Gene PKA-2 (S.moellendorffii)

PKA-2

Species: S.moellendorffii
Alias: PKA-2
External Links:
Annotation:

Classification

Group: AGC
Family: PKA

Sequence

Name Sequence Type Origin Length Description Download
PKA-2.AA Protein None 292 None Fasta, JSON
PKA-2.NA RNA None 879 None Fasta, JSON
PKA-2.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of PKA-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PKA-2.AA AGC 4-263 32 7e-165 430.27 In-house 1-395 (395) Show / Hide 
Range on Protein: 4-263
Range on HMM: 1-395/395
Sequence Identity: 32% (128 aa)

FELGRVLGTGSFGRVQVAHHK------ANKQVCAVKSLSKAS-IVKTK---QACEHSFQ-----------KNILQRLD----------FPYIVN-LLGYC
||. .|.|.||||.|  . .|      ......|.| |.|.  ||..|   ... .. .           .|||....           |.||. |    
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDDRC--VHLVMEYVC---------GG-EFFTYLR---HTGRFDEATSRFYASQ-------VLLAFEHIHG-MDIIYRD-LKPENLLLDEKGNIKIADFG
||..   ...||||..         || |.|..|.   . ||||| ..||||..       ..||.|..|  |.||.|| |||||.||||.|.||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKQIDR-----------------------------------------------------RTYTLCG--TPDYLAPEIILNKGHGKPVDWWA--FGVLIY
..|.. .                                                     ||.|.||  ||.|.||||.    .||..|||.  .|.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLAGYPPFYDD----------DAIGTYQKILAG------KLQFPG----HFSR-RQISCSAKDLVRRLLTADLTKRIGCLKD-----GVDEIKNHSWF
|||.||||||.|          .   ..|||. |      |..||     .|   |..|  ||||...||. | .||.||...     |..||||| ||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKA-2.AA PKA 4-263 56 1.4e-158 533.13 In-house 1-263 (263) Show / Hide 
Range on Protein: 4-263
Range on HMM: 1-263/263
Sequence Identity: 56% (152 aa)

FELGRVLGTGSFGRVQVAHHKANKQVCAVKSLSKASIVKTKQACEHSFQ-KNILQRLDFPYIVN-LLGYCQDDRCVHLVMEYVCGGEFFTYLRHTGRFDE
||. ..|||||||||. . || ... .| | |.|. ||..||  ||    ||||| ...|.||. . . .||||  ..|||||.||| |.|||. |||..
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQV-EHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSN

ATSRFYAS-QVLLAFEHIHGMDIIYRDLKPENLLLDEKGNIKIADFGFAKQIDRRTYTLCGTPDYLAPEIILNK-GHGKPVDWWAFGVLIYEMLAGYPPF
 ...|||  |. ||.| .| ..||||||||||.|.|..|.|||.|||||| .| ||.||||||.|||||||..| ||||.|||||.|.||||||||||||
PHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDDRTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPF

YDD--DAIGTYQKILAGKLQFPGHFSRRQISCSA---KDLVRRLLTADLTKRIGCLKDGVDEIKNHSWF
||.  | ...|.||..||..|| ||. .     |   |||...||..|||||.|..|.||. |||| ||
YDHNRDPMQIYEKICNGKIKFPRHFDSD-----ANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase PKA-2.AA Akt 4-263 42 4.2e-109 349.93 In-house 1-264 (264) Show / Hide 
Range on Protein: 4-263
Range on HMM: 1-264/264
Sequence Identity: 42% (115 aa)

FELGRVLGTGSFGRVQVAHHKANKQVC-AVKSLSKASIVKTKQACEHSFQ-KNILQRLDFPYIVNLLGYCQDDRCVHLVMEYVCGGEFFTYLRHTGRFDE
|.. .||| ||||.|  .  |.....  | |.|.|  |.. .   || .. .||||. ..|.||||    |.     .||.|. ||| |..|.. .||.|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKN-QVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

ATSRFYASQVLLAFEHIHGMDIIYRD-LKPENLLLDEKGNIKIADFGFAKQI---D-RRTYTLCGTPDYLAPEIILNKGHGKPVDWWA-FGVLIYEMLAG
 . |||.... || || | ..||||| |||||.|.|..|.|...||| .|..   |  .|.|.|||| ||||||....||.|.||||. .|...|||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

YPPFYDDDAIGTYQKILAGKLQFPGHFSRRQISCSAKDLVRRLLTADLTKRIGCLKDGVDEIKNHSWF
 ||||..|    ..||. ....||     ..||  .|||...||. | .|| |  .....|||.| ||
RPPFYNQDHHQMFKKIKNQPVKFPDK---DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKA-2.AA AktR 4-263 41 7.69999999999e-106 357.93 In-house 1-268 (268) Show / Hide 
Range on Protein: 4-263
Range on HMM: 1-268/268
Sequence Identity: 41% (112 aa)

FELGRVLGTGSFGRVQVAHHK-ANKQVCAVKSLSKASIVKTKQACEHSFQKNILQ-RLDFPYIVNLLGYCQDDRCVHLVMEYVCGGEFFTYLRHTGRFDE
|.. ..|| | ||.|  . .|  |... | |...|  |.. .|.      .||..   ..| ||.|    |....  ..|||..||| |..|.. ..|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

ATSRFYASQVLLAFEHIHGM-DIIYRDLKPENLLLDEKGNIKIADFGFAK-QIDR----RTYTLCGTPDYLAPEIILN-KGHGKPVDWWAFGVLIYEMLA
 ..|||..|.|||.|. |   .||||||||||.|||| |..||.||| .| |...    ..|..|||| |.|||.|.. |||.|.|||||||..||||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GYPPFYD--DDAIGTYQKILAGKLQFPGHFSRRQISCSAKDLVR-RLLTADLTKRIGCLKDGVDEIKNHSWF
|.||||.  .  .  ..||    ..|| .    ..|  .|||.  .||  . .||.|  . | .|||.| ||
GCPPFYHKNQNQMFQKIKIKQ-QNKFPYPS---YFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKA-2.AA SGK 4-263 38 2e-103 320.28 In-house 1-283 (283) Show / Hide 
Range on Protein: 4-263
Range on HMM: 1-283/283
Sequence Identity: 38% (110 aa)

FELGRVLGTGSFGRVQVAHHKAN------------------KQVCAVKSLSKASIV-------KTKQACEHSFQK-NILQRLDFPYIVNLLGYCQDDRCV
|..  |.| ||||.|  . ||.                   ... |.| |.|..|.       | |..      . .||. .  | ||||    | .   
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

HLVMEYVCGGEFFTYLRHTGRFDEATSRFYASQVLLAFEHIHGMDIIYRDLKPENLLLDEKGNIKIADFGFAK---QIDRRTYTLCGTPDYLAPEIILNK
 .||.|| ||| | .|.  ..| |  .||||... .| |. |  |||||||||||.||| .|.... ||| .|   .    | | |||| |||||... .
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHGKPVDWWAFGVLIYEMLAGYPPFYDDDAIGTYQKILAGKLQFPGHFSRRQISCSAKDLVRRLLTADLTKRIGCLKDGVDEIKNHSWF
.|.. ||||  | . |||. | ||||. .    |..|. ..||.|     .|.| .|.||   ||. | .|| |  |..  ||||| .|
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIP-----PQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase PKA-2.AA S_TKc 4-263 38 4.3e-99 336.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-263
Range on HMM: 1-231/231
Sequence Identity: 38% (104 aa)

FELGRVLGTGSFGRVQVAHHKANKQVCAVKSLSKASIVKTKQACEHSFQ-KNILQRLDFPYIVNLLGYCQDDRCVHLVMEYVCG--GEFFTYLRHTGR--
.|..|..| |.||.|  ..||  ....|.| ..           ||  .  .||.. . |.||.|....||  ....||||. |  |. |.|... ||  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FDEATSRFYASQVLLAFEHIHGMDIIYRDLKPENLLLDEKGNIKIADFGFAKQIDRRTYTLCGTPDYLAPEIILNKGHGK-PVDWWAFGVLIYEML
    |.| . |||. |...| |..| . ||.|||||||.||||  .|||.|||.|.|.    .|.||||.|.|||..   |.|| ..|||..|...||||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

AGYPPFYDDDAIGTYQKILAGKLQFPGHFSRRQISCSAKDLVRRLLTADLTKRIGCLKDGVDE--IKNHSWF
.|||||.  .   ...||.               | .|||..|..|. | .||... .   ||  ||.| ||
CGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKA-2.AA RSK 7-263 39 5.4e-94 318.56 In-house 1-278 (278) Show / Hide 
Range on Protein: 7-263
Range on HMM: 1-278/278
Sequence Identity: 39% (112 aa)

GRVLGTGSFGRVQVAHHK---ANKQVCAVKSLSKASIVKTKQACEHSF-QKNILQRLD-FPYIVNLLGYCQDDRCVHLVMEYVCGGEFFTYLRHTGR---
 .|||.|..| | . . .   ...|. |.| |.|| ||... . .| .   |||.|    | ||.|    |..  ..|.|||. |||.|| |.. ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEATSRFYASQVLLAFEHIHGMDIIYRDLKPENLLLDE---KGNIKIADFGFAKQ--ID--RRTYTLCGTPDYLAPEIIL----NKGHGKPVDWWAFGV
|.| . .||.... || ||.|  .||.||||||| |.|.    | ||. ||||.||  .|   .|.| |.| .|.|||..     ..||.| .||| .||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIYEMLAGYPPFYD---DDAIGTYQKILAGK--LQFPGHFSRRQISCSAKDLVRRLLTADLTKRIGCLKDGVDEIKNHSWF
|.||||.|.|||.    ...  . ..|. ||  | .|   .   .|  ||||.|..|. |  ||.|| .....|||.|.||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQY---LSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKA-2.AA PKG 6-263 44 3.5e-90 305.91 In-house 1-260 (260) Show / Hide 
Range on Protein: 6-263
Range on HMM: 1-260/260
Sequence Identity: 44% (119 aa)

LGRV--LGTGSFGRVQVAHHKANK-QVCAVKSLSKASIVKTKQACEHSFQ-KNILQRLDFPYIVNLLGYCQDDRCVHLVMEYVCGGEFFTYLRHTGRFDE
| ..  || | ||||     .  | .  | | . |. ||.|.|  || .  |||.. .. ..|| |     |.. | . ||   |||  | ||  |.||.
LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQ-EHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDD

ATSRFYASQVLLAFEHIHGMDIIYRDLKPENLLLDEKGNIKIADFGFAKQID--RRTYTLCGTPDYLAPEIILNKGHGKPVDWWAFGVLIYEMLAGYPPF
 |.|||.  |. ||.  |   |||||||||||.||..| .|. ||||||.|   |.|.| |||| | ||||||||||   ||.|| |.|..| | | |||
KTTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPF

YDDDAIGTYQKILAG--KLQFPGHFSRRQISCSAKDLVRRLLTADLTKRIGCLKDGVDEIKNHSWF
   | . ||. || |  ...||     |.|. .|......|     | |.| .| |. .|| |.||
SGSDPMKTYNIILKGIDMWEFP-----RKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase PKA-2.AA CAMK 9-263 24 2.6e-87 281.33 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-425/425
Sequence Identity: 24% (104 aa)

VLGTGSFGRVQVAHHKANK------------QVCAVKSLSKASIV------------KTKQACEH--------SFQK-----NILQR-------LDFPYI
.||.|||| |  . || ..            | .|.| ..|  .             . |. | |        . ..     .|...       || | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLLGYCQD-------------------DRCVHLVM---EYVCGG----EFFTYLRHT---------------GRFDEATSRFYASQVLLAFEHIHGMDI
..|. . .|                   |.....||   ||. ||    . | |..                 |||.|.  |.|  |.. | ...| ..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IYRDLKPENLLLDEK-----------------GNIKIADFGFAKQIDR--------------------------RTYTLCGTPDYLA-PEIILN------
. |||||||.|||..                 .||||.|||||...|.                            .| |||| | | ||...       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KGHGKPVDWWAFGVLIYEMLAGYPPFYDD-------------DAIGTYQKILAGKLQFPGHF--------------------SRRQISCSAK
        ...|...| |. ||. | || ||||||.|             .   ...||..|| .|| ..                    .. ..| ..|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQECK

DLVRRLLTADLTKRIGCLKDGVDEIKNHSWF
||.|..|. | .||. .     ....|| |.
DLIRKMLQVDPEKRMTI-----EQCLNHPWM
Kinase PKA-2.AA Pkinase 4-263 33 2.3e-84 291.37 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-263
Range on HMM: 1-293/293
Sequence Identity: 33% (102 aa)

FELGRVLGTGSFGRVQVAHHKANKQVCAVKSLSKASIVKTKQAC-----EHSFQKNILQRLDFPYIVNLLGYCQDDRCVHLVMEYVCGG----EFFTYLR
...||..| ||||.|  .||| . .. ||| ..| .. . |.       | .    |..||. |.|| |.....|.. ...||||. ||    . |.|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQ----IMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--HTGRF--DEATSRFYASQVLLAFEHIHGMDIIYRDLKPENLLLDEKGNI----KIADFGFAKQI---DRRTYTLCGTPDYLAPEIIL-NKGHGKPVDW
    |.|  .| . .||. |.| . |..| | ||.|||||||.|.|..|.|    ||.|||.|||.   .. ..|.||||.|.|||.|. ....|..||.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WAFGVLIYEMLAGYPPFYDD------DAIGTYQKILAGKLQFPGHFSRR----------------QISCSAKDLVRRLLTADLTKRIGCLKDGVDEIKNH
|..|...|||| |.|||...      | .  ...|. ..| |.   ...                 .| ..||.....|. | .||..      ..|..|
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQH

SWF
 ||
PWF
Kinase PKA-2.AA Ciliate-E2 4-263 26 9e-82 277.98 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-263
Range on HMM: 1-365/365
Sequence Identity: 26% (100 aa)

FELGRVLGTGSFGRVQVAHH-----------------------KANKQVCAVKSLSKASIVKTKQACEHS----------FQKNILQRLDFPYIVNLLGY
... ...|.|.|| |  . .                       |....  |.|...|  |  .||                 ||||..|..|.|...  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CQ--DDRCVHLVMEYVCGGEFFTYLRHT-----------GRFDEATSR---------------FYASQVLLAFEHIHGMD-IIYRDLKPENLLLDEKGNI
 |  || .. |||||. ||. | |...            ..|.|   .               ||. ...||.|..|    ||.||.||||.|.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADFGFAKQID----------------------------------RRTYTLCGTPDYLAPEIILNKG---------HGKPVDWWAFGVLIYEMLAGYPP
||.|||..|..|                                    ..|.|||| |.||||. .|.         ... .|.|..||..|||| |.||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FYDDDAIGTYQKILAGKLQFPGHF-------------SRRQISCSAKDLVRR----LLTADLTKRIGCLKDGVDEIKNHSWF
|        .|.|. .|..||  .             |  ..| ..||| ..    .|  |  |||.    | ..|.|| ||
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase PKA-2.AA Ciliate-E2-Unclassified 4-263 27 1.8e-81 276.96 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-263
Range on HMM: 1-352/352
Sequence Identity: 27% (99 aa)

FELGRVLGTGSFGRVQVAHHKANKQVCAVKSLSKASIVKTKQACE---------HSFQKN-------------ILQRLDFPYIVNLLGYCQDDRCVHLVM
.......|.|.|| |. . || .||. | | ..|. |.| ||  .         . ..|.             ||. .. |.||... . ||. .. .||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYVCGGEFFTYLRHT-----------------GRFDEATSR-----FYASQVLLAFEHIHGMD-IIYRDLKPENLLLDEKG---NIKIADFGFAKQID--
||. ||. . |...                   .|.|  ..     ||. |.|...|..|    ||.||.||||.|.|..|   .|||.|||..|...  
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

----------------RRTYTLCGTPDYL----APEIILNKGHG----KPVDWWAFGVLIYEMLAGYPPFYDDDAIG----------------TYQKILA
                 ...| |||| |.    |||.. .....    . .|.|..||..|||| ||.|||| . .                  ||.|..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

GKLQFPGHFSR---RQISCSAKDLVR----RLLTADLTKRIGCLKDGVDEIKNHSWF
...||| .  .    ..| .|||...    ..|  .. |||     . ..|.|| ||
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-----TFEQILNHPWF
Kinase PKA-2.AA TyrKc 4-247 21 4.9e-17 52.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-247
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

FELGRVLGTGSFGRVQVAHHKANKQVCAVKSLSKASIVKTKQACEHSFQK--NILQRL--DFPYIVNLLGYCQDD-------RCVHLVMEYVCGGEFFTY
 .||..|| | ||.|  .. |   . .|||.| . .        .  | .  .|. .|  . | ||.|.|.| ..         . .||||...|    |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LRHTGR-FDEATSRFYASQVLLAFEHIHGMDIIYRDLKPENLLLDEKGNIKIADFGFAKQIDRR-------TYTLC----GTPD-----YLAPEIILNKG
|| ... .  ..   .. |.    |..| . .| |||   | |..|.. .||.||| .. |.          |       |. .      .||| |  . 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

HGKPVDWWAFGVLIYEMLA-GYPPFYD-----DDAIGTYQKILAG-KLQFPGH-----FSRRQISCSAKDLVRRLLT------------ADLTKRI
     | |.|||...|..  | .| ..      ...  .... .|  .  | .     |      |  ... .  ..            ... ...
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PKA-2.AA Pkinase_Tyr 4-152 29 2.5e-14 49.14 Pfam 1-161 (270) Show / Hide 
Range on Protein: 4-152
Range on HMM: 1-161/270
Sequence Identity: 29% (48 aa)

FELGRVLGTGSFGRVQVAHHK----ANKQVCAVKSLSKASIVKTKQACEHSFQK--NILQRL-DFPYIVNLLGYCQ-DDRC--VHLVMEYVCGGEFFTYL
 ..|..|| |.||.|  .. |     .|. .|||.| | .  .    |  .| .  .|.  | . | ||.|.| |  ...   . .||||...|   .||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RH----TGRFDEATSRFYASQVLLAFEHIHGMDIIYRDLKPENLLLDEKGNIKIADFGFAKQI
|      ....  .   .. |.  . |. . . .| |||   | |..|.. .||.||| |. |
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase PKA-2.AA Pkinase_Tyr 183-201 38 0.307157 4.82 Pfam 198-218 (270) Show / Hide 
Range on Protein: 183-201
Range on HMM: 198-218/270
Sequence Identity: 38% (8 aa)

WAFGVLIYEMLA-GYPP-FYD
|.||||..|..  |  | ...
WSFGVLMWEIFTYGEQPTYPG