Gene AqueK693 (A.queenslandica)

AqueK693

Species: A.queenslandica
Alias: AqueK693
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
AqueK693.AA Protein None 520 None Fasta, JSON
AqueK693.kin_dom Protein Kinase Domain None 173 None Fasta, JSON

Protein domain

Protein domains of AqueK693.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK693.AA TKL 344-510 22 7.7e-35 122.07 In-house 1-244 (364) Show / Hide 
Range on Protein: 344-510
Range on HMM: 1-244/364
Sequence Identity: 22% (57 aa)

LGRGSYAVVTVGIFRG----------LRVAVKSLHNIIVSDYNL-------------------------GIFSREMSIASRVRHPNLVQFIGATK-----
.|.|....|  |..||            |||| ..   ..  ..                           . .|. . || ||||.|||.|. .     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------VGNPLILTELM-STSLNHEIRRNRLANQQILSIGQDVALGLNYLHLFKP-----QPIIHRDVSSPNILLKPC---------SRAAGYEAKV
          |.. | .|..   || | .       .|.... .|.|.|.||||  .|      ||||||  |.|||..           ...| . .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

ADYGTAKVV-------------------QANSTSTGTVMPGNVAYAAPEA
.|.|.....                   | |. .|     |. .. |||.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEV
Kinase AqueK693.AA MLK 338-510 24 9e-29 97.0 In-house 1-204 (291) Show / Hide 
Range on Protein: 338-510
Range on HMM: 1-204/291
Sequence Identity: 24% (50 aa)

TLTKEELGRGSYAVVTVGIFRGLR-----VAVKSLH----NIIVSDYNLGIFSREMSIASRVRHPN----LVQFIGA-TKVGN-PLILTELMST-SLNHE
 ...| .| ||. .|  | .|. .     ||||  .     . ...     | .|  ......|||     .|| |. .. ..  .|..| ..  ||.. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IRRNR---------------LANQQILSIGQDVALGLNYLHLFKPQPIIHRDVSSPNILLKP-CSRAAGYEAKVADYGTAKVVQANSTSTGTVMPGNVAY
.. .|                  ......  ..| |..|||  .|.||||||  |.|||.   |.  ..  .|..| ||.. .. .  .. . ..|..|.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

AAPEA
 |||.
MAPEV
Kinase AqueK693.AA TKL-Unique 340-509 27 4.2e-26 89.15 In-house 1-196 (290) Show / Hide 
Range on Protein: 340-509
Range on HMM: 1-196/290
Sequence Identity: 27% (54 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSLH-NIIVSDYNLGIFSREMSIASRVR-HPNLVQFIGATK---VGNP--LILTELMS----TSLNHE-------
  . .|.|.|..|  |..||  ||.|..| |  .|   .  |..| .. .. . |||.|...|...   | .|   | .| ..     .. |        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-IRRNRLANQQILSIGQDVALGLNYLHLFKPQPIIHRDVSSPNILLKPCSRAAGYEAKVADYGTAKVVQANSTSTGT--------VMPGNVAYAAPE
 .. . | .||.... .|.|.|..|||  .|  |||||  |.|.|.   |  | . .|..| |..|.   ....| .        .  |.  ..|||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE
Kinase AqueK693.AA Dicty4 340-509 29 1.9e-24 78.61 In-house 3-187 (277) Show / Hide 
Range on Protein: 340-509
Range on HMM: 3-187/277
Sequence Identity: 29% (56 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSL--HNIIVSDYNLGIFSREMSIASRVRHPNLVQFIGA-T----KVGNPLILTELM-STSLNHEIRR------N
. ...|.||.. |  |. ||  |||| |  ||. .. . |  | .| .| .  ||||...| || |    . | ..| ||.| ...|   ..        
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

RLANQ--QILS---IGQDVALGLNYLHLFKPQPIIHRDVSSPNILLKPCSRAAGYEAKVADYGTAKVVQANSTSTG--TVMPGNVAYAAPE
.   .   |..   .. |.|.|.|.||   |  |||||  | |.|       . . .||.| | ... .  .. .   . . | ... |||
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLV-----DKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPE
Kinase AqueK693.AA TK 338-483 14 2e-21 67.93 In-house 1-296 (486) Show / Hide 
Range on Protein: 338-483
Range on HMM: 1-296/486
Sequence Identity: 14% (44 aa)

TLTKEELGRGSYA---VVTVGIFRGL---------------------------RVAVKSLH---NIIVSDYNLGIFS---------REMSIASRVR----
    ..||.| .    .|  |. ||.                           .|||| |.   .    .  . ..          .|.....  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVQFIG-ATKVGN------------PLILTELMS-TS----LNHEIRRNR----------------------------------------------
 |||.|...|  |....            ..|..|.|.  .    | .  |..|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LANQQILSIGQDVALGLNYLHLFKP---QPIIHRDVSSPNILLKPCSRAA------GYEAKVADYG
                               |  .| | . ...| |. |||  .    | ..|||.   |.|.    . .      |. .|.||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG
Kinase AqueK693.AA STE 339-509 18 1.5e-19 65.83 In-house 1-232 (359) Show / Hide 
Range on Protein: 339-509
Range on HMM: 1-232/359
Sequence Identity: 18% (45 aa)

LTK-EELGRGSYAVVTVGIFR-----------------GLRVAVKSLH---------------NIIVSDYNLGIFSREMSIASRVR--HPNLVQFIGATK
... |..|.|.. .|  .. .                 | ..|.| ..               . .. . ..  . .|..| .. .  ||| |...|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG--------NPLILTELMS-TSLNHEIRRN---------------RLANQQILSIGQDVALG-LNYLHLFKPQPIIHRDVSSPNILLKPCSRAAGYEAK
..        .  |  |.|.  ||   |...               |.  .||  | ...  | |.|||  .   |||||. . ||||          .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------VK

VADYGTAKVVQAN--------------STS-TGTVMPGNVAYAAPE
 .| |... .. .              ...   . . |   . |||
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Pkinase_Tyr AqueK693.AA Pkinase_Tyr 337-483 25 1.2e-15 53.6 Pfam 1-156 (270) Show / Hide 
Range on Protein: 337-483
Range on HMM: 1-156/270
Sequence Identity: 25% (42 aa)

VTLTKEELGRGSYAVVTVGIFR------GLRVAVKSLHNIIVSDYN--LGIFSREMSIASRV-RHPNLVQFIGATK-VGNP---LILTELMST-SLNHEI
.|.  ..||.|.. .|  |. .      .. ||||.| .   .. .  .  | ||..| .   .|||.|...|.    | |   .| .|.|   .| .  
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RRN-----RLANQQILSIGQDVALGLNYLHLFKPQPIIHRDVSSPNILLKPCSRAAGYEAKVADYG
|..     .|  ...|.. ...| |..||.  .   .||||.   |.|..      .  .|..| |
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVT-----ENNVVKICDFG
Kinase AqueK693.AA LRRK 338-509 22 6.2e-15 49.25 In-house 1-249 (351) Show / Hide 
Range on Protein: 338-509
Range on HMM: 1-249/351
Sequence Identity: 22% (57 aa)

TLTKEELGRGSYA-VVTVGIFRG----------------------------LRVAVKSLHNI-----------------------------IVSDYNLGI
    |..|||... .|  ...||                              ||.|... .                             ....  . .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FS---REMSIASRVRHPNLVQFIGATKVGNPLIL-TELMST-SLNHEIR---RNRL----AN---QQILSIGQDVALGLNYLHLFKPQPIIHRDVSSPNI
|.   .|..| |. .|||.|. .| .   .||.. .|...  .|.| ..   ....    |.   . .| |  ..| |..||| ..| ||||||  ||||
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNI

LLKPCSRA-------AGYEAKVADYGTAKVVQANSTSTGTVMPGNVAYAAPE
||.  .         | . ||.||.|.  . |.  ..    . ||  . |||
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPE
Kinase AqueK693.AA HH498 430-509 42 1.7e-13 38.79 In-house 121-195 (284) Show / Hide 
Range on Protein: 430-509
Range on HMM: 121-195/284
Sequence Identity: 42% (34 aa)

QQILSIGQDVALGLNYLHLFKPQPIIHRDVSSPNILLKPCSRAAGYEAKVADYGTAKVVQANSTSTGTVMPGNVAYAAPE
| .. |  ||| | ||||   ..||||||  | |||.     . |  |.|||.|    |.     . |  |||  . |||
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH----EDGH-AVVADFGESRFVCDMHDDNMTKQPGNLRWMAPE
Kinase AqueK693.AA DRK 345-415 41 7.5e-13 39.9 In-house 8-80 (258) Show / Hide 
Range on Protein: 345-415
Range on HMM: 8-80/258
Sequence Identity: 41% (30 aa)

GRGSYAVVTVGIFRGLRVAVKSLHNIIVSDYN-LGIFSREMSIASRVRHPNLVQFIGA-TKVGNPLILTELMS
|||.|. |  |  ||  |||| | |  . | | |  | ||  . .. |||| .||.|. .    ..| .| |.
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMP
Kinase AqueK693.AA CZAK 433-466 57 2.3e-12 41.36 In-house 108-142 (279) Show / Hide 
Range on Protein: 433-466
Range on HMM: 108-142/279
Sequence Identity: 57% (20 aa)

LSIGQDVALGLNYLHL-FKPQPIIHRDVSSPNILL
...  |.| | ||||  .|| ||.||| || ||||
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
Kinase AqueK693.AA Pkinase 338-509 22 1.4e-11 42.04 Pfam 1-181 (293) Show / Hide 
Range on Protein: 338-509
Range on HMM: 1-181/293
Sequence Identity: 22% (43 aa)

TLTKEELGRGSYAVVTVGIFRGLR--VAVKSLHNIIVSDYNLGIFSR--EMSIASRVRHPNLVQFIGATK-VGNPLILTELMST-----SLNHEIR---R
  ... .|.||...|  .. .| .  |||| .     ..  . .  |  | .|  |..||| |.....    ... . .|..       .| . |.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NRL--ANQQILSIGQDVALGLNYLHLFKPQPIIHRDVSSPNILLK-PCSRAAGYEAKVADYGTAKVVQANSTSTGTVMPGNVA---YAAPE
...    ... ..   .. ||.|.|      |||||. . |||..  .  .|    |..| | ||...   .  .. | . .    |.|||
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPE
Kinase AqueK693.AA S_TKc 338-520 14 1.4e-10 -21.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 338-520
Range on HMM: 1-231/231
Sequence Identity: 14% (39 aa)

TLTKEELGRGSYAVVTVGIFRG--LRVAVKSLHNIIVSDYNLGIFSREMSIASRVRHPNLVQFIGATKVGNPLILTELMST---SLNHEIRRNR------
    ...|.|....|  .. ..   .||.| ..           . ||..| .. .|||.|.....   ..  . .|....   .| . |....      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LANQQILSIGQDVALGLNYLHLFKPQPIIHRDVSSPNILLKPCSRAAGYEAKVADYGTAKVVQANSTSTGTVMPGNVAYAAPEAPIPDQH---------
 .   .. .. . ....|.|.|  .   |||||.   ||||         . |..| | |...        | . |   | |||   .  .         
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQL--------TTFCGTPWYMAPEVL-GYGKCKCDWWSCG

---------------------------------------------------------SPAM
                                                          | .
CILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK693.AA TyrKc 338-520 15 1.7e-09 -69.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 338-520
Range on HMM: 1-280/280
Sequence Identity: 15% (47 aa)

TLTKEELGRGSYAVVTVGIFRGLRVAVKSLHNIIVSDYNLGIFSREMSIASRV--RHPNLVQFIGATKV--------GNPLILTELMST-SLNHEIRRNR
   ...||.| . .|  |. . . ||||.|..       .  | ||..| ...  .|||.|...|.           . ..|..|.|.  .|.. .|..|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LANQQILSIGQDVALGLNYLHLFKPQPIIHRDVSSPNILLKPCSRAAGYEAKVADYGTAKVVQAN--------STST----GTVMPGNVAYAAPEAP-
  | ... ||.  ..| | .|||     ..||||    |.|.     .... .|..| | .. .             ..    |. ..  .   |||.  
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLV-----GENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

----------------------------------------------------IPDQ---------------------------------HSPAM
                                                    .|.                                      .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK693.AA CZAK 339-414 30 2.1e-08 26.8 In-house 1-84 (279) Show / Hide 
Range on Protein: 339-414
Range on HMM: 1-84/279
Sequence Identity: 30% (26 aa)

LTKE-ELGRGSYAVVTVGIFRGLRVAVKSLHNIIVSDYNL----GIFSREMSIASRVRHPNLVQFIGATKVGN---PLILTELM
|. . . |.| .  |  .  ||  ||.| .| .   .        .| .| || |  .||| |||.||   ..     | .| |
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWM
Kinase AqueK693.AA HH498 340-402 33 4.4e-05 11.63 In-house 3-71 (284) Show / Hide 
Range on Protein: 340-402
Range on HMM: 3-71/284
Sequence Identity: 33% (23 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSLH-NIIVSDYN-----LGIFSREMSIASRVRHPNLVQFIGAT
..|  | ||.  |  | .|.  ||||    . . .           | || || .|  ||. |||..|.
FHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYAC
Kinase AqueK693.AA DRK 432-465 44 0.00077 8.93 In-house 100-132 (258) Show / Hide 
Range on Protein: 432-465
Range on HMM: 100-132/258
Sequence Identity: 44% (15 aa)

ILSIGQDVALGLNYLHLFKPQPIIHRDVSSPNIL
..... |.| |..|||   |  |||||  | | |
MKQMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLL