Gene AqueK698 (A.queenslandica)

AqueK698

Species: A.queenslandica
Alias: AqueK698
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
AqueK698.AA Protein None 455 None Fasta, JSON
AqueK698.kin_dom Protein Kinase Domain None 200 None Fasta, JSON

Protein domain

Protein domains of AqueK698.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK698.AA TKL 21-266 18 5.7e-43 149.08 In-house 1-355 (364) Show / Hide 
Range on Protein: 21-266
Range on HMM: 1-355/364
Sequence Identity: 18% (71 aa)

LGRGAYGVVTEVIVSG----------TTCAAKKLHPAIVQGYTL-------------------------KRFCDEVLLHSQQRHPNIVLLIG-VYYPRR-
.|.|..|.|   .  |          .. | ||..   ..  |.                         ...  |....|. ||||||...| . .|.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------SKLPMLVMEYLPL-S-LTQCLEREELPLQMKYSILLDVAKGLCYLHGKR------PPIVHRDLTANNVLLTSSYS--------------AK
         .. ...|||| |  | | . .      .. . .. ||.|.|..||| ..      |||.||||. .|.|. . .               .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

ISDLGVSRLAD---TFKMHE---------------LTTAPGNAMVMPPEALKDNP---------------VYDHKLDVFSYGCLILHVLTGQFPQPTNQF
|.|.| ||  .     .. .               . |  |.   |.||.|....                |. | ||.|.| ..  .||..        
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------

VQEPGKEPFKRVP--------------EWDRRSSYIKNIP--------------KVNELLPLAKHCLSDAPSSRP
       |..  |              ...   ..   ||                 ..  |...| .  |..||
-------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRP
Kinase AqueK698.AA TK 18-204 17 8.7e-33 106.66 In-house 4-384 (486) Show / Hide 
Range on Protein: 18-204
Range on HMM: 4-384/486
Sequence Identity: 17% (65 aa)

GKELGRGAYG---VVTEVIVSG---------------------------TTCAAKKLHPAIVQGYTLKR---------------FCDEVLLHSQ--QRHP
||.||.|..|   .| . .. |                           |..| | |..   .  . ..               .. |  . ..   .||
GKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHP

NIVLLIGVYYPRRS----------KLPMLVMEYLPL-----SLTQCLE--REE-----------------------------------------------
||| |.||    ..          . .|.|||| |.     || . |   |..                                               
NIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDD

----------------------------LPLQMKYSILLDVAKGLCYLHGKRP----PIVHRDLTANNVLLTSSYS-----------AKISDLGVSR---
                            |... .  . ...|.|. ||| |.      .||||| | |.|.....            .||.| | ||   
LIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGS

--LADTFKMHELTTAPG------------------------NAMV----MPPEALKDNP--------VYDHKLDVFSYGCLI
  ||     ..  .. .                        ....    |.||.|.|.         .. .| ||.|.|.|.
GVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
S_TKc AqueK698.AA S_TKc 15-275 22 4.4e-32 113.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-275
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

KETGKELGRGAYGVVTEVIV--SGTTCAAKKLHPAIVQGYTLKRFCDEVLLHSQQRHPNIVLLIGVYYPRRSKLPMLVMEYLPL---SLTQCLEREE---
 | ....|.||.|.|  ..   .|  .| |...         .... |. .... .||||| |..|..    .   .||||..    .| . ...     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTFKMHELTTAPGNAMVMPPEALKDNPVYDH-KLDVFSYG
    .|  .  ...  ....| |.| .   |.||||   |.||..    ||.| |..|.         ||  |    |.|| |     |.. | |. | |
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG

CLILHVLTGQFPQPTNQFVQEPGKEPFKRVPEWDRRSSYIKNIPKVNELLPLAKHCLSDAPSSRPEIVDSYH---------FV
|..   |.|. | |         .. ||..                 |.. . ..||   |. || . .  .         ..
CILYEMLCGYPPFP-------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK698.AA TKL-Unique 17-201 29 2.5e-31 107.81 In-house 1-215 (290) Show / Hide 
Range on Protein: 17-201
Range on HMM: 1-215/290
Sequence Identity: 29% (64 aa)

TGKELGRGAYGVVTEVIVSGTTCAAKKLHP-AIVQGYTLKRFCDEVLLHSQQR-HPNIVLLIGVYYPRRSKLP--MLVMEYLPL-SLTQCLE--------
 .. .|.|.||.|  ..  |.  | |..|| . .    .. | .|| . .  . |||||...|.      . |   .||||.|. ||   |         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

---REELPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSS-----YSAKISDLGVSRLADTF---KMHEL-----TTAPGNAMVMPPEALKD
     .|..|..... .|.|.|..||| . ||| ||||.  |.|...      ...||.| | |.....    .  |.     .|  |..  |.|| |..
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

N-PVYDHKLDVFSYG
|   |. | ||.|.|
NFCQYSEKSDVYSFG
Kinase AqueK698.AA Pkinase_Tyr 16-204 28 2.3e-27 93.28 Pfam 2-204 (270) Show / Hide 
Range on Protein: 16-204
Range on HMM: 2-204/270
Sequence Identity: 28% (59 aa)

ETGKELGRGAYGVVTEVIVS------GTTCAAKKLHPAIVQGY-TLKRFCDEVLLHSQQ-RHPNIVLLIGVYY-PRRSKLPMLVMEYLPL-SLTQCLERE
. ||.||.||.|.| . .        ....| |.| .   .    .. |  |. . .|  .||||| |.|| .  .... ...|||| |. .|   | . 
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

-----ELPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTFKMHELT-TAPGNAMV----MPPEALKDNPVYDHKL
      |..... .. ...|||. ||. |.  ..|||| | |.|.|..  .||.| | .|.       .   .. |....    |.||.....  . .| 
REDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKS

DVFSYGCLI
|| |.| |.
DVWSFGVLM
Kinase AqueK698.AA LRRK 15-213 25 8.1e-27 91.89 In-house 1-282 (351) Show / Hide 
Range on Protein: 15-213
Range on HMM: 1-282/351
Sequence Identity: 25% (73 aa)

KETGKELGRGAYG-VVTEVIVSG----------------------------TTCAAKKLHPA-----------------------------IVQGYTLKR
 . ....|||..| .|   .. |                            .. |.||..                               ..   ... 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FCD---EVLLHSQQRHPNIVLLIGV-YYPRRSKLPMLVMEYLPL-SLTQCLE---REE-------LPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTAN
|.    || . |  .||||| |.|.   |.     ..||||.|. .| . |.   . .       .. ..|. | |..|||. ||| ..|||.||||.  
FREFRHEVWIMSHLNHPNIVSLKGFCIHPL-----CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSP

NVLLTSS------------YSAKISDLGVSR-LADTFKMHELTTAPGNAMVMPPEALKDN--PVYDHKLDVFSYGCLILHVLTGQ-FP
|.|| ||            . |||.| | ||    .|.|  . .  ||   | || ...|   .|. | |..|.| .. . ||.| .|
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase AqueK698.AA HH498 109-213 38 4.5e-26 79.31 In-house 120-225 (284) Show / Hide 
Range on Protein: 109-213
Range on HMM: 120-225/284
Sequence Identity: 38% (41 aa)

LQMKYSILLDVAKGLCYLHG-KRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTFKMHELTTAPGNAMVMPPEALKDNPVYDHKLDVFSYGCLILHV
|| |  | .|||.|  |||    .||.||||.  |.|.     |.. | | ||         .|  |||   | ||  . .  |. | |||||.  |   
LQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEM

LTGQFP
.|.  |
HTREVP
Kinase AqueK698.AA STE 15-213 22 4.2e-25 85.66 In-house 1-267 (359) Show / Hide 
Range on Protein: 15-213
Range on HMM: 1-267/359
Sequence Identity: 22% (61 aa)

KETGKELGRGAYGVVTEVIVS-----------------GTTCAAKKLH---------------PAIVQGYTLKRFCDEVLLHSQQR--HPNIVLLIGVYY
 |  ...|.||.|.|   .                   |. .| |...               . ...   ....  |. .... .  |||||  .| |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

PR------RSKLPMLVMEYLP-LSLTQCLER-----EELP----------LQMKYSILLDVAKG-LCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLG
        ...|  ..|||..  ||.. ...     ..|.           .    |. .. || | ||| ..  |.|||. . |.||     .|..| |
KEGHNHKNDDEL-WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFG

VSR-LADTFK-------------MH-ELTTAPGNAMVMPPEALKD-----NPVYDHKLDVFSYGCLILHVLTGQFP
|.  |.|.               |  . .|  |    | || ..      .. || | |. | ||.|.. .||. |
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP
Kinase AqueK698.AA Dicty4 16-201 29 3.9e-24 77.54 In-house 2-204 (277) Show / Hide 
Range on Protein: 16-201
Range on HMM: 2-204/277
Sequence Identity: 29% (61 aa)

ETGKELGRGAYGVVTEVIVSGTTCAAKKL--HPAIVQGYTLKRFCDEVLLHSQQRHPNIVLLIGVYY-PRRSK-LPMLVMEYLPL-SLTQCLER------
 .....|.|..| |   .. |.  | |||  |   .  ..|. |  || . .. |||||.|. |    ||  .  .. |.||.|  .|   |        
NIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQ

EELPLQ--MKYS---ILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTFKMHEL--TTAPGNAMVMPPEALKDNPVYDHKLDV
.. .|.     .   . .|.|.|. .||.  | |.|||| . | |   .. .|..|.| |..  . ..|    .|| | .  | || .  .| |. | ||
QSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQP-YNEKADV

FSYG
.|.|
YSFG
Kinase AqueK698.AA TK-Unique 15-204 26 1.1e-23 78.61 In-house 1-229 (294) Show / Hide 
Range on Protein: 15-204
Range on HMM: 1-229/294
Sequence Identity: 26% (62 aa)

KETGKELGRGAYGVVTEVIVSG-------TTCAAKKLHPAIVQGYTLKRFCDEVLLHSQQR-HPNIVLLIGVYYPRRSKLPMLVMEYLPLS-----LTQC
 | |...|.||.| |    |.|       ..|.| |.. . ... . . | .|  ....   ||||| ..|.        .|..|||.| .     | .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

L-----------------------EREELPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSR-LADTFKMHELTT-APGN
                        ..|.. ..  |... ..|.|. ||.. |  |||||| | |||||. . .||.|.| .| . .. .    ..  .  
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

AMVMPPEALK--DNPVYDHKLDVFSYGCLI
 . |.||.||  ... .  | || |.|.|.
IRWMAPESLKCYHGMYHTTKSDVWSFGVLM
Kinase AqueK698.AA Pkinase 15-213 25 2.8e-23 83.42 Pfam 1-211 (293) Show / Hide 
Range on Protein: 15-213
Range on HMM: 1-211/293
Sequence Identity: 25% (55 aa)

KETGKELGRGAYGVVTEVIVSGTTC-----AAKKLHPAIVQGYTLKRFCDEVLLHSQQRHPNIVLLIGVYYPRRSKLPMLVMEYLPL-----SLTQCLE-
 ..|. .|.|..|.| . .  || .       || |    . .|. |   |. ..   .||||| |.....   .. . .||||..      .|   .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

REELPL--QMKY--SILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSA----KISDLGVSRLADTFKMHELTTAPGNAMVMPPEALKDNPVYDHKL
... ..  ...   .... ...|| |.| .   |.||||   |.|. . .      ||.| |.....|. . . .||  |    |.|| ..... |..| 
WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVFSYGCLILHVLTGQFP
|..|.||..  .|.|..|
DMWSCGCILYEMLCGRPP
Kinase AqueK698.AA Ciliate-E2-Unclassified 16-221 18 7.1e-23 76.2 In-house 2-277 (352) Show / Hide 
Range on Protein: 16-221
Range on HMM: 2-277/352
Sequence Identity: 18% (52 aa)

ETGKELGRGAYGVVTEVIVSGTT--CAAKKLHPAIVQGYTLKRFCD---EVLLHSQQR------------------HPNIVLLIGVYYPRRSKLPMLVME
. .| .|.|..|.| ... . .    | | .. ....   .... |     ... ...                  ||.....  .|. .  . . .|||
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

YLP-LSLTQCLE------------------REELPLQMKY-----SILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSY---SAKISDLGVSRLADTF
|.. ..| |...                  |.... |         ..  . .||.||| |   |.|||.. .|.|....      ||.|.| |.  ...
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------KMHELTTAPGNAMVM----PPEALKDNPVYD---HKLDVFSYGCLILHVLTGQFPQPTNQFVQ
              | ....|  |. . |    .|| |. .  ..   .| |..| |...   |.|..| . |.  |
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQ
Kinase AqueK698.AA RIPK 21-213 25 2.2e-22 73.05 In-house 1-227 (290) Show / Hide 
Range on Protein: 21-213
Range on HMM: 1-227/290
Sequence Identity: 25% (57 aa)

LGRGAYGVVTEVI-VSGTTCAAKKLHPAIV-----QGYTLKRFCDEVLLHSQQRHPNIVLLIGVYYPR----RSKLPMLVMEYLPL-SLTQCLEREE---
.|.|. | |  .  ..  . .|||  |        .    .    |.    . |. .|| . |.         .||. .|||| .  ||   | ..    
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTFKMHE----------LTTAP--GNAMVMPPEALK---DN
   .|.  .  ..  .. | ||||.. ||| ||||   |.|. . . .||.|.|..    . . |            . ..  |    ||||..     .
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKK

P--VYDHKLDVFSYGCLILHVLTGQFP
|  | . | || |.. ..  |||.  |
PIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase AqueK698.AA TyrKc 15-275 24 1.1e-17 63.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-275
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

KETGKELGRGAYGVVTEVIVSGTTCAAKKLHPAIVQGYTLKRFCDEVLLHSQQ--RHPNIVLLIGVYYPR-----RSKLPMLVMEYLPL-SLTQCLEREE
 . ||.||.||.|.| . . . ...| |.|..       .. |..|  . ..   .||||| |.||          .. .|.|||| |. .| . | . .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTF----KMHELTTA----PGNAMV----MPPEALKDNPVYD
  |... . |. ...|.|  ||| |  ...|||| | |.|... . .|||| | ||  .        ..  ..     |..|.    |.||..... .. 
PKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG-KFT

HKLDVFSYGCLILHVLTGQFPQPTNQFVQEPGKEPFKRVPEWDRRSSYIKNIPK---------VNELLPLAKHCLSDAPSSRPEIVDSYHFV
.| ||.|.| ..  ..|   . . ..  |   . . ..| |. ..  . .  |            |.  . | |    |..||   . ... 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF