35-218 23 7.8e-34 118.73 In-house 1-288 (364) Show / Hide 
Range on Protein: 35-218
Range on HMM: 1-288/364
Sequence Identity: 23% (71 aa)

IGVGASGRVRFATHKG----------RDVAVKYFRSVSEKE----------------------------EFEQEVLNSKALQNHDNIVAILG--TGPNK-
|| |..| |  ....|          .||||| |.| ...|                            .|| |.....   .|.||| ..|  . |.. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LFIVREFAPY-SLNRVLHGSYPHRYTYEYDHVMHWARQIAVGLEYLHSVR--------IIYRGVEPSNLLLFGNGSL-----------
            |.|| |..|  ||  .||           .. ..||..|| |..|||| .        ||.|   ..|.|.. |.             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--LKLCDF--SHIPDALL-------------------------CGPVRYIAPEVFLDV-NSISY-----------PLEKRDIFDFAITLWEMLARQEP
  .|.|||  |   .                            ||  |. ||||. .  |  ..             || |.. |.| |||.|.|..|
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
Kinase AqueK669.AA MLK 29-218 29 1.8e-29 99.44 In-house 1-235 (291) Show / Hide 
Range on Protein: 29-218
Range on HMM: 1-235/291
Sequence Identity: 29% (70 aa)

KPENTLIGVGASGRVRFATHKGRD-----VAVKYFR--------SVSEKEEFEQEVLNSKALQNHDN----IVAILGT---GPNKLFIVREFAPY-SLNR
  . . ||.|..| |  .. ...|     |||| .|        . .|...||.|.   . | .| |    |....|.    |....|| |.... ||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRIL-SHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

VLHGSYPHRY----------TYEYDHVMHWARQIAVGLEYLHSVR---IIYRGVEPSNLLLFG-----NGSLLKLCDF--SH-IPDA-----LLCGPVRY
||||  .. .          .|  ||.| || |.| |..||||     || |   ..|.|.       ..  || |||  |. . .        .| ...
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

IAPEVF--LDVNSISYPLEKRDIFDFAITLWEMLARQEP
 ||||.  .  .  |   || |.. ... |||||.|..|
MAPEVIQQFRCEKYS---EKCDVWSWGVVLWEMLTREVP
Kinase AqueK669.AA TAK1 29-167 30 4.1e-27 88.55 In-house 1-150 (284) Show / Hide 
Range on Protein: 29-167
Range on HMM: 1-150/284
Sequence Identity: 30% (46 aa)

KPENTLIGVGASGRVRFATHKGRDVAVKYFR------SVSEKEEFEQEVLNSKALQNHDNIVAILGT---GPNKLFIVREFAPY-SLNRVLHGSYPHRYT
.    ..| |. | |. |. .....||| |.      . .|. ..| |.     . .| ||... |.     ..   | |..   ||  .|||. |. . 
IQNEHFVGKGTYGVVCKAKWRNKEIAVKRFEFIKYSSEECEQKNIEREIMQ-WSRVDHPNIIKLYGMYACHRQCQCLVMEYMDCGSLHNFLHGAKPKWE-

YEYDHVMHWARQIAVGLEYLHSVR---IIYRGVEPSNLLLFGNGSLLKLCDF
|  .|.| |..|.| |. ||||     .| | . | |.||   .  ||.|||
YTHAHAMSWMHQCAQGVAYLHSMQPKPQIHRDIKPQNMLLCNKHRTLKICDF
Kinase AqueK669.AA Pkinase 35-167 30 4.1e-19 68.65 Pfam 7-156 (293) Show / Hide 
Range on Protein: 35-167
Range on HMM: 7-156/293
Sequence Identity: 30% (47 aa)

IGVGASGRVRFATHKGRD--VAVKYFRSVSEKEEFEQ------EVLNSKALQNHDNIVAILGTG--PNKLFIVREFAPY-----SLNRVLH-GSYPHRYT
|| |..|.|. ..|||    |||| .. ..||....|      |.   | | ||.||| ....   .... .| |...      .| ....  ..   | 
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-

YEYDHVMHWARQIAVGLEYLHSVRIIYRGVEPSNLLLFGNGSL---LKLCDF
 ..... ....||. ||||.|| .||.| . |.|.|.  || .   .|.|||
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF
Kinase AqueK669.AA TK 35-189 14 1.1e-16 51.67 In-house 7-359 (486) Show / Hide 
Range on Protein: 35-189
Range on HMM: 7-359/486
Sequence Identity: 14% (52 aa)

IGVGASG---RVRFATHKGR---------------------------DVAVKYFR---SVSEKEEFE-------------QEVLNSKALQN----HDNIV
.| |. |   .|. .. .||                           .||||  .   . |..|.|.             .|..  | ...    |.|||
LGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIV

AILG----TGP----------NKLFIVREFAPY-----SLNRVLH--GSYPHRYTYEYDHVMH-------------------------------------
 ..|     .|            . || |..|.     ||   |.    . . . ...|.. .                                     
RLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIK

--------------------------------WARQIAVGLEYLHSV------RIIYRGVEPSNLLLFGNGS----------LLKLCDFS--------HI
                                ...||| |.|||||       ... | .   | |.. |.             |..||         . 
DHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLA

PDA----------------------------------LLCGPVRYIAPEVFLD
 |                                       |.|. |||...|
RDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLND
S_TKc AqueK669.AA S_TKc 28-321 20 3.5e-16 60.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 28-321
Range on HMM: 1-231/231
Sequence Identity: 20% (63 aa)

FKPENTLIGVGASGRVRFATHKG--RDVAVKYFRSVSEKEEFEQEVLNSKALQNHDNIVAILGTGP-NKLFIVREFAPY---SLNRVLHGSYPHR--YTY
..  . .|| || |.|. ..||.  | ||.|  .     | ...|.   |   .|.||| ....   ..|..| |...    .| ....   .|.  . .
YEILR-KIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

EYDHVMHWARQIAVGLEYLHSVRIIYRGVEPSNLLLFGNGSLLKLCDF---SHIPDALLCGPVRYIAPEVFLDVNSISYPLEKRDIFDFAITLWEMLARQ
   |. ....||. .|||.|| .||.| . |.|.||      .|.|||    ..    .||   |.||||.      .|  .| |.  . ..|.|||...
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL--TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLCGY

EPVVTGDDTKTIFEMLNQMANAVGKWMEEGSVDLTVTRVNMLGAPGAGKTCSQLLLLNEDPPTNDTSTPIACPAVRATKVAVSDKLVWNRVTRANLLDEL
 |        ....|....                                                        .  |  ..  |...   |    . |
PPFP------QMQMMFKKIG------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

A-------TDLT
.           
QDEWDIKCHPWF
Kinase AqueK669.AA Ciliate-E2-Unclassified 28-187 18 1.4e-14 47.04 In-house 1-238 (352) Show / Hide 
Range on Protein: 28-187
Range on HMM: 1-238/352
Sequence Identity: 18% (45 aa)

FKPENTLIGVGASGRVRFATHKG-------------RDVAVKYFRSVSEKEEFEQEVLNSK--------------ALQNHDNIVAILGTGPNK----LFI
.|  .  || |. | |. . ||              .....|. ...   . .|.. .|.|               |.||.... .      .    ..|
YK-IIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VREFAPYSLNRVLHGSYPH--------------RYTYEYDHVM-----HWARQIAVGLEYLHSV-RIIYRGVEPSNLLLFGNGS--LLKLCDFSHI----
| |....   .  . ....              |   .  ..      ....|| .||||||.   ||.|   |.|.|.  ||.   .|..||. .    
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

----------------PDALL---CGPVRYI----APEVF
                .. ..   ||  .|.    ||||.
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL
Kinase AqueK669.AA TKL-Unique 33-168 31 7.1e-14 45.48 In-house 3-162 (290) Show / Hide 
Range on Protein: 33-168
Range on HMM: 3-162/290
Sequence Identity: 31% (50 aa)

TLIGVGASGRVRFATHKGRDVAVKYFR-----SVSEKEEFEQEVLNSKALQNHDNIVAILGTGP------NKLFIVREFAPY-SLNRVLH------GSYP
 .|| |..|.|  ....| .||.| |      | ....||| ||  .| |. |.||| . |.        ....|| |. |  ||. |||         .
NKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

HRYTYEYDHVMHWARQIAVGLEYLHSVR--IIYRGVEPSNLLLFGNG----SLLKLCDFS
  ..  .  ... |..|| |..|||.    || |   .||.|.  |        |.|||.
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFG
Kinase AqueK669.AA CAMK 34-167 15 1.3e-13 39.5 In-house 1-240 (425) Show / Hide 
Range on Protein: 34-167
Range on HMM: 1-240/425
Sequence Identity: 15% (38 aa)

LIGVGASGRVRFATHK-GRD-------------VAVKYFR------------------------------SVSEKEEFEQEVLNSKALQ------NHDNI
 .| |. | |. ..||                 ||.|                                 . . ......|.   | ||      .| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VAILG---------------TGPN-------KLFIVR---EFAPYS------LNRVL-HGS----------YPHRYTYEYDHVMHWARQIAVGLEYLHSV
. ..                |  .       ....|    |...        ....  ||.             |  .. . . .. |||. ...|.|| 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

RIIYRGVEPSNLLLFGNG----------------SLLKLCDF
 |. |   | |.||  |.                  .|..||
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF
Kinase AqueK669.AA CMGC 35-167 17 2.1e-13 39.5 In-house 7-248 (513) Show / Hide 
Range on Protein: 35-167
Range on HMM: 7-248/513
Sequence Identity: 17% (44 aa)

IGVGASGRVRFATH----------------KGRDVAVKYFRSVSEKEEFEQ--------------EVLNSKALQ----------------NHDNIV----
|| |. | |  ...                 .. ||.| ....  .|| ..              |.   | |.                .| |||    
IGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYD

AILGTGPN---------------KLFIVREFAPYSLNRVLH-------------GSYPH------------RYTYEYDHVMHWARQIAVGLE--YLHSVR
 .   ...               .|..| |. ...| ....              |  |               .   |.  ...||  ||.  |.|| .
IFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHW

--IIYRGVEPSNLLLFGNGSL-------------------LKLCDF
  || |   |.|.|.  |. |                   ||.|||
GNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDF
TyrKc AqueK669.AA TyrKc 26-316 19 7.8e-11 -47.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-316
Range on HMM: 1-280/280
Sequence Identity: 19% (65 aa)

LKFKPENTLIGVGASGRVRFATHKGRDVAVKYFRSVSEKEEFEQEVLNSKAL-QNHDNIVAILG--TGP-------NKLFIVREFAPY-SLNRVLHGSYP
...   .  .| || |.|. .| | ..||||  .. . .|.| .|    . |  .|.|||...|  | .         |.|| |..|. .|.  |. . |
ITL---GKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

HRYTYEYDHVMHWARQIAVGLEYLHSVRIIYRGVEPSNLLLFGNGSLLKLCDFS---HIPDA----------------LLC--GPVRYIAPEVFLDVNSI
.      ..  ... ||| | ||||| ..| |     | |.  |.   | .||     | |                       |.|  |||..    ..
K---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGK

SYPLEKRDIFDFAITLWEMLARQEPVVTGDDT--KTIFEMLNQMANAVGKWMEEG----SVDLTVTRVNMLGAPGAGKTCSQLLLLNEDPPTNDTSTPIA
    .| |.. | ...||.. . ..   |.    .. .|....  .       .     |                                   .    
FT--TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------------F--VC

CPAVRATKVAVS--DKLVWNRVTRANLLDEL
||.   . .  .  .    .| | ... ...
CPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK669.AA TAK1 177-218 26 9.5e-09 25.57 In-house 165-224 (284) Show / Hide 
Range on Protein: 177-218
Range on HMM: 165-224/284
Sequence Identity: 26% (16 aa)

GPVRYIAPEV------------------FLDVNSISYPLEKRDIFDFAITLWEMLARQEP
|  |. ||||                  |  |   . . .| ||. ..|..||...|..|
GTCRWMAPEVRELFDFKSNRIIINQPTGFQKVFRCEKYNMKCDIYSWGIIMWEVISRKHP
Kinase AqueK669.AA Dicty5 32-155 29 1.2e-08 25.87 In-house 4-137 (260) Show / Hide 
Range on Protein: 32-155
Range on HMM: 4-137/260
Sequence Identity: 29% (41 aa)

NTLIGVGASGRVRFATHKGRDVAVKYFRSVS----EKEEFEQEVLNSKALQ-NHDNIVAILGTG---PNKLFIVREFAPY-SLNRVLHGSYPHRY----T
   |  ||||||     ||.|||.| . .      . .||. ||    . |  |.|..  .| .    ...|.| |.    ||   |      |      
HDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLND---QRKTTGQP

YEYDHVMHWARQIAVGLEYLHSVRIIYRGVEPSNLLL
  |   .| |  || ....|||. || | .   | |.
IAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLI
Kinase AqueK669.AA STE 30-100 18 1.4e-07 23.0 In-house 1-118 (359) Show / Hide 
Range on Protein: 30-100
Range on HMM: 1-118/359
Sequence Identity: 18% (22 aa)

PEN-TLIGVGASGRVRFATHK-----------------GRDVAVKYFRSVS-------------------EKEEFEQEVLNSKALQN-HDNIVAILGTGP
 |.   || ||.| |  | ..                 |. .|.|  .  .                   |......|.   | ... |.|||  .|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

---------NKLFIVREF
         ..|.|. |.
KEGHNHKNDDELWICMEY
Pkinase_Tyr AqueK669.AA Pkinase_Tyr 26-144 30 5e-06 21.0 Pfam 1-133 (270) Show / Hide 
Range on Protein: 26-144
Range on HMM: 1-133/270
Sequence Identity: 30% (42 aa)

LKFKPENTLIGVGASGRVRFATHK------GRDVAVKYF--RSVSE---KEEFEQEVLNSKALQNHDNIVAILG--T---GPNKLFIVREFAPY-SLNRV
..|  .   .| || |.|. .| |      . .||||     . .|   .|.| .|.   | | .|.|||  .|  |   .||...|| |..|. .|   
ITFGKK---LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LHGS--YPHRYTYEYDHVMHWARQIAVGLEYLHSVRII
|.     ... | .  .  ....||| |.|||.| ..|
LRKHREDKQPLTMK--DLLQMCWQIAKGMEYLESKNCI
Kinase AqueK669.AA Dicty5 181-218 42 5.2e-05 13.18 In-house 169-202 (260) Show / Hide 
Range on Protein: 181-218
Range on HMM: 169-202/260
Sequence Identity: 42% (16 aa)

YIAPEVFLDVNSISYPLEKRDIFDFAITLWEMLARQEP
. |.|.|   |.  |  .| |.. |.| ||||..| ||
WMACELF---NGQPY-HQKCDVYSFGIVLWEMFTRKEP
Kinase AqueK669.AA STE 128-167 51 8.4e-05 13.02 In-house 157-191 (359) Show / Hide 
Range on Protein: 128-167
Range on HMM: 157-191/359
Sequence Identity: 51% (21 aa)

ARQIAVG-LEYLHSVRIIYRGVEPSNLLLFGNGSLLKLCDF
.|||  | |.|||| .|| | . |.| ||       |||||
CRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDF
Kinase AqueK669.AA TKL-Unique 172-216 36 0.000624 9.96 In-house 183-225 (290) Show / Hide 
Range on Protein: 172-216
Range on HMM: 183-225/290
Sequence Identity: 36% (17 aa)

DALLCGPVRYIAPEVFLDV-NSISYPLEKRDIFDFAITLWEMLARQ
..  ||  |..||||. .. . .|   || |.. |.| |||.. |.
NQTRCGSFRWMAPEVLRMNFCQYS---EKSDVYSFGIVLWEIATRK