Gene AqueK670 (A.queenslandica)

AqueK670

Species: A.queenslandica
Alias: AqueK670
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: TAK1

Sequence

Name Sequence Type Origin Length Description Download
AqueK670.AA Protein None 716 None Fasta, JSON
AqueK670.kin_dom Protein Kinase Domain None 206 None Fasta, JSON

Protein domain

Protein domains of AqueK670.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK670.AA TKL-Unique 1-204 32 4.1e-65 222.65 In-house 49-290 (290) Show / Hide 
Range on Protein: 1-204
Range on HMM: 49-290/290
Sequence Identity: 32% (80 aa)

MNTLR-HPNVVLLLAASP----SPPKLAIVMEYVGGGSLYSHLH---------IDKTIFSVDVIAQLLADITRGLQYLHSIN--ILHRDLKSKNVLLTNP
|..|. |||.|.. ...     .||.. |||||. |||||..||         .... ..  .. ..  || .|. |||. .  |.||||||.|.|..| 
MKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDN-

PPL-----CKAKLCDFGLARMRLESATMTGN----------VGTVHWTAPEVLNC--GRYHFSADVYSFGMVLYEMVTRSI------PFSHLPPPAVIVA
         ..|.|||||.. .  . .|| |          .|.  | |||||.     |  ..||||||.||.|..|| |      |.... . ... .
--NSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEM

VLI--RRERPSLSSDCHQTFRTLFEKCTSWDPVDRPSLLSILRDL
|    .. || ....| . .| | ..|   ||..|||. .|.  |
VHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK670.AA TKL 1-204 30 1.6e-64 220.67 In-house 79-364 (364) Show / Hide 
Range on Protein: 1-204
Range on HMM: 79-364/364
Sequence Identity: 30% (89 aa)

MNTLRHPNVVLLLAASPSPPK-------------LAIVMEYVGGGSLYSHLHIDKTIFSVDVIAQLLADITRGLQYLHSIN--------ILHRDLKSKNV
|. |||||.|...... .||.             |.|||||. ||||...||        ... ..  || ||..|||| |        |.||||||||.
MSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI

LLT-----------NPPPLCKAKLCDFGLARMRLESATMTGN--------------------VGTVHWTAPEVLN----------------CGRYHFSAD
|.            ||.  ...|.|||||.|.  .|  |. .                    .||  | |||||.                .. |  ..|
LVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCD

VYSFGMVLYEMVTRSIPFSHLPPPAVI---------VAVLIRRERPSLS------------SDCHQTFRTLFEKCTSWDPVDRPSLLSILRDL
|||||.||.|..|| .|....|.. .|         . |  ...|| .             .|| . .. | ..| . || .||| . ||  |
VYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK670.AA MLK 4-204 34 6.3e-59 202.08 In-house 62-291 (291) Show / Hide 
Range on Protein: 4-204
Range on HMM: 62-291/291
Sequence Identity: 34% (79 aa)

LRHPN----VVLLLAASPSPPK-LAIVMEYVGGGSLYSHLHIDKT-------------IFSVDVIAQLLADITRGLQYLHSIN---ILHRDLKSKNVLLT
|.|||    .. ..... .||. ..|||||. |||||. ||  ..             . ..|....   .. ||..||||     | ||||||.|.|..
LSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILID

N--PPPLC--KAKLCDFGLARMRLES-ATMTGNVGTVHWTAPEVL---NCGRYHFSADVYSFGMVLYEMVTRSIPFS-HLPPPAVIVAVLIRRERPSLSS
.    ...  ..| ||||..|.  .. ..|..| ||. | ||||.    |..|  ..||.|.|.||.||.|| .|.. |. | |..  |   ..|| . |
EICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPS

DCHQTFRTLFEKCTSWDPVDRPSLLSILRDL
.|   .  | ..| . || .|||  .|.  |
TCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK670.AA LRRK 1-206 31 2.4e-57 196.83 In-house 111-351 (351) Show / Hide 
Range on Protein: 1-206
Range on HMM: 111-351/351
Sequence Identity: 31% (76 aa)

MNTLRHPNVVLLLAASPSPPKLAIVMEYVGGGSLYSHLH---IDK-----TIFSVDVIAQLLADITRGLQYLHSIN--ILHRDLKSKNVLL---TNPP--
|..|.|||.| |.  . .|  |..||||.  |.||..||    |.     . .|  .. ..  .| .|..|||| |  |.|||||| |.||   ....  
MSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSP

----PLCKAKLCDFGLAR--MRLESATMTGNVGTVHWTAPEVLNCG---RYHFSADVYSFGMVLYEMVTRS-IPFSHLP-P-----PAVIVAVLIRRERP
    .  .||..|||. |    . ..   | ||.  | |||... .    |.  .|.|||||.|.| .||. .|| ... .        |    |.  ||
NYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRP

SLSSD-CHQ-----TFRTLFEKCTSWDPVDRPSLLSILRDLML
..... |..      . .| ..| . || .||.  .|.  |  
TIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK670.AA Dicty4 1-208 33 2.4e-56 186.51 In-house 52-277 (277) Show / Hide 
Range on Protein: 1-208
Range on HMM: 52-277/277
Sequence Identity: 33% (77 aa)

MNTLRHPNVVLLLAASP----SPPKLAIVMEYVGGGSLYSHLHI------DKTIFS-VDVIA--QLLADITRGLQYLHS-I-NILHRDLKSKNVLLTNPP
|  .||||..|.. |.      |.|. ||.||.  |.||| ||       ...  .  ....  ..  |. ||...||. . .|.|||||| | |     
MCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKN-

PLCKAKLCDFGLAR-MRLES--AT-MTGNVGTVHWTAPEVLNCGRYHFSADVYSFGMVLYEMVTRSIPFS--HLPPPAVIVAVLIRRERPSLSSDCHQTF
   ..| |||||.. |. ..   . ... .||. |.||||.   .|  .|||||||.||.|..|| .|..  | |.. .. ||    .||.....|   .
--WRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSW

RTLFEKCTSWDPVDRPSLLSILRDLMLLL
..| ..| . ||  |||   |.  ..|  
KHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK670.AA Pkinase 1-206 27 3.3e-48 171.26 Pfam 54-293 (293) Show / Hide 
Range on Protein: 1-206
Range on HMM: 54-293/293
Sequence Identity: 27% (67 aa)

MNTLRHPNVVLLLAASPSPPKLAIVMEYVGGG----SLYSHLH-IDKTIF--SVDVIAQLLADITRGLQYLHSINILHRDLKSKNVLLTNPPPLC--KAK
|. |.|||.| |. .  ..... .||||..||    .|.....  ... |  | ...   .  | |||.|.|| .|.|||||. |.|.    . .  . |
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVK

LCDFGLARM--RLESATMTGNVGTVHWTAPEVLN-CGRYHFSADVYSFGMVLYEMVTRSIPFSHL--PPPAVIVAVLIRRERP-SLSSDCH---------
.||||||.      .  ||. .|| .. ||||.. .  |  ..|..|.| .||||...  ||..   ... .   ..|.| ..  |..|.          
ICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF

--------------QTFRTLFEKCTSWDPVDRPSLLSILRDLML
              .... . ..|  .|| .||.   || .  .
FRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK670.AA DRK 1-206 37 3.8e-47 157.74 In-house 51-258 (258) Show / Hide 
Range on Protein: 1-206
Range on HMM: 51-258/258
Sequence Identity: 37% (80 aa)

MNTLRHPNVVLLLAASPSPPKLAIVMEYVGGGSLYSHLHIDKTIFSVDVIAQLLADITRGLQYLHSIN--ILHRDLKSKNVLLTNPPPLCKAKLCDFGLA
|  |||||... . .   ||   |.|||   ||||. || ..   .   . |.  |. .|. |||. |  |.|||||| | |        . |  ||||.
MCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDE---HWQVKVADFGLS

R----MRLESATMTGNVGTVHWTAPEVLNCGRYHFSADVYSFGMVLYEMVTRSIPFSHLPPPAVIVAVLIRRERPSLSSDCHQTFRTLFEKCTSWDPVDR
     ..   ..||  .||  |||||||   ||   ||||||. || |.||| .|.   |.  |. .|    .||     |   .  |   | . ||  |
TRFKKHKQHKFAMT-MCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHR

PSLLSILRDLML
||.  .|  |  
PSMQECLERLEA
Kinase AqueK670.AA HH498 4-204 30 3.9e-43 134.35 In-house 59-284 (284) Show / Hide 
Range on Protein: 4-204
Range on HMM: 59-284/284
Sequence Identity: 30% (69 aa)

LRHPNVVLLLAASPSPPK-LAIVMEYVGGGSLYSHL--------------HIDK---TIFSVDVIAQLLADITRGLQYLHS---INILHRDLKSKNVLLT
| ||.||  . |.   |. .||| .|. .|||.| |              | .|    | .   .  .  |. .| .|||.     | |||| | |.|. 
LNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH

NPPPLCKAKLCDFGLAR--MRLESATMTGNVGTVHWTAPEVLN-CGRYHFSADVYSFGMVLYEMVTRSIPFSHLPPPAVIVAVLIRRERPSLSSD----C
      .|.  |||  |    ..  .||   |   | ||||   |..|   .||.|..|...|| || .||.|. | |    .  .. || .        
E---DGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQI

HQTFRTLFEKCTSWDPVDRPSLLSILRDL
 .    |   | .  | .||.   |.. |
PHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase AqueK670.AA Pkinase_Tyr 1-204 29 6.7e-42 142.54 Pfam 57-270 (270) Show / Hide 
Range on Protein: 1-204
Range on HMM: 57-270/270
Sequence Identity: 29% (65 aa)

MNTL-RHPNVVLLLAASP--SPP-KLAIVMEYVGGGSLYSHLHID---KTIFSVDVIAQLLADITRGLQYLHSINILHRDLKSKNVLLTNPPPLCKAKLC
| .| .|||.| |...    . | .. |||||. .|.|...|.     |  ...  . |  ..| .|..||.|.|. ||||  .|.|.|.  .. ..| |
MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--NN-VVKIC

DFGLARMR-----LESATMTGNVGTVHWTAPEVLNCGRYHFSADVYSFGMVLYEMVTRS-IP-FSHLPPPAVIVAVL-IRRERPSLSSDCHQTFRTLFEK
||||||         . . .|    . |.|||..| |..    ||.||| ...|..|.  .| .  . ... ... .  ...|     .|..   .|  .
DFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQ

CTSWDPVDRPSLLSILRDL
|  .|| |||.   |...|
CWHYDPEDRPTFSEIHEQL
Kinase AqueK670.AA Dicty4-Unclassified 4-204 30 1.8e-41 139.8 In-house 55-263 (263) Show / Hide 
Range on Protein: 4-204
Range on HMM: 55-263/263
Sequence Identity: 30% (65 aa)

LRHPNVVLLLAASPSP----PKLAIVMEYVGGGSLYSHLH-----IDKTIFSVD-VIAQLLADITRGLQYLHSINILHRDLKSKNVLLTNPPPLCKAKLC
. ||| | .  ..  |      . ||||    | |    |      .. |   | .|     || .|.|.||. |. |||.|| |.|.        .|  
IQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDK---HFNIKIA

DFGLARMRLESATMTGNVGTVHWTAPEVLNCGRYHFSADVYSFGMVLYEMVTRSIPFSHLP-PPAVIVAVLIRRERPSLSSDCHQTFRTLFEKCTSWDPV
|||..|      .||   ||. |..||.|    |   .||||..|.|||..|   |.   . .  .   |  .  || ... |   .. |   | . || 
DFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPN

DRPSLLSILRDL
 ||..  |   |
KRPTMNQIIQYL
Kinase AqueK670.AA STE 1-206 22 9.5e-41 141.63 In-house 82-359 (359) Show / Hide 
Range on Protein: 1-206
Range on HMM: 82-359/359
Sequence Identity: 22% (65 aa)

MNTLR--HPNVVLLLAASP-------SPPKLAIVMEYVGGGSLYSHLH---IDK----------TIFSVDVIAQLLADITRG-LQYLHSINILHRDLKSK
|. ..  |||.|  . .         .  .| |.|||..|||| . ..   . .          . |. ..||  . .| .| |.|||| .| |||.|. 
MKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPA

NVLLTNPPPLCKAKLCDFGLAR--------------------MRLESATMTGNVGTVHWTAPEVLNCGR------YHFSADVYSFGMVLYEMVTRSIPFS
|.||        .||||||..                     |  .. |..|      | ||||.....      | ...|..|.| .. ||.|   |..
NILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP----WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWH

HLPPPAVIVAVLIR--------------RERPSLSS-------------------DCHQTFRTLFEKCTSWDPVDRPSLLSILR--DLML
 ..|. .. . ..                . |.| .                    . . |.   .||   || .||.    |.     .
DMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase AqueK670.AA RAF 5-204 30 2.6e-40 135.65 In-house 54-275 (275) Show / Hide 
Range on Protein: 5-204
Range on HMM: 54-275/275
Sequence Identity: 30% (69 aa)

RHPNVVLLLAASPSP--PKLAIVMEYVGGGSLYSHLHIDKT-IFSVDVIAQLLADITRGLQYLHSINILHRDLKSKNVLLTNPPPLCKAKLCDFGLARMR
|| |.|| . .  .|  | .|||.    | .||.|.|  ||  | .  . |    |. |  |||. ||.||||||||..| |.    . .. ||||. . 
RHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMNWTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNG---KVVVITDFGLFTVK

-LESA-----TMTGNVGTVHWTAPEVLNCG-------R-----YHFSADVYSFGMVLYEMVTRSIPFS-HLPPPAVIVAVLIRRERPSLS---SDCHQTF
 .. .     .     | . | ||||.          .     . |..|||.|| |.||..... |.. . .  ..|  |   . |. .|   ..| .. 
RCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDVYAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEM

RTLFEKCTSWDPVDRPSLLSILRDL
. | . | | .| .|||.  |.  .
KELLMECWSYQPEERPSFQQIMKMI
Kinase AqueK670.AA S_TKc 1-206 25 8.1e-33 116.27 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-206
Range on HMM: 19-231/231
Sequence Identity: 25% (61 aa)

MNTL-----------------------RHPNVVLLLAASPSPPKLAIVMEYVGG--GSLYSHLHIDKTI-----FSVDVIAQLLADITRGLQYLHSINIL
 ..                        .|||.| |. .  .  .| .||||..|  |.|.....  ..      |.  ... ... | ..|.|.|| .|.
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGII

HRDLKSKNVLLTNPPPLCKAKLCDFGLARMRLESATMTGNVGTVHWTAPEVLNCGRYHF-SADVYSFGMVLYEMVTRSIPFSHLPPPAVIVAVLIRRERP
|||||  |.||..       |.|||||||        |  .|| .. |||||    | . ..|..|.| .||||...  ||.    ....  ..      
HRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----

SLSSDCHQTFRTLFEKCTSWDPVDRPSLLSILR-------DLML
       . .. . .||  .|| .||.   .|.       .  .
------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK670.AA TyrKc 1-204 20 7.7e-17 49.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-204
Range on HMM: 1-280/280
Sequence Identity: 20% (57 aa)

MN-------------------------------------------TL--RHPNVVLLLAASPSP-------PKLAIVMEYVGGGSLYSHLHIDKTIFSVD
                                              |  .|||.| |...  ..       . | |||||. .|.| ..|.  .  ....
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

VIAQLLADITRGLQYLHSINILHRDLKSKNVLLTNPPPLCKAKLCDFGLARMRLES-------ATMT------GN-VGTVHWTAPEVLNCGRYHFSADVY
   .   .| .| .|||| |. ||||   |.|....     .| .||||.|   .         . .      |. .  . |.|||..| |.. .  ||.
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVW

SFGMVLYEMVTRSIPFSHL-----PPPAVIVAVLIRRERPSLSSD--------CHQTFRTLFEKCTSWDPVDRPSLLSILRDL
||| ...|. |.  .          ... ... . ...|.    .        |..   .. ..|   || |||.   | ...
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF