CDC2-S2_a

Species: S.moellendorffii
Alias: CDC2-S2_a
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2-smoe2

Sequence

Name Sequence Type Origin Length Description Download
CDC2-S2_a.AA Protein None 251 None Fasta, JSON
CDC2-S2_a.NA RNA None 756 None Fasta, JSON
CDC2-S2_a.kin_dom Protein Kinase Domain None 194 None Fasta, JSON

Protein domain

Protein domains of CDC2-S2_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase CDC2-S2_a.AA Pkinase 7-219 27 1.9e-51 182.06 Pfam 1-228 (293) Show / Hide
Range on Protein: 7-219
Range on HMM: 1-228/293
Sequence Identity: 27% (65 aa)

ASDARLLGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLYDTIIN-----ESEILEEVAHDNVVNLLGLTCNNQGTFMVMELMDG-----SLRDVIS---S
    | .|.|. |.|. . |..||..||.|..  ..   .  ..     | .|. .. |.|.| |..   ...   ||||...|     .| |.||   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RKL--GEHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADFTTAR---RLQTRPWSNKVGTLTFNAPELLKGATSFGTAIDVWS
...   |...| .|.|||. |. .|...|.| |.| .|.|....|. .   ||..||  |.       .  .  .||. . |||...|..  |...|.||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

AGCIFAEMLLGSNPFD--VPDEEDGDSLNYFVA
.|||..|||.|  ||.  . .... .. .. ..
CGCILYEMLCGRPPFPGHC-WHDN-HDQMQMIC

Kinase CDC2-S2_a.AA CMGC 7-203 19 8.9e-46 147.84 In-house 1-342 (513) Show / Hide
Range on Protein: 7-203
Range on HMM: 1-342/513
Sequence Identity: 19% (68 aa)

ASDARLLGAGADGEVRVGFH--------------RKTGDKVAMKKMYEHEYLYD------------TIINESEILEEVA-----------------HDNV
    . .| |. |.|  ...              ..|. .||.||. . .|  .            ... | .||...                  | |.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNLLGLTCNNQ-----------------GTFMVMELMDGSLRDVISSRK----------LGEHD------------IKAVM------RQILERLA--WIH
|.|.     ..                   ..|.|.|| .| ..| . .          | |              ||  |      .|||. |.   .|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

AHR--IVHQDIKTSNVLVKRDGEK---------------NKFVVKLADFTTARRLQTR-----------------------PWSNKVGTLTFNAPELLKG
 |.  |.| |.| .|.|.  ..|                 ....|..||  || . ..                       | .. | |.   |||.| |
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

A---------TSFGTAIDVWSAGCIFAEMLLG-------SNPF
.         . ..|.||.||.|||||||..|         |.
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL

Kinase CDC2-S2_a.AA S_TKc 7-251 28 3.5e-41 144.05 SMART 1-231 (231) Show / Hide
Range on Protein: 7-251
Range on HMM: 1-231/231
Sequence Identity: 28% (75 aa)

ASDARLLGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLYDTIINESEILEEVAHDNVVNLLGLTCNNQGTFMVMELMDG---SLRDVISSRK-------L
    |..| || |.|. . |.||| .||.|..       ..|..| .||..  |.|.|.|..   . .  .||||..||   .|.|.| .|.       .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

GEHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADFTTARRLQTRPWSNKVGTLTFNAPELLKGATSFGT-AIDVWSAGCIFAE
 | ... .|.||.. |. .| |.|.| |.| .|.|. .       ..|..||  ||.|     .  .||. . |||.|    ..|. ..|.|| |||..|
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MLLGSNPFDVPDEEDGDSLNYFVADFAKKLDIDGCDMGYQDKRRERACERIL-------EKMT
|| |  ||.    ..   ..  . .   |  |..| . .  ..|  | |              
MLCGYPPFP----QMQMMFKKIG-SPEAKDFIRKC-LQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase CDC2-S2_a.AA CAMK 12-210 17 4.3e-39 123.11 In-house 1-341 (425) Show / Hide
Range on Protein: 12-210
Range on HMM: 1-341/425
Sequence Identity: 17% (60 aa)

LLGAGADGEVRVGFHRKTG------------DKVAMKKMY-----------------------------EHEYLYDTIINESEILEEVA-------HDNV
 || |. |.|. ..|..|.             |||.| .                              . ..  . . .| ||.  .        | |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLLGLTC------------NNQG--------TFMVM---ELMDG-----SLRDVISSR----------------KLGEHDIKAVMRQILERLAWIHAHR
..|.                . .          .|||   |...|      | | | ..                .. |.. . ..|||.. .. .| | 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHQDIKTSNVLVKRDGEKNK------------FVVKLADFTTARRLQT-------------------------RPWSNKVGTLTFNA-PELLKG-----
||| |.|  |.|.  ... .             . .|..||  |....                           . .  .||. . | ||.|.|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------ATSFGTAIDVWSAGCIFAEMLLGSNPFDVPDEED
         .  | ..|.||.|.|   || |  ||. .....
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNE

Kinase CDC2-S2_a.AA CDK 54-203 32 4.9e-37 115.92 In-house 61-225 (284) Show / Hide
Range on Protein: 54-203
Range on HMM: 61-225/284
Sequence Identity: 32% (57 aa)

ILEEVAHDNVVNLLGLTCNN-----------QGTFMVMELMDGSLRDVISSRKLGEHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGE-KNKF
.| |  |.|.|.|.     .              .||.| ||  |  ...        ||  |.|.|. |. .| ..|.| |.|..| |. ..|| |   
LLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVK-CG

VVKLADFTTARRLQ--------TRPWSNKVGTLTFNAPELLKGATSFG--TAIDVWSAGCIFAEMLL---GSNPF
..|.|||  ||  .        .|. ...| ||   ||||| |..  .  |.||.||.|||||||..   .   |
RLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLF

Kinase CDC2-S2_a.AA STE 7-203 23 7.8e-37 127.63 In-house 1-268 (359) Show / Hide
Range on Protein: 7-203
Range on HMM: 1-268/359
Sequence Identity: 23% (65 aa)

ASDARLLGAGADGEVRVGFHRK---------------TGDKVAMKKMYEHEY------------------LYDTIINESEILEEVA--HDNVVNLLGLTC
  . . .| || |.|  . ..|               ||. .|.|.|   .                     . |..| .|. .    |.|.|. .|   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NN-------QGTFMVMELMD-GSLRDVIS---SRKLG------------EHDIKAVMRQILER-LAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLAD
..       .  ...||.|| |||.|.|    ... .            |. |... ||||.  |. .| |.|.| ||| .|.|.          |||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCD

FTTARRLQT-----------------RPWS-NKVGTLTFNAPELLKG-----ATSFGTAIDVWSAGCIFAEMLLGSNPF
| .. .|.                     .   |||  . ||| ...         .|  |.|| ||   ||. |  |.
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW

Kinase CDC2-S2_a.AA CDK7 8-198 34 1.3e-36 94.74 In-house 2-198 (288) Show / Hide
Range on Protein: 8-198
Range on HMM: 2-198/288
Sequence Identity: 34% (70 aa)

SDARLLGAGADGEVRVGFHRKTGDKVAMKKMY---EHEYLYDTI----INESEILEEVAHDNVVNLLGLTCNNQGTFMVMELMDGSLRDVISSRK--LGE
   ...|.|  . |  .   .|| .|| ||       .   | |    | |  || |  ||||..|.          .|...||  |  ||   .  |  
EKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILTP

HDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADFTTARRLQT--RPWSNKVGTLTFNAPELLKGATSFGTAIDVWSAGCIFAEM
 .||| | ..|  | . |.. | | |.|  | |.  .|     ..|.|||  ||      | .. .| |  . ||||| || ..||..|.|| |||||| 
AHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENG-----QLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAEL

LL
.|
ML

Kinase CDC2-S2_a.AA TKL 13-210 17 6.7e-32 112.14 In-house 1-296 (364) Show / Hide
Range on Protein: 13-210
Range on HMM: 1-296/364
Sequence Identity: 17% (54 aa)

LGAGADGEVRVGFHRK--------TGDKVAMKKMYEHE----------------------------YLYDTIINESEILEEVAHDNVVNLLGLTCNNQG-
.| |. |||  | .|         ||  ||.||. .|.                             . .....|  ..    |.|.| ..|  |.... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------TFMVMELM-DGSLRDVISSRKLGEHDIKAVMRQILERLAWIHAHR--------IVHQDIKTSNVLVKRDGE---------KNKFVVKL
             ..|||..  |||....       | .   ...|   ... |...        |.| |.|..|.||.....         ..  ..|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

ADFTTARRLQTRP---------------------WSNKVGTLTFNAPELLKGAT---------------SFGTAIDVWSAGCIFAEMLLGSNPFDVPDEE
.|| ..|.....                       ....||. . |||.|.|..               .. ...||.| | .. |.| .  |.. ....
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYM

D
.
P

Kinase CDC2-S2_a.AA CDC2 8-196 31 1.4e-30 90.8 In-house 2-199 (301) Show / Hide
Range on Protein: 8-196
Range on HMM: 2-199/301
Sequence Identity: 31% (65 aa)

SDARLLGAGADGEVRVGFHRKTGDKVAMKKM-YEHEYLY----DTIINESEILEEVA-HDNVVNLLGLTCNNQGTFMVMELMDGSLRDVIS----S-RKL
   . .| |  |.|  . ...|.. ||.||   |.|        |.| |  .| |   |.|.| |     . .  .|| | .|  |.        .  ..
QKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHM

GEHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADFTTARRLQT--RPWS--NKVGTLTFNAPELLKGATSFGTAIDVWSAGCI
 .. .|  | |||. ..  |..||.| |.| .| |. ..|.     .|.|||  ||  ..  |.      | ||   |||.| |.    |..|.|| |||
PPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-----IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCI

FAEM
||||
FAEM

Kinase CDC2-S2_a.AA ASK 12-203 34 1.3e-26 85.36 In-house 1-197 (254) Show / Hide
Range on Protein: 12-203
Range on HMM: 1-197/254
Sequence Identity: 34% (69 aa)

LLGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLY-DTIINESEILEEVAHDNVVNLLGLTCNNQGTFMVMELM-DGSLRDVISSR----KLGEHDIKAVM
 || |. | |  |  ..|  ..|.| . |..  |   . .| .. ... | |.|  || . .|.   . || .  ||| ... |.    |  |. ..   
VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYT

RQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADFTTARRL-QTRPWSNK-VGTLTFNAPELL-KGATSFGTAIDVWSAGCIFAEMLLGSNP
.|||| | ..| ..||| |||  ||||         |||..|| |..||    | ..   ||| . |||.. .|   .| . |.|| ||   ||  |  |
KQILEGLKYLHENQIVHRDIKGDNVLV----NTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPP

F
|
F

Kinase CDC2-S2_a.AA Ciliate-E2 11-203 19 3e-26 87.09 In-house 5-296 (365) Show / Hide
Range on Protein: 11-203
Range on HMM: 5-296/365
Sequence Identity: 19% (60 aa)

RLLGAGADGEVRVGFHRKTGD---------------------------KVAMKKMYEHEYLYDTII----------NESEILEEVAHDNVVNLLGLTC--
...| |. | |. . ..|..                            |. .|.. |.    . |.          || .|||.. |.|....       
KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEK

NNQGTFMVMELMDG-SLRDVISSR------------KLGEHDIKAVMRQILE---------------RLAWIHAHR-IVHQDIKTSNVLVKRDGEKNKFV
...  ..|||. .| .|.| | ..            .. |  || .|.|||.                |  .|    |.| ||| .|.|.          
DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------

VKLADFTTARRLQTRPWSNK---------------------------------VGTLTFNAPELLKGATS--------FGTAIDVWSAGCIFAEMLLGSN
.|..|| .......    .                                  .||. . ||| |.|            ....|.||.|.|. ||| |  
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PF
||
PF

Kinase CDC2-S2_a.AA PAKA 8-199 31 1.5e-24 83.11 In-house 2-199 (260) Show / Hide
Range on Protein: 8-199
Range on HMM: 2-199/260
Sequence Identity: 31% (65 aa)

SDARLLGAGADGEVRVGFHRKTGDK--VAMKKMY-EHEYLYDTIINESEILEEVAHDNVVNLLGLTCNNQGTFMVMELMD-GSLRDVISSRK------LG
     .| || ||| |.  .||...  ||.|.|  . .   ..||||  .. |  |.|.|| .     .   ..||| |. |.| |||.         . 
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD

EHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADFTTARRLQT--RPWSNKVGTLTFNAPELLKGATSFGTAIDVWSAGCIFAE
|  | .| |..|  |  ||.. ..| |||  |.|.  ||.     ||..||  . .|.   .  .  |||  . |||....    .  .|.|| | .  |
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGS-----VKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQ-YDEKVDIWSLGIMAIE

MLLG
|. |
MIEG

Kinase CDC2-S2_a.AA TyrKc 7-250 20 9.6e-12 -32.82 SMART 1-280 (280) Show / Hide
Range on Protein: 7-250
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

ASDARLLGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLYDTIINESEILEEV--AHDNVVNLLGLTCNN-------QGTFMVMELMD-GSLRDVISSRK-
 .  . || || |||. |  .    .|| |.. |.      ...| .|. ..   |.|.|.|.|            .  ..|||.|. |.|.| . ... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LGEHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADFTTARRLQTR------PWSNKV-----GT--LTFN--APELLKGATS
 |   |    . || .  . .| ....| |. . |.||....     .|| .||  .| .             ..     |   |     ||| .   ..
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYG

-FGTAIDVWSAGCIFAEML-LGSNPFDVPDE--EDGDSLNYFVADFAKKLDIDG--------CDMGYQD--------KRRERAC-ERILEKM
 | |. |||| |    |.. .|  |   . .   . . .  .| .       .         |     .        .  .| . . | |..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase CDC2-S2_a.AA Pkinase_Tyr 11-148 26 1.3e-07 26.46 Pfam 5-155 (270) Show / Hide
Range on Protein: 11-148
Range on HMM: 5-155/270
Sequence Identity: 26% (41 aa)

RLLGAGADGEVRVGFHR----KTGDKVAMKKM---YEHEY-LYDTIINESEILEEV-AHDNVVNLLGLTC-NNQG--TFMVMELMDG-SLRDVISSR---
. ||.|| |||. |  .    .|. .|| |..   . ||  . .  ..| .|. .   |.|.|.|.|      .    ..|||.| . .|.|   ..   
KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRED

--KLGEHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGEKNKFVVKLADF
  .|  .|.    .|| . ... ......| |. . |.||..     ..||| .||
KQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-----NNVVKICDF