CAMK1c-S3_a

Species: S.moellendorffii
Alias: CAMK1c-S3_a
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMK1
Subfamily: CAMK1c

Sequence

Name Sequence Type Origin Length Description Download
CAMK1c-S3_a.AA Protein None 298 None Fasta, JSON
CAMK1c-S3_a.NA RNA None 897 None Fasta, JSON
CAMK1c-S3_a.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of CAMK1c-S3_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc CAMK1c-S3_a.AA S_TKc 22-281 26 1.1e-59 205.53 SMART 1-231 (231) Show / Hide
Range on Protein: 22-281
Range on HMM: 1-231/231
Sequence Identity: 26% (74 aa)

YRVVMELGSGGQGTVHLVMGSK---LLAAKSLPEAAQRELRVMLKLAGCQGTIQLYDVVLEEDRKFKGGRWWGTLILELGSC---TLSERLHKAGGK---
|... ..|.|. |.|...   |   . | | ..| ..||.... |  ..   ..||||  .       .. .  ...|. .    .| ....| |..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK--HHPNIVKLYDVFQD-------DHLY--MVMEYCDGDLGDLFDYIKKRGRHGLR

--MEEQEAAFVVKSLAEALERVHSLGVVHRDVKLDNVLLTRLLPPYEVKLADFGLATDVAEDMHENCGTNGYISPDVLRAGKDGWPFYYTK-AVDLWGLG
  . | .|.|... ...|||  ||.|..|||.| .|.||..     ..|..|||||. .    .  |||  |..| ||          |.| ..| | .|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL---------GYGKCKCDWWSCG

LIAYELVTGWGVFSNVFDVECFLKSAGDAEVERALKWGGGVSKEARELILGMLKVNPEQRLTVEEVIR-------HPWV
 | ||...|   |.   ...  .|  |              |.||...| ..|...||.|.|. |. .       |||.
CILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase CAMK1c-S3_a.AA Pkinase 48-281 23 2.4e-43 154.33 Pfam 39-293 (293) Show / Hide
Range on Protein: 48-281
Range on HMM: 39-293/293
Sequence Identity: 23% (63 aa)

KSLPEAAQR--ELRVMLKLAGCQGTIQLYDVVLEEDRKFKGGRWWGTLILELGSC-----TLSERLH-KAGGKM--EEQEAAFVVKSLAEALERVHSLGV
.. .... |  |...|..| ..   ..|||.. .      ... .  ...|.  .      |..... ...|..  .|.|. |... ....||  || |.
SWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED------KDHIY--MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGI

VHRDVKLDNVLLT-RLLPPYEVKLADFGLA----TDVAEDMHENCGTNGYISPDVLRAGKDGWPFYYTKAVDLWGLGLIAYELVTGWGVFSNV-----FD
.|||.|..|.|.  .  ..  ||..|||||    .   . |.  ||| .|..| |.|        ||...|| |..|.| ||...|   |..       |
IHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-----GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHD

VECFLKSAGDAEVERALKWGGGVS-----------------KEARELILGMLKVNPEQRLTVEEVIRHPWV
    ..  .......   |   .|                 .|....| ..|...|..|.| |..  |||.
QMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase CAMK1c-S3_a.AA Ciliate-E2 105-281 22 1.7e-37 126.23 In-house 132-365 (365) Show / Hide
Range on Protein: 105-281
Range on HMM: 132-365/365
Sequence Identity: 22% (55 aa)

RLHK---AGGKMEEQEAAFVVKSLAE---------------ALERVHSLG-VVHRDVKLDNVLLTRLLPPYEVKLADFGLATDVAEDMHEN---------
|.|.   . ... |.|.... | ...               |||  || . ..||| |..|.|.        .|..||||.... .|. ..         
RNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWY

-------------------------CGTNGYISPDVLRAGKDG---WPFYYTKAVDLWGLGLIAYELVTG---WGVFSNVFDVECFLKSAG-----DAEV
                         ||| || .| .|. .|..      .|....|.| || | ||...|   .  . .  . .. . ..      . ..
MFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--QQQIKQCKIDFPCPEWQKDTQ-CI

ERALKW--GGGVSKEARELILG----MLKVNPEQRLT-VEEVIRHPWV
   .||     .|.|.  ||      ||...||.|.|  |... ||| 
-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase CAMK1c-S3_a.AA AGC 93-219 22 1.5e-36 90.77 In-house 110-302 (395) Show / Hide
Range on Protein: 93-219
Range on HMM: 110-302/395
Sequence Identity: 22% (46 aa)

LILEL-----------GSCTLSERLHK--AGGKMEEQEAAFVVKS-------LAEALERVHS-LGVVHRD-VKLDNVLLTRLLPPYEVKLADFGLATDVA
...|.           | | |  .|..    |...|..| |           .. |||  || .|..||| .|..|.||..      .||.||||.. . 
FVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLTDFGLCKEGM

ED-----------------------------------------------------MHENCG--TNGYISPDVLRAGKDGWPFYYTKAVDLWG--LGLIAY
 |                                                      .  ||  |  |..| .|          |.||.| |.  || . |
NDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----------YGKACDWWSFGLGCLMY

ELVTGW
|..||.
EMLTGY

Kinase CAMK1c-S3_a.AA CAMK 27-218 17 3e-35 110.53 In-house 1-330 (425) Show / Hide
Range on Protein: 27-218
Range on HMM: 1-330/425
Sequence Identity: 17% (60 aa)

ELGSGGQGTVHLVMGS---------------KLLAAKSLP-----------------------------------EAAQRELRVMLKLAG------CQGT
.||.|. |.|.|..                 .  |.| ..                                   .  .||...| || |          
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQLYD----------------------------VVLEEDRKFKGGRWWGTLILELGSCT-----LSERLHKAGG--------------KMEEQEAAFVVK
|.||.                             |.|              | |. |       | ... . |.              ...|.||.....
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVME--------------IMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR

SLAEALERVHSLGVVHRDVKLDNVLL-TRL-------------LPPYEVKLADFGLATDVAE--------------------------DMHENCGTNGYI
 ...|..  ||...|||| |..|.|| ..              .  . .|..|||.|. . .                           |.. ||| .|.
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

S-PDVLRA-GKDGW-------PFYYTKAVDLWGLGLIAYELVTG
. | ||.  |.. .         ||....| | .| | | ...|
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCG

Kinase CAMK1c-S3_a.AA CAMK-Unique 106-281 23 8.6e-33 105.42 In-house 145-363 (363) Show / Hide
Range on Protein: 106-281
Range on HMM: 145-363/363
Sequence Identity: 23% (52 aa)

LHKAGGKMEE--QEAAFVVKSLAEALERVHSLGVVHRDVKLDNVLLTRLLP-------------PYEVKLADFGLATDVA---ED--MHENCGTNGYISP
| .  |...|   ...|.. .|..|..  ||...|||| ||.|...   ..              . .||.||||....    ..  |.. |||  |..|
LKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAP

--------------DVLRAGKDGWPFYYTKAV----DLWGLGLIAYELVTGWGVFSNVFDV--------ECFLK-SAGDA-EVERALKWGGG--VSKEAR
               |. . .      |   .    |.| || |.|.. .|   |   ..         | | . ..||  ....  .|.|   .|.|| 
EIVFCKNYQEMTRDEVINMQC------YDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWK-MWHGPDYISQEAK

ELILGMLKVNPEQRLTVEEVIRHPWV
 .. . ..| | .|.. .| . |.|.
DFVKCCMTVDPDHRWSAKELLEHQWI

Kinase CAMK1c-S3_a.AA MSK 111-218 33 3.8e-25 81.93 In-house 96-206 (277) Show / Hide
Range on Protein: 111-218
Range on HMM: 96-206/277
Sequence Identity: 33% (38 aa)

GKMEEQEAAFVVKSLAEALERVHSLGVVHRDVKLDNVLLTRLLPPYEVKLADFGLATDVAED----MHENCGTNGYISPDVLRAGKDGWPFYYTKAVDLW
....|.|..... .|  |..  |..|..||| |. |.|..   .  .||| |||.|    .|    |.  |.|  | .|..|| | .  .  | .|.|.|
EHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRG-YAQDGGYDEACDWW

GLGLIAYELVTG
.|| | |.. ||
SLGVILYTMLTG

Kinase CAMK1c-S3_a.AA DCAMKL 111-213 34 6.5e-24 70.81 In-house 110-210 (279) Show / Hide
Range on Protein: 111-213
Range on HMM: 110-210/279
Sequence Identity: 34% (37 aa)

GKMEEQEAAFVVKSLAEALERVHSLGVVHRDVKLDNVLLTR-LLPPYEVKLADFGLATDVAE---DMHENCGTNGYISPDVLRAGKDGWPFYYTKAVDLW
.| .| .||  .  |..||.  |....||||.|. | |. .      ..||.|||||. | .    .   |||  |. | .|.  . |    |   || |
TKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILM--ETG----YGCKVDIW

GLGLIAY
 .| | |
AAGVILY

Kinase CAMK1c-S3_a.AA CAMK1 115-213 38 1.8e-23 65.03 In-house 107-207 (276) Show / Hide
Range on Protein: 115-213
Range on HMM: 107-207/276
Sequence Identity: 38% (40 aa)

EQEAAFVVKSLAEALERVHSLGVVHRDVKLDNVLLTRLLPPYEVK--LADFGLATDVAED---MHENCGTNGYISPDVLRAGKDGWPFYYTKAVDLWGLG
|..|. ..| ...|.|  ||.|.|||| |  | |.    .  ..|  .|||||.. . .|   |   ||| ||. |.||   |   .  | ||.|.|. |
EKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK---DKPYDKACDMWSIG

LIAY
 | |
VITY

Kinase CAMK1c-S3_a.AA Ciliate-E2-Unclassified 114-218 26 3.3e-22 73.83 In-house 136-266 (352) Show / Hide
Range on Protein: 114-218
Range on HMM: 136-266/352
Sequence Identity: 26% (35 aa)

EEQEAA-----FVVKSLAEALERVHSLG-VVHRDVKLDNVLLTRLLPPYEVKLADFGLATDVAED------------------MHENCGTNGYI----SP
.||.|.     |  . . ..||  |. . ..||| |..|.|..     |..|..|||..    ..                  |. .|||..|.    .|
TEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAP

DVLRA-GKDGWPFYYTKAVDLWGLGLIAYELVTG
 ||.  . |.  .   ...| |.|| |.||...|
EVLQGQNYDHSKA---YKCDIWSLGVILYEMLFG

Kinase CAMK1c-S3_a.AA RSK 102-218 29 1.6e-21 75.67 In-house 88-208 (278) Show / Hide
Range on Protein: 102-218
Range on HMM: 88-208/278
Sequence Identity: 29% (37 aa)

LSERLHKAGGK--MEEQEAAFVVKSLAEALERVHSLGVVHRDVKLDNVLLTR-LLPPYEVKLADFGLATD-VAE---DMHENCGTNGYISPDVLRAGKDG
| ..| | . .  . | ||.|.   .. |.|  |..|..||| |..|.|..     . ..|| |||..   ...    ..  |.|  |. | .|. ..  
LFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN--

WPFYYTKAVDLWGLGLIAYELVTG
 .  ..||.|.| || . ||. ||
QQGGHDKACDWWSLGVLMYEMLTG

Kinase CAMK1c-S3_a.AA CAMKL 93-218 28 6.2e-21 63.41 In-house 98-232 (297) Show / Hide
Range on Protein: 93-218
Range on HMM: 98-232/297
Sequence Identity: 28% (40 aa)

LILELGSCT---LSERLHKAG---GKMEEQEAAFVVKSLAEALERVHSLGVVHRDVKLDNVLLT-RL-LPPYEVKLADFGLATDVA------ED-MHENC
|..|. |     | ... | |   |.|.| || .  . . .|..  ||.|.|||| |..|.||. .       .|..|||...         .. ... |
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDFGFSNMYRPCIFGPGQKLKTFC

GTNGYISPDVLRAGKDGWPFYYTKAVDLWGLGLIAYELVTG
|.  | .| ..  ...    |. ..|| | .| | | .|.|
GSPPYMAPEIFQGNNKP---YDGPKVDIWSCGVILYAMVCG

Kinase CAMK1c-S3_a.AA CAMK 246-281 36 5.7e-16 47.26 In-house 382-425 (425) Show / Hide
Range on Protein: 246-281
Range on HMM: 382-425/425
Sequence Identity: 36% (16 aa)

WGGGVSKE--------ARELILGMLKVNPEQRLTVEEVIRHPWV
| ...|.|        .. || .||.|.||.|.|.|.. .|||.
WWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase CAMK1c-S3_a.AA CAMK1 248-281 37 3.5e-15 40.54 In-house 242-276 (276) Show / Hide
Range on Protein: 248-281
Range on HMM: 242-276/276
Sequence Identity: 37% (13 aa)

GGVSKE-ARELILGMLKVNPEQRLTVEEVIRHPWV
. .|.. | ..| .||.|.|..|.|.|....|||.
DNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI

Kinase CAMK1c-S3_a.AA CAMKL 250-281 50 1.1e-14 43.11 In-house 267-297 (297) Show / Hide
Range on Protein: 250-281
Range on HMM: 267-297/297
Sequence Identity: 50% (16 aa)

VSKEARELILGMLKVNPEQRLTVEEVIRHPWV
|| ..| || .||.||||.| |.... .|||.
VS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM

Kinase CAMK1c-S3_a.AA AGC 250-281 35 1.3e-14 32.71 In-house 354-395 (395) Show / Hide
Range on Protein: 250-281
Range on HMM: 354-395/395
Sequence Identity: 35% (15 aa)

VSKEARELILGMLKVNPEQRLT----------VEEVIRHPWV
.|.||. || ..|...||.||.          .||. .||| 
FSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF

Kinase CAMK1c-S3_a.AA DCAMKL 249-281 48 6e-14 39.23 In-house 247-279 (279) Show / Hide
Range on Protein: 249-281
Range on HMM: 247-279/279
Sequence Identity: 48% (16 aa)

GVSKEARELILGMLKVNPEQRLTVEEVIRHPWV
..|  |..||  ||.|.||.| | |..  ||||
NISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV

Kinase CAMK1c-S3_a.AA RSK 250-281 40 6.3e-12 40.23 In-house 242-278 (278) Show / Hide
Range on Protein: 250-281
Range on HMM: 242-278/278
Sequence Identity: 40% (15 aa)

VSKEARELILGMLKVNPEQRLT-----VEEVIRHPWV
.|.||..|| .||...|..||.     .||. .||| 
LSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase CAMK1c-S3_a.AA Ciliate-E2-Unclassified 249-281 40 5.4e-10 30.89 In-house 316-352 (352) Show / Hide
Range on Protein: 249-281
Range on HMM: 316-352/352
Sequence Identity: 40% (15 aa)

GVSKEARELIL----GMLKVNPEQRLTVEEVIRHPWV
..|.|| ..|      |||.||..|.| |... ||| 
HWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase CAMK1c-S3_a.AA MSK 249-281 30 6.6e-09 26.24 In-house 245-277 (277) Show / Hide
Range on Protein: 249-281
Range on HMM: 245-277/277
Sequence Identity: 30% (10 aa)

GVSKEARELILGMLKVNPEQRLTVEEVIRHPWV
..|..|..|| ..| ..|. ||....   | | 
NMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK

Kinase CAMK1c-S3_a.AA TyrKc 22-279 21 2.7e-08 -88.43 SMART 1-280 (280) Show / Hide
Range on Protein: 22-279
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YRVVMELGSGGQGTVHLVMGSKLLAAKSLPEAA----QRELRVMLKL-AGCQGTIQLYDVVLEEDRKF--KGGRWWGTLILELGSCTLSERLHKAGGKME
 .   .||.|  |.|.. . .   | |.| | |     ||.|.| ||    .  ..|| |.... |.|   .  .  .   ..|.  | ..|.| ..|  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD--LKDYLRKHRPKLC

EQEAAFVVKSLAEALERVHSLGVVHRDVKLDNVLLTRLLPPYEVKLADFGLATDVAED-MHENCGTNGYISPDVLRA----GKDG-WPFY----------
 ..        |.  |  || ...|||    |.|... .    || .||||. |. .| ..         | |. |.    |... .|            
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-------ESKDYYRKKEHKGGKTMLPIRWMAPECINYG

-YTKAVDLWGLGLIAYELVTGWGVFSNVFDVECFLKSAGDAEVERALKWGGGVSKEAR--------------ELILGMLKVNPEQRLTVEEVIRHP
 .| . | |  |   .|. |  |      ...       ..|| . .| |.   . .               ....   . .||.| | .|...  
KFTTKSDVWSFGVCMWEIFT-YGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase CAMK1c-S3_a.AA Pkinase_Tyr 133-172 40 0.000159 15.95 Pfam 128-164 (270) Show / Hide
Range on Protein: 133-172
Range on HMM: 128-164/270
Sequence Identity: 40% (16 aa)

HSLGVVHRDVKLDNVLLTRLLPPYEVKLADFGLATDVAED
.| . .|||.   |.|.|.   .  || .||||| |. .|
ESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYND

Kinase CAMK1c-S3_a.AA AGC 22-39 33 0.003902 2.36 In-house 1-18 (395) Show / Hide
Range on Protein: 22-39
Range on HMM: 1-18/395
Sequence Identity: 33% (6 aa)

YRVVMELGSGGQGTVHLV
....  .| |. |.|.||
FEFLKVIGKGSFGKVYLV

Kinase CAMK1c-S3_a.AA Ciliate-E2-Unclassified 22-39 33 0.017677 4.44 In-house 1-18 (352) Show / Hide
Range on Protein: 22-39
Range on HMM: 1-18/352
Sequence Identity: 33% (6 aa)

YRVVMELGSGGQGTVHLV
|...  .|.||.|.|...
YKIIKQIGQGGFGKVYKC

Kinase CAMK1c-S3_a.AA CAMKL 22-40 42 0.026995 2.96 In-house 1-19 (297) Show / Hide
Range on Protein: 22-40
Range on HMM: 1-19/297
Sequence Identity: 42% (8 aa)

YRVVMELGSGGQGTVHLVM
||.. .|| |. |.| | .
YRIGKTLGKGSFGKVKLAT

Kinase CAMK1c-S3_a.AA Ciliate-E2 22-39 27 0.08657 1.9 In-house 1-18 (365) Show / Hide
Range on Protein: 22-39
Range on HMM: 1-18/365
Sequence Identity: 27% (5 aa)

YRVVMELGSGGQGTVHLV
| ..  .|.|..|.| ..
YKFIKKIGQGNFGSVYKC

Kinase CAMK1c-S3_a.AA Pkinase 22-36 40 1.09561 3.51 Pfam 1-15 (293) Show / Hide
Range on Protein: 22-36
Range on HMM: 1-15/293
Sequence Identity: 40% (6 aa)

YRVVMELGSGGQGTV
|...  .|||. |.|
YHIGRKIGSGSFGCV