Gene CDK11b (Human)

CDK11b

Species: Human
Alias: CDK11b
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK11

Sequence

Name Sequence Type Origin Length Description Download
CDK11b.AA Protein None 793 None Fasta, JSON
CDK11b.NA RNA None 2861 None Fasta, JSON
CDK11b.kin_dom Protein Kinase Domain None 286 None Fasta, JSON

Protein domain

Protein domains of CDK11b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK11b.AA PITSLRE 436-721 75 8.8e-242 809.52 In-house 1-295 (295) Show / Hide 
Range on Protein: 436-721
Range on HMM: 1-295/295
Sequence Identity: 75% (223 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKME--KEKEGFPITSLREINTILKA-QHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMK---
|||||||.|||||||||||||.|||||||||||||  |||||||||||||||.||.| ||||||.|.|||.||||||||.||.|||||||||||.||   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

QPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGEL
|||.|||.|.||.||||||.|.|||||.||||||||||.||.||||..|||||||||||.|.|||.||| ||||||||||.|.|||.||||||||||.|.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

LTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT-FSEHPYNNLRKRFG--ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF
.|.||||.|.|||||||..|||.|||.||||||..|||..|.|. |...|||||||||.  ...||.||||.|..|||.| .||.|.|.|||..|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDK11b.AA CDK 436-721 45 4.1e-172 555.1 In-house 1-284 (284) Show / Hide 
Range on Protein: 436-721
Range on HMM: 1-284/284
Sequence Identity: 45% (146 aa)

FQCLNRIEEGTYGVVYRAKDKKTD-----EIVALKRLKMEK-----EKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMD---------KIYIVMNY
...|..| ||||||||.|.||.|.     .|||||...||.     ||||||||..|||..  .  |||||.........|||         |.|.|. |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGI-----LKVGDFGLAREYGS------PLKAYTPVVVTQWYRAPE
..||||..|.          .|..| |||||. ..|.|||.|||||..|.|... |.     ||..||||||..|.      |...||..||| ||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLLGAKEYS--TAVDMWSVGCIFGELLT---QKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNK
||||.|.||  |..|||||||||.|..|    ||||||.|||||. |.|. .|||.|..||| ..||                            ||.||
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNK

FLTYFPGRRISAEDGLKHEYF
.|.| | .|||||. |.|.||
MLCYDPKKRISAEQALQHPYF
Kinase CDK11b.AA CDK10 436-721 55 2.5e-143 482.46 In-house 1-285 (285) Show / Hide 
Range on Protein: 436-721
Range on HMM: 1-285/285
Sequence Identity: 55% (160 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG
|  |||. |||||.||||.| ..|||||||. .|.|||.| || .||||  ... .|.||| ..|.|||  .| |..||.| | || ||.. | |||   
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPFTET

EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPL
.|| .|.|.|||.| ||||...||||| ||||..  | .|| |||||| || | |  || .|| ||||||||||...  ||.||| |||| |||| .|||
QVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVHKPL

FPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF
.|||||| ||. . . ||||||.||||.|.||.|.. | .. |||||...|  .||. |  |.|  . | | .|  ||. |. .||
MPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKF-HWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase CDK11b.AA CDC2 436-721 45 3.8e-141 436.8 In-house 1-301 (301) Show / Hide 
Range on Protein: 436-721
Range on HMM: 1-301/301
Sequence Identity: 45% (138 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG--FPITSLREINTILKAQ-HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLME-TMK--
.|....| ||||||||..||..|..|||||. . | | ||  .| |..||| .. . . |||||. .....     |.|.|  |...||| .|.   .  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

QPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV--VVTQWYRAPELLLGAKEYSTAVDMWSVGCIFG
... |  || .|.|.|.|| ..| . |.||||| .|.|.. .| .|..||||||  | |...||.   ||| ||||||.|||.| |||.|||||.|||| 
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EL---LTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGA--------LLSDQGFDLMNKFLTYFPGRRISAEDGL
|.    | ||||.| |||||. |.|. ||||.|..||| ..||   |.|| . . ..|.| .           | ..|.|| .. | | | .||||.. |
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDY-KNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEAL

KHEYF
.| ||
QHPYF
Kinase CDK11b.AA CMGC 436-721 27 2.9e-139 460.76 In-house 1-513 (513) Show / Hide 
Range on Protein: 436-721
Range on HMM: 1-513/513
Sequence Identity: 27% (140 aa)

FQCLNRIEEGTYGVVYRAKD--------------KKTDEIVALKRLK---MEK------EKEGFPITSLREINTILKAQ-----------------HPNI
......| ||||||||...|              ..|.||||.|..|   .|       ||.||||..||||    . .                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VTVREIVVGSNMD---------------KIYIVMNYVEHDLKSLMETMK--------QPFLPGE------------VKTLM------IQLLRGVK--HLH
|. ..|.. .|.|               ..|.|. |..|||. ... ..        .|. . .            .| .|       |.|||.|  ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

DNW--ILHRDLKTSNLLLSHA--------------------GILKVGDFGLAREYGSP---------------------LKAYTPVVVTQWYRAPELLLG
 .|  |.||||| .|.|..|                     |.||..|||||| |...                     ...||. ||| ||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

AKEYS---------TAVDMWSVGCIFGELLTQ--------KPLFPGNSE-----------IDQINKVFKELGTPS---------------EKIWPGYSEL
.|.|.         |..|||||||||.|..|         ||||||.||           |||..| || ||||.               |..||....|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PVVKK-------------MT------------FSEHPYNNLRKRFGA----------------------------------LLSDQGFDLMNKFLTYFPG
|  .|             ..            | ..|...... |                                    ....|..||..| |.| | 
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

RRISAEDGLKHEYF
.||.||. |.|.||
KRITAEQALQHPYF
Kinase CDK11b.AA CDK7 436-721 40 8.70000000001e-139 372.42 In-house 1-288 (288) Show / Hide 
Range on Protein: 436-721
Range on HMM: 1-288/288
Sequence Identity: 40% (120 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLK----MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQP
.. .  | ||....||.| |..|..||| |. |     .  | |   | .|||      ||.|..  . |      . |. |. . . ||    .  .  
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFM--HKSNIQLVFDFMDWDLEVVIKDKSII

FLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLT
. | ..|  |...|.|. ..| |||||||||  |||..  |.||..|||||| |||| ..||. ||| |||||||| ||. | |.|||||||||| ||. 
LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML

QKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPY---NNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF
  | .|| |.|||. ..|. ||||.|. ||. ....    ..| ..|      ||..| |  ||   ||| . .|  | .|... . ||..||
RVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY--IKFKDFPGYSRTPLRHIFTA-ASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDK11b.AA CDK5 436-721 41 1.7e-118 376.18 In-house 1-287 (287) Show / Hide 
Range on Protein: 436-721
Range on HMM: 1-287/287
Sequence Identity: 41% (121 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG
.. ...| |||||.||.|..|.| ||||||| ... | || | | .|||  .   .|.|||    ..   .  |. .|  ..  |||  |. ..    . 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEK--KLTLVFEFCDQDLKKYMDSCNGEMDMH

EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELL-TQKP
 .| .| |||.|.   |.. .||||||  ||| .  |.|| .|||||| .| | . |.  ||| |||.|  |.|.| ||| .||||.|||| |.  . .|
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRP

LFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVK--KMTFSEHPYNN-LRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF
|||||.. ||  ..|| .|||.|  ||. ..||  |     .  .| .  . .     |. .| ||..| | . |  ||||...|.| ||
LFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK11b.AA CRK7 436-721 36 2.8e-108 366.02 In-house 1-343 (343) Show / Hide 
Range on Protein: 436-721
Range on HMM: 1-343/343
Sequence Identity: 36% (126 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE---KEGFPITSLREINTILKAQHPNIVTVREIVVG------SNMDK--IYIVMNYVEHDLKSL
.. .. | ||||| || ||.|.| |.||||...|. |   |||||||. |||      .|.|||. .|||.       .. .|  .| |  |. |||  |
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

METM-KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPL--KAYTPVVVTQWYRAPELLLGAKEY--------
.|    . | ....| .| ||| |.  .|.. .||||.| ||.|.   |..|  |||||| | |    . ||  |.| |||.||||||...|        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------STAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLR
                               ...||||.|||.|||.|.||.|.|| |..|. |..|  |.|    ||   .||  . |         ||
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

KRFGA-----LLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF
. |       ... . .||. | |.. |  |..||. | |..|
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK11b.AA S_TKc 436-721 27 2.9e-94 320.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 436-721
Range on HMM: 1-231/231
Sequence Identity: 27% (84 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEH---DLKSLMETMKQP-
.. |. | .|..|.||....|||..|||.|..|         .. .|||.   | .|||||.  .. .    |..|.|| |...   ||..... .. . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYST-AVDMWSVGCIF
    | . ... .| |........|...|.||||| .|.||..   .|..||||||..       | ...| ||.|||.|     |.. ..|.||.|||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

GELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLK-------HE
 |.|. .|.||      |....|| .|                                     |... |...| |.. | .|..| . |.       |.
YEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

YF
.|
WF
Kinase CDK11b.AA CDK4 436-721 41 7.7e-91 308.1 In-house 1-290 (290) Show / Hide 
Range on Protein: 436-721
Range on HMM: 1-290/290
Sequence Identity: 41% (123 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKE--GFPITSLREINTILK----AQHPNIVTVREIVVGSNMDK----IYIVMNYVEHDLKSLM
.||.. | || || |||| | .|  .||||. .   . |  | |.  .||| ....      |||||   ..   .  |     | .|.  .. ||. ..
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREI-SVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYL

ETMKQPFLPGE-VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGC
. . .| .| . .| .| ||||||  || . | |||||  |.|..  | .|  ||||||.|..   | |||||| |||||| || .  | | ||||||||
DKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQM-ALTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGC

IFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF
|| |.   .|||.|.|| ||  |.|.  |.| |. ||  . ||      |      .... |   .. || ||..| |.| . .|.||. .|.| ||
IFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP---WDHFPQRHPRPFKD-FCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDK11b.AA PFTAIRE 436-721 39 7.8e-87 294.78 In-house 1-287 (287) Show / Hide 
Range on Protein: 436-721
Range on HMM: 1-287/287
Sequence Identity: 39% (115 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG
.. |..  ||.|  ||... . .  .||||  ....| || | |  ||       .| |||.   |.         .|  ||. ||.  |.       | 
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQE-EGTPFTAIREASLLKNLKHANIVCLHDIIHTKET--LTFVFEYVHTDLCQYMDKHPGGMHPN

EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPL
 |.  . |||||    |   .||||||  |||.||.| ||  ||||||    | . |   ||| ||| |  |||. |||| .||| ||||| |... .|.
NVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPA

FPGN-SEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFS--EHPYNNLRKRFGALL-SDQGFDLMNKFLTYFPGRRISAEDGLKHEYF
|||     || .|.|| |||| |  ||| ..||  |.  |    .   .|.. .  ..   ...|||.|.| ..|  |.||.. ..|.||
FPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDK11b.AA Pkinase 436-721 31 4.9e-86 296.93 Pfam 1-293 (293) Show / Hide 
Range on Protein: 436-721
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR--EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM-----
.... .| .|..|.||....|.| .|||.|..| ..||.....| .|  ||   .. .|||||. ....     |.||.|| |.|..|. .|. .     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYIST

--KQPF--LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGIL----KVGDFGLAREY-GSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDM
  . .|   . |.|  | |.|||....|...|.||||| .|.|... | .    |..|||||. .   .   .| ...| ||.|||...|...|...|||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSVGCIFGELLTQKPLFPGN----SEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG
||.|||. |.|. .|.|||     . .||. .... .|.| .  ||  .. .  .  .. . .    ...|  ..|. . |.... |.. | .|..||. 
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQI

LKHEYF
|.|..|
LQHPWF
Kinase CDK11b.AA Pkinase_Tyr 444-621 30 1e-15 53.87 Pfam 9-199 (270) Show / Hide 
Range on Protein: 444-621
Range on HMM: 9-199/270
Sequence Identity: 30% (61 aa)

EGTYGVVYRAKDK----KTDEIVALKRL---KMEKE--KEGFPITSLREINTILKA-QHPNIVTVREIVV--GS-NMDKIYIVMNYVEH-DLKSLMETM-
|| .|.||... |    .|.  || | |    |...  .| |    .||...  .  .|||||    ...  |  |  .||||| |..| ||..   .  
EGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHR

--KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQ-------WYRAPELLLGAKEYSTAVDM
  |||. . .     .|  .|  .|... . |||| . | |... .. |..||||||      . |  .....       |. ||| .   | ..|. | 
EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDV

WS
||
WS
Kinase CDK11b.AA TyrKc 436-721 23 4.1e-13 -10.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 436-721
Range on HMM: 1-280/280
Sequence Identity: 23% (74 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKA--QHPNIVTVREIVVGS-----NMDKIYIVMNYVEH-DLKSLMET
 . .  . || .|.||... |   . || | || .. .| |    .||..   |   .|||||    ... .       . ..||| |..| |||.    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDF----MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-----LKAYTPV---VVTQ------WYRAPELLLGAKEY
 .  . . .    ..|  .|  .||.. . |||| . | |... .. |..||||.|. ..       | |  .     .       |. ||| .   ...
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

STAVDMWSVGCIFGELLTQ-KPLFPG-------NSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF
.|. | || |    |..|  ..  ||       |.|. .  |  . .  | .   |  |                     |    .|  ...| .   . 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS---------------------F-VCCPDEMYQIMKQCWHED

PGRRISAEDGLKHEYF
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PEDRPTFSEI--HECF