Gene CDK11 (Mouse)

CDK11

Species: Mouse
Alias: CDK11, Cdc2l1
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK11

Sequence

Name Sequence Type Origin Length Description Download
CDK11.AA Protein None 784 None Fasta, JSON
CDK11.NA RNA None 2589 None Fasta, JSON
CDK11.kin_dom Protein Kinase Domain None 286 None Fasta, JSON

Protein domain

Protein domains of CDK11.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK11.AA PITSLRE 427-712 75 1.6e-242 811.94 In-house 1-295 (295) Show / Hide 
Range on Protein: 427-712
Range on HMM: 1-295/295
Sequence Identity: 75% (223 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKME--KEKEGFPITSLREINTILKA-QHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMK---
|||||||.|||||||||||||.|||||||||||||  |||||||||||||||.||.| ||||||.|.|||.||||||||.||.|||||||||||.||   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

QPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGEL
|||.|||.|.||.|||.||.|.|||||.||||||||||.||.||||..|||||||||||.|.|||.||||||||||||||.|.|||.||||||||||.|.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

LTQKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMT-FSEYPYNNLRKRFG--ALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYF
.|.||||.|||.|||||.|||..|||.||||||...||..|.|. |..||||||||||.  ...||.||||.|..|||.| .||.|.|.|||..|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDK11.AA CDK 427-712 45 1.4e-171 553.34 In-house 1-284 (284) Show / Hide 
Range on Protein: 427-712
Range on HMM: 1-284/284
Sequence Identity: 45% (145 aa)

FQCLNRIEEGTYGVVYRAKDKKTD-----EIVALKRLKMEK-----EKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMD---------KIYIVMNY
...|..| ||||||||.|.||.|.     .|||||...||.     ||||||||..|||..  .  |||||.........|||         |.|.|. |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VEHDLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGI-----LKVGDFGLAREYGS------PLKAYTPVVVTLWYRAPE
..||||..|.          .|..| |||.|. ..|.|||.|||||..|.|... |.     ||..||||||..|.      |...||..||||||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLLGAKEYS--TAVDMWSVGCIFGELLT---QKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNLRKRFGALLSDQGFDLMNK
||||.|.||  |..|||||||||.|..|    ||||||.|.|||. |||. .|||.|..|||  .||                            ||.||
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNK

FLTYYPGRRINAEDGLKHEYF
.|.| | .||.||. |.|.||
MLCYDPKKRISAEQALQHPYF
Kinase CDK11.AA CDC2 427-712 45 3.4e-143 443.23 In-house 1-301 (301) Show / Hide 
Range on Protein: 427-712
Range on HMM: 1-301/301
Sequence Identity: 45% (138 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG--FPITSLREINTILKAQ-HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLME-TMK--
.|....| ||||||||..||..|..|||||. . | | ||  .| |..||| .. . . |||||. .....     |.|.|  |...||| .|.   .  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

QPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV--VVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG
... |  || .|.|.|.|| ..| . |.||||| .|.|.. .| .|..||||||  | |...||.   ||||||||||.|||.| |||.|||||.|||| 
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EL---LTQKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNLRKRFGA--------LLSDQGFDLMNKFLTYYPGRRINAEDGL
|.    | ||||.|.| |||. |||. ||||.|..|||  .||   |.|| ... ..|.| .           | ..|.|| .. | | | .||.|.. |
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDY-KNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEAL

KHEYF
.| ||
QHPYF
Kinase CDK11.AA CDK10 427-712 55 5.9e-142 477.89 In-house 1-285 (285) Show / Hide 
Range on Protein: 427-712
Range on HMM: 1-285/285
Sequence Identity: 55% (159 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG
|  |||. |||||.||||.| ..|||||||. .|.|||.| || .||||  ... .|.||| ..|.|||  .| |..||.| | || ||.. | |||   
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPFTET

EVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPL
.|| .|.|.| |.| ||||...||||| ||||..  | .|| |||||| || | |  || .|||||||||||||...  ||.||| |||| |||| .|||
QVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVHKPL

FPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYF
.|| |.| ||. | . ||||||.||||. |||.|.. | .. |||||...|  .||. |  |.|  . | | .|  ||. |. .||
MPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKF-HWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase CDK11.AA CMGC 427-712 27 8.60000000001e-139 459.18 In-house 1-513 (513) Show / Hide 
Range on Protein: 427-712
Range on HMM: 1-513/513
Sequence Identity: 27% (139 aa)

FQCLNRIEEGTYGVVYRAKD--------------KKTDEIVALKRLK---MEK------EKEGFPITSLREINTILKAQ-----------------HPNI
......| ||||||||...|              ..|.||||.|..|   .|       ||.||||..||||    . .                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VTVREIVVGSNMD---------------KIYIVMNYVEHDLKSLMETMK--------QPFLPGE------------VKTLM------IQLLSGVK--HLH
|. ..|.. .|.|               ..|.|. |..|||. ... ..        .|. . .            .| .|       |.| |.|  ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

DNW--ILHRDLKTSNLLLSHA--------------------GILKVGDFGLAREYGSP---------------------LKAYTPVVVTLWYRAPELLLG
 .|  |.||||| .|.|..|                     |.||..|||||| |...                     ...||. |||.||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

AKEYS---------TAVDMWSVGCIFGELLTQ--------KPLFPGKSD-----------IDQINKIFKDLGTPS---------------EKIWPGYNDL
.|.|.         |..|||||||||.|..|         ||||||.|.           |||..|||| ||||.               |..||....|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PAVKK-------------MT------------FSEYPYNNLRKRFGA----------------------------------LLSDQGFDLMNKFLTYYPG
|  .|             ..            | ..|...... |                                    ....|..||..| |.| | 
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

RRINAEDGLKHEYF
.|| ||. |.|.||
KRITAEQALQHPYF
Kinase CDK11.AA CDK7 427-712 41 1.4e-136 366.41 In-house 1-288 (288) Show / Hide 
Range on Protein: 427-712
Range on HMM: 1-288/288
Sequence Identity: 41% (122 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLK----MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQP
.. .  | ||....||.| |..|..||| |. |     .  | |   | .|||      ||.|..  . |      . |. |. . . ||    .  .  
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFM--HKSNIQLVFDFMDWDLEVVIKDKSII

FLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLT
. | ..|  |...| |. ..| |||||||||  |||..  |.||..|||||| |||| ..||. ||| |||||||| ||. | |.|||||||||| ||. 
LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML

QKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPY---NNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYF
  | .|| |||||. .||. ||||.|. ||.   ..    ..| ..|      ||..| |  ||   ||| . .|  | .|. . . ||..||
RVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY--IKFKDFPGYSRTPLRHIFTA-ASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDK11.AA CDK5 427-712 42 1.5e-118 376.33 In-house 1-287 (287) Show / Hide 
Range on Protein: 427-712
Range on HMM: 1-287/287
Sequence Identity: 42% (122 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG
.. ...| |||||.||.|..|.| ||||||| ... | || | | .|||  .   .|.|||    ..   .  |. .|  ..  |||  |. ..    . 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEK--KLTLVFEFCDQDLKKYMDSCNGEMDMH

EVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELL-TQKP
 .| .| ||| |.   |.. .||||||  ||| .  |.|| .|||||| .| | . |.  |||||||.|  |.|.| ||| .||||.|||| |.  . .|
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRP

LFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVK--KMTFSEYPYNN-LRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYF
|||| .. ||  .||| .|||.|  ||.  .||  |     .  || .  . .     |. .| ||..| | . |  || |...|.| ||
LFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK11.AA CRK7 427-712 36 5.1e-108 365.17 In-house 1-343 (343) Show / Hide 
Range on Protein: 427-712
Range on HMM: 1-343/343
Sequence Identity: 36% (126 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE---KEGFPITSLREINTILKAQHPNIVTVREIVVG------SNMDK--IYIVMNYVEHDLKSL
.. .. | ||||| || ||.|.| |.||||...|. |   |||||||. |||      .|.|||. .|||.       .. .|  .| |  |. |||  |
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

METM-KQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPL--KAYTPVVVTLWYRAPELLLGAKEY--------
.|    . | ....| .| ||| |.  .|.. .||||.| ||.|.   |..|  |||||| | |    . ||  |.|||||.||||||...|        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------STAVDMWSVGCIFGELLTQKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNLR
                               ...||||.|||.|||.|.||.|.|.  ..|. ||.|  |.|    ||   .||  . |         ||
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

KRFGA-----LLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYF
. |       ... . .||. | |.. |  |. ||. | |..|
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK11.AA S_TKc 427-712 27 2.9e-95 323.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 427-712
Range on HMM: 1-231/231
Sequence Identity: 27% (84 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEH---DLKSLMETMKQP-
.. |. | .|..|.||....|||..|||.|..|         .. .|||.   | .|||||.  .. .    |..|.|| |...   ||..... .. . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYST-AVDMWSVGCIF
    | . ... .| |........|...|.||||| .|.||..   .|..||||||..       | ...|.||.|||.|     |.. ..|.||.|||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

GELLTQKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLK-------HE
 |.|. .|.||      |....|| .|                                     |... |...| |.. | .|. | . |.       |.
YEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

YF
.|
WF
Kinase CDK11.AA CDK8 431-712 34 3e-94 295.92 In-house 1-329 (329) Show / Hide 
Range on Protein: 431-712
Range on HMM: 1-329/329
Sequence Identity: 34% (113 aa)

NRIEEGTYGVVYRAKDKKT----DEIVALKRLKMEK------EKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDL-------K
  |  |||| || ||.||.    .  .|||... ||      | .|.  .  |||  .   .|||... ...    .  ...... | ||||       .
KYIGRGTYGHVYKAKRKKQKKKPNKEYALKQFRTEKDGVEQLEGTGISMSACREIALCRELHHPNVICLQRVFLNHKDKCVWMLFDYAEHDLWHIIKFHR

SLMETMKQPF-LPGE-VKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAG------ILKVGDFGLAREYGSPLKAYT---PVVVTLWYRAPELLLGAK
    .||.|  .|   || .| |.|.|.  || ||.|||||| .| ..   |        |..|.|.|| . .|||      |||||.|||||||||||.
HNKAHMKDPTMVPRNMVKSIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMCGCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELLLGAR

EYSTAVDMWSVGCIFGELLTQKPLFPGKSD-----------IDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTF-----SEYPYNNLRKRFGAL---LSD
 |  |.| |..|||| ||.| .|.|..|              ||. .||. .|.|..|.||    .|  ....      ..|| . | . ...       
HYTKAIDIWAIGCIFAELITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMGFPQDKMWPDIKKMPEHQRLMKDFRRMQTYPNCSLHWYMEKHKIKRDS

QGFDLMNKFLTYYPGRRINAEDGLKHEYF
. ..|  | ||. |  || .|. . | ||
HAYHLLYKMLTMDPTKRITCEQAMEHPYF
Kinase CDK11.AA CDK4 427-712 40 2.9e-91 309.48 In-house 1-290 (290) Show / Hide 
Range on Protein: 427-712
Range on HMM: 1-290/290
Sequence Identity: 40% (121 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKE--GFPITSLREINTILK----AQHPNIVTVREIVVGSNMDK----IYIVMNYVEHDLKSLM
.||.. | || || |||| | .|  .||||. .   . |  | |.  .||| ....      |||||   ..   .  |     | .|.  .. ||. ..
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREI-SVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYL

ETMKQPFLPGE-VKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGC
. . .| .| . .| .| |||.||  || . | |||||  |.|..  | .|  ||||||.|..   | ||||||||||||| || .  | | ||||||||
DKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQM-ALTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGC

IFGELLTQKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYF
|| |.   .|||.|.|. ||  |||.  |.| |. ||   |  ..    |  .   .... |   .. || ||..| |.| . .|. |. .|.| ||
IFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWP--RDV-SLPWDHFPQRHPRPFKD-FCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDK11.AA Pkinase 427-712 31 6.3e-88 303.22 Pfam 1-293 (293) Show / Hide 
Range on Protein: 427-712
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR--EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM-----
.... .| .|..|.||....|.| .|||.|..| ..||.....| .|  ||   .. .|||||. ....     |.||.|| |.|..|. .|. .     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYIST

--KQPF--LPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGIL----KVGDFGLAREY-GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDM
  . .|   . |.|  | |.|.|....|...|.||||| .|.|... | .    |..|||||. .   .   .| ...|.||.|||...|...|...|||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSVGCIFGELLTQKPLFPGK----SDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDG
||.|||. |.|. .|.|||.    . .||. .|....|.| .  ||  .. .  .  .. . .    ...|  ..|. . |.... |.. | .|..||. 
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQI

LKHEYF
|.|..|
LQHPWF
Kinase CDK11.AA Pkinase_Tyr 435-612 30 2.9e-15 52.32 Pfam 9-199 (270) Show / Hide 
Range on Protein: 435-612
Range on HMM: 9-199/270
Sequence Identity: 30% (61 aa)

EGTYGVVYRAKDK----KTDEIVALKRL---KMEKE--KEGFPITSLREINTILKA-QHPNIVTVREIVV--GS-NMDKIYIVMNYVEH-DLKSLMETM-
|| .|.||... |    .|.  || | |    |...  .| |    .||...  .  .|||||    ...  |  |  .||||| |..| ||..   .  
EGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHR

--KQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTL-------WYRAPELLLGAKEYSTAVDM
  |||. . .     .|  .|  .|... . |||| . | |... .. |..||||||      . |  ....        |. ||| .   | ..|. | 
EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDV

WS
||
WS
Kinase CDK11.AA TyrKc 427-712 21 1.4e-13 -3.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 427-712
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKA--QHPNIVTVREIVVGS-----NMDKIYIVMNYVEH-DLKSLMET
 . .  . || .|.||... |   . || | || .. .| |    .||..   |   .|||||    ... .       . ..||| |..| |||.    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDF----MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP------LKAYTP-----VV--VTLWYRAPELLLGAKEYS
 .  . . .    ..|  .|  .||.. . |||| . | |... .. |..||||.|. ..        . |..         . .   ||| .   ....
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

TAVDMWSVGCIFGELLTQ-KPLFPG-----KSDIDQINKIFKDLGTPSEKI----WPGYNDLPAVKKMTFSEYPYNNLRKRFGALLSDQGFDLMNKFLTY
|. | || |    |..|  ..  ||     .|... |... .    |  .                               |    .|  ...| .   .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------F-VCCPDEMYQIMKQCWHE

YPGRRINAEDGLKHEYF
 |  | . ..   ||.|
DPEDRPTFSEI--HECF