Gene CDC2-S1_d (S.moellendorffii)

CDC2-S1_d

Species: S.moellendorffii
Alias: CDC2-S1_d
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2-smoe1

Sequence

Name Sequence Type Origin Length Description Download
CDC2-S1_d.AA Protein None 267 None Fasta, JSON
CDC2-S1_d.NA RNA None 804 None Fasta, JSON
CDC2-S1_d.kin_dom Protein Kinase Domain None 239 None Fasta, JSON

Protein domain

Protein domains of CDC2-S1_d.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDC2-S1_d.AA S_TKc 12-250 22 2.9e-14 32.16 SMART 8-231 (231) Show / Hide 
Range on Protein: 12-250
Range on HMM: 8-231/231
Sequence Identity: 22% (59 aa)

GYGESSVVAHGYDDL-GERVVIKNMGKGKEVHKQILKEFEIMVNCKHENVLDVIDMGLDKDGNYYMVFEHTNG---NVLEYLQMDLSKAGKESELGSRFF
| |  ..|  ...   |..| || .       ..|..| .|. . .|.|.   .|.  |  ...|||.|. .|   ....|..   ..       | || 
GKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH-------GLRFP

TREEKIKEIMRQLLLGLAWLHERGVAHQGMTKDNVLVKVKGCDFKVKLGDFSCARRLCNN--------PPETTLKVGT-AVDIWSAGILLVGMIL---PL
  |  .. .|.|....|. .|..|. |     .|.|.        .|..||  ||.| .         .||   . |. ..|.|| |..|  |.    | 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPF

EMPELPEKEAKGEVLETIKKFLRALDDLIKDKDALELVKSMLASDPV---TARQALA----------F
.           .. ...|| .        ...|..... .|  ||    || .||.          |
P-----------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDC2-S1_d.AA STE 27-189 20 3.4e-14 46.62 In-house 39-259 (359) Show / Hide 
Range on Protein: 27-189
Range on HMM: 39-259/359
Sequence Identity: 20% (47 aa)

GERVVIK--NMGKGK----------------EVHKQILKEFEIMVNCK--HENVLDVIDMGLDK------DGNYYMVFEHTN-GNVLEYLQ------MDL
||.. ||  |. . .                | ..||||| .|| .|.  |.|.   ... ...      |.. ... |. . | . . ..      ..|
GEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPL

SKAGKESELGSRFFTREEKIKEIMRQLLLG-LAWLHERGVAHQGMTKDNVLVKVKGCDFKVKLGDFSCARRLCN--------------------------
..  .    .  ..  |. |. | ||.| | |. ||. .. |     .|.|.        ||| || .. .| .                          
NHNRQ----H-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVG

---NPPETTLK--------VGTAVDIWSAGILLV
     ||  ..         .| .|||| |....
TPWMAPEVIQQNGQGRDKGYDTKCDIWSLGCTII
Kinase CDC2-S1_d.AA CAMK 23-188 15 9.9e-14 39.91 In-house 28-324 (425) Show / Hide 
Range on Protein: 23-188
Range on HMM: 28-324/425
Sequence Identity: 15% (46 aa)

YDDLGERVVIKN-------------------MGKGKEVH----------KQILKEFEIMVNCK-------HENVLDVID-------------------MG
| . |..| ||                    . | |. |          |....| ||| ...       |.|..  ..                     
YTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVF

LDKDGNYYMVF---EHTNGNVL-EYLQMDLSKAGKESE-------LGSRFFTREEKIKEIMRQLLLGLAWLHERGVAHQGMTKDNVLVKVKG--------
 .|| ..|||.   |.  |  | ..|   . . |...|       . .|.   |.  . ..||.. ... .|.....|     .|.|.  ..        
-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEH

------CDFKVKLGDFSCARRLCNN-------------------------------------P-PETTLK----------------VGTAVDIWSAGILL
       ....|. ||  |...  .                                     . ||  ..                .| ..|.||.|..|
DEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase CDC2-S1_d.AA CMGC 12-193 14 8.3e-12 34.15 In-house 8-330 (513) Show / Hide 
Range on Protein: 12-193
Range on HMM: 8-330/513
Sequence Identity: 14% (49 aa)

GYGESSVVAHGYD---------------DLGERVVIKNM--GKGKEVHKQ-----------ILKEFEIMVNCK-----------------HENVLDVIDM
| |  .||  ..|               . .|.| || .   . .| ...           .| | .|. . .                 |.|..  .|.
GEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDI

GLDKD----------------GNYYMVFEHTNGNVLEYLQ-------------MDLSKAGKESELGSRFFTRE--EKIKEIM------RQLLLGLA--WL
  .|.                 . |.|||.   . ..|..             ..  . .|. .       |.  . || .|      .|.| ||.   .
FYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKH-P------HRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HERG--VAHQGMTKDNVLVKVKG-----------------CDFKVKLGDFSCARRLCNN-----------------------------------PPETTL
| ..  . |  .   |.|.  ..                  ....|..||  || . ..                                   .||  |
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

KV------------GTAVDIWSAGILLVGMIL
              .|..|.||.|  .  |..
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYT
Kinase CDC2-S1_d.AA CDK 46-134 21 9.4e-12 33.71 In-house 56-131 (284) Show / Hide 
Range on Protein: 46-134
Range on HMM: 56-131/284
Sequence Identity: 21% (21 aa)

LKEFEIMVNCKHENVLDVIDMGLDK----------DGNYYMVFEHTNGNVLEYLQMDLSKAGKESELGSRFFTREEKIKEIMRQLLLGLAWLHERGVAH
. |  .. .. |.|.  ..|  ..|          . . |||||.      .|.                       || .|.||| ||. .|.... |
IREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD----------------------IKCYMWQLLRGLHYCHSNWIMH
Kinase CDC2-S1_d.AA Pkinase 31-134 23 1.1e-09 35.34 Pfam 31-131 (293) Show / Hide 
Range on Protein: 31-134
Range on HMM: 31-131/293
Sequence Identity: 23% (26 aa)

VIKNMGKGKEVHKQILK--EFEIMVNCKHENVLDVIDMGLDKDGNYYMVFEHTNG-----NVLEYLQMDLSKAGKESELGSRFFTREEKIKEIMRQLLLG
.||  .. ...... ..  | .|| ...|.|..  .|.  | ....|||.|. .|        .|..          . . .|   |. .| .|.|.| |
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST---------WRHGCFYFSEWECKFYMYQILRG

LAWLHERGVAH
|. .|..|. |
LEYCHSMGIIH
Kinase CDC2-S1_d.AA Ciliate-E2 43-188 18 1.4e-09 29.06 In-house 78-286 (365) Show / Hide 
Range on Protein: 43-188
Range on HMM: 78-286/365
Sequence Identity: 18% (41 aa)

KQILKEFEIMVNCKHENVLDVIDMGLD-KDGNYYMVFEHTNGNVLEYLQMDL-SKAGKESE-LGSRFFTREEKIKEIMRQLLL---------------GL
|.| .| .|. . .| |..  ..   . .| |.|.|.|  .|. |...  .   | ..| |    .|   |..||.||.|.|                .|
KKI-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYF--TEKEIKYIMKQILQGFKTKAEFYIACIILAL

AWLHERG-VAHQGMTKDNVLVKVKGCDFKVKLGDFSCAR---------------------------------------------RLCNNPPETTLKVG--
  ||... . |     .|.|.        .|. ||  ..                                              .   .||   . .  
EYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYD

---------TAVDIWSAGILL
         ...||||.|..|
NQQKQKGYDYKCDIWSLGVIL
Kinase CDC2-S1_d.AA CDC2 56-158 25 4.7e-09 23.42 In-house 58-147 (301) Show / Hide 
Range on Protein: 56-158
Range on HMM: 58-147/301
Sequence Identity: 25% (27 aa)

K-HENVLDVIDMGLDKDGNYYMVFEHTNGNVLEYLQMDLSKAGKESELGSRFFTREEKIKEIMRQLLLGLAWLHERGVAHQGMTKDNVLVKVKGCDFKVK
| |.|.    |       . |||||  . .  .|. | ..|              ....|..| |.| |.. .| |.. |     .| |.  ||    .|
KDHPNIVKLHDVIHQ--NKLYMVFEYLDMDLKKYMDMSIPKN---------KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN---IK

LGDF
..||
IADF
Kinase CDC2-S1_d.AA ULK 14-134 19 2.9e-08 25.06 In-house 10-153 (329) Show / Hide 
Range on Protein: 14-134
Range on HMM: 10-153/329
Sequence Identity: 19% (30 aa)

GESSVVAHGY---DD--LGERVVIKNMGKGKEVHKQ-----------ILKEFEIMVNCK--------HENVLDVIDMGLDKDG-NYYMVFEHTNG-NVLE
|   .|  |.   ..   .| |..| . | |.  |.           . .| .||   |        |.|.   .|.  ...  |.|...|  || .  .
GSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQ

YLQ------MDLSKAGKESELGSRFFTREEKIKEIMRQLLLGLAWLHERGVAH
|..      .|              .  |........|.| |. .||.... |
YIKKNKKLPEDT-E--------EKKRLSEQEAIQFFKQILNGFKELHKHNIIH
Kinase CDC2-S1_d.AA Ciliate-E2-Unclassified 43-188 18 3.5e-08 24.5 In-house 68-260 (352) Show / Hide 
Range on Protein: 43-188
Range on HMM: 68-260/352
Sequence Identity: 18% (37 aa)

KQILKEFEIMVNCKHENVLDVIDMGLDKDGNYYMVFEHTNGNVLEYLQMDLSK--AGKESELGSRFFT-R---EEKIK-----EIMRQLLLGLAWLHERG
..|...  |..|..|....  ...   .. | |.| |  .|. |..   . .|    |  .|. .  . .   |...|      ...|.|.||  ||. .
NKIMQQ--ILLNHPHPFIVKMFYC-FQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQ-KGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN

-VAHQGMTKDNVLVKVKGCDFKVKLGDFSCARRLCNN---------------------------------PPETTLKVGTA------VDIWSAGILL
 . |   . .|.|.. .|  ...|. ||. .... .|                                 .||   . .        .|||| |..|
NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL
Kinase CDC2-S1_d.AA RCK 85-169 28 2.9e-07 18.8 In-house 78-169 (298) Show / Hide 
Range on Protein: 85-169
Range on HMM: 78-169/298
Sequence Identity: 28% (27 aa)

VLEYLQMDLSKAGKE-SELGSRFFTREEK--IKEIMRQLLLGLAWLHERGVAHQGMTKDNVLVKV------KGCDFKVKLGDFSCARRLCNNPP
|.||..|.|..  |.  | . . .. |..  || || |.|.||| .|. |  |  .   | ...       .  .. .|..||. .|   ..||
VFEYMDMNLYQMMKDFKE-RRKYLP-ENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPP
Kinase CDC2-S1_d.AA Ciliate-E2a 105-134 45 5.5e-07 16.64 In-house 95-125 (275) Show / Hide 
Range on Protein: 105-134
Range on HMM: 95-125/275
Sequence Identity: 45% (14 aa)

RFFTREEKIKEIMRQLL-LGLAWLHERGVAH
|||. ...|..||.|||  ||. .| |.. |
RFFEEIQEICDIMQQLLWQGLHYMHQRNIMH
TyrKc CDC2-S1_d.AA TyrKc 3-248 13 8.8e-07 -112.96 SMART 16-280 (280) Show / Hide 
Range on Protein: 3-248
Range on HMM: 16-280/280
Sequence Identity: 13% (43 aa)

VLGRYNYASGYGESSVVAHGYDDLGERVVIKNMGKGKEVHKQILKEFEIMVNC--KHENVLDVIDMGLDK------DGNYYMVFEH-TNGNVLEYLQMDL
..|...                   . | .| . ...  .. ...| .|| .   .|.|..  .   ...      .. ...|.|.  .|. ..||.   
YKGTWK-------------------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

SKAGKESELGSRFFTREEKIKEIMRQLLLGLAWLHERGVAHQGMTKD----NVLVKVKGCDFKVKLGDFSCARRL-------------------CNN---
 |               ..  ... |   | . ||.... |     |    |.||. ..    || .||  .| .                   . .   
PK------------LCMKDLLSFCWQIACGMEYLHSKNCIH----RDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML

-----PPETTLKV--GTAVDIWSAGILL-----VGMILP-------LEMPELPEKEAKGEVLETIKK-----FLRALDDLIKDKDALELVKSMLASDP--
     .||.  .    |. |.|| |...      |.  .       ..  |. |.  .|. ..  .      |       .  ..  .. |.  . ||  
PIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF------VCCPDEMYQIMKQCWHEDPED

----VTARQAL
     . .. .
RPTFSEIHECF
Kinase CDC2-S1_d.AA Pkinase 176-241 15 0.043908 8.45 Pfam 190-278 (293) Show / Hide 
Range on Protein: 176-241
Range on HMM: 190-278/293
Sequence Identity: 15% (14 aa)

GTAVDIWSAGILLVGMIL--PLEMPELPEKEAKGEVLETIKKFLRALDDLIKD-----------------------KDALELVKSMLASDP
|..||.||.|..|  |..  |.   .    .   . .. |.. ...  .   .                       .......|..|. ||
GPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP
Kinase CDC2-S1_d.AA CDK 176-185 60 0.048662 2.13 In-house 200-209 (284) Show / Hide 
Range on Protein: 176-185
Range on HMM: 200-209/284
Sequence Identity: 60% (6 aa)

GTAVDIWSAG
||..|.||.|
GTPIDMWSVG