CDC2-S1_b

Species: S.moellendorffii
Alias: CDC2-S1_b
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2-smoe1

Sequence

Name Sequence Type Origin Length Description Download
CDC2-S1_b.AA Protein None 287 None Fasta, JSON
CDC2-S1_b.NA RNA None 864 None Fasta, JSON
CDC2-S1_b.kin_dom Protein Kinase Domain None 222 None Fasta, JSON

Protein domain

Protein domains of CDC2-S1_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDC2-S1_b.AA CAMK 3-224 18 2.2e-30 94.53 In-house 80-425 (425) Show / Hide
Range on Protein: 3-224
Range on HMM: 80-425/425
Sequence Identity: 18% (65 aa)

REVELMKECK-------HENIMRVLD---------------IGQE-----EDGDYMVL---EHLCDA------RDLQYERFYY------------KLSDV
||.|.|| ..       |.|| . ..                 .      ..  |||.   |.           |   |. .|            .  . 
REIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTE

GLIKETIRQLLVGLASLHEREVVHQDIVPACIRFELNHSN--------------FVVKLGDFHCSRRLST------------------------PPNVDT
   .  .||.. ... .|.. .|| |. |  | .  |...              . .|. ||  ....                           .   |
REARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKT

MGGSMGFTA-PEVISRE------------TEKIGKGVDMWGVGAVLANMLLGENPFLEG-------------IDLSLSCDANKAKVMDNMKKFL------
. |. .. | |||....             . .|. .||| .| .|  || |. || .               |  |     |.|     ..|       
FCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNY

KRDWYEMIEDE-------DAVDLLRCLLVWDPDKRITAEQALKSMYF
. .|   | ||       .. ||.|..|. ||.||.|.||.|.   .
GPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase CDC2-S1_b.AA Ciliate-E2 3-224 16 2.6e-23 76.84 In-house 71-365 (365) Show / Hide
Range on Protein: 3-224
Range on HMM: 71-365/365
Sequence Identity: 16% (55 aa)

REVE----------LMKECKHENIMRVLDIGQ--EEDGDYMVLEHLCDARDLQY---------------ERFYYKLSDVG-LIKETIR-----------Q
||..          .... .| ||..  .  |   ..  |.|.| .|.  ||..               .  |...  .. ..|. ..           .
REINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVME-YCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIAC

LLVGLASLHERE-VVHQDIVPACIRFELNHSNFVVKLGDFHCSRRLSTPPNVDT----MG----------------------------GSMGFTAPEVIS
....| .||..  ..| || |  | |        .|. ||  |...... .  |    ..                            |. |. |||...
IILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILN

RETEK-------IGKGVDMWGVGAVLANMLLGENPFLEGIDLSLSCDANKAKVMDNMKKFLKRDWY-------------------EMIEDEDAVDLLRC-
.. .         .. .|.| .| .|  || |. ||                    ... .. ..                        .... ||..  
GKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKF

---LLVWDPDKRIT-AEQALKSMYF
   .|. ||.|||| .||.|.  .|
GKRMLQKDPEKRITGWEQILNHPWF

Kinase CDC2-S1_b.AA Pkinase 92-224 25 3.4e-23 83.09 Pfam 142-293 (293) Show / Hide
Range on Protein: 92-224
Range on HMM: 142-293/293
Sequence Identity: 25% (40 aa)

HSNFVV----KLGDFHCSRR--LSTPPNVDTMGGSMGFTAPEVISRETEKIGKGVDMWGVGAVLANMLLGENPFLEGIDLSLSCDANKAKVMDNMKKFLK
..| ..    |..|| ...   .   .  .|  |. .. |||||  . ...|. ||||..| .|. ||.|. || . .  . . .  ....  .|.. |.
DNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLH

RDWYEMIED------------------EDAVDLLRCLLVWDPDKRITAEQALKSMYF
.||.. ..                   |.. |.....| .|| ||.||||.|.. .|
FDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase CDC2-S1_b.AA Ciliate-E2-Unclassified 57-224 22 8.3e-22 72.43 In-house 140-352 (352) Show / Hide
Range on Protein: 57-224
Range on HMM: 140-352/352
Sequence Identity: 22% (51 aa)

IK-----ETIRQLLVGLASLHERE-VVHQDIVPACIRFELNHSNFVVKLGDFHCSRRLSTPPN----------------VDTMGGSMGFT----APEVIS
.|       ..|.|.|| .||.   ..| || |  | |  |..|. .|. ||  |... ...|                 .|. |. ..     ||||. 
AKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ

R-ETEKIG-KGVDMWGVGAVLANMLLGENPFL--EGID---------------LSLSCDANK-------------AKVMDNMKKFLKRDWYEMIEDEDAV
. . ..   . .|.|..| .|  || |. ||     ..                 ..   .|              .. .. | |..             
GQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN-------------

DLLRCLLVWDPDKRITAEQALKSMYF
|||...|...|.||||.||.|.  .|
DLLQKMLKKNPNKRITFEQILNHPWF

S_TKc CDC2-S1_b.AA S_TKc 1-224 21 4.8e-20 73.85 SMART 1-231 (231) Show / Hide
Range on Protein: 1-224
Range on HMM: 1-231/231
Sequence Identity: 21% (59 aa)

MV-----------------------------------REVELMKECKHENIMRVLDIGQEEDGDYMVLEHLCDA--RDLQYERFYYKL------SDVGLI
                                     ||....|. .|.|| . .|. |. |  |||.| .||    ||      ..        .   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVME-YCDGDLGDLFDYIKKRGRHGLRFPFPE-HA

KETIRQLLVGLASLHEREVVHQDIVPACIRFELNHSNFVVKLGDFHCSRRLSTPPNVDTMGGSMGFTAPEVISRETEKIGK-GVDMWGVGAVLANMLLGE
.  ..|.. .|. .|.. ..| |. |. | .       ..|..||  .|.|      .|. |.  . ||||.     . ||  .|.| .| .|. || |.
RFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGY

NPFLEGIDLSLSCDANKAKVMDNMKKFLKRDWYEMIEDEDAVDLLRCLLVWDPDKRITAEQALK-------SMYF
 ||            . ........            ...| |..| .|..||.||.|| .||.         .|
PPFP-----------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase CDC2-S1_b.AA MSK 61-224 24 1.1e-16 52.9 In-house 107-277 (277) Show / Hide
Range on Protein: 61-224
Range on HMM: 107-277/277
Sequence Identity: 24% (42 aa)

IRQLLVGLASLHEREVVHQDIVPACIRFELNHSNFVVKLGDFHCSRRLSTPPNVDTMG--GSMGFTAPEVISR---ETEKIGKGVDMWGVGAVLANMLLG
.|.| . . ..|.. ..| |. |  | |. . .|  ||| ||  .| . . ..  .    ... . |||.. |   . .  .. .|.|..|..|  || |
MRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTG

ENPFL---EGIDLSLSCDANKAKVMDNMKKFLK-RDWYEMIEDEDAVDLLRCLLVWDPDKRITAEQALKSMYF
  ||    .....| .  .  .| .   .  .    | .|  ..|| ||.. ||  || || ...  ....  
QVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNM--SPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK

Kinase CDC2-S1_b.AA STE 3-224 18 2.1e-16 54.52 In-house 77-359 (359) Show / Hide
Range on Protein: 3-224
Range on HMM: 77-359/359
Sequence Identity: 18% (55 aa)

REVELMKECK--HENIMRVLDIGQEE-------DGDYMVLEHLC--DARDLQYERFYYKLSD-----------VGLIKETIRQLLVG-LASLHEREVVHQ
.|...||.|.  |.|| . ..    |       |  ....|..    ..|.  ...  . ..             .|.  .||.| | |. ||.  ..| 
KEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHR

DIVPACIRFELNHSNFVVKLGDFHCSRRLST-----------------PPNVDTMGGSMGFTAPEVISRETEK----IGKGVDMWGVGAVLANMLLGENP
|| || | .        ||| || .. .|.                    . .|. |.  . |||||......     .  .|.| .| ..  |. |. |
DIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP

FLEGIDLSLSCDAN--KAKV--MDNMKKFLKRDWYEMIED---------------------EDAVDLLRCLLVWDPDKRITAEQALK--SMYF
. .. ...    ..  ....  .. . . .. .     ..                     ..  | ..  |. ||.|| ||.| ||     .
WHDMHPMRAMFMIPFNYHMQQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase CDC2-S1_b.AA CMGC 193-224 62 2.6e-14 42.53 In-house 482-513 (513) Show / Hide
Range on Protein: 193-224
Range on HMM: 482-513/513
Sequence Identity: 62% (20 aa)

EDEDAVDLLRCLLVWDPDKRITAEQALKSMYF
.|..|.|||  .|..||||||||||||.  ||
CDPQAIDLLKKMLQYDPDKRITAEQALQHPYF

Kinase CDC2-S1_b.AA MAPK 185-224 45 7.4e-14 44.08 In-house 283-328 (328) Show / Hide
Range on Protein: 185-224
Range on HMM: 283-328/328
Sequence Identity: 45% (21 aa)

KRDWYEMIED------EDAVDLLRCLLVWDPDKRITAEQALKSMYF
|..|..|. .       .|.|||  .||.|||||||.|.||   ||
KKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF

Kinase CDC2-S1_b.AA Ciliate-E2a 194-224 45 1.6e-11 30.18 In-house 245-275 (275) Show / Hide
Range on Protein: 194-224
Range on HMM: 245-275/275
Sequence Identity: 45% (14 aa)

DEDAVDLLRCLLVWDPDKRITAEQALKSMYF
. .. ||.. .|. || |||||.|||.. .|
SKECKDLMKKMLEKDPKKRITAQQALNHPWF

Kinase CDC2-S1_b.AA ERK7 195-224 60 5.1e-10 30.12 In-house 263-292 (292) Show / Hide
Range on Protein: 195-224
Range on HMM: 263-292/292
Sequence Identity: 60% (18 aa)

EDAVDLLRCLLVWDPDKRITAEQALKSMYF
.||.|||. |||  |.||.||||||.  | 
DDAIDLLKRLLVFNPKKRLTAEQALQHPYV

Kinase CDC2-S1_b.AA CDK 199-224 61 5.3e-10 28.02 In-house 259-284 (284) Show / Hide
Range on Protein: 199-224
Range on HMM: 259-284/284
Sequence Identity: 61% (16 aa)

DLLRCLLVWDPDKRITAEQALKSMYF
|||  .|. ||.|||.|||||.. ||
DLLNKMLCYDPKKRISAEQALQHPYF

Kinase CDC2-S1_b.AA Ciliate-E2a 3-159 24 5.4e-10 25.64 In-house 48-216 (275) Show / Hide
Range on Protein: 3-159
Range on HMM: 48-216/275
Sequence Identity: 24% (42 aa)

REVELMKECKHENIMRVLDIGQEEDGDYMVLEHLCDARDLQYERFYYKL-SDVG--LIKETIRQLL-VGLASLHEREVVHQDIVPACIRFE-LNHSN---
.|. .|.. .| ||..  .. . |.  |.|.| .|. ..| |... ..   .     |.. ..|||  ||. .| | ..| |. |  | |. .. ..   
NEINIMRQLDHPNIIKLYEVYEDENNYYLVME-YCEGGEL-YDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQN

FVVKLGDFHCSRRLSTPPN--VDTMGGSMGFTAPEVISRETE----KIGKGVDMWGVGAVLANMLLGENPF
. .|. ||  ... ..  .  . .. |. |. ||||.  . .    . .. .||| .|...  .| |. ||
SDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPF

Kinase CDC2-S1_b.AA ERK7 3-155 28 5.5e-08 23.06 In-house 47-203 (292) Show / Hide
Range on Protein: 3-155
Range on HMM: 47-203/292
Sequence Identity: 28% (47 aa)

REVELMKECK-HENIMRVLDIGQ-EEDGD-YMVLEHLCDARDLQYERF-YYKLSDVGLIKETIRQLLVGLASLHEREVVHQDIVPACIRFELNHSNFVVK
||. ...| . |.||.|.... . . | | |.| |..    ||         | |.   . .. |||  .  .|  .|.| |. |. |   |  |. .||
REIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFM--ETDLHAVIRKGNILKDI-HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNI---LLDSECMVK

LGDFHCSRRLSTPPNVDTMGGSMG-------FTAPEVISRETEKIGKGVDMWGVGAVLANMLLG
. ||   | ..  ...|   . .        . |||.     ..  ||||||..| .|. || |
VCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLG-SHRYTKGVDMWSIGCILGEMLRG

Kinase CDC2-S1_b.AA CDK 2-81 26 9e-07 17.52 In-house 56-134 (284) Show / Hide
Range on Protein: 2-81
Range on HMM: 56-134/284
Sequence Identity: 26% (25 aa)

VREVELMKECKHENIMRVLDIGQEEDGD-----------YMVLEHLCDARD----LQYERFYYKLSDVGLIKETIRQLLVGLASLHEREVVHQDI
.||. |.||. |.|| ...|.   .. |           ||| |..    |    .              ||  ..||| ||. .|.. ..| |.
IREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYM--DHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDL

Kinase CDC2-S1_b.AA CMGC 3-81 17 4.1e-05 11.72 In-house 70-210 (513) Show / Hide
Range on Protein: 3-81
Range on HMM: 70-210/513
Sequence Identity: 17% (25 aa)

REVELMKECK-----------------HENIMRVLDIGQEEDGD-----------------YMVLEHLCDARDLQYERFYYKL----SDVGL--------
||....|. .                 |.|| . .|| . .. |                 |.| | ..|   .|| . . ..      ..|        
REIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFE-YMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHP

-------IKETI------RQLLVGLA--SLHERE--VVHQDI
       ||  .      .|.| ||.   .| .   ..| |.
HRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDL

Kinase CDC2-S1_b.AA CMGC 125-162 24 6.6e-05 11.05 In-house 293-345 (513) Show / Hide
Range on Protein: 125-162
Range on HMM: 293-345/513
Sequence Identity: 24% (13 aa)

APEVISRET--------EKIGKGVDMWGVGAVLANMLLG-------ENPFLEG
|||.. . .         . ....|||.|| ..| |..|         |.  |
APEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPG

Kinase CDC2-S1_b.AA MAPK 3-22 47 0.000422 9.82 In-house 53-73 (328) Show / Hide
Range on Protein: 3-22
Range on HMM: 53-73/328
Sequence Identity: 47% (10 aa)

REVELMKEC-KHENIMRVLDI
||. |.... .||||...|||
REIKLLRHFHHHENIIKLLDI

Kinase CDC2-S1_b.AA CDK 137-159 34 0.001493 7.05 In-house 200-225 (284) Show / Hide
Range on Protein: 137-159
Range on HMM: 200-225/284
Sequence Identity: 34% (9 aa)

GKGVDMWGVGAVLANMLL---GENPF
| ..|||.|| ..| |..   ..  |
GTPIDMWSVGCIFAEMFTDVTRKPLF

Kinase CDC2-S1_b.AA Pkinase 2-81 29 0.002868 12.64 Pfam 46-134 (293) Show / Hide
Range on Protein: 2-81
Range on HMM: 46-134/293
Sequence Identity: 29% (27 aa)

VR--EVELMKECKHENIMRVLDIGQEEDGDYMVLEHLCDAR----DLQ------YERFYYKLSDVGLIKETIRQLLVGLASLHEREVVHQDI
.|  |...||...|.|| | .|. ...|  |||.| .|.      ||       ... .| .|.   .|  ..|.| ||. .|.. ..| |.
RRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVME-YCEGGLYVMDLFDYISTWRHGCFY-FSE-WECKFYMYQILRGLEYCHSMGIIHRDL

Kinase CDC2-S1_b.AA MAPK 138-155 52 0.116182 1.25 In-house 213-231 (328) Show / Hide
Range on Protein: 138-155
Range on HMM: 213-231/328
Sequence Identity: 52% (10 aa)

KGVDMWGVGAVLANMLL-G
|.|||| ||  .| ||  .
KAVDMWSVGCIFAEMLTDR