Gene CAMK1c-S4_c (S.moellendorffii)

CAMK1c-S4_c

Species: S.moellendorffii
Alias: CAMK1c-S4_c
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMK1
Subfamily: CAMK1c

Sequence

Name Sequence Type Origin Length Description Download
CAMK1c-S4_c.AA Protein None 306 None Fasta, JSON
CAMK1c-S4_c.NA RNA None 921 None Fasta, JSON
CAMK1c-S4_c.kin_dom Protein Kinase Domain None 250 None Fasta, JSON

Protein domain

Protein domains of CAMK1c-S4_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc CAMK1c-S4_c.AA S_TKc 20-269 28 1.4e-55 191.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-269
Range on HMM: 1-231/231
Sequence Identity: 28% (78 aa)

YIRHEKLGHGGQGQVYLLSDAARNRHRYAGKMFKSESCAERETRILDKLRPIPGVVFLHGLRRERKVGGRCFGTMVMELCGP---SLRDLAMKGP-----
|  ..|.|.|. |.||.  .     ...| |. |    ..|| .|| |    | .| |..  ..       .  ||||.|.    .|.|.  | .     
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LREEEVAEIVKELAETLKGVHSSGIVHRDLKLENVFTKLQDASTITPVIGDFGVATDDAREMSQSCGTEKYMAPELIFVERYGLSYTK-AVDVWGLGV
  . | ... ....... |.  || ||.||||| ||..         .  |.|||.|.      .  |||  |||||..       .|.| ..|.| .|.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGC

IAYELLKGYN---RSNLEMHLLREGEFQWPANLSPEAKNLIMGMLDLDPRKRLTLDQVIN-------HPWI
| ||.| ||      .. .....          |||||..|...|. ||.||.|  .. .       |||.
ILYEMLCGYPPFPQMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CAMK1c-S4_c.AA CAMK 25-269 18 1.6e-45 144.25 In-house 1-425 (425) Show / Hide 
Range on Protein: 25-269
Range on HMM: 1-425/425
Sequence Identity: 18% (80 aa)

KLGHGGQGQVYLLSDAARNR-----------HRYAGKMFK---------------------------------SESCAERETRILDKLRP------IPGV
.||.|. |.|.|  .   ..           ...| |. .                                 ..   .|| .|. ||.        | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VFLHGLRRERK---------VGGR-CFGT------MVM---ELCGPS------LRDLAMKGP---------------LREEEVAEIVKELAETLKGVHSS
. |.     ..            .  | |      |||   |.|         .  .  .|.               . |.|.. ... ... ..  || 
IKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GIVHRDLKLENVFTKLQDASTI-------------TPVIGDFGVATDDAR--------------------------EMSQSCGTEKYMA-PELIFVERYG
.|||||||.||.     . ..              .  | ||| |.   .                           |. .|||  ||| ||..  .. .
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

LS----------YTKAVDVWGLGVIAYELLKG----YNR-------------SNLEMH-LLREGEFQWPAN------------------------LSPEA
 .          |....|.| .||| | .| |    |               .  |..   ..|....|                          .|.|.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KNLIMGMLDLDPRKRLTLDQVINHPWI
|.|| .||  || ||.|..|. ||||.
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Pkinase CAMK1c-S4_c.AA Pkinase 20-269 27 1.9e-45 161.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 20-269
Range on HMM: 1-293/293
Sequence Identity: 27% (85 aa)

YIRHEKLGHGGQGQVYLLSDAARNRHRYAGKMFKSESCAE---------RETRILDKLRPIPGVVFLHGLRRERKVGGRCFGTMVMELCGP-----SLRD
| ...|.| |. |.||.  .   .. ..| | .| ..  .         .| .|. .|.  | .| |..  ..   ....   ||||.|.      .| |
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFED---KDHIY--MVMEYCEGGLYVMDLFD

LAM---KGPL--REEEVAEIVKELAETLKGVHSSGIVHRDLKLENVFTKLQDASTITP----VIGDFGVA----TDDAREMSQSCGTEKYMAPELIFVER
. .   .|..   |.|.  ....... |.  || ||.|||||.||.   | | .. ..     |.|||.|    .   . |.  |||  |||||.|    
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENI---LID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---

YGLSYTKAVDVWGLGVIAYELLKG----YNR------SNLEMHLLREG---EFQWPANLS-------------------PEAKNLIMGMLDLDPRKRLTL
 |  |...||.|..|.| ||.| |    ...      . ..|. .. |   .|.||   |                   .|.| .| ..|..|| ||.| 
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

DQVINHPWI
.|. .|||.
EQILQHPWF
Kinase CAMK1c-S4_c.AA Ciliate-E2 94-269 23 7.7e-38 127.46 In-house 111-365 (365) Show / Hide 
Range on Protein: 94-269
Range on HMM: 111-365/365
Sequence Identity: 23% (64 aa)

MVMELC-GPSLRD--------------LAMKGPLREEEVAEIVKELAE---------------TLKGVHSSG-IVHRDLKLENVFTKLQDASTITPVIGD
.|||.| | .|.|                  ... |.|...| |....                |.  || . |.|||.|.||..          . | |
LVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIID

FGVATDDARE------MSQS----------------------------CGTEKYMAPELIFVERY-----GLSYTKAVDVWGLGVIAYELLKGYNRSNLE
|| ...   .      ..|.                            |||  ||||| .  . |     .  |....|.| |||| ||.| |.      
FGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---

MHLLREGEFQWP------------------ANLSPEAKNLIMG----MLDLDPRKRLT-LDQVINHPWI
.    ..... |                   ..|.|.|.||      ||. || ||.|  .|..||||.
QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CAMK1c-S4_c.AA AGC 160-269 20 2.9e-37 92.64 In-house 196-395 (395) Show / Hide 
Range on Protein: 160-269
Range on HMM: 196-395/395
Sequence Identity: 20% (43 aa)

IGDFGVATDDARE-----------------------------------------------------MSQSCG--TEKYMAPELIFVERYGLSYTKAVDVW
. ||| ..   ..                                                      .  ||  |  ||||| .        |.||.| |
LTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--------YGKACDWW

G--LGVIAYELLKG----YNRSNL----------EMHLLRE-------GEFQWP----------ANLSPEAKNLIMGMLDLDPRKRLT----------LD
.  ||.. ||.| |    |. ..           ||. . .        . ..|           ..|||||.|| ..|  ||.|||.           .
SFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAE

QVINHPWI
.. |||| 
EIKNHPWF
Kinase CAMK1c-S4_c.AA MSK 109-269 32 9.4e-35 114.9 In-house 95-277 (277) Show / Hide 
Range on Protein: 109-269
Range on HMM: 95-277/277
Sequence Identity: 32% (60 aa)

KGPLREEEVAEIVKELAETLKGVHSSGIVHRDLKLENV-FTKLQDASTITPVIGDFGVATDDAREMSQ---S-CGTEKYMAPELIFVERYGLS-YTKAVD
..  .|.|...|. ||   ..  |. ||.|||||.||. |.  .|  ..  .. ||| |    .....   | |.|  |||||.. .   . . | .|.|
REHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHV--KLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACD

VWGLGVIAYELLKG---YN--RSNLE---------MHLLREGEFQWP----ANLSPEAKNLIMGMLDLDPRKRLTLDQVINHPWI
.|.|||| |..| |   .    .  .         |   ..|||  |     | ||.||.|| ..|  || |||...    | |.
WWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase CAMK1c-S4_c.AA CAMKL 94-269 27 6.9e-34 105.42 In-house 98-297 (297) Show / Hide 
Range on Protein: 94-269
Range on HMM: 98-297/297
Sequence Identity: 27% (58 aa)

MVMELCGPS---LRDLAMKGP-----LREEEVAEIVKELAETLKGVHSSGIVHRDLKLENVFTKLQDASTITPVIGDFGVAT--DD-----AREMSQSCG
.|||.|.     | |   | .     . |.|   . . . . ..  || ||||||.|.||.    .. .  .  | ||| ..  ..      . .. .||
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCG

TEKYMAPELIFVERYG--LSYT-KAVDVWGLGVIAYELLKGYNR-------------SNLEMHLLREGEFQWPAN--LSPEAKNLIMGMLDLDPRKRLTL
.  |||||..     |   .|  ..||.| .||| | .. ||                 ....  ..| ...|    .| ....|| .||  .| || |.
SPPYMAPEIF----QGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTI

DQVINHPWI
.|. |||| 
HQIMNHPWM
Kinase CAMK1c-S4_c.AA RSK 110-269 30 5.6e-33 115.88 In-house 99-278 (278) Show / Hide 
Range on Protein: 110-269
Range on HMM: 99-278/278
Sequence Identity: 30% (56 aa)

GPLREEEVAEIVKELAETLKGVHSSGIVHRDLKLENVFTKLQDASTITPVIGDFGVATD-DAR--EMSQS-CGTEKYMAPELIFVERYGLS-YTKAVDVW
| . |.|....  |.. ...  |. ||.|||||.||.    .. .  . .. ||| .   ...  .. .. |.|  |||||.. .   . . ..||.|.|
GCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWW

GLGVIAYELLKGY--------NRSNLEMHLLREGE--FQWP--ANLSPEAKNLIMGMLDLDPRKRLT-----LDQVINHPWI
 |||. ||.| |.        | ..  |   ..|.  .  |  ..||.|||.|| .||  || |||.     .... .|||.
SLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase CAMK1c-S4_c.AA ULK 109-269 24 1.7e-30 103.75 In-house 114-329 (329) Show / Hide 
Range on Protein: 109-269
Range on HMM: 114-329/329
Sequence Identity: 24% (53 aa)

KGP----------LREEEVAEIVKELAETLKGVHSSGIVHRDLKLENVFTKLQDAST--------ITPVIGDFGVATD-DAR------EMSQS-----CG
...          | |.|. .. | ... .|  |. .|.|||.|..|.  .  ...|        ..  |.||| |   |        .|...     ||
NKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCG

TEKYMAPELIFVERYGLSYT-KAVDVWGLGVIAYELLKGY------NRSNLEMHLLRE-------------GEFQWP-----ANLSPEAKNLIMGMLDLD
|  ||||...  .  .  |. . .|.| ||.| ||.| |.      ...  .... ..               .|.|      ..||| |.|| .||  |
TPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYD

PRKRLTLDQVINHPWI
...| . ....||||.
EKDRISWEELFNHPWF
Kinase CAMK1c-S4_c.AA ULK 112-269 26 3e-28 97.39 In-house 123-324 (324) Show / Hide 
Range on Protein: 112-269
Range on HMM: 123-324/324
Sequence Identity: 26% (54 aa)

LREEEVAEIVKELAETLKGVHSSGIVHRDLKLENVFTKLQDAST--------ITPVIGDFGVATD-DAREMS-QSC----------GTEKYMAPELIFVE
| |.|. .. | ... .|  |. .|.|||.|..|   .  ...|        ..  |.||| |   |  .|. | |          ||  ||||...  .
LSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQ

RYGLSYT-KAVDVWGLGVIAYELLKGY-N---R-SNLE-------------MHLLREGEFQWP-----ANLSPEAKNLIMGMLDLDPRKRLTLDQVINHP
  .  |. . .|.| ||.| ||.| |.     . ....             . . .   .|.|      ..||| |.||..||  |...| . ....|||
GEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHP

WI
|.
WF
Kinase CAMK1c-S4_c.AA Ciliate-E2-Unclassified 94-217 25 4.5e-24 80.41 In-house 98-267 (352) Show / Hide 
Range on Protein: 94-217
Range on HMM: 98-267/352
Sequence Identity: 25% (43 aa)

MVMELC-GPSLRDLAMK------------------GPLREEEVA-----EIVKELAETLKGVHSSG-IVHRDLKLENVFTKLQDASTITPVIGDFGVAT-
.|||.| | .|..   |                    . |....      . ... . |.  |... |.|||.|.||.. . .      . | ||| .  
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKK

--DD---------------AREMSQSCGTEKYM----APELIFVERYGLSYTKAVDVWGLGVIAYELLKGY
  ..                 .|.. |||  ||    |||..  . |. |  ...|.|.||||.||.| ||
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY
Kinase CAMK1c-S4_c.AA MAPKAPK 114-217 35 1.3e-22 66.46 In-house 102-215 (292) Show / Hide 
Range on Protein: 114-217
Range on HMM: 102-215/292
Sequence Identity: 35% (41 aa)

EEEVAEIVKELAETLKGVHSSGIVHRDLKLENVFTKLQDASTITPV-IGDFGVATD-------DAR----EMSQSCGTEKYMAPELIFVERYGLSYTKAV
|.|...|.|. .. ..  || .| |||||.||.    .| . . || ..||| |         . .    |.   |.|  ||||| . ...  . | |  
EREASQIMKDICSAVDFLHSMNIAHRDLKPENIL--CTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFKEAHTYDKSC

DVWGLGVIAYELLKGY
| | |||| | .| ||
DMWSLGVIMYIMLCGY
Kinase CAMK1c-S4_c.AA MAPKAPK 239-269 61 8.4e-13 35.52 In-house 262-292 (292) Show / Hide 
Range on Protein: 239-269
Range on HMM: 262-292/292
Sequence Identity: 61% (19 aa)

SPEAKNLIMGMLDLDPRKRLTLDQVINHPWI
| |||.||  .|  || .|||  ||.|||||
SEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI
Kinase CAMK1c-S4_c.AA Ciliate-E2-Unclassified 235-269 46 1.7e-12 39.69 In-house 314-352 (352) Show / Hide 
Range on Protein: 235-269
Range on HMM: 314-352/352
Sequence Identity: 46% (18 aa)

PANLSPEAKNLIM----GMLDLDPRKRLTLDQVINHPWI
| ..|||||..|      ||. .| ||.|..|..||||.
PKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase CAMK1c-S4_c.AA TyrKc 20-269 22 8e-08 -96.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-269
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

YIRHEKLGHGGQGQVYL--LSDAARNRHRYAGKMFKSESCAE--RETRILDKL-RPIPGVVFLHGLRRER-----KVGGRCFGTMVMELCGP-SLRDLAM
    .|||.|  |.||.  ..         | || |... ..  || ||. ||    | .| |.|  ..       ..  .   .|||..   .|.|   
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLM---IVMEYMPHGDLKDYLR

KGP--LREEEVAEIVKELAETLKGVHSSGIVHRDLKLENVFTKLQDASTITPVIGDFGVATDDARE-------MSQSC----GTE-----KYMAPELIFV
|    |  ..  ..    |.     || ...||||   |.  . .     |  |.||| . |   .          .     |.      . |||| |  
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

ERYGLSYTKAVDVWGLGVIAYELLKG-----YN-----RSNLE-MHLLREGEFQWPANL---------SPEAKNLIMGMLDLDPRKRLTLDQVINHPWI
 .||  .| . |||  ||  .|..       ..      || | ......|.   .            ..|  ...    . || .| |  ..  |  .
-NYGK-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CAMK1c-S4_c.AA AGC 132-146 64 1.6e-07 13.99 In-house 170-186 (395) Show / Hide 
Range on Protein: 132-146
Range on HMM: 170-186/395
Sequence Identity: 64% (11 aa)

HS-SGIVHRD-LKLENV
||  ||.||| ||.||.
HSHMGIIHRDYLKPENI
Kinase CAMK1c-S4_c.AA Ciliate-E2 20-39 35 0.000378 10.12 In-house 1-20 (365) Show / Hide 
Range on Protein: 20-39
Range on HMM: 1-20/365
Sequence Identity: 35% (7 aa)

YIRHEKLGHGGQGQVYLLSD
|. ..|.| |..|.||. ..
YKFIKKIGQGNFGSVYKCKV
Kinase CAMK1c-S4_c.AA Ciliate-E2-Unclassified 20-39 35 0.000562 9.71 In-house 1-20 (352) Show / Hide 
Range on Protein: 20-39
Range on HMM: 1-20/352
Sequence Identity: 35% (7 aa)

YIRHEKLGHGGQGQVYLLSD
|. ....|.||.|.||.. .
YKIIKQIGQGGFGKVYKCQH
Kinase CAMK1c-S4_c.AA ULK 20-35 43 0.003641 7.0 In-house 1-16 (329) Show / Hide 
Range on Protein: 20-35
Range on HMM: 1-16/329
Sequence Identity: 43% (7 aa)

YIRHEKLGHGGQGQVY
|. ...||.|  |.||
YCLNHCLGKGSFGKVY
Kinase CAMK1c-S4_c.AA ULK 20-35 41 0.003838 7.07 In-house 1-17 (324) Show / Hide 
Range on Protein: 20-35
Range on HMM: 1-17/324
Sequence Identity: 41% (7 aa)

YIRHEKLGHGGQG-QVY
|. ...||.|  | .||
YCLNHCLGKGSFGVKVY
Kinase CAMK1c-S4_c.AA CAMKL 20-36 41 0.101824 1.09 In-house 1-17 (297) Show / Hide 
Range on Protein: 20-36
Range on HMM: 1-17/297
Sequence Identity: 41% (7 aa)

YIRHEKLGHGGQGQVYL
|.  . ||.|. |.| |
YRIGKTLGKGSFGKVKL
Kinase CAMK1c-S4_c.AA RSK 23-36 50 0.33488 0.6 In-house 1-14 (278) Show / Hide 
Range on Protein: 23-36
Range on HMM: 1-14/278
Sequence Identity: 50% (7 aa)

HEKLGHGGQGQVYL
.. || ||.| |.|
LKVLGQGGYGKVFL