Gene CDC2-S2_n (S.moellendorffii)

CDC2-S2_n

Species: S.moellendorffii
Alias: CDC2-S2_n
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2-smoe2

Sequence

Name Sequence Type Origin Length Description Download
CDC2-S2_n.AA Protein None 294 None Fasta, JSON
CDC2-S2_n.NA RNA None 885 None Fasta, JSON
CDC2-S2_n.kin_dom Protein Kinase Domain None 248 None Fasta, JSON

Protein domain

Protein domains of CDC2-S2_n.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDC2-S2_n.AA S_TKc 11-258 30 1e-62 215.61 SMART 5-231 (231) Show / Hide 
Range on Protein: 11-258
Range on HMM: 5-231/231
Sequence Identity: 30% (81 aa)

RLLGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLYDAIINESEILEEVVHDNVVNLLGLTCNNQGTFMVMELMDR---SLSDVISSRK-------LGEHD
|..| || |.|. . |.||| .||.|..       . |..| .||..  |.|.|.|..   . .  .||||..|    .| |.| .|.       . | .
RKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

IRAVMRQILKGLVWIHAHRIVHQDVKTSNVLF--VVKLADFATARRLQTRPWSNKVGTLTFNAPELLKGATSFGT-AIDVWGAGCIFAEMLLGSNPFDVP
.| .|.||...|  .| |.|.| |.| .|.|.  ..|..||  ||.|     .  .||. . |||.|    ..|. ..|.|  |||..||| |  ||.  
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP--

DEEDGDSLDYFQSREIELLRAGEFPDGCPLSDEAEDLICGMLAVEPSERLTLDGVLE-------HPWI
           . . .....          |.|| |.|...| ..|..|.|   .|.       |||.
----------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDC2-S2_n.AA Pkinase 11-258 25 3.7e-61 214.28 Pfam 5-293 (293) Show / Hide 
Range on Protein: 11-258
Range on HMM: 5-293/293
Sequence Identity: 25% (76 aa)

RLLGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLYDAIIN-----ESEILEEVVHDNVVNLLGLTCNNQGTFMVMELMDR-----SLSDVIS---SRKL-
| .|.|. |.|. . |..||..||.|..  ..   .  ..     | .|. .. |.|.| |..   ...   ||||...      .|.|.||   .... 
RKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY

-GEHDIRAVMRQILKGLVWIHAHRIVHQDVKTSNVLFV----V----KLADFATAR---RLQTRPWSNKVGTLTFNAPELLKGATSFGTAIDVWGAGCIF
  |.... .|.|||.||  .|...|.| |.| .|.|..    .    |..||  |.       .  .  .||. . |||...|..  |...|.|..|||.
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL

AEMLLGSNPFD--VPDEEDGDSLDYFQSREIELLRAGEFPDGCPLS-----------------DEAEDLICGMLAVEPSERLTLDGVLEHPWI
.|||.|  ||.  . .... .. ..   |  .     ..|  |. |                 .|. |.|...|.. |..|.| . .|.|||.
YEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CDC2-S2_n.AA CAMK 12-258 18 3.6e-56 179.14 In-house 1-425 (425) Show / Hide 
Range on Protein: 12-258
Range on HMM: 1-425/425
Sequence Identity: 18% (78 aa)

LLGAGADGEVRVGFHRKTG------------DKVAMKKMY-----------------------------EHEYLYDAIINESEILEEVV-------HDNV
 || |. |.|. ..|..|.             |||.| .                              . ..  . . .| ||.  .        | |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLLGLTC------------NNQG--------TFMVM---ELMDR-----SLSDVISSR----------------KLGEHDIRAVMRQILKGLVWIHAHR
..|.                . .          .|||   |...       | | | ..                .. |.. | ..|||. ..  .| | 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHQDVKTSNVLFV---------------------VKLADFATARRLQT-------------------------RPWSNKVGTLTFNA-PELLKG-----
||| | |  |.|..                     .|..||  |....                           . .  .||. . | ||.|.|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------ATSFGTAIDVWGAGCIFAEMLLGSNPFDVPDEEDGDSLDYFQSR----EIELLR---AGEFP-DGCP-----------------------LS
         .  | ..|.| .|.|   || |  ||. .....  . |  . .    . ||..   .|..  .  .                       .|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D--E-WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVS

DEAEDLICGMLAVEPSERLTLDGVLEHPWI
.|. |||..|| |.|..|.|.. .|.|||.
QECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CDC2-S2_n.AA CMGC 11-194 19 6.8e-42 134.84 In-house 5-342 (513) Show / Hide 
Range on Protein: 11-194
Range on HMM: 5-342/513
Sequence Identity: 19% (67 aa)

RLLGAGADGEVRVGFH--------------RKTGDKVAMKKMYEHEYLYDAI------------INESEILEEV----------------VHDN-VVNLL
. .| |. |.|  ...              ..|. .||.||. . .|  .|             . | .||...                 |.| .|.|.
KKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLY

GLTCNNQ-----------------GTFMVMELMDRSLSDVISSRK----------LGEHD------------IRAVM------RQILKGLV--WIHAHR-
     ..                   ..|.|.|| .| ..| . .          | |              |.  |      .|||.||    .| |. 
DIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWG

-IVHQDVKTSNVLFV------------------------VKLADFATARRLQTR-----------------------PWSNKVGTLTFNAPELLKGA---
 |.| | | .|.|.                         .|..||  || . ..                       | .. | |.   |||.| |.   
NIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHY

------TSFGTAIDVWGAGCIFAEMLLG-------SNPF
      . ..|.||.|..|||||||..|         |.
TNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL
Kinase CDC2-S2_n.AA CAMKL 6-258 24 4.7e-39 122.18 In-house 1-297 (297) Show / Hide 
Range on Protein: 6-258
Range on HMM: 1-297/297
Sequence Identity: 24% (73 aa)

WASGARLLGAGADGEVRVGFH-RKTGDKVAMKKMYEHEYLYDAIIN----------------ESEILEEVV---HDNVVNLLGLTCNNQG------TFMV
.  |   || |. |.|. . | | || |||.| .       | ...                | .|.. .    | |.. |.    . .        ..|
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MELMDRS---LSDVISSR-----KLGEHDIRAVMRQILKGLVWIHAHRIVHQDVKTSNVLFV------VKLADFATARRLQ------TRPWSNKVGTLTF
||. .     | | | ..     .. ||. |   |||. ..  .| |.||| | |  |.|.       .|..||  .   .       .  .   |.. .
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

NAPELLKG--ATSFGTAIDVWGAGCIFAEMLLGSNPFDVPDEEDGDSLDYFQSREIELLRAGEFPDGCP--LSDEAEDLICGMLAVEPSERLTLDGVLEH
 |||...|      | ..|.| .| |   |. |  ||| .. .     .  . .. .  . | . .  .  .| ...||| .|| | |..| |.. ...|
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYN-K-QGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWI
|| 
PWM
Kinase CDC2-S2_n.AA Ciliate-E2 11-258 18 1.4e-36 123.03 In-house 5-365 (365) Show / Hide 
Range on Protein: 11-258
Range on HMM: 5-365/365
Sequence Identity: 18% (72 aa)

RLLGAGADGEVRVGFHRKTGDKVAMK-----------------KMYEHEYL----YDAIINESEILEEVV----------------HDNVVNLLGLTC--
...| |. | |. . ..|.. ..|.|                 |.|. ...      .| .|  |. |.                 |.|....       
KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEK

NNQGTFMVMELMDR-SLSDVISSR------------KLGEHDIRAVMRQILK---------------GLVWIHAHR-IVHQDVKTSNVLFVVKLADFATA
...  ..|||. .  .| | | ..            .. |  |. .|.|||.               .|  .|    |.| | | .|.|| .|..|| ..
DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-IKIIDFGLS

RRLQTRPWSNK---------------------------------VGTLTFNAPELLKGATS--------FGTAIDVWGAGCIFAEMLLGSNPFDVPDEED
.....    .                                  .||. . ||| |.|            ....|.| .|.|. ||| |  ||       
KKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------

GDSLDYFQSREIELLRAGEFPDGCP------------------LSDEAEDLICG----MLAVEPSERLT-LDGVLEHPWI
           ..    ...   ||                  .|.|. |||      || ..|..|.|  . .|.|||.
-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CDC2-S2_n.AA STE 7-194 24 1.7e-36 126.38 In-house 1-268 (359) Show / Hide 
Range on Protein: 7-194
Range on HMM: 1-268/359
Sequence Identity: 24% (65 aa)

ASGARLLGAGADGEVRVGFHRK---------------TGDKVAMKKMYEHEY------------------LYDAIINESEILEEVV--HDNVVNLLGLTC
  | . .| || |.|  . ..|               ||. .|.|.|   .                     . |..| .|. .    |.|.|. .|   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NN-------QGTFMVMELMD-RSLSDVIS---SRKLG------------EHDIRAVMRQILKG-LVWIHAHRIVHQDVKTSNVLFVVKLADFATARRLQT
..       .  ...||.||  ||.|.|    ... .            |. |... |||||| |  .| |.|.| |.| .|.|. |||.|| .. .|. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-VKLCDFGVCGQLTD

-----------------RPWS-NKVGTLTFNAPELLKG-----ATSFGTAIDVWGAGCIFAEMLLGSNPF
                    .   |||  . ||| ...         .|  |.|  ||   ||. |  |.
SMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW
Kinase CDC2-S2_n.AA CDK7 8-189 34 1.3e-34 89.23 In-house 2-198 (288) Show / Hide 
Range on Protein: 8-189
Range on HMM: 2-198/288
Sequence Identity: 34% (68 aa)

SGARLLGAGADGEVRVGFHRKTGDKVAMKKMY---EHEYLYDAI----INESEILEEVVHDNVVNLLGLTCNNQGTFMVMELMDRSLSDVISSRK--LGE
   ...|.|  . |  .   .|| .|| ||       .   | |    | |  || |  ||||..|.          .|...||  |  ||   .  |  
EKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILTP

HDIRAVMRQILKGLVWIHAHRIVHQDVKTSNVLF----VVKLADFATARRLQT--RPWSNKVGTLTFNAPELLKGATSFGTAIDVWGAGCIFAEMLL
 .| | | ..|.|| . |.. | | | |  | |.    ..|.|||  ||      | .. .| |  . ||||| || ..||..|.|  |||||| .|
AHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML
Kinase CDC2-S2_n.AA CDK 54-194 30 3.8e-33 103.29 In-house 61-225 (284) Show / Hide 
Range on Protein: 54-194
Range on HMM: 61-225/284
Sequence Identity: 30% (53 aa)

ILEEVVHDNVVNLLGLTCNN-----------QGTFMVMELMDRSLSDVISSRKLGEHDIRAVMRQILKGLVWIHAHRIVHQDVKTSNVLFV---------
.| |  |.|.|.|.     .              .||.| ||  |. ...        |.  |.|.|.||  .| ..|.| | |..| |           
LLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGR

VKLADFATARRLQ--------TRPWSNKVGTLTFNAPELLKGATSFG--TAIDVWGAGCIFAEMLL---GSNPF
.|.|||  ||  .        .|. ...| ||   ||||| |..  .  |.||.|..|||||||..   .   |
LKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLF
Kinase CDC2-S2_n.AA Ciliate-E2-Unclassified 11-258 21 3.8e-29 98.26 In-house 5-352 (352) Show / Hide 
Range on Protein: 11-258
Range on HMM: 5-352/352
Sequence Identity: 21% (74 aa)

RLLGAGADGEVRVGFHRKTGDKV-------AMKKMYEHEYLY-DAIINESEILEE-----------------VVHDNVVNLLGLTCN--NQGTFMVMELM
. .| |. |.|.   |.|.. ..        ...   . ... | |.|| .....                 . |.. . .  . |    |  ..|||..
KQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYC

-DRSLSDVISSRK------------------LGEHDIR-----AVMRQILKGL-VWIHAHRIVHQDVKTSNVLF-------VVKLADFATARRLQT----
 . .|.. |..||                  . |  ..       ..|||.||   .| . |.| | | .|.||        .|..||  ....|.    
EGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNC

---------RPWSNKV----GTLTFN----APELLKGATSFG---TAIDVWGAGCIFAEMLLGSNPFDVPDEEDGDSLDY--------FQSREIELLRAG
         ......     ||. .     |||.|.|    .    ..|.|. |.|. ||| |  ||. ...|. . | .        .| ... . .  
DTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNI

EFPDGCP------LSDEAEDLIC----GMLAVEPSERLTLDGVLEHPWI
.||   .      .|.||.|.|      || . |..|.|.. .|.|||.
QFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase CDC2-S2_n.AA ULK 7-258 23 5.8e-29 98.3 In-house 1-329 (329) Show / Hide 
Range on Protein: 7-258
Range on HMM: 1-329/329
Sequence Identity: 23% (77 aa)

ASGARLLGAGADGEVRVGFHRKT----GDKVAMKKMY------------EHEYLYDAIINESEILEEVV----HDN----VVNLLGLTCNNQG--TFMVM
 .  . || |. | |  |.. ||    . ||| |..             . .|. . ..|| .|. .      | |    .| |.  . . .   ....|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG-QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

ELMDR-SLSDVISSR-KLGEHD----------IRAVMRQILKGLVWIHAHRIVHQDVKTSNVL----F------------VVKLADFATARRLQTR----
|. .   |.. |. . ||.|            .. ...||| |. ..| |.|.| | | .|.|    .            |.|.|||  |. ..      
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ

-PWSNKV------GTLTFNAPELLK---GATSFGTA-IDVWGAGCIFAEMLLGSNPFDVPDEEDGDSLDYFQSREIELLRA-------GEFP---DGCPL
      |      ||  . ||..|.   .   ....  |.|  |||| ||| |  ||  .  .| . . . . .....  .        .||   .. ..
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

SDEAEDLICGMLAVEPSERLTLDGVLEHPWI
|.| .||| .|| .....| . . ...|||.
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase CDC2-S2_n.AA ULK 7-258 22 1.2e-28 98.84 In-house 1-324 (324) Show / Hide 
Range on Protein: 7-258
Range on HMM: 1-324/324
Sequence Identity: 22% (74 aa)

ASGARLLGAGADG-EVRVGFHRKT---GDKVAMKKMY------------EHEYLYDAIINESEILEEVV---HDN--VVNLLGLTCNNQG--TFMVMELM
 .  . || |. |  |  |.. ||   . .|| |..             . .|. . ..|| .|. .     | |  .| |.  . . .   ....||. 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEG-QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYC

DR-SLSDVISSR-KLGEHD----------IRAVMRQILKGLVWIHAHRIVHQDVKTSNVL--F--------------VVKLADFATARRLQ---TRPWSN
.   |.. |  . ||.|            .. ...||. |. ..| | |.| | | .| |                 |.|.|||  |. ..        .
NGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMC

--KV------GTLTFNAPELLK---GATSFGTA-IDVWGAGCIFAEMLLGSNPFDVP-DEEDG---DSLD----YFQSREIELLRAG---EFPDGC---P
   |      ||  . ||..|.   .   ....  |.|  |||| ||| |. ||  .  ...    . ..    .      ...      .||...   .
QTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQ------QIYIKNQPIQFPKPPKDPK

LSDEAEDLICGMLAVEPSERLTLDGVLEHPWI
.|.| .||| .|| .....| . . ...|||.
ISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase CDC2-S2_n.AA TyrKc 7-258 22 1.9e-11 -37.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 7-258
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

ASGARLLGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLYDAIINESEILEEV--VHDNVVNLLGLTCNN-------QGTFMVMELMDR-SLSDVISSRK-
 .  . || || |||. |  .    .|| |.. |.     ....| .|. ..   |.|.|.|.|            .  ..|||.|.  .| | . ... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LGEHDIRAVMRQILKGLVWIHAHRIVHQDVKTSNVL----FVVKLADFATARRLQTR------PWSNKV-----GT--LTFN--APELLKGATS-FGTA
 |   |    . || .|   .| ....| |  . |.|    ..|| .||  .| .             ..     |   |     ||| .   .. | |.
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTTK

IDVWGAGCIFAEML-LGSNPFDVPDEEDGDSLDYFQSREIELLRAGEFPDGCPL---------SDEAEDLICGMLAVEPSERLTLDGVLEHPWI
 |||  |    |.. .|  |   . ..   | .      ||....|. ..  |          .||  ...    . .|..| |   .  |  .
SDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEV----IEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CDC2-S2_n.AA CMGC 227-258 34 6.8e-10 27.74 In-house 482-513 (513) Show / Hide 
Range on Protein: 227-258
Range on HMM: 482-513/513
Sequence Identity: 34% (11 aa)

LSDEAEDLICGMLAVEPSERLTLDGVLEHPWI
....| ||...||  .|..|.| .  |.||..
CDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase CDC2-S2_n.AA CDK7 228-258 38 5.8e-07 14.11 In-house 258-288 (288) Show / Hide 
Range on Protein: 228-258
Range on HMM: 258-288/288
Sequence Identity: 38% (12 aa)

SDEAEDLICGMLAVEPSERLTLDGVLEHPWI
||.. ||.|||.. .|..|.|    |..|  
SDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDC2-S2_n.AA CDK 220-258 28 8.4e-07 17.62 In-house 254-284 (284) Show / Hide 
Range on Protein: 220-258
Range on HMM: 254-284/284
Sequence Identity: 28% (11 aa)

EFPDGCPLSDEAEDLICGMLAVEPSERLTLDGVLEHPWI
..||         ||...||. .|. |.. .  |.||. 
KLPDY--------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDC2-S2_n.AA Pkinase_Tyr 11-125 26 1.1e-05 19.89 Pfam 5-137 (270) Show / Hide 
Range on Protein: 11-125
Range on HMM: 5-137/270
Sequence Identity: 26% (35 aa)

RLLGAGADGEVRVGFHR----KTGDKVAMKKM---YEHEY-LYDAIINESEILEEV-VHDNVVNLLGLTC-NNQG--TFMVMELMDR-SLSDVISSR---
. ||.|| |||. |  .    .|. .|| |..   . ||  . .. ..| .|. .   |.|.|.|.|      .    ..|||.|   .| |   ..   
KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRED

--KLGEHDIRAVMRQILKGLVWIHAHRIVHQDV
  .|  .|.    .|| ||. . ......| |.
KQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase CDC2-S2_n.AA STE 227-258 35 0.012069 5.31 In-house 326-359 (359) Show / Hide 
Range on Protein: 227-258
Range on HMM: 326-359/359
Sequence Identity: 35% (12 aa)

LSDEAEDLICGMLAVEPSERLTLDGVLE--HPWI
.|.|  | |   |  .|..| | .  |.  ||.|
WSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI