Gene CDC2-S1_j (S.moellendorffii)

CDC2-S1_j

Species: S.moellendorffii
Alias: CDC2-S1_j
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2-smoe1

Sequence

Name Sequence Type Origin Length Description Download
CDC2-S1_j.AA Protein None 323 None Fasta, JSON
CDC2-S1_j.NA RNA None 972 None Fasta, JSON
CDC2-S1_j.kin_dom Protein Kinase Domain None 236 None Fasta, JSON

Protein domain

Protein domains of CDC2-S1_j.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc CDC2-S1_j.AA S_TKc 15-270 23 1.9e-36 128.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-270
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

EQKVGKLG-----CVLRVACDQEGEKVLIKSVDNELYDYVREFELMRECKHENVVKVLDMGKEEDGGYLVLEHLW----DIREFNKDER---LRYKLSKV
 ... |.|     .| ..     |..| || ..    .  || ..... .|.|.|| .|.  . |  |.|.|..     | ... |. .   ||....  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

GWIKETMRQLLVGLASLHEREVVHQDILPECLKFELNSNNFVVKLGDFGCARKLSTPPTVHIGSLGFRAPEVISKEIEKFGK-GVDMWGAGVVFAVLLLG
 ...  |.|.. .|. .|.. ..| |. || . .       ..|..||| ||.|    |  .|.. ..||||.     ..||  .|.|  |.... .| |
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCG

KKPFGGYRNYNLSWEEDEAKVMDKMKKLPEKDWSMKIEDNDAVNLLQGLLAWDPDKRLTAAQALK-------SMYF
. ||            .......|..            . .| ......| .||.||.|| .||.         .|
YPPFP-----------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDC2-S1_j.AA CAMK 33-270 16 7.4e-28 86.26 In-house 31-425 (425) Show / Hide 
Range on Protein: 33-270
Range on HMM: 31-425/425
Sequence Identity: 16% (64 aa)

GEKVLIKSVDNE--------------------------------LYDYVREFELMRECK-------HENVVKVLD--------------------MGKEE
|.|| || .| .                                .    || |.|. ..       |.|..| ..                    . . .
GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVF-TKD

DGGYLVLEHLWDIREFNKDE----RLRYKLSKVGW--------------------IKETMRQLLVGLASLHEREVVHQDILPECLKFELNSNN-------
.  |.|.|    | |.        .|  .. . |                      .  .||.. ... .|.. .|| |. || . .  |...       
KHMYMVME----IMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHD

-------FVVKLGDFGCARKLST--------------------------PPTVHIGSLGFRA-PEVISKE------------IEKFGKGVDMWGAGVVFA
       . .|. ||| |.|.                            . .   |.... | |||....            ..  |. .||| .||.  
EIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY

VLLLGKKPFGG----------------YRNYNLSWEEDEAKVMDKMKKLP---EKDWSMKIEDN-------DAVNLLQGLLAWDPDKRLTAAQALKSMYF
..| |. || |                |. .    . .     .......    ..|  .| |.       .. .|....|  ||.||.|..|.|.   .
IMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CDC2-S1_j.AA Ciliate-E2 109-270 19 3e-26 87.07 In-house 151-365 (365) Show / Hide 
Range on Protein: 109-270
Range on HMM: 151-365/365
Sequence Identity: 19% (46 aa)

MRQLLV---------------GLASLHERE-VVHQDILPECLKFELNSNNFVVKLGDFGCARKLSTPPTVH-----------------------------
|.|.|                .| .||..  ..| || || . |        .|. ||| ..|....   .                             
MKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQN

-----IGSLGFRAPEVIS-KEIEK------FGKGVDMWGAGVVFAVLLLGKKPFGGYRNYNLSWEEDEAKVMDKMKKLPEKDW------------SMKIE
     .|..|. |||... |....       .. .|.| .||..  .| || ||             . . ...  ..|...|            | |  
MFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKW

DNDAVNLLQG----LLAWDPDKRLT-AAQALKSMYF
.... .|..     .|  ||.||.| . |.|.  .|
SQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CDC2-S1_j.AA Ciliate-E2-Unclassified 19-270 19 1.8e-24 81.79 In-house 10-352 (352) Show / Hide 
Range on Protein: 19-270
Range on HMM: 10-352/352
Sequence Identity: 19% (66 aa)

GKLGCVLRVACDQEGEKV-------LIKSVDNELYDYV--------REFELM---------------RECKHENVVKVLDMGKEEDGGYLVLEH-----L
|  |.| .. ..... ..        |....  .. ..        ......               . ..|...|| ... . ..  |.|.|      |
GGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDL

WDIREFNKD---------ERLRY-KLSKVGWIK-----ETMRQLLVGLASLHERE-VVHQDILPECLKFELNSNNFVVKLGDFGCARKLSTPPTVH----
|.. . .|          ..... |      .|       ..|.|.|| .||.   ..| || || . |  | .|. .|. ||| ..|. ...       
WQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQ

--------------IGSLGFR----APEVISK-EIE--KFGKGVDMWGAGVVFAVLLLGKKPFGGYR---NYNLSWE--------EDEAKVMDKMKKLPE
              .|....     ||||. . . .  |. . .|.|. ||..  .| |. ||...    ...|. .        . . . ..|  . |.
QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPK

KDW-----SMKIEDNDAVN-LLQGLLAWDPDKRLTAAQALKSMYF
 .|         |  | .| ||| .| ..|.||.|. |.|.  .|
FPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase CDC2-S1_j.AA Pkinase 138-270 20 2.5e-23 83.58 Pfam 141-293 (293) Show / Hide 
Range on Protein: 138-270
Range on HMM: 141-293/293
Sequence Identity: 20% (34 aa)

LNSNNFV---VKLGDFGCARKL---STPPTVHIGSLGFRAPEVISKEIEKFGKGVDMWGAGVVFAVLLLGKKPFGGYRNYNLSWEED------EAKVMDK
...|. .   ||..|||.|...   .. .|.  |.....|||||  . .. |. ||||..|.... .|.|.          . . ..      . ..| .
IDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGR----------PPFPGHCWHDNHDQMQMIC

MKKLPEKDWSMKIED--------------------NDAVNLLQGLLAWDPDKRLTAAQALKSMYF
... |. ...   ..                     ..  .. ..|..|| ||.||.|.|.. .|
RIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CDC2-S1_j.AA CAMK2 50-270 30 1.7e-20 66.05 In-house 47-259 (259) Show / Hide 
Range on Protein: 50-270
Range on HMM: 47-259/259
Sequence Identity: 30% (70 aa)

REFELMRECKHENVVKVLDMGKEEDGGYLVLEHLWDIREFNKDERLRYKLSKVGWIKETMRQLLVGLASLHEREVVHQDILPECLKFELNSNNFVVKLGD
||  . |  || |.|.. |  .||.  ||| . |    |   |   |   |        ..|.|  ..  |....|| |. || |     .    ||| |
REARICRKLKHPNIVRLHDSIQEEGFHYLVFD-LVTGGELFEDIVAREYYSEAD-ASHCIQQILESVNHCHQNGIVHRDLKPENLLLASKCKGAAVKLAD

FGCARKLSTPPT---VHIGSLGFRAPEVISKEIEKFGKGVDMWGAGVVFAVLLLGKKPFGGYRNYNLSWEEDEAKVMDKMK----KLPEKDWSMKIEDND
|| |  .           |  |. .|||. |.   .|| ||.|  ||.  .|| |  ||         |.||  ..  ..|      |  .|       .
FGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP--YGKPVDIWACGVILYILLVGYPPF---------WDEDQHRLYQQIKAGAYDYPSPEWDTVTP--E

AVNLLQGLLAWDPDKRLTAAQALKSMYF
| ||.. .|. .|.||.||..|||  . 
AKNLINQMLTINPKKRITADEALKHPWI
Kinase CDC2-S1_j.AA CMGC 28-205 16 2.1e-20 62.91 In-house 18-342 (513) Show / Hide 
Range on Protein: 28-205
Range on HMM: 18-342/513
Sequence Identity: 16% (53 aa)

ACD---------------QEGEKVLIKSVDNELYDYV----------------REFELMRECK-----------------HENVVKVLDMGKEED-----
. |               . .|.| || . |.  .                  || ..... .                 |.|.|| .|. . ..     
CRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNE

------------GGYLVLEHL-WDIREFNKDERLRYKL-SKVGW---------------IKETM------RQLLVGLA--SLHERE--VVHQDILPECLK
              ||| |.. .|  .. |. . .|.   ...                ||  |      .|.| ||.   .| .   ..| |. || . 
YEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENIL

FELNSNN-----------------FVVKLGDFGCARKLSTPP------------------------TVHIGSLGFRAPEVISKEI--------EKFGKGV
.  |  .                 ...|..||| ||......                        |  . ..  ||||..             ......
INHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPI

DMWGAGVVFAVLLLG-------KKPF
|||..| .|| ...|       .||.
DMWSVGCIFAEMYTGYQSLIFRGKPL
Kinase CDC2-S1_j.AA Ciliate-E2a 105-207 33 2.6e-20 56.52 In-house 103-218 (275) Show / Hide 
Range on Protein: 105-207
Range on HMM: 103-218/275
Sequence Identity: 33% (39 aa)

IKETMRQLL-VGLASLHEREVVHQDILPECLKFE-LNSNN---FVVKLGDFGCARKL--STP--PTVHIGSLGFRAPEVISKEIE----KFGKGVDMWGA
|.. |.|||  ||. .| | ..| |. || . |. ...|.   . .|. ||| |..     .    .. |. |. ||||.  . .    . .. .||| .
ICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSC

GVVFAVLLLGKKPFGG
||.|  || || || |
GVIFYILLCGKPPFKG
Kinase CDC2-S1_j.AA MSK 109-270 25 2.7e-19 61.9 In-house 107-277 (277) Show / Hide 
Range on Protein: 109-270
Range on HMM: 107-277/277
Sequence Identity: 25% (45 aa)

MRQLLVGLASLHEREVVHQDILPECLKFELNSNNFVVKLGDFGCARKLSTPPTVHIGS----LGFRAPEVISK---EIEKFGKGVDMWGAGVVFAVLLLG
||.| . . ..|.. ..| |. || . |. .. |  ||| ||| || . . ..    |    | . |||.. .   . . ... .|.|. ||.   .| |
MRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTG

KKPFGGYRNYNLSWEEDEAKVMDKMKKLPEKDWSMK-----IEDNDAVNLLQGLLAWDPDKRLTAAQALKSMYF
. ||   .    . .   .   . ||.  ... |         . || .|.|.||  || |||..   ....  
QVPF---QQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase CDC2-S1_j.AA CDK7 49-200 31 1.6e-15 37.36 In-house 50-198 (288) Show / Hide 
Range on Protein: 49-200
Range on HMM: 50-198/288
Sequence Identity: 31% (49 aa)

VREFELMRECKHENVVKVLDMGKEEDGGYLVLEHL-WDIREFNKDERLRYKLSKVGWIKETMRQLLVGLASLHEREVVHQDILPECLKFELNSNNFVVKL
.||  . .| .|.||.  .|     .  .||.. . ||  .  ||  .  . .    ||  | ..| ||  .|   . | |. |  |   | . | ..|.
IREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILTPAH---IKAYMMMTLQGLEYCHRNWILHRDLKPNNL---LMNENGQLKI

GDFGCARKLSTPP---TVHIGSLGFRAPEVISKEIEKFGKGVDMWGAGVVFAVLLL
.||| ||    |    | ..    .||||        .| |||||  |..|| |.|
ADFGLARFYGSPNRIYTHQVVTRWYRAPELLF-GARHYGTGVDMWSVGCIFAELML
Kinase CDC2-S1_j.AA CDK7 241-270 40 1.4e-14 34.85 In-house 259-288 (288) Show / Hide 
Range on Protein: 241-270
Range on HMM: 259-288/288
Sequence Identity: 40% (12 aa)

NDAVNLLQGLLAWDPDKRLTAAQALKSMYF
.|.. |..|... .| ||.|..|.||. ||
DDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDC2-S1_j.AA CMGC 237-270 52 5.2e-13 38.17 In-house 480-513 (513) Show / Hide 
Range on Protein: 237-270
Range on HMM: 480-513/513
Sequence Identity: 52% (18 aa)

KIEDNDAVNLLQGLLAWDPDKRLTAAQALKSMYF
| .| .|..||...| .|||||.||.|||.  ||
KCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase CDC2-S1_j.AA CDC2 49-159 28 1.7e-12 34.22 In-house 48-156 (301) Show / Hide 
Range on Protein: 49-159
Range on HMM: 48-156/301
Sequence Identity: 28% (32 aa)

VREFELMRECK-HENVVKVLDMGKEEDGGYLVLEHL-WDIREFNK-DERLRYKLSKVGWIKETMRQLLVGLASLHEREVVHQDILPECLKFELNSNNFVV
.||  .. | | |.|.||  |  ..    |.| | |  | ... .  .  ..... .  .|. | |.| |.. .| | ..| |. |  .   | ... ..
IREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHMP-PQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNI---LIDKKGNI

KLGDFGCARKLSTP
|..||| ||  ..|
KIADFGLARAFGIP
Kinase CDC2-S1_j.AA CDK 49-161 25 2.7e-12 35.47 In-house 56-173 (284) Show / Hide 
Range on Protein: 49-161
Range on HMM: 56-173/284
Sequence Identity: 25% (35 aa)

VREFELMRECKHENVVKVLDMGKEE-----------DGGYLVLEHLWD-----IREFNKDERLRYKLSKVGWIKETMRQLLVGLASLHEREVVHQDILPE
.||  |..|. |.|.||..|    .              |.| |..       ..                 ||  |.||| ||. .|.. ..| |. | 
IREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD-----------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQ

CLKFELNSNNFV-----VKLGDFGCARKLSTP-----PT
 .   | .|| .     .|..||| ||. . |     |.
NI---LINNNGEVKCGRLKIADFGLARAFGIPHQMSEPN
Kinase CDC2-S1_j.AA Ciliate-E2a 240-270 38 4.9e-11 28.76 In-house 245-275 (275) Show / Hide 
Range on Protein: 240-270
Range on HMM: 245-275/275
Sequence Identity: 38% (12 aa)

DNDAVNLLQGLLAWDPDKRLTAAQALKSMYF
.... .|....|  || ||.||.|||.. .|
SKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase CDC2-S1_j.AA CDK 226-270 35 5.3e-11 31.27 In-house 252-284 (284) Show / Hide 
Range on Protein: 226-270
Range on HMM: 252-284/284
Sequence Identity: 35% (16 aa)

MKKLPEKDWSMKIEDNDAVNLLQGLLAWDPDKRLTAAQALKSMYF
..|||.             .||...|. ||.||..| |||.. ||
VTKLPDY------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDC2-S1_j.AA CDC2 240-270 41 2.4e-10 27.48 In-house 271-301 (301) Show / Hide 
Range on Protein: 240-270
Range on HMM: 271-301/301
Sequence Identity: 41% (13 aa)

DNDAVNLLQGLLAWDPDKRLTAAQALKSMYF
|.... ||. .|. || ||..| .||.  ||
DPEGIDLLMQMLQYDPQKRISAKEALQHPYF
TyrKc CDC2-S1_j.AA TyrKc 15-268 18 2.2e-07 -103.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-268
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

EQKVGKLG---------CVLRVACDQEGEKVLIKSVDNE-LYDYVREFELMREC--KHENVVKVLDMGKEE-------DGGYLVLEHLW--DIREFNKDE
 ..  |||         ....       ..| .|.. .. . |  || ..|..   .|.|.|. .    ..       .  ..|.|.    | ... .. 
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

RLRYKLSKVGWIKETMRQLL-------VGLASLHEREVVHQDILPE-CLKFELNSNNFVVKLGDFGCARKLSTP-------PTVHI-----GS--LGFR-
| .           .|..||        | . ||.. ..| |.    ||   ...|. .|| .||| .|..           . .      |   |  | 
RPK----------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL---VGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

-APEVISKEIEKFGKGVDMWGAGVVFAVLL-----LGKKPFGG---YRNYNLSWEEDEAKVMDKMKKLPEKD-----WSMKIEDNDAVNLLQGLLAWDPD
 |||.|     ||    | |     | |..     .|..|  |        .|..|  ..|.. .   . ..           |     . .   . ||.
MAPECI--NYGKFTTKSDVWS----FGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQ-IMKQCWHEDPE

KRLTAAQALKSM
.| | ..  . .
DRPTFSEIHECF
Kinase CDC2-S1_j.AA Pkinase 35-83 24 0.005908 11.53 Pfam 30-82 (293) Show / Hide 
Range on Protein: 35-83
Range on HMM: 30-82/293
Sequence Identity: 24% (13 aa)

KVLIKSVDNELYDYV----REFELMRECKHENVVKVLDMGKEEDGGYLVLEHL
|.. |. ...  |.     .| ..|....|.|.|. .|.  ..|  |.|.|..
KIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYC
Kinase CDC2-S1_j.AA CDK 183-205 36 0.009149 4.49 In-house 200-224 (284) Show / Hide 
Range on Protein: 183-205
Range on HMM: 200-224/284
Sequence Identity: 36% (9 aa)

GKGVDMWGAGVVFAVLLL--GKKPF
| ..|||..| .|| ...   .||.
GTPIDMWSVGCIFAEMFTDVTRKPL