Gene CDC2-S1_g (S.moellendorffii)

CDC2-S1_g

Species: S.moellendorffii
Alias: CDC2-S1_g
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2-smoe1

Sequence

Name Sequence Type Origin Length Description Download
CDC2-S1_g.AA Protein None 258 None Fasta, JSON
CDC2-S1_g.NA RNA None 777 None Fasta, JSON
CDC2-S1_g.kin_dom Protein Kinase Domain None 224 None Fasta, JSON

Protein domain

Protein domains of CDC2-S1_g.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc CDC2-S1_g.AA S_TKc 5-253 21 1.6e-14 36.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 5-253
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

GRYNYAFGYGESSAVAHGYDDL-GERVVIKNMGKGEEVHKQILKEFEIMVNCKHENVLDVIDMGLDKDGNYYMVFEHTDG---NMLEYLEMDLSKAGKES
 .     | |  . |  ...   |..| || .       ..|..| .|. . .|.|.   .|.  |  ...|||.|. ||   ....|..   ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH-----

ELGSRFFTREEKIKEIMRQLLLGLAWLHERGVAHQGMTKDNVLVKVKGCDFKVKLSDFSCARRLCNN--------PPETTLKVGT-AEDIWSAGILLAGM
  | ||   |  .. .|.|....|. .|..|. |     .|.|.        .|..||  ||.| .         .||   . |. . |.|| |..|. |
--GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEM

LL---PLEMPELPEKEAKGEVLETIKKFLRDLDDLIKDKDALELVKSMLASDPV---TARQALA-------FRYL
|    | .           .. ...|| .        ...|..... .|  ||    || .||.         ..
LCGYPPFP-----------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDC2-S1_g.AA CDK 46-134 22 1.9e-13 39.25 In-house 56-131 (284) Show / Hide 
Range on Protein: 46-134
Range on HMM: 56-131/284
Sequence Identity: 22% (22 aa)

LKEFEIMVNCKHENVLDVIDMGLDK----------DGNYYMVFEHTDGNMLEYLEMDLSKAGKESELGSRFFTREEKIKEIMRQLLLGLAWLHERGVAH
. |  .. .. |.|.  ..|  ..|          . . |||||. |    .|..                      || .|.||| ||. .|.... |
IREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD----------------------IKCYMWQLLRGLHYCHSNWIMH
Kinase CDC2-S1_g.AA STE 27-188 20 3.1e-13 43.22 In-house 39-258 (359) Show / Hide 
Range on Protein: 27-188
Range on HMM: 39-258/359
Sequence Identity: 20% (48 aa)

GERVVIK--NMGKGE----------------EVHKQILKEFEIMVNCK--HENVLDVIDMGLDK------DGNYYMVFEHTD-GNMLEYLE------MDL
||.. ||  |. . .                | ..||||| .|| .|.  |.|.   ... ...      |.. ... |. | |   . ..      ..|
GEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPL

SKAGKESELGSRFFTREEKIKEIMRQLLLG-LAWLHERGVAHQGMTKDNVLVKVKGCDFKVKLSDFSCARRLCN--------------------------
..  .    .  ..  |. |. | ||.| | |. ||. .. |     .|.|.        |||.|| .. .| .                          
NHNRQ----H-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVG

---NPPETTLK--------VGTAEDIWSAGILL
     ||  ..         .|  |||| |...
TPWMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase CDC2-S1_g.AA CAMK 23-188 14 1.1e-11 33.21 In-house 28-324 (425) Show / Hide 
Range on Protein: 23-188
Range on HMM: 28-324/425
Sequence Identity: 14% (43 aa)

YDDLGERVVIKNMGK-----------------------------GEEVHKQILKEFEIMVNCK-------HENVLDVID-------------------MG
| . |..| || . |                              ..  |....| ||| ...       |.|..  ..                     
YTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVF

LDKDGNYYMVF---EHTDG-NMLEYLEMDLSKAGKESE-------LGSRFFTREEKIKEIMRQLLLGLAWLHERGVAHQGMTKDNVLVKVKG--------
 .|| ..|||.   |. .|  ....|   . . |...|       . .|.   |.  . ..||.. ... .|.....|     .|.|.  ..        
-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEH

------CDFKVKLSDFSCARRLCNN-------------------------------------P-PETTLK----------------VGTAEDIWSAGILL
       ....|..||  |...  .                                     . ||  ..                .| . |.||.|..|
DEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase CDC2-S1_g.AA CMGC 19-193 14 4.1e-11 31.82 In-house 15-330 (513) Show / Hide 
Range on Protein: 19-193
Range on HMM: 15-330/513
Sequence Identity: 14% (48 aa)

VAHGYD---------------DLGERVVIKNM--GKGEEVHKQ-----------ILKEFEIMVNCK-----------------HENVLDVIDMGLDKD--
|  ..|               . .|.| || .   . .| ...           .| | .|. . .                 |.|..  .|.  .|.  
VYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSD

--------------GNYYMVFEHTDGNMLEYLE-------------MDLSKAGKESELGSRFFTRE--EKIKEIM------RQLLLGLA--WLHERG--V
               . |.|||. | . ..|..             ..  . .|. .       |.  . || .|      .|.| ||.   .| ..  .
GNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKH-P------HRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNI

AHQGMTKDNVLVKVKG-----------------CDFKVKLSDFSCARRLCNN-----------------------------------PPETTLKV-----
 |  .   |.|.  ..                  ....|. ||  || . ..                                   .||  |       
IHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTN

-------GTAEDIWSAGILLAGMLL
       .|. |.||.|  .| |..
HNYSMHYTTPIDMWSVGCIFAEMYT
Kinase CDC2-S1_g.AA CDC2 56-158 26 7.9e-11 28.98 In-house 58-147 (301) Show / Hide 
Range on Protein: 56-158
Range on HMM: 58-147/301
Sequence Identity: 26% (28 aa)

K-HENVLDVIDMGLDKDGNYYMVFEHTDGNMLEYLEMDLSKAGKESELGSRFFTREEKIKEIMRQLLLGLAWLHERGVAHQGMTKDNVLVKVKGCDFKVK
| |.|.    |       . |||||  | .  .|..| ..|              ....|..| |.| |.. .| |.. |     .| |.  ||    .|
KDHPNIVKLHDVIHQ--NKLYMVFEYLDMDLKKYMDMSIPKN---------KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN---IK

LSDF
..||
IADF
Kinase CDC2-S1_g.AA Pkinase 31-134 23 8e-10 35.82 Pfam 31-131 (293) Show / Hide 
Range on Protein: 31-134
Range on HMM: 31-131/293
Sequence Identity: 23% (26 aa)

VIKNMGKGEEVHKQILK--EFEIMVNCKHENVLDVIDMGLDKDGNYYMVFEHTDG-----NMLEYLEMDLSKAGKESELGSRFFTREEKIKEIMRQLLLG
.||  .. ...... ..  | .|| ...|.|..  .|.  | ....|||.|. .|        .|..          . . .|   |. .| .|.|.| |
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST---------WRHGCFYFSEWECKFYMYQILRG

LAWLHERGVAH
|. .|..|. |
LEYCHSMGIIH
Kinase CDC2-S1_g.AA MLCK 110-179 22 2.5e-09 20.21 In-house 96-164 (257) Show / Hide 
Range on Protein: 110-179
Range on HMM: 96-164/257
Sequence Identity: 22% (16 aa)

EEKIKEIMRQLLLGLAWLHERGVAHQGMTKDNVLVKVKGCDFKVKLSDFSCARRLCNNPPETTLKVGTAE
|. . ..|||.. |.. .|.....|  .  .|..   .  . ..|. ||  ||.. .. . .... || |
EREVIHYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSH-QIKIIDFGLARKYDPDEKKVKVMFGTPE
Kinase CDC2-S1_g.AA Ciliate-E2 43-188 18 2.1e-07 21.48 In-house 78-286 (365) Show / Hide 
Range on Protein: 43-188
Range on HMM: 78-286/365
Sequence Identity: 18% (41 aa)

KQILKEFEIMVNCKHENVLDVIDMGLD-KDGNYYMVFEHTDG-NMLEYLEMDLSKAGKESE-LGSRFFTREEKIKEIMRQLLL---------------GL
|.| .| .|. . .| |..  ..   . .| |.|.|.|  .| ....|..    | ..| |    .|   |..||.||.|.|                .|
KKI-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYF--TEKEIKYIMKQILQGFKTKAEFYIACIILAL

AWLHERG-VAHQGMTKDNVLVKVKGCDFKVKLSDFSCAR---------------------------------------------RLCNNPPETTLKVG--
  ||... . |     .|.|.        .|..||  ..                                              .   .||   . .  
EYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYD

---------TAEDIWSAGILL
         .. ||||.|..|
NQQKQKGYDYKCDIWSLGVIL
TyrKc CDC2-S1_g.AA TyrKc 3-248 13 3e-06 -121.02 SMART 16-280 (280) Show / Hide 
Range on Protein: 3-248
Range on HMM: 16-280/280
Sequence Identity: 13% (42 aa)

VLGRYNYAFGYGESSAVAHGYDDLGERVVIKNMGKGEEVHKQILKEFEIMVNC--KHENVLDVIDMGLDK------DGNYYMVFEHTD-GNMLEYLEMDL
..|...                   . | .| . ..   .. ...| .|| .   .|.|..  .   ...      .. ...|.|. . |. ..||    
YKGTWK-------------------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

SKAGKESELGSRFFTREEKIKEIMRQLLLGLAWLHERGVAHQGMTKD----NVLVKVKGCDFKVKLSDFSCARRLCNN------PPETTLKV-GTAE---
 |               ..  ... |   | . ||.... |     |    |.||. ..    || |||  .| . .           . |  . .    
PK------------LCMKDLLSFCWQIACGMEYLHSKNCIH----RDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML

-------------------DIWSAGILL------AGMLLP------LEMPELPEKEAKGEVLETIKK-----FLRDLDDLIKDKDALELVKSMLASDP--
                   |.|| |...       ..  |      ..  |. |.  .|. ..  .      |       .  ..  .. |.  . ||  
PIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF------VCCPDEMYQIMKQCWHEDPED

----VTARQAL
     . .. .
RPTFSEIHECF
Kinase CDC2-S1_g.AA CRK7 110-164 30 5e-06 16.6 In-house 111-162 (343) Show / Hide 
Range on Protein: 110-164
Range on HMM: 111-162/343
Sequence Identity: 30% (17 aa)

EEKIKEIMRQLLLGLAWLHERGVAHQGMTKDNVLVKVKGCDFKVKLSDFSCARRL
.. .| .|.|||.|.. .|.... |      |.|.  .|   .||. ||  || .
HQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQG---EVKIADFGLARLY
Kinase CDC2-S1_g.AA RAD53 109-158 21 6e-06 13.16 In-house 107-171 (305) Show / Hide 
Range on Protein: 109-158
Range on HMM: 107-171/305
Sequence Identity: 21% (14 aa)

REEKIKEIMRQLLLGLAWLHERGVAHQGMTKDNVLVKVKG--C-------------DFKVKLSDF
.| ..|.. .|.....  ||..| .|     .|.| . ..  |             .|..|..||
DEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDF
Kinase CDC2-S1_g.AA RCK 86-131 36 1.8e-05 13.04 In-house 79-125 (298) Show / Hide 
Range on Protein: 86-131
Range on HMM: 79-125/298
Sequence Identity: 36% (18 aa)

LEYLEMDLSKAGKE-SELGSRFFTREEK--IKEIMRQLLLGLAWLHERG
.||..|.|..  |.  | . . .. |..  || || |.|.||| .|. |
FEYMDMNLYQMMKDFKE-RRKYLP-ENQRSIKNIMYQILQGLAHMHKHG
Kinase CDC2-S1_g.AA RCK 227-253 43 0.002952 5.86 In-house 269-298 (298) Show / Hide 
Range on Protein: 227-253
Range on HMM: 269-298/298
Sequence Identity: 43% (13 aa)

KDALELVKSMLASDP---VTARQALAFRYL
.|..||.. ||. ||    || |||  .| 
QDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase CDC2-S1_g.AA RAD53 43-79 29 0.003191 4.87 In-house 49-85 (305) Show / Hide 
Range on Protein: 43-79
Range on HMM: 49-85/305
Sequence Identity: 29% (11 aa)

KQILKEFEIMVNCKHENVLDVIDMGLDKDGNYYMVFE
.|. .| ||. . .|...   .|   ... .|||| |
DQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLE
Kinase CDC2-S1_g.AA CDC2 226-253 32 0.003779 4.94 In-house 271-301 (301) Show / Hide 
Range on Protein: 226-253
Range on HMM: 271-301/301
Sequence Identity: 32% (10 aa)

DKDALELVKSMLASDP---VTARQALAFRYL
|.....| ..||. ||   ..|..||. .|.
DPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase CDC2-S1_g.AA Pkinase 180-253 16 0.010411 10.66 Pfam 194-293 (293) Show / Hide 
Range on Protein: 180-253
Range on HMM: 194-293/293
Sequence Identity: 16% (17 aa)

DIWSAGILLAGMLL--PLEMPELPEKEAKGEVLETIKKFLRDLDDLIKD-----------------------KDALELVKSMLASDPV---TARQALAFR
|.||.|..|. ||.  |.   .    .   . .. |.. ..   .   .                       .......|..|. ||    ||.|.|   
DMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YL
..
WF
Kinase CDC2-S1_g.AA CRK7 226-253 32 0.013228 4.57 In-house 313-343 (343) Show / Hide 
Range on Protein: 226-253
Range on HMM: 313-343/343
Sequence Identity: 32% (10 aa)

DKDALELVKSMLASDP---VTARQALAFRYL
.|..| |   ||. ||   .|| ..|   ..
PKECLDLLDKMLCLDPKKRFTAEECLQHDWF