Gene RSK-p3_a (S.moellendorffii)

RSK-p3_a

Species: S.moellendorffii
Alias: RSK-p3_a
External Links:
Annotation:

Classification

Group: AGC
Family: RSK
Subfamily: RSK-p3

Sequence

Name Sequence Type Origin Length Description Download
RSK-p3_a.AA Protein None 968 None Fasta, JSON
RSK-p3_a.NA RNA None 2907 None Fasta, JSON
RSK-p3_a.kin_dom Protein Kinase Domain None 292 None Fasta, JSON

Protein domain

Protein domains of RSK-p3_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PAC RSK-p3_a.AA PAC 274-316 20 1.9e-08 35.33 SMART 1-43 (43) Show / Hide 
Range on Protein: 274-316
Range on HMM: 1-43/43
Sequence Identity: 20% (9 aa)

CGRLLNYKKNGTPFWNLLTIAPIKDEDGKVLKYIGMLVEVSQF
 . . .|.|.|...| .... || |..|... .|..   ... 
TWEYRFYRKDGSWIWVQVSWTPIRDWQGQPQYWICVHRDITER
PAS RSK-p3_a.AA PAS 224-313 16 6.6e-07 25.6 Pfam 24-120 (120) Show / Hide 
Range on Protein: 224-313
Range on HMM: 24-120/120
Sequence Identity: 16% (16 aa)

ILYASAGFFSMTGYTAKEVIGRNCR-FLQGTETDP--VDVSKIRVALEQGKSFCGRLLNYKK-----NGTPFWNLLTIAPIKDEDGKVLKYIGMLVEV
|||... . .|.|....||.|..   ..  .. ..   ...... ...|| . ..   . ..     .|.|.| ... .|. |..|... .....  .
ILYWNRAAERMFGWSREEVMGKMLYDLIHHDDHRCCLEFHDQLWQCMQQGEE-RMFEITFRTPGQHRDGRPRWCEVRWCPYRDPGGEIHGFCCFMHDI
PAS_4 RSK-p3_a.AA PAS_4 205-318 16 1e-06 27.12 Pfam 1-123 (123) Show / Hide 
Range on Protein: 205-318
Range on HMM: 1-123/123
Sequence Identity: 16% (21 aa)

LSSFQQTFVVCDATDPELPILYASAG----FFS-MTGYTAKEVIGRNCR--FLQGTET--DPVDVSKIRVALEQGKSFCGRLLNYKK-NGTPFWNLLTI-
. . .. ..||.  ||.. ..|| .     . . . |....|.||| ..  .. . ..  .  ...    .. .|. .. ... .   || . | .... 
FDHSPDCIAVCK--DPDGRYRYANPACSNWYREWWFGWPPEEWIGRTWWGEMWPPELEDPHQQRFHRQWRRVLEGEEPIFFHHHHHHPNGEERWWEWRYQ

APIKDEDGKVLKYIGMLVEVSQFTE
 |. |.||.|. .|......... .
HPLRDPDGEVIGVIWICRDITERRR
PAS RSK-p3_a.AA PAS 199-268 19 0.003545 17.49 SMART 1-68 (68) Show / Hide 
Range on Protein: 199-268
Range on HMM: 1-68/68
Sequence Identity: 19% (14 aa)

EDLKDALSSFQQTFVVCDATDPELPILYASAGFFSMTGYTAKEVIGRNCRFLQGTETD--PVDVSKIRVALE
|..  .|..    ..|.|   ..  |.|... .  |.||. .|.||..   |   |    .     .. ...
ERYRAILENMPDGIWVWD---HDGRITYWNPAACQMFGYSPEELIGQSWWDLIHPEDRNLERFQE-HQRLQQ
PAS_3 RSK-p3_a.AA PAS_3 281-310 29 0.023006 10.31 Pfam 64-94 (94) Show / Hide 
Range on Protein: 281-310
Range on HMM: 64-94/94
Sequence Identity: 29% (9 aa)

KKNGTPFWNLLTIAPIK-DEDGKVLKYIGML
.|.|.  |   .  .|. ||.|.....|| .
HKDGEWRWVRDRGRVIRWDENGQPVRMIGVH
PAS_3 RSK-p3_a.AA PAS_3 224-246 39 0.023481 10.28 Pfam 1-23 (94) Show / Hide 
Range on Protein: 224-246
Range on HMM: 1-23/94
Sequence Identity: 39% (9 aa)

ILYASAGFFSMTGYTAKEVIGRN
|.|.| ... |.|||. |..|..
IIYWSPRWEEMFGYTPEEFHGKS
PAC RSK-p3_a.AA PAC 514-556 32 8.4e-09 36.48 SMART 1-43 (43) Show / Hide 
Range on Protein: 514-556
Range on HMM: 1-43/43
Sequence Identity: 32% (14 aa)

TVQLLNYTKRGKPFWNLFHLQPMRDNKGELQYFIGVQLDGSQH
|... .|.| | ..| ... .|.|| .|..||.|.|. | .. 
TWEYRFYRKDGSWIWVQVSWTPIRDWQGQPQYWICVHRDITER
PAS RSK-p3_a.AA PAS 464-553 20 6.1e-07 25.71 Pfam 24-120 (120) Show / Hide 
Range on Protein: 464-553
Range on HMM: 24-120/120
Sequence Identity: 20% (20 aa)

IIFASDSFLELTEYSREEILGKNCRFLQGPDTNQ---ETVTRIRYAIRDQKSITVQLLNYTK-----RGKPFWNLFHLQPMRDNKGELQYFIGVQLDG
| ...... ... .||||..||.   |  .|...   |.. ... ..... . . .  . ..      |.|.| . .  |.|| .||. .|...  | 
ILYWNRAAERMFGWSREEVMGKMLYDLIHHDDHRCCLEFHDQLWQCMQQGEE-RMFEITFRTPGQHRDGRPRWCEVRWCPYRDPGGEIHGFCCFMHDI
PAS_3 RSK-p3_a.AA PAS_3 464-550 21 0.001128 14.73 Pfam 1-94 (94) Show / Hide 
Range on Protein: 464-550
Range on HMM: 1-94/94
Sequence Identity: 21% (20 aa)

IIFASDSFLELTEYSREEILGKN----CRFLQGPDTNQETVTRIRY--AIRDQKSITVQLLNYTKRGKPFWNLFHLQPMR-DNKGELQYFIGVQ
||..|....|.. |..||..||.     . .  ||  . .   ..   ...........    .| |.  |   . ...| |  |.  ..||| 
IIYWSPRWEEMFGYTPEEFHGKSTYEDWYHHIHPDDRERVRQAHQEHWKLKKGQPYECEYRIRHKDGEWRWVRDRGRVIRWDENGQPVRMIGVH
PAS RSK-p3_a.AA PAS 439-508 16 0.002489 18.31 SMART 1-68 (68) Show / Hide 
Range on Protein: 439-508
Range on HMM: 1-68/68
Sequence Identity: 16% (12 aa)

IDLATTLERIEKNFVITDPRLPDNPIIFASDSFLELTEYSREEILGKNCRFLQGPDTN--QETVTRIRYAIR
 .... || .   ....|   .|  |........... ||.||..|..   |  |.    ..    .. ...
ERYRAILENMPDGIWVWD---HDGRITYWNPAACQMFGYSPEELIGQSWWDLIHPEDRNLERFQE-HQRLQQ
Kinase RSK-p3_a.AA AGC 638-929 30 2.2e-153 399.86 In-house 1-395 (395) Show / Hide 
Range on Protein: 638-929
Range on HMM: 1-395/395
Sequence Identity: 30% (123 aa)

FRPVKALGSGDTGGVHLVELR------ETGQFFAMKAMEKSS---MLNRNKVHRTLME------------RDILDMMD----------HPFLPT-LYGSF
|. .| .| |  | |.||. .       ||...||| ..|.    ....|.|..|. |            |.|| ...          |||.   |. ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETEAH--VCLITDFCP---------GG-ELFLLLDRQ-PSKTFNEPTVCFYAAE-------VVVALEYLHC-RGVVYRD-LKPENILVQRNGHLLLTDFD
... |  .... ...|         || |||| |  .  ...|.|....|||||       .| ||||||  .|...|| |||||||  ..||. |||| 
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSFVSNPRAQVIRPPP------------------------PASERRKRKKEAPVPPTFVVEPVARSNSFVG--TEEYIAPEVINGSGHSSAVDWWA--LG
|. . . .  .  . .                        |....|..  .   ..|   .  .| ..|.|  | ||.|||..    .. |.|||.  ||
LCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNN-MSQE-DDTTR-KKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLG

ILLYEMLVGWTPFRGKNRQ----------KTFHNIL------HKELKFPS-------TVQVVSPSAKELIHRLLQKDPSQRLGSSM------GANEIKHH
.|.||||.|..||.|.|.|          ..|..|.      ....|||.       ... .|| || || .||.|||..|||.        ||.||| |
CLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH

PFF
|.|
PWF
Kinase RSK-p3_a.AA RSK-Unclassified 638-929 43 8.10000000001e-126 397.37 In-house 1-283 (283) Show / Hide 
Range on Protein: 638-929
Range on HMM: 1-283/283
Sequence Identity: 43% (127 aa)

FRPVKALGSGDTGGVHLVELRETGQFFAMKAMEKSSMLNRNKVHRTLMERDILDMMDHPFLPTLYGSFETEAHVCLITDFCPGGELFLLLDRQPSKTFNE
|   . .| || | | ||. ..| | .||| ..|. |. .||. . . |..|. . .|||  ||| || |.    |. ..|.||..|  |    .| | |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

PTVCFYAAEVVVALEYLHCRGVVYRDLKPENILVQRNGHLLLTDFDLSFVS-NPRAQVIRPPPPASERRKRKKEAPVPPTFVVEPVARSNSFVGTEEYIA
  | |||.||..|||||| |...||||||.||.    ||  |||||||    . .  |.          |   ..    | ...   | |||.|||||.|
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVM----------KGSAQSTYVDTKICDHGFRTNSFCGTEEYLA

PEVINGSGHSSAVDWWALGILLYEMLVGWTPFRGKNRQKTFHNILHKELKFPSTVQVVSPSAKELIHRLLQKDPSQRLGSSMG-ANEIKHHPFF
||.| . ||  ||||| |||..||||.| .|..| |.  || ||. ...|||   . .|  ...|| .|||. |. |||. || |..|| ||||
PEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHD-SYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase RSK-p3_a.AA RSK 641-929 36 1.4e-107 363.72 In-house 1-278 (278) Show / Hide 
Range on Protein: 641-929
Range on HMM: 1-278/278
Sequence Identity: 36% (113 aa)

VKALGSGDTGGVHLVELR---ETGQFFAMKAMEKSSMLNRNK-VHRTLMERDILDMMD-HPFLPTLYGSFETEAHVCLITDFCPGGELFLLLDRQPSK-T
.| || |. | | |.       ||| .|||  .|. . .|.| . .|. ||.|| .   |||. ||. .|.|| .. ||...|.|||||  | .. ..  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FNEPTVCFYAAEVVVALEYLHCRGVVYRDLKPENILVQR---NGHLLLTDFDLSFVSNPRAQVIRPPPPASERRKRKKEAPVPPTFVVEPVARSNSFVGT
| | ..|||.||.|.|.|.|| .|...|||||||||      .||. ||||...  .                             . .   . ..|..|
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-----------------------------RCDHNQWTMTFCYT

EEYIAPEVIN----GSGHSSAVDWWALGILLYEMLVGWTPFRG---KNRQKTFHNILHKE--LKFP--STVQVVSPSAKELIHRLLQKDPSQRLGS-SMG
 ||.|||...    ..||. |.||| ||.|.||||.| .||.|   .||.... .|....  |..|  ..   .|. ||.|| ..|..||..|||.  ..
IEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQY---LSQEAKDLIRKMLHRDPHKRLGCGPQD

ANEIKHHPFF
|.||| ||.|
AEEIKQHPWF
Kinase RSK-p3_a.AA AktR 638-929 37 2.1e-102 346.54 In-house 1-268 (268) Show / Hide 
Range on Protein: 638-929
Range on HMM: 1-268/268
Sequence Identity: 37% (115 aa)

FRPVKALGSGDTGGVHLVELR-ETGQFFAMKAMEKSSMLNRNKVHRTLMERDILD-MMDHPFLPTLYGSFETEAHVCLITDFCPGGELFLLLDRQPSKTF
|.  | ||.|  | | ||. . ......|||   |. . .||. |.|..||.|.  ...|||.  |. .|.|. .  .| ..|||||||  | ..  |.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKK--KKF

NEPTVCFYAAEVVVALEYLHCR-GVVYRDLKPENILVQRNGHLLLTDFDLSFVSNPRAQVIRPPPPASERRKRKKEAPVPPTFVVEPV----ARSNSFVG
.| .. ||.|... |||||| .  ..||||||||||   .||. .||| ||                                  ...     . .||.|
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------------------------LQFMMHYDEKAYSFCG

TEEYIAPEVING-SGHSSAVDWWALGILLYEMLVGWTPFRGKNRQKTFHNILHKE-LKFPSTVQVVSPSAKELIH-RLLQKDPSQRLG-SSMGANEIKHH
| ||.|||.|.   ||  .|||||.||..|||..| .||  ||..  |..|. |. .||| .... |. .|.||  .||.|.| .||| ...|. ||| |
TPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYF-SSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSH

PFF
|.|
PWF
Kinase RSK-p3_a.AA S_TKc 638-929 28 6.6e-93 315.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 638-929
Range on HMM: 1-231/231
Sequence Identity: 28% (85 aa)

FRPVKALGSGDTGGVHLVELRETGQFFAMKAMEKSSMLNRNKVHRTLMERDILDMMDHPFLPTLYGSFETEAHVCLITDFCPG--GELFLLLDRQPS---
.. .. .|.|  | |...  ..||. .|.| .            ... |..|| . .||.. .||..|..  |.......|.|  |.|| .......   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-KTFNEPTVCFYAAEVVVALEYLHCRGVVYRDLKPENILVQRNGHLLLTDFDLSFVSNPRAQVIRPPPPASERRKRKKEAPVPPTFVVEPVARSNSFVGT
 . |.| ...||..... ||||.| .|...|||||||||. .  |. ..|| |. .                                      ..|.||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------TTFCGT

EEYIAPEVINGSGHSS-AVDWWALGILLYEMLVGWTPFRGKNRQKTFHNILHKELKFPSTVQVVSPSAKELIHRLLQKDPSQRLGSSMGAN---EIKHHP
 .|.||||.   |..  ..|||..|..|||||.| .||.  . |..|..|.             ||.||..| ..|||||..|..     .   .|| ||
PWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

FF
.|
WF
Kinase RSK-p3_a.AA Pkinase 638-929 26 4.1e-82 283.9 Pfam 1-293 (293) Show / Hide 
Range on Protein: 638-929
Range on HMM: 1-293/293
Sequence Identity: 26% (87 aa)

FRPVKALGSGDTGGVHLVELRETGQFFAMKAMEKSSMLNRNKVHRTL-MERDILDMMDHPFLPTLYGSFETEAHVCLITDFCPGG----ELFLLLDRQPS
.. .. .|||  | | .   . ||. .|.| ..|..     ...... .|  |. ...||.  .||..||.. |.......|.||    .|| .. .. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KTF--NEPTVCFYAAEVVVALEYLHCRGVVYRDLKPENILVQRNGHL----LLTDFDLS-FVSNPRAQVIRPPPPASERRKRKKEAPVPPTFVVEPVARS
..|   | ...||. ... .|||.| .|...|||||||||. .|||.     ..|| |. ...                                .    
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------------------------Y-NNS-M

NSFVGTEEYIAPEVIN-GSGHSSAVDWWALGILLYEMLVGWTPFRGK------NRQKTFHNILHKELKFPSTVQ------------------VVSPSAKE
..|.|| .|.|||||. |......||.|..|..||||| | .||.|.      . .. . .|....|.|..                      .|...|.
TTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKD

LIHRLLQKDPSQRLGSSMGANEIKHHPFF
.| ..|.|||..|..    | .|..||.|
FIKWCLCKDPKKRPT----AEQILQHPWF
Kinase RSK-p3_a.AA MAST 822-929 43 9.1e-56 168.52 In-house 222-337 (337) Show / Hide 
Range on Protein: 822-929
Range on HMM: 222-337/337
Sequence Identity: 43% (51 aa)

VARSNSFVGTEEYIAPEVINGSG-HSSAVDWWALGILLYEMLVGWTPFRGKNRQK-TFHNILH--KELKFPST-----VQVVSPSAKELIHRLLQKDPSQ
. . .. .|| .|||||||.| | .. .||||..|| .|| ||| .|| | .... .| ||..  .|. .|..        .|| |..|| .|||..|..
IHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKK

RLGSSMGANEIKHHPFF
|||.  || ||| ||||
RLGAN-GADEIKQHPFF
Kinase RSK-p3_a.AA Akt 826-929 47 1.1e-53 169.98 In-house 160-264 (264) Show / Hide 
Range on Protein: 826-929
Range on HMM: 160-264/264
Sequence Identity: 47% (50 aa)

NSFVGTEEYIAPEVINGSGHSSAVDWWA-LGILLYEMLVGWTPFRGKNRQKTFHNILHKELKFPSTVQVVSPSAKELIHRLLQKDPSQRLG-SSMGANEI
..| || ||.|||..|| ||. |||||. ||...|||. |. ||  ..... |..|. ...||| .  ..|| .| ||..||.|||..|||  . .|.||
KTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEI

KHHPFF
| ||.|
KRHPWF
Kinase RSK-p3_a.AA Akt 638-782 42 2.8e-53 168.63 In-house 1-145 (264) Show / Hide 
Range on Protein: 638-782
Range on HMM: 1-145/264
Sequence Identity: 42% (63 aa)

FRPVKALGSGDTGGVHLVELRETGQFF-AMKAMEKSSMLNRNKVHRTLMERDILDMMDHPFLPTLYGSFETEAHVCLITDFCPGGELFLLLDRQPSKTFN
|. .| ||.|  | | ||.   |.... |||.  |.  ...|.|  |. || || ...|||.  |. || |. . ....|.|.||||| .| |.  ..|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRK--RRFS

EPTVCFYAAEVVVALEYLHCRGVVYRD-LKPENILVQRNGHLLLTDF
|..  ||.||.. |.|.|| ....||| |||||||. ..||. ||||
EDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDF
Kinase RSK-p3_a.AA SGK 827-929 47 2.9e-51 156.33 In-house 184-283 (283) Show / Hide 
Range on Protein: 827-929
Range on HMM: 184-283/283
Sequence Identity: 47% (49 aa)

SFVGTEEYIAPEVINGSGHSSAVDWWALGILLYEMLVGWTPFRGKNRQKTFHNILHKELKFPSTVQVVSPSAKELIHRLLQKDPSQRLGSSMGANEIKHH
.| || || ||||... .|. .|||| ||..||||..|  ||  .|.|  . ||....|..|   . .|..|..||  ||||||..|||.  .. ||| |
TFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIP---PQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNH

PFF
|||
PFF
Kinase RSK-p3_a.AA MAST 822-929 43 6.9e-50 158.83 In-house 218-334 (334) Show / Hide 
Range on Protein: 822-929
Range on HMM: 218-334/334
Sequence Identity: 43% (51 aa)

VARSNSFVGTEEYIAPEVINGSG-HSSAVDWWALGILLYEMLVGWTPFRGKNRQKTFHNILHKE---LKFPST-----VQVVSPSAKELIHRLLQKDPSQ
. . .. .|| .|||||||.| | |. .||||..|| .|| ||| .|| .......| |||...    ..| .         || |..|| .||| ||..
IHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRK

RLGSSMGANEIKHHPFF
|||.. || |.| ||||
RLGANNGADEVKQHPFF
Kinase RSK-p3_a.AA PKA 638-782 38 5.8e-48 165.66 In-house 1-145 (263) Show / Hide 
Range on Protein: 638-782
Range on HMM: 1-145/263
Sequence Identity: 38% (57 aa)

FRPVKALGSGDTGGVHLVELRETGQFFAMKAMEKSSMLNRNKVHRTLMERDILDMMDHPFLPT-LYGSFETEAHVCLITDFCPGGELFLLLDRQPSKTFN
|  .. ||.|  | |.|.  ...|...||| . |.    .. |.... |. ||  ..|||. . .|..| .. .  .. ...||||.|  |  . |. |.
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYL--RKSGRFS

EPTVCFYAA-EVVVALEYLHCRGVVYRDLKPENILVQRNGHLLLTDF
.|. .|||| ..| ||||||    .||||||||||  .|||. .|||
NPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDF
Kinase RSK-p3_a.AA SGK 638-785 35 1.7e-45 138.2 In-house 1-172 (283) Show / Hide 
Range on Protein: 638-785
Range on HMM: 1-172/283
Sequence Identity: 35% (62 aa)

FRPVKALGSGDTGGVHLVELRET------------------GQFFAMKAMEKSSML-------NRNKVHRTLMER-DILDMMDHPFLPTLYGSFETEAHV
|.  | .| |  | | .|.  ..                  ..|.|||   | . .       .....  .. || .||  | |||.  |  .| |.   
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CLITDFCPGGELFLLLDRQPSKTFNEPTVCFYAAEVVVALEYLHCRGVVYRDLKPENILVQRNGHLLLTDFDLS
 .  |.  |||.|  | |   | | |. . |||||.| ||||||   ..||||||||||    ||. |||| |.
YFVMDYVNGGEMFYHLQRE--KHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLC
Kinase RSK-p3_a.AA p70 638-785 34 5.8e-43 149.06 In-house 1-175 (299) Show / Hide 
Range on Protein: 638-785
Range on HMM: 1-175/299
Sequence Identity: 34% (61 aa)

FRPVKALGSGDTGGVHLVELRE---TGQFFAMKAMEKSSMLNRNKVHRTLM--------------------------ERDILDMMDHPFLPTLYGSFETE
| ..| || |  | | .|       ||. .||| . | . .   |  .                             || ||.   |||.  |  .| |.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

AHVCLITDFCPGGELFLLLDRQPSKTFNEPTVCFYAAEVVVALEYLHCRGVVYRDLKPENILVQRNGHLLLTDFDLS
    || .. .||||| .| |.   .. | |.|||..|...|||.|| .|..||||||||..    ||. |||| |.
GKLYLILEYLHGGELFMHLERHG--IWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLC
Kinase RSK-p3_a.AA MAST 638-785 41 1.3e-42 134.99 In-house 1-146 (334) Show / Hide 
Range on Protein: 638-785
Range on HMM: 1-146/334
Sequence Identity: 41% (62 aa)

FRPVKALGSGDTGGVHLVELRETGQFFAMKAMEKSSMLNRNKVHRTLMERDILDMMDHPFLPTLYGSFETEAHVCLITDFCPGGELFLLLDRQPSKTFNE
|  .| .. |  |.| ||. ..|...|||| . || |.|.| |.    ||.|| | . ||   .. ||.|. ..|.. ..  || .. ||      .| |
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG--YFDE

PTVCFYAAEVVVALEYLHCRGVVYRDLKPENILVQRNGHLLLTDFDLS
... .| ||.| .|||||  | | |||||.|.|   |||  |||| ||
WMAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLS
Kinase RSK-p3_a.AA MAST 638-785 38 3.6e-42 126.19 In-house 1-149 (337) Show / Hide 
Range on Protein: 638-785
Range on HMM: 1-149/337
Sequence Identity: 38% (58 aa)

FRPVKALGSGDTGGVHLVELRETGQFFAMKAMEKSSMLNRNKVHRTLMERDILDMMDHPFLPTLYGSFET--EAHVCLITDFCPGGELFLLLDRQPSKTF
|  .| .. |  |.| ||. ..|...|||| . .. .. .| |     ||.|| | . ||   .. ||.|  . ..|.. ..  ||  . || |    ..
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLL-RMYGNCM

NEPTVCFYAAEVVVALEYLHCRGVVYRDLKPENILVQRNGHLLLTDFDLS
 |  . .| || | .|||||  | | |||||.|.|   |||. |||| ||
PEWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLS
Kinase RSK-p3_a.AA PKA 830-929 43 4.7e-38 132.75 In-house 160-263 (263) Show / Hide 
Range on Protein: 830-929
Range on HMM: 160-263/263
Sequence Identity: 43% (45 aa)

GTEEYIAPEVINGS-GHSSAVDWWALGILLYEMLVGWTPFRGK--NRQKTFHNILHKELKFPSTVQVVSPSAKELIHRLLQKDPSQRLGSSM-GANEIKH
|| ||.|||.|... ||  .||||||||| ||||.| .||. .  .  ...  |.  ..|||. . .     | || .|||.|...|.|.   |.| ||.
GTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKN

HPFF
|..|
HKWF
Kinase RSK-p3_a.AA p70 827-929 45 9.8e-37 128.36 In-house 197-299 (299) Show / Hide 
Range on Protein: 827-929
Range on HMM: 197-299/299
Sequence Identity: 45% (48 aa)

SFVGTEEYIAPEVINGSGHSSAVDWWALGILLYEMLVGWTPFRGKNRQKTFHNILHKE--LKFPSTVQVVSPSAKELIHRLLQKDPSQRLGSSMG-ANEI
.|.|| || |||.. ..||. |||||.||.|.| ||.|  || | ||.||   ||     || |      ..... || .|| ..|.||.|.  . | .|
TFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPP---YLTHEMRDLIKKLLKRHPTQRWGAGPEDAADI

KHHPFF
. ||||
QEHPFF
Kinase RSK-p3_a.AA TyrKc 638-923 20 1.5e-09 -68.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 638-923
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

FRPVKALGSGDTGGVHLVELRETGQFFAMKAMEKSSMLNRNKVHRTLMERDILDMM--DHPFLPTLYGSFETE-------AHVCLITDFCPGGELFLLL-
 .  | ||.|  | |.. ...   .  | | . ...      .   . |  |. .   .|| .  |||   ..         ..... ..|.| |   | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

DRQPSKTFNEPTVCFYAAEVVVALEYLHCRGVVYRDLKPENILVQRNGHLLLTDFDLSFVSNPR-AQVIRPPPPASERRKRKKEAPVPPTFVVEPVARSN
...|   .. .. . ..  .    |||| .... |||   |.|| .|..   .|| ||       .|       .|.  .||||     |  . |.    
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG------ESKDYYRKKEHKGGKT--MLPIR---

SFVGTEEYIAPEVINGSGHSSAVDWWALGILLYEML-VGWTPFRG-----KNRQKTFHNILHK-ELKFPST------VQVVSPSAKELIHRLLQKDPSQR
         |||.|| .  ... | |. |....|..  | .|  |     .. |  .... .   .. |        |   .   . .. .  . ||..|
-------WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDR

LGSSMGANEI
   |    ..
PTFSEIHECF