Gene PDK1-1 (S.moellendorffii)

PDK1-1

Species: S.moellendorffii
Alias: PDK1-1
External Links:
Annotation:

Classification

Group: AGC
Family: PDK1

Sequence

Name Sequence Type Origin Length Description Download
PDK1-1.AA Protein None 514 None Fasta, JSON
PDK1-1.NA RNA None 1545 None Fasta, JSON
PDK1-1.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of PDK1-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PDK1-1.AA PDK1 68-327 41 1.9e-131 405.15 In-house 15-307 (307) Show / Hide 
Range on Protein: 68-327
Range on HMM: 15-307/307
Sequence Identity: 41% (123 aa)

VVRAKKKDS----GAEFALKIMDKKHITKENKVAYVKMERLILDHLD-----HPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRR--KGRLSLEEARF
|..|. |..    ....|.||  |..| .|.|| ||. |. |..||.     |||.|.|.|||||  .|| .|| | .|.|  ....   | ..   .||
VYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMKKQPFGSFDMDCCRF

YAAEIVDVLEYIHGQGLIHRDLKPENLLLTADGHIKVADFGSA-KVKYLSF-----SCSFLVSFSVHFRFTD-------DKSCTFVGTAEYVSPEVLNGH
|||||.| ||..|. | |||||||||.||. |.||. .|||.|   | |.      .  |   |  | .  |        .. .|||||||||||.|.. 
YAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGTAGFDKILPEYQSQQQNQFQQQFQQHNKGMDKPEEDKQTRCKSFVGTAEYVSPELLTDK

PVTIGADLWALGCIIYQMLEGRPPFKGG-----SEYLTFQKVLAKDLVIPSH--FPSAAKELINKLLNLEPDKRPGA--GPAGYAALKSHAFF
..| ..|.||||||||||. |.|||.|      .||.||||... ....|    ||  ||.|. ||| ..|..|...  .. || ..| | ||
ECTPSCDIWALGCIIYQMVAGQPPFRGMNDATNNEYHTFQKIMKCQYDFPDNFRFPPCAKDLVKKLLVRDPNDRLTSCDECGGYQQIKAHPFF
Kinase PDK1-1.AA AGC 67-327 29 8.20000000001e-131 340.14 In-house 14-395 (395) Show / Hide 
Range on Protein: 67-327
Range on HMM: 14-395/395
Sequence Identity: 29% (116 aa)

QVVRAKKK------DSGAEFALKIMDKKH---ITKENKVAYVKME------------RLILDHLD----------HPGVVR-LFFTFQDTHN--LYMGLE
.|  ..||      |.|  .|.|...|||   |.|.|.|.... |            | || ...          || .|. |...|||  .  ||. .|
KVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVME

CCH---------GG-ELFDQIR---RKGRLSLEEARFYAAE-------IVDVLEYIHG-QGLIHRD-LKPENLLLTADGHIKVADFGSAKV---------
 .          || ||| ...   ..||.. |.|||||||       ||  |||.|  .| |||| |||||.||..||||| .|||..|.         
YMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQ

---------------KYLSFSCSFLVSFSVHFRFT-----------------------DDKSCTFVG--TAEYVSPEVLNGHPVTIGADLWA--LGCIIY
               . .|       ...     |                       .|.  ||.|  |.||..||.|     .  .| |.  |||..|
QSQSNMKFHWHNKKYQ-KS-------NMD-----TNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

QMLEGRPPFKGGS----------EYLTFQKVL------AKDLVIP----------SHFPSAAKELINKLLNLEPDKRPGAGPA-----GYAALKSHAFF
.|| |.||| | .          .. .|||..       ... .|          ..| . || ||.|||. .|.||.|.|.      |.  .|.| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
S_TKc PDK1-1.AA S_TKc 36-327 32 1.3e-86 294.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 36-327
Range on HMM: 1-231/231
Sequence Identity: 32% (97 aa)

FAYGRLLGMGSYSKVANSSCIFPFFIFLPLFQVVRAKKKDSGAEFALKIMDKKHITKENKVAYVKMERLILDHLDHPGVVRLFFTFQDTHNLYMGLECCH
.  .|..| |...||     .                   .| ..|.||..            .. |. || . .|| .|.|. .||| ..||| .|.| 
YEILRKIGKGAFGKVYKCRHKK------------------TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCD

G--GELFDQIRRKGR------LSLEEARFYAAEIVDVLEYIHGQGLIHRDLKPENLLLTADGHIKVADFGSAKVKYLSFSCSFLVSFSVHFRFTDDKSCT
|  |.||| |...||      ..  .||||...|.. |||.| .| |||||||||.||.   |||..|||.|..                         |
GDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------------TT

FVGTAEYVSPEVLNGHPVTI-GADLWALGCIIYQMLEGRPPFKGGSEYLTFQKVLAKDLVIPSHFPSAAKELINKLLNLEPDKRPGAGPAGY--AALKSH
|.|| .|..||||   . .   .| |..|||.| || |.|||    ....|.|..          .. ||..|.|.|. .|.|||.|  |     . |.|
FCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

AFF
 .|
PWF
Kinase PDK1-1.AA RSK 66-327 34 1.9e-82 280.19 In-house 13-278 (278) Show / Hide 
Range on Protein: 66-327
Range on HMM: 13-278/278
Sequence Identity: 34% (96 aa)

FQVVRAKKKDSGAEFALKIMDKKHITKENK-VAYVKMERLILDHLD-HPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRRKGR---LSLEEARFYAAE
|.. .   .|.| ..| |. .|. | . .| ..... || || .   || .|.|. .||.   ||. .|.|.|||||. ......   .| .||.||.||
FLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAE

IVDVLEYIHGQGLIHRDLKPENLLLTA---DGHIKVADFGSAKVKYLSFSCSFLVSFSVHFRFT-DDKSCTFVGTAEYVSPEVLNG--HPV--TIGADLW
||  .|..| || ||||||||| |..    .||||. ||| .| .                |     .  ||..|.||. ||.|.   ...  .  .|.|
IVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF----------------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWW

ALGCIIYQMLEGRPPFKG---GSEYLTFQKVLAKD--LVIP--SHFPSAAKELINKLLNLEPDKRPGAGPAGYAALKSHAFF
 ||...| || |.|||.|    .   ...... ..  | .|  .    .||.||.|.|  .| ||.|.|| . . .|.|..|
SLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PDK1-1.AA Pkinase 67-327 30 1.9e-73 255.14 Pfam 14-293 (293) Show / Hide 
Range on Protein: 67-327
Range on HMM: 14-293/293
Sequence Identity: 30% (92 aa)

QVVRAKKKDSGAEFALKIMDKKHITKENKVAYVK-MERLILDHLDHPGVVRLFFTFQDTHNLYMGLECCHGG----ELFDQIR--RKGRL--SLEEARFY
.| ....|..| ..|.||..|.|. .. ... .. .|  |. .|.|| .|||. .|.|  ..|| .|.| ||    .||| |.  |.|..  | .|..||
CVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFY

AAEIVDVLEYIHGQGLIHRDLKPENLLLTADGHI----KVADFGSAKVKYLSFSCSFLVSFSVHFRFTDDKSCTFVGTAEYVSPEVLN-GHPVTIGADLW
. .|.  |||.| .| |||||||||.|.  .|||    |..|||.||...                  .    ||.|| .|..|||.. | . .  .| |
MYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

ALGCIIYQMLEGRPPFKGG------SEYLTFQKVLAKDLVIPSHFP---------------------SAAKELINKLLNLEPDKRPGAGPAGYAALKSHA
..|||.|.|| |||||.|       ...  ..... ..|  ..  .                     ...|..|...|.. | |||.      . .. | 
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHP

FF
.|
WF
Kinase PDK1-1.AA CAMK 41-311 23 1e-72 233.46 In-house 1-414 (425) Show / Hide 
Range on Protein: 41-311
Range on HMM: 1-414/425
Sequence Identity: 23% (100 aa)

LLGMGSYSKVANSSCIFPFFIFLPLFQVVRAKKKDSG------------AEFALKIMDKKHITK-------------------------ENKVAYVKMER
 || ||..||                   ... | ..             ..| ||.||| ...                         ... . |. | 
TLGRGSFGKVK------------------LCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREI

LILDH-------LDHPGVVRLFFTFQDTHN-------------------LYMGL---ECCHGGEL----FDQIRRK---------------GRLSLEEAR
 |. .       |||| ...|. ...|.|.                   .|| .   | | ||||    || |...               ||.. .|||
EIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREAR

FYAAEIVDVLEYIHGQGLIHRDLKPENLLLTAD-----------------GHIKVADFGSAKV---KYLSFSCSFLVSFSVHFRF------TDDKSCTFV
.|   |.. ..|.| .. .||||||||.||. .                 . ||..||| |..   .  .| ||   . .   .       ...|  ||.
RYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFC

GTAEYVS-PEVLNG--------------HPVTIGADLWALGCIIYQMLEGRPPFKGG-------------SEYLTFQKVLAKDLV-IPSHFPS-------
|| ||.. ||||||               ...  .| |..|.| | || |.||| |              ..| .|.|... .   .|..|.        
GTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGP

----------------AAKELINKLLNLEPDKRP
                 .| ||.|.|. .|.||.
EWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRM
Kinase PDK1-1.AA AktR 71-327 37 3.4e-68 232.86 In-house 18-268 (268) Show / Hide 
Range on Protein: 71-327
Range on HMM: 18-268/268
Sequence Identity: 37% (100 aa)

AKKK-DSGAEFALKIMDKKHITKENKVAYVKMERLILD-HLDHPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRRKGRLSLEEARFYAAEIVDVLEYI
..|| |..  .|.|. .||.| ..|.  .. .|| |.  . .||. |.|...||.  .|.  .| | |||||. ...|...| |.||||.|.|.  ||| 
VQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFYFAQILLALEYL

HGQ-GLIHRDLKPENLLLTADGHIKVADFGSAKVKYLSFSCSFLVSFSVHFRFT---DDKSCTFVGTAEYVSPEVLNG-HPVTIGADLWALGCIIYQMLE
| .   | |||||||.||  |||.| .||| .|                   |    |.|  .|.|| ||..||...   . .  .|.||.|. || |. 
HQHMNIIYRDLKPENILLDEDGHVKITDFGLSK-----------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRPPFKGGSEYLTFQKVLAKD-LVIPSH--FPSAAKELIN-KLLNLEPDKRPGAGPAGYAALKSHAFF
| |||  ..    ||| . |. . .| .  | |..|.||. |||.  | ||.| . .|   .||| .|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PDK1-1.AA Ciliate-E2 36-327 23 4.5e-68 232.48 In-house 1-365 (365) Show / Hide 
Range on Protein: 36-327
Range on HMM: 1-365/365
Sequence Identity: 23% (92 aa)

FAYGRLLGMGSYS-----KVANSSCIFPFFIFLPLFQVVRAK--KKDSGAEFALKIMDKKHITKENKVAYVK----------MERLILDHLDHPGVVRLF
.   ...| |...     || .  . |   |.    | .| .   |. . ..|.||| |. |   ... ..           .|. || .|.|| .....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

FTFQ--DTHNLYMGLECCHGGELFDQIR------------RKGRLSLEEAR---------------FYAAEIVDVLEYIHGQG-LIHRDLKPENLLLTAD
 .||  |..|.|. .| | ||.||| |.              ......|..               ||.|.|.. |||.| ..  ||||.||||.|.   
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

GHIKVADFGSAK----------------------VKYLSFSCSFLVSFSVHFRFTDDKSCTFVGTAEYVSPEVLNGHP---------VTIGADLWALGCI
  ||..||| .|                       .. ......       ... ..   |..||..|..||.||| .          .  .|.|.||.|
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMD-------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVI

IYQMLEGRPPFKGGSEYLTFQKVLAKDLVIP------------------SHFPSAAKELINK----LLNLEPDKRPGAGPAGYAALKSHAFF
.|.|| |.|||        .|. . ... .|                   . .  .| ||.|    .|. .|.||..    |.  .. | .|
LYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase PDK1-1.AA RSK-Unclassified 72-327 33 1.1e-67 211.46 In-house 19-283 (283) Show / Hide 
Range on Protein: 72-327
Range on HMM: 19-283/283
Sequence Identity: 33% (89 aa)

KKKDSGAEFALKIMDKKHITKENKVAYVKMERLILDHLDHPGVVRLFFTFQDTHNLYMGLECCHGGELFD--QIRRKGRLSLEEARFYAAEIVDVLEYIH
.|||.   .|.|.. |. . . ||. ||  |. |.   .|| .|.|.. ||    ||. .| | ||..|   | |.. ... ...||||.|..  ||| |
RKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCEDDVRFYASEVTAALEYLH

GQGLIHRDLKPENLLLTADGHIKVADFGSAKVKYLSFSCSFL---VSFSVHFRFTDDKSCT--FVGTAEYVSPEVLNGHPVTIGADLWALGCIIYQMLEG
 ...| |||||.| .|  .||..  ||.  .    |          |  |  .  |. . |  |.|| ||. ||.. .   |   | | || ..| || |
KRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFG

RPPFKGGSEYLTFQKVLAKDLVIP--SHFPSAAKELINKLLNLEPDKRPGAGPAGYAALKSHAFF
 ||..|  .  ||. .. ... .|  |     ...|| |||.  | || |..    .  | | ||
CPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase PDK1-1.AA PKA 71-200 46 1.3e-51 177.74 In-house 18-149 (263) Show / Hide 
Range on Protein: 71-200
Range on HMM: 18-149/263
Sequence Identity: 46% (61 aa)

AKKKDSGAEFALKIMDKKHITKENKVAYVKMERLILDHLDHPGVVR-LFFTFQDTHNLYMGLECCHGGELFDQIRRKGRLSLEEARFYAA-EIVDVLEYI
...|.||  .|.|...|  | ... |  |. |. ||  ..|| .|. . .||||  .||| .| . |||.|. .|..||.|  .|.|||| .||  |||.
CRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNPHAKFYAASQIVLALEYL

HGQGLIHRDLKPENLLLTADGHIKVADFGSAK
| | .|.|||||||.|.  .||||..||| ||
HSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase PDK1-1.AA Akt 67-197 45 1.2e-49 156.82 In-house 14-146 (264) Show / Hide 
Range on Protein: 67-197
Range on HMM: 14-146/264
Sequence Identity: 45% (60 aa)

QVVRAKKKDSGAEF-ALKIMDKKHITKENKVAYVKMERLILDHLDHPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRRKGRLSLEEARFYAAEIVDVL
.|. .||||..  . |.|.  |..| . |.|...| || || | .|| .| | . ||. ..||. .. | |||||  ..||.| | ..||||.|||.  .
KVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAI

EYIHGQGLIHRD-LKPENLLLTADGHIKVADFG
|. | .. | || |||||.|. .||||...|||
EHLHSKNIIYRDYLKPENILMDKDGHICLTDFG
Kinase PDK1-1.AA RSK 68-200 39 8.3e-41 141.89 In-house 17-153 (271) Show / Hide 
Range on Protein: 68-200
Range on HMM: 17-153/271
Sequence Identity: 39% (55 aa)

VVRAK-KKDSGAEFALKIMDKKHITKENKVAYVKMERLILDHLDHPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRRKGRLSLEEARFYAAEIVDVLE
|.. .  ||.. ..| || .|. .    .  . ..|| || . .|| .|.|.  |||  ..|| .. . ||.||| . ... .| .|..||.|||   .|
VCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSEREVKFYMAEIALAME

YIHGQGLIHRDLKPENLLLTAD----GHIKVADFGSAK
| | || .|||||||| |. ..    ||||..||| ||
YLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAK
Kinase PDK1-1.AA Akt 227-327 40 2.7e-28 87.47 In-house 161-264 (264) Show / Hide 
Range on Protein: 227-327
Range on HMM: 161-264/264
Sequence Identity: 40% (42 aa)

TFVGTAEYVSPEVLNGHPVTIGADLWA-LGCIIYQMLEGRPPF-KGGSEYLTFQKVLAKDLVIP--SHFPSAAKELINKLLNLEPDKRPGAGPAGYAALK
|| ||.|| .||.|||.  |  .| |. |||..| |. ||||| .   . . |.| . ... .|  . .  ..| ||..|||  |.||.|.|| .   .|
TFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQM-FKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIK

SHAFF
.| .|
RHPWF
Kinase PDK1-1.AA RSK 227-327 30 1.7e-23 80.83 In-house 164-271 (271) Show / Hide 
Range on Protein: 227-327
Range on HMM: 164-271/271
Sequence Identity: 30% (33 aa)

TFVGTAEYVSPEVLNGHPVTIGADLWALGCIIYQMLEGRPPFKGGSEYLTFQKVLAKDLVI-------PSHFPSAAKELINKLLNLEPDKRPGAGPAGYA
|| .||.|. ||||.    .  .| | .| . | || |..|| ..    .... .  .|..       ..     ||.|. ..|   | .|.|||| | .
TFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVE

ALKSHAFF
  |.|..|
QIKQHPWF
Kinase PDK1-1.AA PKA 230-327 36 4.3e-19 69.76 In-house 160-263 (263) Show / Hide 
Range on Protein: 230-327
Range on HMM: 160-263/263
Sequence Identity: 36% (38 aa)

GTAEYVSPEVLNGH-PVTIGADLWALGCIIYQMLEGRPPFKGG--SEYLTFQKVLAKDLVIPSHFPSAA---KELINKLLNLEPDKRPGAGPAGYAALKS
|| ||  ||..... .   . | ||||..|| || | |||     .   ...| .. ..  |.|| |.|   | ||.|||.  . || |   .|    | 
GTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKN

HAFF
| .|
HKWF
Kinase PDK1-1.AA TyrKc 36-321 18 1.2e-10 -50.47 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-321
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

FAYGRLLGMGSYSKVANSSCIFPFFIFLPLFQVVRAKKKDSGAEFALKIMDKKHITKENKVAYVKMERLILDHL--DHPGVVRLFFTFQDT-------HN
   |. || | . .|     .                      . | | . . .      ..    |  |. .|  .|| .|||.    .        . 
ITLGKKLGEGAFGEVYKGTWK---------------------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEP

LYMGLECCHGGELFDQIRRKGR-LSLEEARFYAAEIVDVLEYIHGQGLIHRDLKPENLLLTADGHIKVADFGSAKVKYLS-FSCSFLVSFSVHFRFTDDK
|.. .| . .| | | .|.... |....   ..  | .  ||.| ...|||||   | |.......|..||| ..  |    .       .   | .  |
LMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHK

SCTFVGTAEYVSPEVLNGHPVTIGADLWALGCIIYQMLE-GRPPFKG-----GSEYLTFQKVLAK-DLVIPSH--------FPSAAKELINKLLNLEPDK
.. ..      .||..| .  |.  | |. |  .. ..  | .|  |      | .  ...| .   . .| .         |..  ... .  . .|..
GGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED

RPGAGPAGYAAL
||      .  .
RPTFSEI-HECF
Kinase PDK1-1.AA Pkinase_Tyr 165-197 42 0.000329 14.88 Pfam 124-156 (270) Show / Hide 
Range on Protein: 165-197
Range on HMM: 124-156/270
Sequence Identity: 42% (14 aa)

LEYIHGQGLIHRDLKPENLLLTADGHIKVADFG
.|| . ...|||||   | |.| ....|..|||
MEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase PDK1-1.AA PDK1 36-50 53 0.001908 5.84 In-house 1-15 (307) Show / Hide 
Range on Protein: 36-50
Range on HMM: 1-15/307
Sequence Identity: 53% (8 aa)

FAYGRLLGMGSYSKV
|  |. .| ||||.|
FIFGKNIGEGSYSTV
Kinase PDK1-1.AA AGC 36-50 40 0.002852 2.72 In-house 1-15 (395) Show / Hide 
Range on Protein: 36-50
Range on HMM: 1-15/395
Sequence Identity: 40% (6 aa)

FAYGRLLGMGSYSKV
|   ...| ||..||
FEFLKVIGKGSFGKV
Kinase PDK1-1.AA AktR 36-50 40 0.087088 3.2 In-house 1-15 (268) Show / Hide 
Range on Protein: 36-50
Range on HMM: 1-15/268
Sequence Identity: 40% (6 aa)

FAYGRLLGMGSYSKV
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FHVYKCLGKGAFGKV
Kinase PDK1-1.AA RSK 36-50 40 0.402275 0.05 In-house 1-15 (271) Show / Hide 
Range on Protein: 36-50
Range on HMM: 1-15/271
Sequence Identity: 40% (6 aa)

FAYGRLLGMGSYSKV
.   . .| ||.|||
YELHECIGQGSFSKV
Kinase PDK1-1.AA Pkinase 36-50 40 6.192471 0.85 Pfam 1-15 (293) Show / Hide 
Range on Protein: 36-50
Range on HMM: 1-15/293
Sequence Identity: 40% (6 aa)

FAYGRLLGMGSYSKV
.  || .| ||...|
YHIGRKIGSGSFGCV
PDK1_PH PDK1-1.AA PDK1_PH 413-513 49 9e-60 204.89 In-house 1-112 (112) Show / Hide 
Range on Protein: 413-513
Range on HMM: 1-112/112
Sequence Identity: 49% (55 aa)

EPWQKFLF-EGETILASSRVRKFRKLSV----KKRQLILTDRPRLFYVHPIKLVFKGEVPWS-RDIYVRVE-----NDLKFCICTPKRTYNLEDTKGQAR
.||..||. |||.||. ..|.|...|..    |.|||||||.||||||.|...|.|||.||| .|.||...     |. .|.|.||.|||..||.||.|.
TPWHQFLMPEGEHILKCGWVYKRKGLFAKPKKKRRQLILTDGPRLFYVDPMTMVIKGEIPWSSKDLYVEYKPDRKNNFKHFFIHTPNRTYYFEDPKGCAN

VWKESIEKLVNA
.|.| |||... 
KWCEAIEKVCKR