Gene CDC2-S2_a (S.moellendorffii)
CDC2-S2_a
Species: S.moellendorffii
Alias: CDC2-S2_a
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| CDC2-S2_a.AA | Protein | None | 251 | None | Fasta, JSON |
| CDC2-S2_a.NA | RNA | None | 756 | None | Fasta, JSON |
| CDC2-S2_a.kin_dom | Protein Kinase Domain | None | 194 | None | Fasta, JSON |
Protein domains of CDC2-S2_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Pkinase | CDC2-S2_a.AA | Pkinase | 7-219 | 27 | 1.9e-51 | 182.06 | Pfam | 1-228 (293) | Show / Hide |
Range on Protein: 7-219
Range on HMM: 1-228/293
Sequence Identity: 27% (65 aa)
ASDARLLGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLYDTIIN-----ESEILEEVAHDNVVNLLGLTCNNQGTFMVMELMDG-----SLRDVIS---S
| .|.|. |.|. . |..||..||.|.. .. . .. | .|. .. |.|.| |.. ... ||||...| .| |.|| .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH
RKL--GEHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADFTTAR---RLQTRPWSNKVGTLTFNAPELLKGATSFGTAIDVWS
... |...| .|.|||. |. .|...|.| |.| .|.|....|. . ||..|| |. . . .||. . |||...|.. |...|.||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS
AGCIFAEMLLGSNPFD--VPDEEDGDSLNYFVA
.|||..|||.| ||. . .... .. .. ..
CGCILYEMLCGRPPFPGHC-WHDN-HDQMQMIC
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| Kinase | CDC2-S2_a.AA | CMGC | 7-203 | 19 | 8.9e-46 | 147.84 | In-house | 1-342 (513) | Show / Hide |
Range on Protein: 7-203
Range on HMM: 1-342/513
Sequence Identity: 19% (68 aa)
ASDARLLGAGADGEVRVGFH--------------RKTGDKVAMKKMYEHEYLYD------------TIINESEILEEVA-----------------HDNV
. .| |. |.| ... ..|. .||.||. . .| . ... | .||... | |.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI
VNLLGLTCNNQ-----------------GTFMVMELMDGSLRDVISSRK----------LGEHD------------IKAVM------RQILERLA--WIH
|.|. .. ..|.|.|| .| ..| . . | | || | .|||. |. .|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH
AHR--IVHQDIKTSNVLVKRDGEK---------------NKFVVKLADFTTARRLQTR-----------------------PWSNKVGTLTFNAPELLKG
|. |.| |.| .|.|. ..| ....|..|| || . .. | .. | |. |||.| |
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG
A---------TSFGTAIDVWSAGCIFAEMLLG-------SNPF
. . ..|.||.||.|||||||..| |.
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL
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| Kinase | CDC2-S2_a.AA | S_TKc | 7-251 | 28 | 3.5e-41 | 144.05 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 7-251
Range on HMM: 1-231/231
Sequence Identity: 28% (75 aa)
ASDARLLGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLYDTIINESEILEEVAHDNVVNLLGLTCNNQGTFMVMELMDG---SLRDVISSRK-------L
|..| || |.|. . |.||| .||.|.. ..|..| .||.. |.|.|.|.. . . .||||..|| .|.|.| .|. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF
GEHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADFTTARRLQTRPWSNKVGTLTFNAPELLKGATSFGT-AIDVWSAGCIFAE
| ... .|.||.. |. .| |.|.| |.| .|.|. . ..|..|| ||.| . .||. . |||.| ..|. ..|.|| |||..|
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE
MLLGSNPFDVPDEEDGDSLNYFVADFAKKLDIDGCDMGYQDKRRERACERIL-------EKMT
|| | ||. .. .. . . | |..| . . ..| | |
MLCGYPPFP----QMQMMFKKIG-SPEAKDFIRKC-LQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | CDC2-S2_a.AA | CAMK | 12-210 | 17 | 4.3e-39 | 123.11 | In-house | 1-341 (425) | Show / Hide |
Range on Protein: 12-210
Range on HMM: 1-341/425
Sequence Identity: 17% (60 aa)
LLGAGADGEVRVGFHRKTG------------DKVAMKKMY-----------------------------EHEYLYDTIINESEILEEVA-------HDNV
|| |. |.|. ..|..|. |||.| . . .. . . .| ||. . | |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VNLLGLTC------------NNQG--------TFMVM---ELMDG-----SLRDVISSR----------------KLGEHDIKAVMRQILERLAWIHAHR
..|. . . .||| |...| | | | .. .. |.. . ..|||.. .. .| |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
IVHQDIKTSNVLVKRDGEKNK------------FVVKLADFTTARRLQT-------------------------RPWSNKVGTLTFNA-PELLKG-----
||| |.| |.|. ... . . .|..|| |.... . . .||. . | ||.|.|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
--------ATSFGTAIDVWSAGCIFAEMLLGSNPFDVPDEED
. | ..|.||.|.| || | ||. .....
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNE
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| Kinase | CDC2-S2_a.AA | CDK | 54-203 | 32 | 4.9e-37 | 115.92 | In-house | 61-225 (284) | Show / Hide |
Range on Protein: 54-203 Range on HMM: 61-225/284 Sequence Identity: 32% (57 aa) ILEEVAHDNVVNLLGLTCNN-----------QGTFMVMELMDGSLRDVISSRKLGEHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGE-KNKF .| | |.|.|.|. . .||.| || | ... || |.|.|. |. .| ..|.| |.|..| |. ..|| | LLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVK-CG VVKLADFTTARRLQ--------TRPWSNKVGTLTFNAPELLKGATSFG--TAIDVWSAGCIFAEMLL---GSNPF ..|.||| || . .|. ...| || ||||| |.. . |.||.||.|||||||.. . | RLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLF |
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| Kinase | CDC2-S2_a.AA | STE | 7-203 | 23 | 7.8e-37 | 127.63 | In-house | 1-268 (359) | Show / Hide |
Range on Protein: 7-203 Range on HMM: 1-268/359 Sequence Identity: 23% (65 aa) ASDARLLGAGADGEVRVGFHRK---------------TGDKVAMKKMYEHEY------------------LYDTIINESEILEEVA--HDNVVNLLGLTC . . .| || |.| . ..| ||. .|.|.| . . |..| .|. . |.|.|. .| WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF NN-------QGTFMVMELMD-GSLRDVIS---SRKLG------------EHDIKAVMRQILER-LAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLAD .. . ...||.|| |||.|.| ... . |. |... ||||. |. .| |.|.| ||| .|.|. |||.| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCD FTTARRLQT-----------------RPWS-NKVGTLTFNAPELLKG-----ATSFGTAIDVWSAGCIFAEMLLGSNPF | .. .|. . ||| . ||| ... .| |.|| || ||. | |. FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW |
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| Kinase | CDC2-S2_a.AA | CDK7 | 8-198 | 34 | 1.3e-36 | 94.74 | In-house | 2-198 (288) | Show / Hide |
Range on Protein: 8-198 Range on HMM: 2-198/288 Sequence Identity: 34% (70 aa) SDARLLGAGADGEVRVGFHRKTGDKVAMKKMY---EHEYLYDTI----INESEILEEVAHDNVVNLLGLTCNNQGTFMVMELMDGSLRDVISSRK--LGE ...|.| . | . .|| .|| || . | | | | || | ||||..|. .|...|| | || . | EKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILTP HDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADFTTARRLQT--RPWSNKVGTLTFNAPELLKGATSFGTAIDVWSAGCIFAEM .||| | ..| | . |.. | | |.| | |. .| ..|.||| || | .. .| | . ||||| || ..||..|.|| |||||| AHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENG-----QLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAEL LL .| ML |
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| Kinase | CDC2-S2_a.AA | TKL | 13-210 | 17 | 6.7e-32 | 112.14 | In-house | 1-296 (364) | Show / Hide |
Range on Protein: 13-210
Range on HMM: 1-296/364
Sequence Identity: 17% (54 aa)
LGAGADGEVRVGFHRK--------TGDKVAMKKMYEHE----------------------------YLYDTIINESEILEEVAHDNVVNLLGLTCNNQG-
.| |. ||| | .| || ||.||. .|. . .....| .. |.|.| ..| |....
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------TFMVMELM-DGSLRDVISSRKLGEHDIKAVMRQILERLAWIHAHR--------IVHQDIKTSNVLVKRDGE---------KNKFVVKL
..|||.. |||.... | . ...| ... |... |.| |.|..|.||..... .. ..|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI
ADFTTARRLQTRP---------------------WSNKVGTLTFNAPELLKGAT---------------SFGTAIDVWSAGCIFAEMLLGSNPFDVPDEE
.|| ..|..... ....||. . |||.|.|.. .. ...||.| | .. |.| . |.. ....
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYM
D
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P
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| Kinase | CDC2-S2_a.AA | CDC2 | 8-196 | 31 | 1.4e-30 | 90.8 | In-house | 2-199 (301) | Show / Hide |
Range on Protein: 8-196 Range on HMM: 2-199/301 Sequence Identity: 31% (65 aa) SDARLLGAGADGEVRVGFHRKTGDKVAMKKM-YEHEYLY----DTIINESEILEEVA-HDNVVNLLGLTCNNQGTFMVMELMDGSLRDVIS----S-RKL . .| | |.| . ...|.. ||.|| |.| |.| | .| | |.|.| | . . .|| | .| |. . .. QKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHM GEHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADFTTARRLQT--RPWS--NKVGTLTFNAPELLKGATSFGTAIDVWSAGCI .. .| | |||. .. |..||.| |.| .| |. ..|. .|.||| || .. |. | || |||.| |. |..|.|| ||| PPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-----IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCI FAEM |||| FAEM |
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| Kinase | CDC2-S2_a.AA | ASK | 12-203 | 34 | 1.3e-26 | 85.36 | In-house | 1-197 (254) | Show / Hide |
Range on Protein: 12-203 Range on HMM: 1-197/254 Sequence Identity: 34% (69 aa) LLGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLY-DTIINESEILEEVAHDNVVNLLGLTCNNQGTFMVMELM-DGSLRDVISSR----KLGEHDIKAVM || |. | | | ..| ..|.| . |.. | . .| .. ... | |.| || . .|. . || . ||| ... |. | |. .. VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYT RQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADFTTARRL-QTRPWSNK-VGTLTFNAPELL-KGATSFGTAIDVWSAGCIFAEMLLGSNP .|||| | ..| ..||| ||| |||| |||..|| |..|| | .. ||| . |||.. .| .| . |.|| || || | | KQILEGLKYLHENQIVHRDIKGDNVLV----NTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPP F | F |
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| Kinase | CDC2-S2_a.AA | Ciliate-E2 | 11-203 | 19 | 3e-26 | 87.09 | In-house | 5-296 (365) | Show / Hide |
Range on Protein: 11-203 Range on HMM: 5-296/365 Sequence Identity: 19% (60 aa) RLLGAGADGEVRVGFHRKTGD---------------------------KVAMKKMYEHEYLYDTII----------NESEILEEVAHDNVVNLLGLTC-- ...| |. | |. . ..|.. |. .|.. |. . |. || .|||.. |.|.... KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEK NNQGTFMVMELMDG-SLRDVISSR------------KLGEHDIKAVMRQILE---------------RLAWIHAHR-IVHQDIKTSNVLVKRDGEKNKFV ... ..|||. .| .|.| | .. .. | || .|.|||. | .| |.| ||| .|.|. DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------- VKLADFTTARRLQTRPWSNK---------------------------------VGTLTFNAPELLKGATS--------FGTAIDVWSAGCIFAEMLLGSN .|..|| ....... . .||. . ||| |.| ....|.||.|.|. ||| | IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP PF || PF |
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| Kinase | CDC2-S2_a.AA | PAKA | 8-199 | 31 | 1.5e-24 | 83.11 | In-house | 2-199 (260) | Show / Hide |
Range on Protein: 8-199
Range on HMM: 2-199/260
Sequence Identity: 31% (65 aa)
SDARLLGAGADGEVRVGFHRKTGDK--VAMKKMY-EHEYLYDTIINESEILEEVAHDNVVNLLGLTCNNQGTFMVMELMD-GSLRDVISSRK------LG
.| || ||| |. .||... ||.|.| . . ..|||| .. | |.|.|| . . ..||| |. |.| |||. .
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD
EHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADFTTARRLQT--RPWSNKVGTLTFNAPELLKGATSFGTAIDVWSAGCIFAE
| | .| |..| | ||.. ..| ||| |.|. ||. ||..|| . .|. . . ||| . |||.... . .|.|| | . |
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGS-----VKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQ-YDEKVDIWSLGIMAIE
MLLG
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MIEG
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| Kinase | CDC2-S2_a.AA | TyrKc | 7-250 | 20 | 9.6e-12 | -32.82 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 7-250 Range on HMM: 1-280/280 Sequence Identity: 20% (61 aa) ASDARLLGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLYDTIINESEILEEV--AHDNVVNLLGLTCNN-------QGTFMVMELMD-GSLRDVISSRK- . . || || |||. | . .|| |.. |. ...| .|. .. |.|.|.|.| . ..|||.|. |.|.| . ... ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP -LGEHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADFTTARRLQTR------PWSNKV-----GT--LTFN--APELLKGATS | | . || . . .| ....| |. . |.||.... .|| .|| .| . .. | | ||| . .. KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYG -FGTAIDVWSAGCIFAEML-LGSNPFDVPDE--EDGDSLNYFVADFAKKLDIDG--------CDMGYQD--------KRRERAC-ERILEKM | |. |||| | |.. .| | . . . . . .| . . | . . .| . . | |.. KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | CDC2-S2_a.AA | Pkinase_Tyr | 11-148 | 26 | 1.3e-07 | 26.46 | Pfam | 5-155 (270) | Show / Hide |
Range on Protein: 11-148 Range on HMM: 5-155/270 Sequence Identity: 26% (41 aa) RLLGAGADGEVRVGFHR----KTGDKVAMKKM---YEHEY-LYDTIINESEILEEV-AHDNVVNLLGLTC-NNQG--TFMVMELMDG-SLRDVISSR--- . ||.|| |||. | . .|. .|| |.. . || . . ..| .|. . |.|.|.|.| . ..|||.| . .|.| .. KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRED --KLGEHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADF .| .|. .|| . ... ......| |. . |.||.. ..||| .|| KQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-----NNVVKICDF |
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