Gene MLCK-like-2 (S.moellendorffii)

MLCK-like-2

Species: S.moellendorffii
Alias: MLCK-like-2
External Links:
Annotation:

Classification

Group: CAMK
Family: MLCK-like

Sequence

Name Sequence Type Origin Length Description Download
MLCK-like-2.AA Protein None 529 None Fasta, JSON
MLCK-like-2.NA RNA None 1590 None Fasta, JSON
MLCK-like-2.kin_dom Protein Kinase Domain None 297 None Fasta, JSON

Protein domain

Protein domains of MLCK-like-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLCK-like-2.AA CAMK1 16-312 34 8.60000000001e-115 335.13 In-house 1-276 (276) Show / Hide 
Range on Protein: 16-312
Range on HMM: 1-276/276
Sequence Identity: 34% (108 aa)

YIIGPVLGYGGFSVVRKGVHKE---DGTEVAIKTLRKQGFGYGDKKNGGRPLAGATKRGRGSRGRKSTAGPTQDSLISE----ALVANEIIVMQRIVENV
|..| ..| | ||.|....|||   .| ..||| . |                                   .    ..    ... ||| .|..    |
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK----------------------------------KKFMKKKDMQKQEALENEIEIMKK----V

S--PHPNIVHLHDVYEDEAGVHLVLELCSGGELFDRIVAQEKYSEAQAAKVVKELATGLCSLHDAGIVHRDLKPENCLFLTPEEDNHLK--IMDFGLSQI
|   ||||. ....||..  ..||.||..|||||||||  ..|.| .|....|...  .  .|. ||||||||||| |. ...||  .|  |.|||||.|
SKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKI

DGATS-PIVGMFGSVDYVAPETLSH---RDVLPASDMWSLGVILYILLCGYPPFHGTS-NKEKLDLILAGDVNFEEYTWKTISSH-AKQLIRDLLAVDPH
 .  .     ..|. .||||| |          | |||| |||.|||||||||| . . ..| ...|. ....| .  |  ||.. ||..|. .| ||| 
FDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPK

RRPSAKALVSDPWV
 |....    .||.
KRYTCEQCLNHPWI
Kinase MLCK-like-2.AA CAMK 21-312 23 2.7e-93 300.93 In-house 1-425 (425) Show / Hide 
Range on Protein: 21-312
Range on HMM: 1-425/425
Sequence Identity: 23% (103 aa)

VLGYGGFSVVRKGVHKEDG------------TEVAIKTLRKQGFGYGDKKNGGRPLAGATKRGRGSRGRKSTAGPTQDS----------LISEALVANEI
.|| |.|..|....||...            ..|||| . |.      . ..  .          .     .    ..|            ... | .||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQN-QDY-S----------N-----CY-KIDKSKCKHRYCWRRPKDRKNVRREI

IVMQRIVENVS--PHPNIVHLHDVYED-------------------EAGVHLVL---ELCSGGEL----FDRIVAQEK---------------YSEAQAA
 .|... ..     ||||..|..||||                   .  ...|.   |.||||||    ||.||....               ..|..|.
EIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREAR

KVVKELATGLCSLHDAGIVHRDLKPENCLFLTPEED--------------NHLKIMDFGLS--QIDGA----------------------TSPIVGMFGS
.... .. ..  .|. .|||||||||| |. . ..|              | .|| |||..   ..|                       . .   ..|.
RYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGT

VDYVA-PETLSH-------------RDVL-PASDMWSLGVILYILLCGYPPFHGTSNKEKLD-------------LILAGDVNFEEYT------------
  |.| || |.              ..   |..||||.||||||.||||||| | ...| ..              |..|. .|...             
PEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEW

WKTISSH--------AKQLIRDLLAVDPHRRPSAKALVSDPWV
|. ||          .|.||| .| ||| .|....   ..||.
WDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MLCK-like-2.AA S_TKc 16-312 28 6.5e-89 302.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-312
Range on HMM: 1-231/231
Sequence Identity: 28% (90 aa)

YIIGPVLGYGGFSVVRKGVHKEDGTEVAIKTLRKQGFGYGDKKNGGRPLAGATKRGRGSRGRKSTAGPTQDSLISEALVANEIIVMQRIVENVSPHPNIV
| |. ..| |.|..|.|..||..| .|||| ..                                             . .|| ....       |||||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------EHIRREIQILKK------HHPNIV

HLHDVYEDEAGVHLVLELCSG--GELFDRIVAQEK------YSEAQAAKVVKELATGLCSLHDAGIVHRDLKPENCLFLTPEEDNHLKIMDFGLSQIDGA
.|.||..|   ...|.|.|.|  |.|||.|. . .      ..| .|........ .|  .|. ||.|||||||| |. .     |.|| ||||. .   
KLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--

TSPIVGMFGSVDYVAPETLSHRDVLP-ASDMWSLGVILYILLCGYPPFHGTSNKEKLDLILAGDVNFEEYTWKTISSHAKQLIRDLLAVDPHRRPSAKAL
      . |. .|.||| |      . ..|.||.|.|||..|||||||.    .. ...|.              |. ||..|| .| .|| .||.|  .
----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EA

VS-------DPWV
         .||.
LQDEWDIKCHPWF
Kinase MLCK-like-2.AA Pkinase 16-312 28 8.3e-81 279.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-312
Range on HMM: 1-293/293
Sequence Identity: 28% (97 aa)

YIIGPVLGYGGFSVVRKGVHKEDGTEVAIKTLRKQGFGYGDKKN---GGRPLAGATKRGRGSRGRKSTAGPTQDSLISEALVANEIIVMQRIVENVSPHP
| || ..| |.|..|.|..|| .| .||.|...|..   . ...                                       .|| .|.|.      ||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----------------------------------SEIQIMKRL-N----HP

NIVHLHDVYEDEAGVHLVLELCSGG----ELFDRIV--AQEKY--SEAQAAKVVKELATGLCSLHDAGIVHRDLKPENCLFL-TPEEDNHLKIMDFGLSQ
||| |.|..||.  ...|.|.| ||    .|||.|   .. ..  || .. ....... ||  .|. ||.||||||||.|.  ... | ..|| ||||. 
NIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK

I--DGATSPIVGMFGSVDYVAPETLS-HRDVLPASDMWSLGVILYILLCGYPPFHGT------SNKEKLDLILAGDVNFEEYTWKTIS------------
       |   .  |. .|.||| .  ...  |..||||.|.|||..|||.||| |       . ......|. ... |....| .||            
QFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWT

-----SHAKQLIRDLLAVDPHRRPSAKALVSDPWV
     . .|..|...|..||..||.|. .. .||.
FHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLCK-like-2.AA CDPK 16-312 32 5.2e-80 245.12 In-house 1-271 (271) Show / Hide 
Range on Protein: 16-312
Range on HMM: 1-271/271
Sequence Identity: 32% (101 aa)

YIIGPVLGYGGFSVVRKGVHK-EDGTEV-AIKTLRKQGFGYGDKKNGGRPLAGATKRGRGSRGRKSTAGPTQDSLISEALVANEIIVMQRIVENVSPHPN
|.|..||| |.|..|||..||  .. |  |.|.  |      ..                                 .  . ||| ..  .      |||
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQ---------------------------------QQQFFNEIEILKQL-----DHPN

IVHLHDVYEDEAGVHLVLE--LCSGGELFDRIVAQEKYSEAQAAKVVKELATGLCSLHDAGIVHRDLKPENCLFLTPEEDN----HLKIMDFGLSQIDGA
|. .  .|.||  ...|.|  .|.||||||.|... ...| .||.... .   .   |. .|||||||||| ||.. ..|.     .|. |.|.| . . 
IIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQ

T-----SPIVGMFGSVDYVAPETLSHRDVLPASDMWSLGVILYILLCGYPPFHGTSNKEKLDLILAGDVNFEEYTWKTISSHAKQLIRDLLAVDPHRRPS
        .  ..| . |.||| | ..     .| ||.|||||||||||||| | . .| .. .  |  .||   |. ||. ||.||| .| .||  | |
NQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMS

AKALVSDPWV
|     .||.
AQQALQHPWF
Kinase MLCK-like-2.AA CAMKL 16-312 29 1.3e-75 240.74 In-house 1-297 (297) Show / Hide 
Range on Protein: 16-312
Range on HMM: 1-297/297
Sequence Identity: 29% (98 aa)

YIIGPVLGYGGFSVVRKGVH-KEDGTEVAIKTLR--KQGF-GYGDKKNGGRPLAGATKRGRGSRGRKSTAGPTQDSLISEAL-VANEIIVMQRIVENVSP
|.||..|| |.|..|. ..| .  |..|||| .   |     . .|.  |               .|.          .  . .  ||  |...  | ..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCG---------------QKH----------ESDMRIRREIQIMKML--N-IG

-HPNIVHLHDVYEDEAG------VHLVLELCSGGE--LFDRIVAQ----EKYSEAQAAKVVKELATGLCSLHDAGIVHRDLKPENCLFLTPEEDNHLKIM
 ||||..|..|.|..        ..||.|.|||||  |||.||..    .. .| .| .  . .  ..  .|. ||||||.|||| . |.   .| .|| 
KHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPEN-ILLDENGNNNIKII

DFGLS-----QIDGATSPIVGMFGSVDYVAPETLSH--R-DVLPASDMWSLGVILYILLCGYPPFHGTSNK-----EKLDLILAGDVNFEEY-TWKTISS
|||.|     .|.|         ||  | ||| ..   .    |. |.||.||||| ..||| || . ...      .  | .   .  ...  |. .| 
DFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-

HAKQLIRDLLAVDPHRRPSAKALVSDPWV
 ...||| .| |.| .||... ....||.
DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase MLCK-like-2.AA RSK 18-312 28 2.2e-70 240.16 In-house 1-278 (278) Show / Hide 
Range on Protein: 18-312
Range on HMM: 1-278/278
Sequence Identity: 28% (90 aa)

IGPV--LGYGGFSVVRKGVHKEDGTEVAIKTLRKQGFGYGDKKNGGRPLAGATKRGRGSRGRKSTAGPTQDSLISEALVANEIIVM--QRIVENVSPHPN
.     .||| ....|| .|.  |.. | | |.|  .   .|                                          .|  ..| | .  ||.
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKD--------------------------------------TRHTMTERNILERCQQHPF

IVHLHDVYEDEAGVHLVLELCSGGELFDRIVAQEK---YSEAQAAKVVKELATGLCSLHDAGIVHRDLKPENCLFLTPEED-NHLKIMDFGLSQI-DGA-
||.||.....|  ..|..|.|.|||||...  ..     ||  |. .  |..  .  ||. ||.||||||||.|.   . .  |.|. |||.. . .   
IVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDH

TSPIVGMFGSVDYVAPETLS---HRD-VLPASDMWSLGVILYILLCGYPPFHG---TSNKEKLDLILAGDVNFEEYTWKTISSHAKQLIRDLLAVDPHRR
...     ....|.||| |    ..     | | |||||..| .| |.|||.|    . || .. |. |. ...   |...|  || ||| .| .|||.|
NQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKR

PS-----AKALVSDPWV
..     |. . ..|| 
LGCGPQDAEEIKQHPWF
Kinase MLCK-like-2.AA Ciliate-E2a 85-312 34 9e-70 204.56 In-house 37-275 (275) Show / Hide 
Range on Protein: 85-312
Range on HMM: 37-275/275
Sequence Identity: 34% (84 aa)

QDSLISEALVANEIIVMQRIVENVSPHPNIVHLHDVYEDEAGVHLVLELCSGGELFDRIVAQEKYSEA--QAAKVVKELA-TGLCSLHDAGIVHRDLKPE
... . .. . |||  |...      ||||  |..|||||    ||.|.|.||||.|.|. . .. |   ..... . |   ||  .|  .|.|||||||
YQQKKGKEYFMNEINIMRQL-----DHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPE

NCLFL--TPE--EDNHLKIMDFGLSQIDGATSP--IVGMFGSVDYVA------PETLSHRDVLPASDMWSLGVILYILLCGYPPFHGTSNKEKLDLILAG
| ||    ..  ..  .|| ||||..     ..  .  . |.  |||      .|.|.|..     ||||.|||.||||||.||| | . .| | .. . 
NILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKC

DVNFEEYT-WKTISSHAKQLIRDLLAVDPHRRPSAKALVSDPWV
  .|.    |. .|. .|.|.. .| .||  |..|. .  .||.
KIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase MLCK-like-2.AA DCAMKL 91-312 39 4.6e-68 210.66 In-house 59-279 (279) Show / Hide 
Range on Protein: 91-312
Range on HMM: 59-279/279
Sequence Identity: 39% (90 aa)

EALVANEIIVMQRIVENVSPHPNIVHLHDVYEDEAGVHLVLELCSGGELFDRIVAQEKYSEAQAAKVVKELATGLCSLHDAGIVHRDLKPENCLFLT-PE
| .. ||. .||.|      ||.|. |..... |.   ||.|. .|| ||| |.   |..| .||  . .|.  |  ||. .|||||.|||| |    . 
EHMIDNEVSIMQKIK-----HPHIIQLYEHWDTETHYYLVMEYVQGGDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHED

EDNHLKIMDFGL-SQIDGATSPIVGMFGSVDYVAPETLSHRDVLPASDMWSLGVILYILLCGYPPFHGT-SNKEKL-DLILAGDVNFEEYTWKTISSHAK
    ||  ||||   ..|   |.    |   ||||| |.        |.|..||||||||||.||| .   . |.| |.|..|...|    |. ||. ||
GEKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILMETGYGCKVDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAK

QLIRDLLAVDPHRRPSAKALVSDPWV
 ||. .| ||| .|..|.   . |||
DLISHMLQVDPEKRYTAEQIMQHPWV
Kinase MLCK-like-2.AA CAMK-Unique 111-312 27 8e-68 222.91 In-house 75-363 (363) Show / Hide 
Range on Protein: 111-312
Range on HMM: 75-363/363
Sequence Identity: 27% (79 aa)

HPNIVHLHDV----YEDEA---------------GVHLVLELCSGGELFDRIVA--------------------QEKYSE--AQAAKVVKELATGLCSLH
||||..| |.    ..|.                  ..|.|.| ||.||| |..                    | ..||  .... .. .|.  .  .|
HPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMH

DAGIVHRDLKPENCLFLTPEE-------------DNHLKIMDFGLS-QIDGATSP--IVGMFGSVDYVAP--------------ETLSHRD----VLPAS
. .|||||||.||... ...              ..|.|. ||||. ....  ..  .  | |. .|.||              |..  ..    . |||
SQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPAS

DMWSLGVILYILLCGYPPFHGTSNK--------EKLDLILAGDV-NFEEYTWKT---ISSHAKQLIRDLLAVDPHRRPSAKALVSDPWV
| ||||||.|..|||.||| .....        | .. |..||. ||..  |     ||  ||... ... |||  | ||| | . .|.
DIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase MLCK-like-2.AA RAD53 111-312 32 8.9e-67 197.74 In-house 63-305 (305) Show / Hide 
Range on Protein: 111-312
Range on HMM: 63-305/305
Sequence Identity: 32% (80 aa)

HPNIVHLHDVYED-EAGVHLVLELCSGGELFDRIVAQEK----YSEAQAAKVVKELATGLCSLHDAGIVHRDLKPENCLFLTPEEDN-------------
||.|. ..|.... .  . .|||| .|||||..||....    ..|...    . . ...  ||| ||.|||||||| |. ...|..             
HPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNKRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEI

--HLKIMDFGLSQIDGATSPIVGMFGSVDYVAPETLSHRDV---------------LPASDMWSLGVILYILLCGYPPFHGTSNK----EKLDL-ILA-G
   .|| ||||| . | .|    | |.  ||||| .   .                 .. |.||.|.||||.|||||||   .       .|.  |.  |
SFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQG

DVNFEEYTWKTISSHAKQLIRDLLAVDPHRRPSAKALVSDPWV
  .|.   |. ||. || ||. .| |||..|.... . . || 
KYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNHPWM
Kinase MLCK-like-2.AA RSK 111-312 34 2.9e-58 199.88 In-house 60-271 (271) Show / Hide 
Range on Protein: 111-312
Range on HMM: 60-271/271
Sequence Identity: 34% (74 aa)

HPNIVHLHDVYEDEAGVHLVLELCSGGELFDRIVAQEKYSEAQAAKVVKELATGLCSLHDAGIVHRDLKPENCLFLTP-EEDNHLKIMDFGLS-QIDGAT
||.|| ||.|..||  | ...... ||.||||...|   ||  .. .  |.|  .  ||  ||||||||||| |.     .  |.|| |||.. |  . .
HPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDEN

SPIVGMFGSVDYVAPETLSHRDVLPASDMWSLGVILYILLCGYPPFHGTSNKEKLDLIL-AGDVN--FEEYTWKTISSHAKQLIRDLLAVDPHRRPSA--
       ... |.||| |. .    |.| ||.||..|. | |..||... ...  ..|. ....   .    | .||  || |.| .| .|||.|..|  
GMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGP

---KALVSDPWV
   .   . ||.
NGVEQIKQHPWF
Kinase MLCK-like-2.AA TyrKc 16-310 20 1.5e-13 -3.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-310
Range on HMM: 1-280/280
Sequence Identity: 20% (67 aa)

YIIGPVLGYGGFSVVRKGVHKEDGTEVAIKTLRKQGFGYGDKKNGGRPLAGATKRGRGSRGRKSTAGPTQDSLISEALVANEIIVMQRI-VENVSPHPNI
   | .|| | | .|.||. |   ..||.|.|..                                         ..   .|. .| ..       ||||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------------------------------------REDFMREARIMCKLGG----HHPNI

VHLHDVYEDE-------AGVHLVLELCSGGELFDRIVAQEK-YSEAQAAKVVKELATGLCSLHDAGIVHRDLKPENCLFLTPEEDNHLKIMDFGLSQIDG
| |. |  ..         . .|.|....| | |.. . ..  . ..  .     | |   ||. ...||||   |||   .    . || |||||   .
VRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIY

AT------SPIVGMFG--SVD------YVAPETLSHRDVLPASDMWSLGVILY-ILLCGYPPFHG-----TSNKEKLDLILAGDVNFEEYT-----WKTI
        .    . .  . .        |||.. ..   ..|| || || .. |.  | .|  |      ||.| . .. .|.              . 
DDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCC

SSHAKQLIRDLLAVDPHRRPSAKALVSDP
..   |....  . ||. ||. ...... 
PDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLCK-like-2.AA RAD53 16-50 34 3e-12 32.27 In-house 1-35 (305) Show / Hide 
Range on Protein: 16-50
Range on HMM: 1-35/305
Sequence Identity: 34% (12 aa)

YIIGPVLGYGGFSVVRKGVHKEDGTEVAIKTLRKQ
|... .|| |.|..|.... |...  |||| . |.
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKK
Kinase MLCK-like-2.AA CAMK-Unique 16-51 30 7.5e-07 18.44 In-house 1-36 (363) Show / Hide 
Range on Protein: 16-51
Range on HMM: 1-36/363
Sequence Identity: 30% (11 aa)

YIIGPVLGYGGFSVVRKGVHKEDGTEVAIKTLRKQG
|. . ..| |.|..|...  .| |.. |.| ..||.
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQT
Kinase MLCK-like-2.AA DCAMKL 16-45 41 2e-06 15.65 In-house 1-31 (279) Show / Hide 
Range on Protein: 16-45
Range on HMM: 1-31/279
Sequence Identity: 41% (13 aa)

YIIGPVLGYGGFSVVRKGVHKEDG-TEVAIK
| || . | | |.|| . .|.|.| .. | |
YQIGRIIGDGNFAVVHECRHRETGDHKYAMK
Kinase MLCK-like-2.AA RSK 16-49 32 5e-06 17.73 In-house 1-37 (271) Show / Hide 
Range on Protein: 16-49
Range on HMM: 1-37/271
Sequence Identity: 32% (12 aa)

YIIGPVLGYGGFS---VVRKGVHKEDGTEVAIKTLRK
|..  ..| | ||   |..| .||  ... |.| ..|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKK
Kinase MLCK-like-2.AA Ciliate-E2a 16-49 28 1.6e-05 12.25 In-house 1-35 (275) Show / Hide 
Range on Protein: 16-49
Range on HMM: 1-35/275
Sequence Identity: 28% (10 aa)

YIIGPVLGYGGFSVVRKGVHKEDGTE-VAIKTLRK
| .  ..| | | .|..  ||..| . ...|  .|
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKK
Kinase MLCK-like-2.AA Pkinase_Tyr 16-51 37 0.000251 15.28 Pfam 1-39 (270) Show / Hide 
Range on Protein: 16-51
Range on HMM: 1-39/270
Sequence Identity: 37% (15 aa)

YIIGPVLGYGGFSVVRKGVHK----EDGTEVAIKTLRKQG
 ..| .|| | | .|.||. |    .....||.|.| |.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEG
Kinase MLCK-like-2.AA Pkinase_Tyr 111-178 25 0.004536 11.02 Pfam 63-137 (270) Show / Hide 
Range on Protein: 111-178
Range on HMM: 63-137/270
Sequence Identity: 25% (19 aa)

HPNIVHLHDVYE-DEAG--VHLVLELCSGGELFDRIVA----QEKYSEAQAAKVVKELATGLCSLHDAGIVHRDL
||||| |. |   ..    . .|.|.. .| | |   .    ... .  .  .   . | |.  |.. ...||||
HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Efhand MLCK-like-2.AA efhand 410-438 27 0.004741 15.58 Pfam 1-29 (29) Show / Hide 
Range on Protein: 410-438
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

LAPRIFDLFDHNRDGAVDMREIVCGFTSL
 . ..|..|| ..|| .|  | . ....|
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh MLCK-like-2.AA EFh 410-438 31 0.020679 10.08 SMART 1-29 (29) Show / Hide 
Range on Protein: 410-438
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

LAPRIFDLFDHNRDGAVDMREIVCGFTSL
   ..|..|| ..|| .|  | . ...||
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh MLCK-like-2.AA EFh 446-474 41 5.3e-08 33.82 SMART 1-29 (29) Show / Hide 
Range on Protein: 446-474
Range on HMM: 1-29/29
Sequence Identity: 41% (12 aa)

ALKLCFQMYDSDGSGYISKDELASMLRAL
 .| .|.|.| ||.|||...|.  |...|
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand MLCK-like-2.AA efhand 446-474 41 9.1e-08 32.84 Pfam 1-29 (29) Show / Hide 
Range on Protein: 446-474
Range on HMM: 1-29/29
Sequence Identity: 41% (12 aa)

ALKLCFQMYDSDGSGYISKDELASMLRAL
 ||  |...| ||.|||...|. .|...|
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
Efhand MLCK-like-2.AA efhand 488-516 34 1.8e-07 31.75 Pfam 1-29 (29) Show / Hide 
Range on Protein: 488-516
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

KLDEMFDRMDANSDGRVSFDEFKDAIQMN
.|.|||. .|.. ||...|.||...... 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh MLCK-like-2.AA EFh 488-516 37 2.1e-07 31.86 SMART 1-29 (29) Show / Hide 
Range on Protein: 488-516
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

KLDEMFDRMDANSDGRVSFDEFKDAIQMN
...|||. .|.. ||...|.||||.... 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL