Gene AqueK687 (A.queenslandica)

AqueK687

Species: A.queenslandica
Alias: AqueK687
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
AqueK687.AA Protein None 409 None Fasta, JSON
AqueK687.kin_dom Protein Kinase Domain None 99 None Fasta, JSON

Protein domain

Protein domains of AqueK687.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK687.AA TKL 7-178 20 1.3e-30 107.43 In-house 124-364 (364) Show / Hide 
Range on Protein: 7-178
Range on HMM: 124-364/364
Sequence Identity: 20% (52 aa)

SLAQYLDDANLPLKVKYDILLDVANGLNYLHNRT------PPIIHRDLTAQNILLTKSFS--------------AKISDLGVSKIVDFTRPRSHTL----
||  ||      . .. .. ||.| |.||||...      ||||||||. .|||. . .               .||.|.| |. .. .   ..|     
SLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMM

--------------VPGNPIVMPPEAYLPN---------------KTYDFKFDVFSYGCLLLHIFNQDPPVPVNQLPSDPLTEWQRRFS-------HVAR
              . |.|  |.||.   .               ..|. | ||.|.| .|  |.   .       | . . . .. |.        .. 
ESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------PYYDYPYMPMIFQDPFEEMFMMVC

MGRHHPLLP---------------------IVKNCLENDPAMRPNMSYIIRVI
  ...|..|                     . . | . ||  ||... |.  .
DKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK687.AA HH498 14-118 38 3.6e-26 79.64 In-house 115-220 (284) Show / Hide 
Range on Protein: 14-118
Range on HMM: 115-220/284
Sequence Identity: 38% (41 aa)

DANLPLKVKYDILLDVANGLNYLHN-RTPPIIHRDLTAQNILLTKSFSAKISDLGVSKIVDFTRPRSHTLVPGNPIVMPPEAYLPNKTYDFKFDVFSYGC
. .. |  |  | .|||.| |||||  ..|||||||. .|||. .   |.. | | |  |        |  |||.  | || .  .  |. | |||||. 
YRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAM

LLLHIF
 .  ..
CIWEMH
Kinase AqueK687.AA MLK 7-114 28 3e-22 74.06 In-house 96-226 (291) Show / Hide 
Range on Protein: 7-114
Range on HMM: 96-226/291
Sequence Identity: 28% (38 aa)

SLAQYLDDAN---------------LPLKVKYDILLDVANGLNYLHNRTP-PIIHRDLTAQNILLT------KSFSAKISDLGVSKIVDFTRPRS-HTLV
||. .| .|.                .. .. .. |..|.|..|||.  | |||||||  .|||..      .   .||.| |.|.  |...  . ..  
SLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR--DWHQMCTNMMSN

PGNPIVMPPEAY--LPNKTYDFKFDVFSYGCLL
.|... | ||.   ... .|. | ||.|.| .|
AGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVL
Kinase AqueK687.AA TKL-Unique 16-111 31 4.8e-20 67.5 In-house 106-215 (290) Show / Hide 
Range on Protein: 16-111
Range on HMM: 106-215/290
Sequence Identity: 31% (35 aa)

NLPLKVKYDILLDVANGLNYLHNRTPPIIHRDLTAQNILLTKS-----FSAKISDLGVSKIVD--FTRPRS-H-----TLVPGNPIVMPPEAYLPN-KTY
.|........ .|.| |..|||.. ||||||||. .|.|..       ...||.| | ||. .   . . . |     . . |... |.||    | ..|
KLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQY

DFKFDVFSYG
. | ||.|.|
SEKSDVYSFG
Kinase AqueK687.AA LISK 8-115 28 1.6e-19 59.89 In-house 84-230 (296) Show / Hide 
Range on Protein: 8-115
Range on HMM: 84-230/296
Sequence Identity: 28% (43 aa)

LAQYLDDA-----NLPLKVKYDILLDVANGLNYLHNRTPPIIHRDLTAQNILLTKS----FSAKISDLGVSKIVDFTR----------------------
| |||.|      .|| ... .| ||.| |. ||| .   ||||||...|.|. ..    ...|. |.|  ...| ..                      
LHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLHSMN--IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPM

------------PRSHTLVPGNPIVMPPEAYLPNKTYDFKFDVFSYGCLLL
            .|. | . |.|. |.||  |  . || . ||||.| .|.
KRKIPKKCMNQRKRRMTIC-GTPYWMAPEM-LLGQSYDESCDVFSFGIVLC
Kinase AqueK687.AA STE 25-123 29 7.4e-18 59.73 In-house 156-267 (359) Show / Hide 
Range on Protein: 25-123
Range on HMM: 156-267/359
Sequence Identity: 29% (35 aa)

ILLDVANG-LNYLHNRTPPIIHRDLTAQNILLTKSFSAKISDLGVSKIVDF---------------TRPRSHTLVPGNPIVMPPEAYLP-----NKTYDF
|. ..  | |.|||.    |||||. ..||||     .|..| ||.....                |.    . . | |  | ||  ..     .| ||.
ICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDT

KFDVFSYGCLLLHIFNQDPP
| |. | ||....  .  ||
KCDIWSLGCTIIEMATGKPP
Kinase AqueK687.AA STE-Unique 25-123 22 7.5e-18 59.51 In-house 408-552 (616) Show / Hide 
Range on Protein: 25-123
Range on HMM: 408-552/616
Sequence Identity: 22% (33 aa)

ILLDVANGLNYLHNRTPPIIHRDLTAQNILLTKSF-----SAKISDLGVSKIVDFTRP-------------------------------------RSHTL
... .. ||.||| .  ||||||| . ||.....      ..||.| | ...  .  .                                     .. . 
YTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKY

VPGNPIVMPPEAYLPN----KTYDFKFDVFSYGCLLLHIFNQDPP
 .|.|. | ||  . .    . || | |..| ||...|. .. ||
CCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPP
Kinase AqueK687.AA Dicty4-Unclassified 27-114 39 2.3e-17 56.02 In-house 116-198 (263) Show / Hide 
Range on Protein: 27-114
Range on HMM: 116-198/263
Sequence Identity: 39% (35 aa)

LDVANGLNYLHNRTPPIIHRDLTAQNILLTKSFSAKISDLGVSKIVDFTRPRSHTLVPGNPIVMPPEAYLPNKTYDFKFDVFSYGCLL
.|.| |. .|| |   .||||. . |||. | | .|| |.|.|  .||.     | . | |    ||  |    |  | ||.||. .|
FDIAQGMQHLHTRN--FIHRDIKSSNILMDKHFNIKIADFGISRVIDFN--FNMTTIAGTPKWESPEC-LMHESYNQKSDVYSYAMML
Kinase AqueK687.AA NEK4 29-112 40 2.7e-17 58.81 In-house 111-190 (257) Show / Hide 
Range on Protein: 29-112
Range on HMM: 111-190/257
Sequence Identity: 40% (34 aa)

VANGLNYLHNRTPPIIHRDLTAQNILLTKSFSAKISDLGVSKIVDFTRPRSHTLVPGNPIVMPPEAYLPNKTYDFKFDVFSYGC
.| .| |.| .   |.||||  ||| |||    || |.|.|.. .       |.. | |  | || .  |. ||.| |. | ||
IAMALQYMHEKH--ILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMI-GTPYYMSPECF-GNRPYDYKSDIWSLGC
Kinase AqueK687.AA TKL-ciliate1 25-114 33 4.8e-16 51.42 In-house 108-209 (279) Show / Hide 
Range on Protein: 25-114
Range on HMM: 108-209/279
Sequence Identity: 33% (34 aa)

ILLDVANGLNYLHNRTPPIIHRDLTAQNILLTKSFSAKISDLGVSKIVDFTRPR---SHTL-----VPGNPIVMPPEAY----LPNKTYDFKFDVFSYGC
.. |.| |. ||| | .|.|||||. ||||. . .  || . .  || || | |   .  .     . . .  | ||       ||. .  | |...|| 
WCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGI

LL
..
VM
Kinase AqueK687.AA Pkinase_Tyr 13-84 31 3.4e-15 52.07 Pfam 104-177 (270) Show / Hide 
Range on Protein: 13-84
Range on HMM: 104-177/270
Sequence Identity: 31% (24 aa)

DDANLPLKVKYDILLDVANGLNYLHNRTPPIIHRDLTAQNILLTKSFSAKISDLGVSKIV---DFT-RPRSHTLVP
|. .|..| . .. ...|.|..||...   .||||| | |.|.|... .||.| | .. .   |   | |... .|
DKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLP
Kinase AqueK687.AA Pkinase 24-125 31 1.2e-12 45.77 Pfam 112-213 (293) Show / Hide 
Range on Protein: 24-125
Range on HMM: 112-213/293
Sequence Identity: 31% (34 aa)

DILLDVANGLNYLHNRTPPIIHRDLTAQNILLTKSFSA----KISDLGVSKIV-DFTRPRSHTLVPGNPIVMPPEAYLPNKTYDFKFDVFSYGCLLLHIF
.... .. ||.|.|..   ||||||  .|||. .        ||.| |..| .     .  .|.. | |  |.||  . .. |. | |..|.||.|   .
FYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC-GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEML

NQDPPVP
.  || |
CGRPPFP
S_TKc AqueK687.AA S_TKc 1-184 17 7.9e-09 -47.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-184
Range on HMM: 1-231/231
Sequence Identity: 17% (45 aa)

MERLQV--------------------------------------------------------------------SLAQYLDDAN-------LPLKVKYDI
 | |..                                                                    .| .|... .       .|  .   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

LLDVANGLNYLHNRTPPIIHRDLTAQNILLTKSFSAKISDLGVSKIVDFTRPRSHTLVPGNPIVMPPEAYLPNKTYDF-KFDVFSYGCLLLHIFNQDPPV
.  ....|.|.|..   ||||||  .||||..    ||.| |.....        | . | |  |.||       |.. | |. | ||.|   .   || 
MYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPF

PVNQLPSDPLTEWQRRFSHVARMGRHHPLLPIVKNCLENDPAMRPNMSYIIR---VIQATAYT
|        . .  ..          .... ....||. ||. ||    . .   .| .  . 
P-------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc AqueK687.AA TyrKc 2-178 18 1e-07 -97.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 2-178
Range on HMM: 1-280/280
Sequence Identity: 18% (52 aa)

ERL------------------------------------------QV-------------------------------------SLAQYLDDAN--LPLK
 .|                                          ..                                     .| .|| .    |..|
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

VKYDILLDVANGLNYLHNRTPPIIHRDLTAQNILLTKSFSAKISDLGVSKIV----------DFTRP----RSHTLVPGNPIV--MPPEAYLPNKTYDFK
 . .. ...|.| .||| .  ..||||| | |.|... . .|||| | |. .          |  |.     ..|..|    .  |.||.    ... .|
DLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP----IRWMAPECI-NYGKFTTK

FDVFSYGCLLLHIFN--QDPPVPVNQ--LPSDPLTEWQRRFSHVARMGR---------HHPLLPIVKNCLENDPAMRPNMSYIIRVI
 ||.|.| ..  ||   | |.  . |  .. . . |. ..     ..           .  .  | | | . ||..||..| |.. .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK687.AA TKL-ciliate1 158-178 33 0.000124 11.78 In-house 259-279 (279) Show / Hide 
Range on Protein: 158-178
Range on HMM: 259-279/279
Sequence Identity: 33% (7 aa)

KNCLENDPAMRPNMSYIIRVI
. |.. .|. ||| . || ..
MRCWCQNPNKRPNFNEIIQIL
Kinase AqueK687.AA Dicty4-Unclassified 157-178 45 0.000422 9.9 In-house 242-263 (263) Show / Hide 
Range on Protein: 157-178
Range on HMM: 242-263/263
Sequence Identity: 45% (10 aa)

VKNCLENDPAMRPNMSYIIRVI
.| |. |||  || |  ||   
IKWCWHNDPNKRPTMNQIIQYL
Kinase AqueK687.AA MLK 158-178 33 0.001517 8.32 In-house 271-291 (291) Show / Hide 
Range on Protein: 158-178
Range on HMM: 271-291/291
Sequence Identity: 33% (7 aa)

KNCLENDPAMRPNMSYIIRVI
|.| . ||. ||....|.   
KQCWNQDPHKRPSFRQIVQHL
Kinase AqueK687.AA Pkinase_Tyr 158-178 38 0.009076 10.0 Pfam 250-270 (270) Show / Hide 
Range on Protein: 158-178
Range on HMM: 250-270/270
Sequence Identity: 38% (8 aa)

KNCLENDPAMRPNMSYIIRVI
| | . ||..|| .|.|.. .
KQCWHYDPEDRPTFSEIHEQL
Kinase AqueK687.AA LISK 152-178 29 0.107548 1.05 In-house 270-296 (296) Show / Hide 
Range on Protein: 152-178
Range on HMM: 270-296/296
Sequence Identity: 29% (8 aa)

PLLPIVKNCLENDPAMRPNMSYIIRVI
|.|... .| . || .||. . |....
PFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase AqueK687.AA TKL-Unique 156-178 30 0.16497 1.31 In-house 268-290 (290) Show / Hide 
Range on Protein: 156-178
Range on HMM: 268-290/290
Sequence Identity: 30% (7 aa)

IVKNCLENDPAMRPNMSYIIRVI
. . |   ||  ||. . ||  .
LIQQCWHHDPSQRPSFDEIIHRL
SH2 AqueK687.AA SH2 309-399 34 1.4e-17 65.61 SMART 1-87 (87) Show / Hide 
Range on Protein: 309-399
Range on HMM: 1-87/87
Sequence Identity: 34% (32 aa)

HEWYYHNISNTIAKGILMEREKKNGTFIVGS--NSTGEYFLSVYFEKTISHIRIYRDTNGYYSLDTMHLYCDKDKSFASLDELVTFYRMNPLV
..||. |||   |  .|. .....|.|.|    .. |.| ||| ... . |.|| |. .| |..|.       ...| || ||| .|. |||.
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDET-----WRRKFPSL-ELVNHYQHNPLG
SH2 AqueK687.AA SH2 311-393 35 1.6e-17 53.27 Pfam 1-81 (81) Show / Hide 
Range on Protein: 311-393
Range on HMM: 1-81/81
Sequence Identity: 35% (31 aa)

WYYHNISNTIAKGILMEREKKNGTFIV-GSN-STGEYFLSVYFEK---TISHIRIYRDTNGYYSLDTMHLYCDKDKSFASLDELVTFY
||. .||   |  .||......|||.|  |  . |.| |||...     . |.|| |. ||       ..|.  .. |.|| ||| .|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNG-------GYYITGRHKFCSLQELVEHY