Gene PKG (S.moellendorffii)

PKG

Species: S.moellendorffii
Alias: PKG
External Links:
Annotation:

Classification

Group: AGC
Family: PKG

Sequence

Name Sequence Type Origin Length Description Download
PKG.AA Protein None 289 None Fasta, JSON
PKG.NA RNA None 870 None Fasta, JSON
PKG.kin_dom Protein Kinase Domain None 249 None Fasta, JSON

Protein domain

Protein domains of PKG.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PKG.AA AGC 1-249 28 9.80000000001e-124 321.41 In-house 10-395 (395) Show / Hide 
Range on Protein: 1-249
Range on HMM: 10-395/395
Sequence Identity: 28% (110 aa)

GLFGKVKLVFCR------RTREYYALKCVSKAK-VIRLQ--EEEHLRNE------------KLFMTEMD----------HPFITK-LIRTYKDDKN--IY
| |||| ||  .       | .|||.|...|.. .....  ..||  .|            .  .....          ||||.| |  ...|...  .|
GSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLY

LLQELTT---------GG-ELFFHME---KVGPLREAEASFYAGA-------VLLVLEYMHG-KGIVYRD-LKPENTLIGDNGYPKLIDMGFAKRIYNR-
.. |.           || |||.|.    | | . | .| |||         ..| |||.|  .||..|| ||||| |. ..|. || | |..|.. |. 
FVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDG

---------------------------------------------------RTYSMCG--TPDYMAPEIIRRQGHGKAVDYWA--LGCLIFELITNTSAF
                                                   ||...||  ||.||||||.    .|||.|.|.  ||||..|..|  . |
EKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPF

NRGEDP--------PQLVFHRIIDG------RVKFP----------PYVSSDCADIVRKLLDPNPETRLGCRKR-----GAADIKEHPFF
.  ..         |  .|..|..|      .||||          ...|... |...||| ..|| ||||...     || .||.||.|
YGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKG.AA PKA 3-249 42 4.6e-106 358.67 In-house 12-263 (263) Show / Hide 
Range on Protein: 3-249
Range on HMM: 12-263/263
Sequence Identity: 42% (107 aa)

FGKVKLVFCRRTREYYALKCVSKAKVIRLQEEEHLRNEKLFMTEMDHPFIT-KLIRTYKDDKNIYLLQELTTGGELFFHMEKVGPLREAEASFYAG-AVL
||.|.|.  . . .|||.|. .|....||  .||  |||  .....||||  |.. |..||...|...|.  |||.| .. |.| . . .| |||   . 
FGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNPHAKFYAASQIV

LVLEYMHGKGIVYRDLKPENTLIGDNGYPKLIDMGFAKRIYNRRTYSMCGTPDYMAPEIIRRQ-GHGKAVDYWALGCLIFELITNTSAFNRGEDPPQLVF
| |||.| . |.|||||||| || .||. |. | ||||.. . ||...||||.|.||||| .  ||||.|| ||||.||.|. .  . |.     |   .
LALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD-RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIY

HRIIDGRVKFPPYVSSDC---ADIVRKLLDPNPETRLGCRKRGAADIKEHPFF
 .|..|..|||....||     | ..||| .... |.|. | |. |||.|..|
EKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase PKG.AA Ciliate-E2b 1-249 37 5.9e-91 276.6 In-house 10-272 (272) Show / Hide 
Range on Protein: 1-249
Range on HMM: 10-272/272
Sequence Identity: 37% (99 aa)

GLFGKVKLVFC-RRTREYYALKCVSKAKVIRLQEEEHLRNEKLFMTEMDHPFITKLIRTYKDDKNIYLLQELTTGGELFFHMEKVG--PLREAEASFYAG
| || | ||.    |..|||.||.||...|    | |. .||  .  ..|||| |.||..|||...|.. |.  |.|||  .  .|   | . .. || .
GQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLSTYDSQFYIA

AVLLVLEYMHGKGIVYRDLKPENTLIGDNGYPKLIDMGFAKRIY--NR---RTYSMCGTPDYMAPEIIR-----RQGHGKAVDYWALGCLIFELITNTSA
 ..| ||| | ..|.|||.|||| ..  .||.|||||| || .|  |    ||....||| |||||||       .| . .|| |..|   .|..     
SICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVP

FNRGEDPPQLVFHRIIDG--RVKFPPYVSSDCA--DIVRKLLDPNPETRLGCRKRGAADIKEHPFF
.    . |  .   || .  ...||.| .   |  ... ..|  .|| ||| .    .  | ||.|
WAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGS---YSWLKSHPWF
Kinase PKG.AA AktR 3-249 38 2.6e-82 279.74 In-house 12-268 (268) Show / Hide 
Range on Protein: 3-249
Range on HMM: 12-268/268
Sequence Identity: 38% (100 aa)

FGKVKLVFCR-RTREYYALKCVSKAKVIRLQEEEHLRNEKLFMT-EMDHPFITKLIRTYKDDKNIYLLQELTTGGELFFHMEKVGPLREAEASFYAGAVL
|||| ||  .  . ..||.| ..| | |... ..|...|.  |  ...|||| ||  . ..........|   |||||.|  | . . | .| ||.  .|
FGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFYFAQIL

LVLEYMHGK-GIVYRDLKPENTLIGDNGYPKLIDMGFAK----RIYNRRTYSMCGTPDYMAPEIIRR-QGHGKAVDYWALGCLIFELITNTSAFNRGEDP
| ||| | .  |.|||||||| |.. .|. |..| | .|    . |. ..|| |||| |||||.|.. .||.|.||.||.|..|.|..|    |. . . 
LALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQN

PQLVFHRIID-GRVKFPPYVSSDCADIVR-KLLDPNPETRLGCRKRGAADIKEHPFF
  . . .|..  ....|.|.|| | |..  |||. ||. |||  . |. .||.||.|
QMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKG.AA S_TKc 1-249 31 2.6e-77 264.05 SMART 10-231 (231) Show / Hide 
Range on Protein: 1-249
Range on HMM: 10-231/231
Sequence Identity: 31% (83 aa)

GLFGKVKLVFCRRTREYYALKCVSKAKVIRLQEEEHLRNEKLFMTEMDHPFITKLIRTYKDDKNIYLLQELTTG--GELFFHMEKVGP------LREAEA
| ||||...  ..| ...|.|...          ||.|.|   . . .||.| ||. .. | ...|.  |.  |  |.|| ...| |.      . | .|
GAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HA

SFYAGAVLLVLEYMHGKGIVYRDLKPENTLIGDNGYPKLIDMGFAKRIYNRRTYSMCGTPDYMAPEIIRRQGHGK-AVDYWALGCLIFELITNTSAFNRG
 ||.  ... |||.| .||..||||||| |. .    |..| |.|...     ...||||.|||||..   |.|| ..| |..||...|...    |   
RFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--

EDPPQLVFHRIIDGRVKFPPYVSSDCADIVRKLLDPNPETRLGCRKRGA--ADIKEHPFF
   .|..|..|           |... |..||.|. .|| |... .  .   ||| ||.|
--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKG.AA RSK 12-249 36 1.7e-76 260.47 In-house 21-278 (278) Show / Hide 
Range on Protein: 12-249
Range on HMM: 21-278/278
Sequence Identity: 36% (94 aa)

RRTREYYALKCVSKAKVIRLQE-EEHLRNEKLFMTEMD-HPFITKLIRTYKDDKNIYLLQELTTGGELFFHMEKVGP---LREAEASFYAGAVLLVLEYM
. |. .|| | ..|||... |   .| . |   . .   |||| .|  ...... .||  |.  ||||| | .| .    . | ||.||.  . | .|..
HDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHL

HGKGIVYRDLKPENTLIGD---NGYPKLIDMGFAKR--IY-NRRTYSMCGTPDYMAPEIIR----RQGHGKAVDYWALGCLIFELITNTSAFNRGED-PP
| .||..||||||| |  |   .|  ||.| ||.|   .  | .|.. |.| .|||||...    . ||.||.|.| ||.|..|. |  . |  ..|  .
HQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNR

QLVFHRIIDGR--VKFP--PYVSSDCADIVRKLLDPNPETRLGCRKRGAADIKEHPFF
. .. ||  |.  ...|  .|.| .. |..||.|  .|. |||| ...|..||.||.|
KEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKG.AA Ciliate-E2 3-249 22 4.4e-76 259.09 In-house 12-365 (365) Show / Hide 
Range on Protein: 3-249
Range on HMM: 12-365/365
Sequence Identity: 22% (84 aa)

FG-----KVKLVFCRR------------------TREYYALKCVSKAKVIRLQEEEHLR----------NEKLFMTEMDHPFITKLIRTYK--DDKNIYL
||     ||..| ..                   .  .||.|...| ... .  |.|.           |||  . ...||.| |.. ...  ||.||||
FGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYL

LQELTTGGELFFHMEKV-----------GPLREAEAS---------------FYAGAVLLVLEYMHGKG-IVYRDLKPENTLIGDNGYPKLIDMGFAKRI
  |.  ||.|| ....            ... | |..               ||.. ..| |||.| |. |..||.|||| |.     .|.||.|..|..
VMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKY

YNR---------------------------------RTYSMCGTPDYMAPEIIRRQG---------HGKAVDYWALGCLIFELITNTSAFNRGEDPPQLV
 .                                   ... |||| ||||||.....         .....|.|.||....|....   |          
DDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------

FHRIIDGRVKFPPY------------------VSSDCADIVRK----LLDPNPETRLGCRKRGAADIKEHPFF
.  |... ..||..                  .| .| |. .|    .|. .|| |..    |. .|..||.|
QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase PKG.AA Pkinase 3-249 29 2.9e-74 257.85 Pfam 12-293 (293) Show / Hide 
Range on Protein: 3-249
Range on HMM: 12-293/293
Sequence Identity: 29% (86 aa)

FGKVKLVFCRRTREYYALKCVSKAKVIRLQEEEHLR-NEKLFMTEMDHPFITKLIRTYKDDKNIYLLQELTTGG----ELFFHME--KVGPL--REAEAS
||.|..   . |.. .|.|...| .    ....|.| .|   | ...||.| .|.... |...||. .|.  ||    .|| ...  . |..   | |. 
FGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECK

FYAGAVLLVLEYMHGKGIVYRDLKPENTLIGDNGYP----KLIDMGFAK---RIYNRRTYSMCGTPDYMAPEIIR-RQGHGKAVDYWALGCLIFELITNT
||.  .|  |||.| .||..||||||| || .||..    |..| |.||      |. ... ||||.|||||.|| .|..|..|| |..||...|...  
FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR

SAFNRGE-----DPPQLVFHRIIDGRVKFPPYVS---------------------SDCADIVRKLLDPNPETRLGCRKRGAADIKEHPFF
  |  |.     . .. .. || .....|. . .                     ..| |.....|...|. |..     |..|..||.|
PPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF
Kinase PKG.AA PKG 1-249 41 4.7e-73 249.01 In-house 10-260 (260) Show / Hide 
Range on Protein: 1-249
Range on HMM: 10-260/260
Sequence Identity: 41% (104 aa)

GLFGKVKLVFCRRTR-EYYALKCVSKAKVIRLQEEEHLRNEKLFMTEMDHPFITKLIRTYKDDKNIYLLQELTTGGELFFHMEKVGPLREAEASFYAGAV
| || | ||       . .||||  |. ..  . .|| ..||  | | . .|| .| ||..|.| .|.| |   ||||   . . |   .  . ||.. |
GGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDKTTRFYCACV

LLVLEYMHGKGIVYRDLKPENTLIGDNGYPKLIDMGFAKRI-YNRRTYSMCGTPDYMAPEIIRRQGHGKAVDYWALGCLIFELITNTSAFNRGEDPPQLV
.  ..| | |.|.|||||||| . . .||.||.| ||||.|  .|.|.  |||| | |||||   ||  .||||||| |..||.| .  | .| || . .
VEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPF-SGSDPMK-T

FHRIIDG--RVKFPPYVSSDCADIVRKLLDPNPETRLGCRKRGAADIKEHPFF
.  |  |   . ||  ..   .....||   ||  |||  | | .||| |  |
YNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase PKG.AA SGK 1-249 33 1.2e-69 214.14 In-house 10-283 (283) Show / Hide 
Range on Protein: 1-249
Range on HMM: 10-283/283
Sequence Identity: 33% (94 aa)

GLFGKVKLVFCRRT------------------REYYALKCVSKAKVI-------RLQEEEHLRNEK-LFMTEMDHPFITKLIRTYKDDKNIYLLQELTTG
| |||| .|    .                     ||.|  .|. .|       .  |. |   |.   .  | |||| .|      ..  |.  .   |
GSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLYFVMDYVNG

GELFFHMEKVGPLREAEASFYAGAVLLVLEYMHGKGIVYRDLKPENTLIGDNGYPKLIDMGFAK-RI-YNRRTYSMCGTPDYMAPEIIRRQGHGKAVDYW
||.|.|. . . . | .| |||  . . ||| | . |.|||||||| | .. |. .| | | .|  |  |  | . |||| |.|||..| |.|...|| |
GEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQPHDRTVDWW

ALGCLIFELITNTSAFNRGEDPPQLVFHRIIDGRVKFPPYVSSDCADIVRKLLDPNPETRLGCRKRGAADIKEHPFF
 |||. .|...    |       |. .  || .  ..||..|.|. |.   ||  .|. |||  ||....||.||||
CLGCVLYEMMYGLPPFYSRNK--QQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase PKG.AA Akt 3-249 37 1e-68 218.77 In-house 12-264 (264) Show / Hide 
Range on Protein: 3-249
Range on HMM: 12-264/264
Sequence Identity: 37% (95 aa)

FGKVKLVFCRRTREYY-ALKCVSKAKVIRLQEEEHLRNEKLFMTEMDHPFITKLIRTYKDDKNIYLLQELTTGGELFFHMEKVGPLREAEASFYAGAVLL
|||| ||    | ..| |.|  .| . |   . ||   |.     ..||||..|     . ...|.  .   |||||.|. . .   | .| ||.  . |
FGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIIL

VLEYMHGKGIVYRD-LKPENTLIGDNGYPKLIDMGFAKRI---YNRRTYSMCGTPDYMAPEIIRRQGHGKAVDYWA-LGCLIFELITNTSAFNRGEDPPQ
 .|. | |.|.||| ||||| |.  .|. .| | | .|..   .. .|...|||| |.||||.  .||.|||| |. |||...|...    |   .| .|
AIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYN-QDHHQ

LVFHRIIDGRVKFP--PYVSSDCADIVRKLLDPNPETRLGCRKRGAADIKEHPFF
. |. |  . ||||  ...| .| |....||  .|. |||  . .| .||.||.|
M-FKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKG.AA RSK 3-249 34 6.8e-63 215.26 In-house 12-271 (271) Show / Hide 
Range on Protein: 3-249
Range on HMM: 12-271/271
Sequence Identity: 34% (89 aa)

FG---KVKLVFCRRTREYYALKCVSKAKVIRLQEEEHLRNEKLFMTEMDHPFITKLIRTYKDDKNIYLLQELTTGGELFFHMEKVGPLREAEASFYAGAV
|.    .| .  . |. .|| | . ||..          .|   . . .|||| ||   . | ...|.  ..  ||.|| .. |.. . | |..||.  .
FSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSEREVKFYMAEI

LLVLEYMHGKGIVYRDLKPENTLIGDN----GYPKLIDMGFAK--RIYNRRTYSMCGTPDYMAPEIIRRQGHGKAVDYWALGCLIFELITNTSAFNRG-E
.| .|| | .|||.||||||| |. |     |  |. | ||||  | .|  ... |.|  |||||...||||..|.|.| .| | .|  | .  |  .  
ALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPR

DPPQLVFHRIIDGRVKF----PPYVSSDCADIVRKLLDPNPETRLGCRKRGAADIKEHPFF
| |     || .|.  .    . ..|  . | .|..|. .|. |||.   |...||.||.|
DTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase PKG.AA TyrKc 1-249 20 7.8e-11 -47.51 SMART 10-280 (280) Show / Hide 
Range on Protein: 1-249
Range on HMM: 10-280/280
Sequence Identity: 20% (59 aa)

GLFGKVKLVFCRRTREYYALKCVSKAKVIRLQEEEHLRNEKLFMTEM--DHPFITKLIRTYKDD-------KNIYLLQELTTGGELFFHMEKVGP-LREA
| ||.| .   .   .  | |.. . .      .| ...|   |..   .|| | .|.    ..       . .... |.  .| |  .  | .| |  .
GAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

EASFYAGAVLLVLEYMHGKGIVYRDLKPENTLIGDNGYPKLIDMGFAKRIYNR-------RTYSMCG--TPD------YMAPEIIRRQGHGKAVDYWALG
.   ..  .    || | |... |||   | |.|.|.  |  | | .. ||.         .|.. .    .       |||| |.      . | |. |
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFG

CLIFELITNTSAFNRGE----DPPQLVFHRIIDG-RVKFPPY--------VSSDCADIVRKLLDPNPETRLGCRKRGAADIKEHPFF
 ...|. |.      |.     ..| |.... .| | . ||.         ...  .| ..  . .|| |   .         | .|
VCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-------HECF