Gene AMPK_a (S.moellendorffii)

AMPK_a

Species: S.moellendorffii
Alias: AMPK_a
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: AMPK

Sequence

Name Sequence Type Origin Length Description Download
AMPK_a.AA Protein None 123 None Fasta, JSON
AMPK_a.NA RNA None 372 None Fasta, JSON
AMPK_a.kin_dom Protein Kinase Domain None 104 None Fasta, JSON

Protein domain

Protein domains of AMPK_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AMPK_a.AA AMPK 11-114 68 2.9e-72 213.87 In-house 1-105 (254) Show / Hide 
Range on Protein: 11-114
Range on HMM: 1-105/254
Sequence Identity: 68% (72 aa)

YKMGKTLGIGSFGKVKVAEHIPTGHKVAIKILNRRKIKAMDMEEKVRREIKILRLFMHPHIIRLYEVV-ETMNDIFVVMEYVKSGELFDYIVEKGRLQED
| .|||.| |.|||||...|| ||.||||||||..|||  || |...|||.||.|| |||||.||||. ||  |||.|||||  |||||||| .|||||.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EARRF
||.||
EACRF
Kinase AMPK_a.AA CAMKL 11-114 44 3.2e-55 174.6 In-house 1-132 (297) Show / Hide 
Range on Protein: 11-114
Range on HMM: 1-132/297
Sequence Identity: 44% (60 aa)

YKMGKTLGIGSFGKVKVAEH-IPTGHKVAIKILNRRKIKA-------------MDMEEKVRREIKILRLFM---HPHIIRLYEVV-------ETMNDIFV
|..||||| ||||||| |.| . ||.||||||....||.               ... ..||||.|....    ||.||.||||.       || ..|. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYL

VMEYVKSGE--LFDYIVEK----GRLQEDEARRF
||||. .||  ||||||..    ||..|.||||.
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRY
Kinase AMPK_a.AA MARK 11-114 48 1.5e-49 160.25 In-house 1-109 (262) Show / Hide 
Range on Protein: 11-114
Range on HMM: 1-109/262
Sequence Identity: 48% (53 aa)

YKMGKTLGIGSFGKVKVAEHIPTGHKVAIKILNRRKIKAMDMEEKVRREIKILRLFMHPHIIRLYEVVE--TMND-IFVVMEYVKSGELFDYIVEK--GR
|||.||.| ||..|||.| |..|| ||||||... |.      ..|.|||.|...  ||.||.|..|.|  | .  |...|||. .|||.|||...  ||
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LQEDEARRF
|.|.||||.
LHEEEARRI
Kinase AMPK_a.AA CAMK 16-114 30 1.7e-44 140.83 In-house 1-184 (425) Show / Hide 
Range on Protein: 16-114
Range on HMM: 1-184/425
Sequence Identity: 30% (56 aa)

TLGIGSFGKVKVAEHIPTG------------HKVAIKILNRRKIK-------------------------AMDMEEKVRREIKILRLFM-------HPHI
||| ||||||| ..|. |.            .||||||....|.|                            ....|||||.|...         ||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRLYEVVE------------TMND--------IFVVM---EYVKSGEL----FDYIVEK---------------GRLQEDEARRF
|.|||| |            | ..        .. ||   ||.  |||    ||||||.               ||..|.||||.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRY
Kinase AMPK_a.AA NuaK 11-114 49 8.6e-42 107.29 In-house 1-104 (252) Show / Hide 
Range on Protein: 11-114
Range on HMM: 1-104/252
Sequence Identity: 49% (51 aa)

YKMGKTLGIGSFGKVKVAEHIPTGHKVAIKILNRRKIKAMDMEEKVRREIKILRLFMHPHIIRLYEVVETMNDIFVVMEYVKSGELFDYIVEKGRLQEDE
|.. |||| | .|||| |  . || .||||   . ||..     ..||||.|.    |||||  ||| |  . | .||||   |||.||| |...| | |
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

ARRF
||.|
ARHF
Kinase AMPK_a.AA BRSK 11-114 48 1.3e-39 132.64 In-house 1-105 (254) Show / Hide 
Range on Protein: 11-114
Range on HMM: 1-105/254
Sequence Identity: 48% (51 aa)

YKMGKTLGIGSFGKVKVAEHIPTGHKVAIKILNRRKIK-AMDMEEKVRREIKILRLFMHPHIIRLYEVVETMNDIFVVMEYVKSGELFDYIVEKGRLQED
|...|||| |  |.||.  |  || |||||| |. |      |  || ||| |..|  |||....|.| |.    . ..|.|  |||||| |.||||.  
YRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINKEKLSNKESMLMKVEREIAIMKLIDHPHVMKMYDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPK

EARRF
|||.|
EARKF
Kinase AMPK_a.AA CAMK1 11-113 40 7.3e-38 107.6 In-house 1-112 (276) Show / Hide 
Range on Protein: 11-113
Range on HMM: 1-112/276
Sequence Identity: 40% (45 aa)

YKMGKTLGIGSFGKVKVAEHIPT---GHKVAIKILN-RRKIKAMDME--EKVRREIKILRLF---MHPHIIRLYEVVETMNDIFVVMEYVKSGELFDYIV
|. ||..| |.|..|. ..|. |   |...|||... .. .|  ||   |....|| |.. .    ||.|| .||. |. |..  |||.|. ||||| ||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

EKGRLQEDEARR
|||   |..||.
EKGNYTEKDARH
Kinase AMPK_a.AA QIK 11-113 36 1e-35 125.0 In-house 1-122 (272) Show / Hide 
Range on Protein: 11-113
Range on HMM: 1-122/272
Sequence Identity: 36% (45 aa)

YKMGKTLGIGSFGKVKVAEHIPTGHKVAIKILNRRKIKAMDMEEKVRREIKILRLFMHPHIIRLYEVVETMNDIFVVMEYVKSGELFDYIVEKGR-----
| ...|.| | |. ||.| |. |  ||||||. . .. . ... |. ||..|. .  |||||.||.| || . ...|.|| ..||.|||....||     
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQ-KCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM

---------------LQEDEARR
               ..|.||||
VNSPDIGDQVLMGVPMAENEARR
Kinase AMPK_a.AA HUNK 11-114 44 2.2e-34 108.29 In-house 1-107 (433) Show / Hide 
Range on Protein: 11-114
Range on HMM: 1-107/433
Sequence Identity: 44% (48 aa)

YKMGKTLGIGSFGKVKVAEHIPTGHKVAIKILNRRKIKAM-DMEEKVRREIKILRLFMHPHIIRLYEVVETMNDIFVVMEYVKSGELFDYIVEKG--RLQ
| .| ..| ||| ||. . |. || |||||.   .|||         ||| .|. .  ||.| ||||| || |  . ||||.  |.| . . ||.  ||.
YLLGDKIGEGSFAKVREGMHVLTGEKVAIKVIDKKKIKKDDYVHKNLRREAQIMQMMRHPNIVRLYEVMETDNNYYLVMEYCPGGDLMHKVCEKKGGRLE

EDEARRF
| .|||.
EGVARRY
Kinase AMPK_a.AA Pkinase 11-114 37 2.1e-33 119.19 Pfam 1-113 (293) Show / Hide 
Range on Protein: 11-114
Range on HMM: 1-113/293
Sequence Identity: 37% (42 aa)

YKMGKTLGIGSFGKVKVAEHIPTGHKVAIKILNRRKIKAMDMEEKVR-REIKILRLFMHPHIIRLYEVVETMNDIFVVMEYVKSG----ELFDYIV--EK
|. |...| ||||.|. . |. ||..||.||...|..|    ....| .||.|.. . ||.|.|||...|. ..| .||||.  |    .|||||   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRL--QEDEARRF
|..  .|.|....
GCFYFSEWECKFY
Kinase AMPK_a.AA MELK 11-114 43 1.2e-32 108.69 In-house 1-102 (254) Show / Hide 
Range on Protein: 11-114
Range on HMM: 1-102/254
Sequence Identity: 43% (45 aa)

YKMGKTLGIGSFGKVKVAEHIPTGHKVAIKILNRRKIKAMDMEEKVRREIKILRLFMHPHIIRLYEVVETMNDIFVVMEYVKSGELFDYIVEKGRLQEDE
|.. ...| | |.|||.| || |...|||||......   |.  .|. |.  |. . | || .|| ..|| . ||.||||   ||.||||... ||.|.|
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQL-GHDL-PRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEE

ARRF
.| |
TRHF
Kinase AMPK_a.AA Pkinase_Tyr 11-105 33 5.7e-15 51.33 Pfam 1-106 (270) Show / Hide 
Range on Protein: 11-105
Range on HMM: 1-106/270
Sequence Identity: 33% (36 aa)

YKMGKTLGIGSFGKVKVAEHI----PTGHKVAIKILNRRKIKAMDME---EKVRREIKILRLF-MHPHIIRLYEVVE-TMND--IFVVMEYVKSGELFDY
 ..||.|| |.||.|. ..       |. .||.|.|.    .||. .   |.  ||.||.. .  ||.|.||| |.        |..||||.. | | ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IVEK---GR
  ..   ..
LRKHREDKQ
Kinase AMPK_a.AA S_TKc 11-121 18 1.5e-08 -51.6 SMART 1-220 (231) Show / Hide 
Range on Protein: 11-121
Range on HMM: 1-220/231
Sequence Identity: 18% (44 aa)

YKMGKTLGIGSFGKVKVAEHIPTGHKVAIKILNRRKIKAMDMEEKVRREIKILRLFMHPHIIRLYEVVETMNDIFVVMEYVKS--GELFDYIVEKGR---
|......| |.||||. . |. ||..|||||..          |..||||.||.   ||.|..||.| .. .....||||.    |.|||||...||   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

----------------------------------------------------------------------------------------------------
                                                                                                    
RFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQMQM

-----------------LQEDEARRFNINMIFW
                 || | ..|  .  .. 
MFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase AMPK_a.AA TyrKc 11-123 12 0.000403 -156.0 SMART 1-265 (280) Show / Hide 
Range on Protein: 11-123
Range on HMM: 1-265/280
Sequence Identity: 12% (35 aa)

YKMGKTLGIGSFGKVKVAEHIPTGHKVAIKILNRRKIKAMDMEEKVRREIKILRLF--MHPHIIRLYEVVETM-------NDIFVVMEYVKSGELFDYIV
 ..||.|| | ||.|  .. .    .||.| |.  .      .|  .||..|.. .   ||.|.||| |. .          ...||||.. | | ||. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

EKG-----------------------------------------------------RLQEDE----------------ARR-------------------
...                                                     |  .|.                 ..                   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

-----------------------FN------------------------IN-----------------MIFWKH
                        .                         |                    |..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE