Gene CDC2-S2_f (S.moellendorffii)

CDC2-S2_f

Species: S.moellendorffii
Alias: CDC2-S2_f
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2-smoe2

Sequence

Name Sequence Type Origin Length Description Download
CDC2-S2_f.AA Protein None 272 None Fasta, JSON
CDC2-S2_f.NA RNA None 819 None Fasta, JSON
CDC2-S2_f.kin_dom Protein Kinase Domain None 189 None Fasta, JSON

Protein domain

Protein domains of CDC2-S2_f.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase CDC2-S2_f.AA Pkinase 46-236 23 8.9e-31 109.91 Pfam 113-293 (293) Show / Hide 
Range on Protein: 46-236
Range on HMM: 113-293/293
Sequence Identity: 23% (46 aa)

MVRQILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADFATVR---RLRTRPWSNKVGTLTFNAPELLTGATSFGTAIDVWGAGCIFAEMLLGS
...|||.||. .|...|.| |.| .|.|....|. .   ||..||   .     . .  .  .||. . |||.. |..  |...|.|..|||..|||.| 
YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR

NPFDVP----DEEDGDSLDYFVADFAKKLDID--GCGMGYQDRRRERARKRILEKMAWWKAEDVRSGIKDPDAVELLKRMLAIDLARRISAQNALKMPYF
 ||.      .  | . . . . .   . |..   ... .  .|. . .          . . ..    .... ...|..|. | ..|..|. .|. |.|
PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CDC2-S2_f.AA CMGC 46-145 24 2.6e-28 89.41 In-house 185-342 (513) Show / Hide 
Range on Protein: 46-145
Range on HMM: 185-342/513
Sequence Identity: 24% (39 aa)

MVRQILEGLA--WIHAHR--IVHQDVKTSNVLVKRDGEK---------------NKFVVKLADFATVRRLRTR-----------------------PWSN
. .|||.||.   .| |.  |.| | | .|.|.  ..|                 ....|..||   | . ..                       | ..
YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTH

KVGTLTFNAPELLTGA---------TSFGTAIDVWGAGCIFAEMLLG-------SNPF
 | |.   |||.| |.         . ..|.||.|..|||||||..|         |.
YVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL
Kinase CDC2-S2_f.AA CDK 48-145 36 3.9e-27 83.73 In-house 115-225 (284) Show / Hide 
Range on Protein: 48-145
Range on HMM: 115-225/284
Sequence Identity: 36% (41 aa)

RQILEGLAWIHAHRIVHQDVKTSNVLVKRDGE-KNKFVVKLADF--ATVRRL------RTRPWSNKVGTLTFNAPELLTGATSFG--TAIDVWGAGCIFA
.|.|.||. .| ..|.| | |..| |. ..|| |   ..|.|||  |            .|. ...| ||   ||||| |..  .  |.||.|..|||||
WQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVK-CGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFA

EMLL---GSNPF
||..   .   |
EMFTDVTRKPLF
Kinase CDC2-S2_f.AA CDK7 49-140 39 5.1e-22 55.03 In-house 110-198 (288) Show / Hide 
Range on Protein: 49-140
Range on HMM: 110-198/288
Sequence Identity: 39% (37 aa)

QILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADFATVRRLRT--RPWSNKVGTLTFNAPELLTGATSFGTAIDVWGAGCIFAEMLL
..| || . |.. | | | |  | |.  .|     ..|.|||   |      | .. .| |  . ||||| || ..||..|.|  |||||| .|
MTLQGLEYCHRNWILHRDLKPNNLLMNENG-----QLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML
Kinase CDC2-S2_f.AA CDK9 46-138 42 1e-21 71.51 In-house 124-219 (340) Show / Hide 
Range on Protein: 46-138
Range on HMM: 124-219/340
Sequence Identity: 42% (43 aa)

MVRQILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADFATVR-------RLRTRP-WSNKVGTLTFNAPELLTGATSFGTAIDVWGAGCIFAE
|... . ||  ||  .| | | |  |||. .||     . |||||   |           || . | | || .  |||| |   .|..||.|||||| ||
MMQHLMNGLYYIHRNKILHRDMKAANVLITKDG-----ILKLADFGLARAFSQPKNDAPNRPLYTNRVVTLWYRPPELLLGDRNYGPPIDMWGAGCIMAE

M
|
M
Kinase CDC2-S2_f.AA PFTAIRE 49-145 39 7.9e-21 70.05 In-house 105-198 (287) Show / Hide 
Range on Protein: 49-145
Range on HMM: 105-198/287
Sequence Identity: 39% (39 aa)

QILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADF--ATVRRLRTRPWSNKVGTLTFNAPELLTGATSFGTAIDVWGAGCIFAEMLLGSNPF
| | ||...|  |. | |.|  | |.   ||      |||||  |  .   .. .|. | || .  |  | |.| . | .|.||.|||| ||. |   |
QLLRGLSYCHQRRVLHRDLKPQNLLISHCGE-----LKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAF
Kinase CDC2-S2_f.AA CRK7 48-139 28 9.1e-21 68.17 In-house 119-247 (343) Show / Hide 
Range on Protein: 48-139
Range on HMM: 119-247/343
Sequence Identity: 28% (38 aa)

RQILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADFATVRRLRT----RPWSNKVGTLTFNAPELLTGATSF---------------------
.|.|||.. .|   . | |.| ||.|.   ||     ||.|||   | .      ||  |.| ||   .|||| |..                       
KQLLEGMDYCHKKNFLHRDIKCSNILMNNQGE-----VKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKELIRNIKSIQLSLL

-----------------GTAIDVWGAGCIFAEML
                 |..||.|. |||..| .
ISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELF
Kinase CDC2-S2_f.AA PCTAIRE 49-138 43 1.6e-20 69.18 In-house 105-191 (291) Show / Hide 
Range on Protein: 49-138
Range on HMM: 105-191/291
Sequence Identity: 43% (40 aa)

QILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADF--ATVRRLRTRPWSNKVGTLTFNAPELLTGATSFGTAIDVWGAGCIFAEM
|.| |||. |  .| | | |  | |.  .||      |||||  |  .   |. .|. | ||    |. | | | . | ||.|| ||||.||
QLLRGLAYCHRRKILHRDLKPQNLLINERGE-----LKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEM
Kinase CDC2-S2_f.AA CDK5 49-138 42 1.7e-20 61.02 In-house 106-192 (287) Show / Hide 
Range on Protein: 49-138
Range on HMM: 106-192/287
Sequence Identity: 42% (39 aa)

QILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADFATVRR--LRTRPWSNKVGTLTFNAPELLTGATSFGTAIDVWGAGCIFAEM
| | |||  |.|.. | | |  | |. . ||      |||||   |      | .|  | || . .|  | |.  . | ||.| .|||||||
QLLKGLAFCHEHHVLHRDLKPQNLLINKNGE-----LKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEM
Kinase CDC2-S2_f.AA GSK 112-141 56 6.8e-16 44.45 In-house 186-215 (328) Show / Hide 
Range on Protein: 112-141
Range on HMM: 186-215/328
Sequence Identity: 56% (17 aa)

APELLTGATSFGTAIDVWGAGCIFAEMLLG
||||. |.| ....|||| .||..||||.|
APELIFGCTNYTCQIDVWSCGCVMAEMLKG
S_TKc CDC2-S2_f.AA S_TKc 2-236 19 2.4e-15 48.21 SMART 16-231 (231) Show / Hide 
Range on Protein: 2-236
Range on HMM: 16-231/231
Sequence Identity: 19% (57 aa)

KKMYEHE----------YLYDAIINGSEILEEVAHNNVVNLLGLTCNNQGTFMVM---------------------------------VRQILEGLAWIH
.| ....             . |..  .||..  | |.|.|..   . .  .|||                                 ..||...|. .|
YKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCH

AHRIVHQDVKTSNVLVKRDGEKNKFVVKLADFATVRRLRTRPWSNKVGTLTFNAPELLTGATSFGT-AIDVWGAGCIFAEMLLGSNPFDVPDEEDGDSLD
 |.|.| |.| .|.|. .       ..|..||   |.|     .  .||. . |||.|    ..|. ..|.|  |||..||| |  ||.           
SHGIIHRDLKPENILLDE-------HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-----------

YFVADFAKKLDIDGCGMGYQDRRRERARKRILEKMAWWKAEDVRSGIKDPDAVELLKRMLAIDLARRISAQNALK-------MPYF
  ..   ||.                                      .|.| ......|  | ..|..|  ||.       .|.|
-QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDC2-S2_f.AA CDK7 208-236 34 1.3e-12 29.47 In-house 260-288 (288) Show / Hide 
Range on Protein: 208-236
Range on HMM: 260-288/288
Sequence Identity: 34% (10 aa)

DAVELLKRMLAIDLARRISAQNALKMPYF
|...|...|.. .  .|...  .||||||
DLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDC2-S2_f.AA CMGC 206-236 54 1e-11 33.86 In-house 483-513 (513) Show / Hide 
Range on Protein: 206-236
Range on HMM: 483-513/513
Sequence Identity: 54% (17 aa)

DPDAVELLKRMLAIDLARRISAQNALKMPYF
||.|..|||.|| .| ..||.|. ||..|||
DPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase CDC2-S2_f.AA CDC2 49-90 40 1.1e-11 31.62 In-house 111-147 (301) Show / Hide 
Range on Protein: 49-90
Range on HMM: 111-147/301
Sequence Identity: 40% (17 aa)

QILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADF
|||.|..  |..||.| | | .| |. ..|.     .|.|||
QILQGVHFCHQRRIMHRDLKPQNILIDKKGN-----IKIADF
Kinase CDC2-S2_f.AA CDC2 206-236 51 2e-11 30.83 In-house 271-301 (301) Show / Hide 
Range on Protein: 206-236
Range on HMM: 271-301/301
Sequence Identity: 51% (16 aa)

DPDAVELLKRMLAIDLARRISAQNALKMPYF
||....||..||..| ..||||. ||. |||
DPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase CDC2-S2_f.AA CDK 189-236 31 3.2e-11 31.99 In-house 252-284 (284) Show / Hide 
Range on Protein: 189-236
Range on HMM: 252-284/284
Sequence Identity: 31% (15 aa)

LEKMAWWKAEDVRSGIKDPDAVELLKRMLAIDLARRISAQNALKMPYF
..|. ..               .|| .||. | ..||||. ||..|||
VTKLPDY---------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDC2-S2_f.AA CDC2 112-138 55 7.3e-09 22.83 In-house 173-199 (301) Show / Hide 
Range on Protein: 112-138
Range on HMM: 173-199/301
Sequence Identity: 55% (15 aa)

APELLTGATSFGTAIDVWGAGCIFAEM
|||.| |.    |..|.|  |||||||
APEILLGCKRYSTPVDMWSIGCIFAEM
Kinase CDC2-S2_f.AA GSK 49-90 42 4.1e-08 20.25 In-house 124-161 (328) Show / Hide 
Range on Protein: 49-90
Range on HMM: 124-161/328
Sequence Identity: 42% (18 aa)

QILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADF
|.. ||| .| | |.| |.| .|.|| .|      |.|..||
QMFRGLAYLHSHGICHRDIKPQNILVDPDT----GVLKICDF
Kinase CDC2-S2_f.AA GSK 205-236 28 1e-07 18.98 In-house 297-328 (328) Show / Hide 
Range on Protein: 205-236
Range on HMM: 297-328/328
Sequence Identity: 28% (9 aa)

KDPDAVELLKRMLAIDLARRISAQNALKMPYF
...|...|....| .|   |.|.  |...|.|
DMQDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase CDC2-S2_f.AA CDK5 211-236 50 1.8e-07 19.15 In-house 262-287 (287) Show / Hide 
Range on Protein: 211-236
Range on HMM: 262-287/287
Sequence Identity: 50% (13 aa)

ELLKRMLAIDLARRISAQNALKMPYF
.||..|| .. . ||||..||. |||
DLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDC2-S2_f.AA CRK7 206-236 29 4e-07 20.4 In-house 313-343 (343) Show / Hide 
Range on Protein: 206-236
Range on HMM: 313-343/343
Sequence Identity: 29% (9 aa)

DPDAVELLKRMLAIDLARRISAQNALKMPYF
..... ||  ||. |   |..|. .|  ..|
PKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDC2-S2_f.AA CDK9 206-236 32 2e-06 17.86 In-house 310-340 (340) Show / Hide 
Range on Protein: 206-236
Range on HMM: 310-340/340
Sequence Identity: 32% (10 aa)

DPDAVELLKRMLAIDLARRISAQNALKMPYF
|..|..|. ..|.|| ..|. . .||   .|
DQQACHLIDKLLNIDPKKRMDSDEALDHDWF
Kinase CDC2-S2_f.AA PFTAIRE 207-236 43 3e-06 17.92 In-house 258-287 (287) Show / Hide 
Range on Protein: 207-236
Range on HMM: 258-287/287
Sequence Identity: 43% (13 aa)

PDAVELLKRMLAIDLARRISAQNALKMPYF
|.| .|.. || .    |.|||.|.. |||
PHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDC2-S2_f.AA PCTAIRE 208-236 37 4.4e-05 13.8 In-house 263-291 (291) Show / Hide 
Range on Protein: 208-236
Range on HMM: 263-291/291
Sequence Identity: 37% (11 aa)

DAVELLKRMLAIDLARRISAQNALKMPYF
.  .||. .|      |.|| .|.| |||
QCQDLLTMLLQYESKNRVSAEKAMKHPYF
TyrKc CDC2-S2_f.AA TyrKc 1-193 14 8.6e-05 -145.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-193
Range on HMM: 1-280/280
Sequence Identity: 14% (41 aa)

MK------------------------KMYEHEYLYDAIINGSEILEEV--AHNNVVNLLGLTCNN-------QGTFMVM---------------------
 .                        ||  ..    ....  .|. ..   | |.|.|.|            .  ..||                     
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

------VRQILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADFATVRRLRTR------PWSNKV-----GT--LTFN--APELLTGATS-FGT
        || .| . .| ....| |  . |.||....     .|| .||   | .             ..     |   |     ||| .   .. | |
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTT

AIDVWGAGCIFAEML-LGSNPFDVPDEEDGDSLDYFVADFAKKLDIDGCGMG--------------------YQDRRRERARKRILEKMA
. |||  |    |.. .|  |   . ..  .  .. |  . |. .   .                        .    .| . . . .  
KSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF