Gene CDC2-S2_k (S.moellendorffii)

CDC2-S2_k

Species: S.moellendorffii
Alias: CDC2-S2_k
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2-smoe2

Sequence

Name Sequence Type Origin Length Description Download
CDC2-S2_k.AA Protein None 361 None Fasta, JSON
CDC2-S2_k.NA RNA None 1086 None Fasta, JSON
CDC2-S2_k.kin_dom Protein Kinase Domain None 293 None Fasta, JSON

Protein domain

Protein domains of CDC2-S2_k.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDC2-S2_k.AA CMGC 51-337 20 8e-77 251.76 In-house 7-513 (513) Show / Hide 
Range on Protein: 51-337
Range on HMM: 7-513/513
Sequence Identity: 20% (107 aa)

LGQGTDGVVRLARN--------------RVTGAMVAVKKLS---SKHDAA----------DMMWECATLRACQ-----------------HKNIIHLHSK
.|.|| |||  .|.              . |. .||.||..    ...|               |.  |.  .                 |.||..|.  
IGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDI

LVTEQ-----------------GLFMVFELMDEDLFSYIWDVREREGK------------------------IPEVAVRSIMKQILEALA--FVHSKG--
.....                  |..|||.|| ||. || . . ..                          ..  ..| .|.|||..|.  . ||..  
FYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGN

LIHRDVKSSNVLINHNKNL--------------NNSVVIKLIDFSRVCFASAG---------------------SCENMGNV---YYRAPELLLGGEKYI
 |||| | .|.|||||. |              . . ..|..||   .. .                       .  .  .|   .|||||.||| ..| 
IIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYT

-------YGREIDIWAAGCIFLELLTG--------FPFGDDDGNFPPNSE-----------LDVMNSIVKWIGPVD---------------ETTWKGVNK
       |. .||.|..|||| |..||         |.      ||..||           .| .. |.| .|. .               | .| ...|
NHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL------FPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LENYNT-------------YKSS----------FPRNPSNLLQSRLGD-------------------------------------SPAYDLLRKMLCLNP
| .||.             ....          ||. | . ...   .                                     . | ||| |||...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

RERITAKEALESDYF
 .||||..||. .||
DKRITAEQALQHPYF
Kinase CDC2-S2_k.AA S_TKc 45-337 27 2.9e-67 230.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 45-337
Range on HMM: 1-231/231
Sequence Identity: 27% (83 aa)

STQSPLLGQGTDGVVRLARNRVTGAMVAVKKLSSKHDAADMMWECATLRACQHKNIIHLHSKLVTEQGLFMVFELMDE---DLFSYIWDVREREGK--IP
 .   ..|.|. |.|...|.. ||  ||.|...      ... | . |.  .|.||..|.   .. . |.||.|..|    |||.|| . . . ..  .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

EVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNLNNSVVIKLIDFSRVCFASAGSCENMGNVYYRAPELLLGGEKYIYGR-EIDIWAAGCIFL
|  .|..|.||..||.. ||.| ||||.| .|.|...        .||..||   ..         |  .|.|||.|       ||. ..|.|. |||. 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL----TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILY

ELLTGFP-FGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNPSNLLQSRLGDSPAYDLLRKMLCLNPRERITAKEALE----
|.|.| | |               |. . | ||                                    ...| |..||.|. .|..|.|| |||.    
EMLCGYPPFP-------------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---SDYF
     .|
IKCHPWF
Kinase CDC2-S2_k.AA Pkinase 45-337 24 8.1e-57 199.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 45-337
Range on HMM: 1-293/293
Sequence Identity: 24% (75 aa)

STQSPLLGQGTDGVVRLARNRVTGAMVAVKKLSSKHDAADMMW-------ECATLRACQHKNIIHLHSKLVTEQGLFMVFELMDE-----DLFSYIWDVR
 .    .|.|. |.|...... || .||||... . .. . ..       |.. .. ..|.||. |.    ... . ||.|...      |||.||    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

EREGKI--PEVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNLNNSVVIKLIDF--SRV--CFASAGSCENMGNVYYRAPELLLGGEKYIYGR
.|.|..  .|  ....|.|||..|.. ||.| ||||.|..|.||..| ...    .|..||  ...     .       |  .|.|||...  .   ||.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--GGQYYGP

EIDIWAAGCIFLELLTG-FPFGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNPSNLLQSRLGDSPAYDLLRKMLCLNPRER
..|.|..|||. |.|.| .|| ... . ...... ... | . . . |. .|  .   .  .. . .    . . .   . .... |.....||..| .|
KVDMWSCGCILYEMLCGRPPFPGHC-WHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIKWCLCKDPKKR

ITAKEALESDYF
.||...|....|
PTAEQILQHPWF
Kinase CDC2-S2_k.AA CAMK 50-337 19 5.9e-53 168.6 In-house 1-425 (425) Show / Hide 
Range on Protein: 50-337
Range on HMM: 1-425/425
Sequence Identity: 19% (88 aa)

LLGQGTDGVVRLARNRVTG------------AMVAVKKLS------------------------------SKHDAADMMWECATLRACQ-------HKNI
 ||.|. |.|.|.... |.              ||.| ..                              . .| . .. | . .. .|       |.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IHLHSKLV------------TEQG--------LFMVF---ELMDE-----DLFSYI------------WDVREREGKIPEVAVRSIMKQILEALAFVHSK
|.|.                | .         ..||.   |...      |||.||             |.  ..|...|  .| ...||..|... ||.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

GLIHRDVKSSNVLINHNKNLNNSVV------------IKLIDFSRVCFASAG--------------------------SCENMGNVYYRA-PELLLG---
. .||| |  |.|...|.. ... |            ||.|||   ..   |                            .  |  .| | ||.|.|   
NIVHRDLKPENILLDDNNDDSDP-VEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

--------GEKYIYGREIDIWAAGCIFLELLTG-FPFGDD---------DGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLE-N-YNTYKSSFPRNPS
        .||  ||...|.|..|.|   .|.| .|| .|                            ||  |. ... . | . . .  | |  ..| .
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEW------------------IGMNDYELFEKIMKGKYDFPPPYFSPISCN-Y

NLLQSRLGD-----------SPAYDLLRKMLCLNPRERITAKEALESDYF
   ..   |             . ||.||||. .| .|.|....|.   .
---GPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CDC2-S2_k.AA Ciliate-E2 50-337 19 4.1e-44 149.32 In-house 6-365 (365) Show / Hide 
Range on Protein: 50-337
Range on HMM: 6-365/365
Sequence Identity: 19% (79 aa)

LLGQGTDGVVRLARNRVTGAM-----------------------VAVKKL-----SSKHDAADMM----------WECATLRACQHKNIIHLHSKLV--T
..|||. |.|...... .. .                       .|.| .      ..    ..|           |   |.  .|.||| ..      .
KIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKD

EQGLFMVFELMDE-DLFSYIWDVREREGKIPE-------VAVRSIMKQILE---------------ALAFVHSKG-LIHRDVKSSNVLINHNKNLNNSVV
.. ...|.|. .  |||.|| . .  .....|         .. ||||||.               || . |||.  |||| | .|.|.           
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----------

IKLIDFS------------RVCFASAGSCENMG------------------------NVYYRAPELLLGGE------KYIYGREIDIWAAGCIFLELLTG
||.|||             .  .  .. . . .                        . .| ||| | |..      .  |. ..|||..|.|. |.|.|
IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

-FPFGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNP--SNLLQ-------SRLGDSPA-YDLLRK----MLCLNPRERIT-
 .||                                    ...    | .|| .   .. .|       | .  |.   ||..|    ||. .| .||| 
KPPF------------------------------------QQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITG

AKEALESDYF
....|.  .|
WEQILNHPWF
Kinase CDC2-S2_k.AA CDK 210-337 38 5.9e-38 118.92 In-house 185-284 (284) Show / Hide 
Range on Protein: 210-337
Range on HMM: 185-284/284
Sequence Identity: 38% (50 aa)

YRAPELLLGGEKYIYGREIDIWAAGCIFLELLT---GFPFGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNPSNLLQSRLG
||||||||| ..|  | .||.|..|||| |..|   . |.      || .||.| .  | . .|  .| .| || || .|                    
YRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPL------FPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------

DSPAYDLLRKMLCLNPRERITAKEALESDYF
     ||| ||||..|  ||.|..||...||
-----DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDC2-S2_k.AA CDK 51-191 30 1.6e-33 104.48 In-house 7-157 (284) Show / Hide 
Range on Protein: 51-191
Range on HMM: 7-157/284
Sequence Identity: 30% (50 aa)

LGQGTDGVVRLARNRVTG-----AMVAVKKLSSKH-------DAADM--MWECATLRACQHKNIIHLHSKLVTE-----------QGLFMVFELMDEDLF
.|.|| |||  ||.. ||      .|| ||.   .       .   .    |...|. . |.||. ||   .|.             |.|||| || || 
IGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLK

SYIWDVREREGKIPEVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNLNNSVVIKLIDF
.|.              ....|.|.|..|.. ||.. .||| | .| |||.| .     ..|. ||
KYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVK-CGRLKIADF
Kinase CDC2-S2_k.AA CAMKL 44-191 29 3.8e-33 103.02 In-house 1-173 (297) Show / Hide 
Range on Protein: 44-191
Range on HMM: 1-173/297
Sequence Identity: 29% (53 aa)

YSTQSPLLGQGTDGVVRLARN-RVTGAMVAVKKLS-SKHDAADMMW----------------ECATLRACQ---HKNIIHLHSKLVTEQG------LFMV
|      ||.|. |.|.||.. | || .||.| .  .|    . |.                | . ..  .   |.|||.|.  . |..       ...|
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

FELMDED---LFSYIWDVREREGKIPEVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNLNNSVVIKLIDF
 |. .     || ||   ..| |..||   | . .||..|... ||.| .||| |  |.|. .|.|     .||.|||
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN----NIKIIDF
Kinase CDC2-S2_k.AA CDC2 51-191 32 3.2e-31 92.81 In-house 7-147 (301) Show / Hide 
Range on Protein: 51-191
Range on HMM: 7-147/301
Sequence Identity: 32% (48 aa)

LGQGTDGVVRLARNRVTGAMVAVKKLSSKHDAAD------MMWECATLRACQ-HKNIIHLHSKLVTEQGLFMVFELMDEDLFSYIWDVREREGKIPEVAV
.| || |||  .... |. .||.||   ... ..       . |  .| . . |.||. ||  ..  . |.|||| .| ||  |       . ..|. .|
IGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLV

RSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNLNNSVVIKLIDF
.|.|.|||....| |... .||| | .| ||. . |      ||. ||
KSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN------IKIADF
Kinase CDC2-S2_k.AA CDC2 210-337 35 5.5e-31 92.05 In-house 171-301 (301) Show / Hide 
Range on Protein: 210-337
Range on HMM: 171-301/301
Sequence Identity: 35% (51 aa)

YRAPELLLGGEKYIYGREIDIWAAGCIFLEL---LTGFPFGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNPSNLLQSRLG
|||||.||| ..|  .  .|.|. |||| |.    |  |.      |.  || |    | . .|  .| || || .|     ||..||| . . |.. . 
YRAPEILLGCKRYSTP--VDMWSIGCIFAEMFMDVTKKPL------FHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPD---YKNTFPRWKPQDLSKICP

D---------SP--AYDLLRKMLCLNPRERITAKEALESDYF
.          .  . |||..||...|  ||.|||||.  ||
NNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase CDC2-S2_k.AA CDK5 210-337 36 1.5e-29 90.12 In-house 164-287 (287) Show / Hide 
Range on Protein: 210-337
Range on HMM: 164-287/287
Sequence Identity: 36% (48 aa)

YRAPELLLGGEKYIYGREIDIWAAGCIFLELL-TGFPFGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNPSNL-LQSRLG-
||.|  |.|  .|     ||.| .|||| |.  .| |       || |.. | .  | | .|   | .| .. || .|.     .|  | .  .|.    
YRPPDVLMGSKHYS--TSIDMWSCGCIFAEMANAGRPL------FPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK

-DSPAYDLLRKMLCLNPRERITAKEALESDYF
 |.   ||| ||| .|| .||.||.||.  ||
LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDC2-S2_k.AA PITSLRE 210-337 38 4.7e-28 99.29 In-house 172-295 (295) Show / Hide 
Range on Protein: 210-337
Range on HMM: 172-295/295
Sequence Identity: 38% (51 aa)

YRAPELLLGGEKYIYGREIDIWAAGCIFLELLTGFPFGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNPSNLLQSRLG---
||||||||| .  .|   .|.|  |||| |..|. |       |. .||.| .| | |  |   |  | |...| . .  .. ||  | | | .| .   
YRAPELLLGCK--KYSTPVDMWSVGCIFAEFITMKPL------FQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNN-FPHYPYNNLRKRFPAEN

--DSPAYDLLRKMLCLNPRERITAKEALESDYF
     ..||| .||..|| .|||| .||  ..|
HISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDC2-S2_k.AA RCK 51-192 33 2e-26 80.59 In-house 7-159 (298) Show / Hide 
Range on Protein: 51-192
Range on HMM: 7-159/298
Sequence Identity: 33% (52 aa)

LGQGTDGVVRLARNRVTGAMVAVKKLSSKH----DAADMMWECATLRACQ-HKNIIHLHSKLVTEQ--GLFMVFELMDEDLFSYIWDVREREGKIPEVA-
|| || |.| .|.|  ||  || ||.  ..    . .    |   ||.   |.||| |.  .  .    |. |||.||..|. .. |  ||. ..||   
LGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQR

-VRSIMKQILEALAFVHSKGLIHRDVKSSNVLINH-----NKNLNNSVVIKLIDFS
 ...||.||| .||. |..|  |||.|  | ...      ..   .. .||..||.
SIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFED--QDQDHIKIADFG
Kinase CDC2-S2_k.AA CDK5 46-180 33 6.1e-25 75.34 In-house 2-137 (287) Show / Hide 
Range on Protein: 46-180
Range on HMM: 2-137/287
Sequence Identity: 33% (47 aa)

TQSPLLGQGTDGVVRLARNRVTGAMVAVKKLSSKHD----AADMMWECATLRACQHKNIIHLHSKLVTEQGLFMVFELMDEDLFSYIWDVREREGKIPEV
 .   .| || |.|  |||. |. .|| |.     .     .  . | . |.  .||||. ||  . .|. | .||| .|.||  |. .. .   ..   
EKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG---EMDMH

AVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNL
 ..|.| | |  ||| |..   ||| |  | ||| | .|
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGEL
Kinase CDC2-S2_k.AA CRK7 52-175 33 3.2e-16 52.24 In-house 8-146 (343) Show / Hide 
Range on Protein: 52-175
Range on HMM: 8-146/343
Sequence Identity: 33% (48 aa)

GQGTDGVVRLARNRVTGAMVAVKKLSSKHD---------AADMMWECATLRACQHKNIIHLHSKLVTEQ-----------GLFMVFELMDEDLFSYIWDV
| || | |  |.|  || ||| ||. ....          |    |   ||  .|.||. |.   ||.              .|||| || ||       
GEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITA--IREIKILRQLNHQNIVNLK-EIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGLL---

REREGK-IPEVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLIN
.  | . . .  ....|||.|| .. .| |. .|||.| ||.|.|
ESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMN
Kinase CDC2-S2_k.AA CRK7 307-337 51 5.8e-13 40.84 In-house 313-343 (343) Show / Hide 
Range on Protein: 307-337
Range on HMM: 313-343/343
Sequence Identity: 51% (16 aa)

DSPAYDLLRKMLCLNPRERITAKEALESDYF
.... ||| |||||.|  |.||.|.|..|.|
PKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDC2-S2_k.AA TyrKc 50-337 18 2.3e-11 -38.85 SMART 6-280 (280) Show / Hide 
Range on Protein: 50-337
Range on HMM: 6-280/280
Sequence Identity: 18% (60 aa)

LLGQGTDGVVRLARNRVTGAMVAVKKLSSKHDAADMMWECATLRAC--QHKNIIHLHSKLVTE-------QGLFMVFELMDE-DLFSYIWDVREREGKIP
 || |  |.|.... .    .||||.| . .  .|.| |   ..    .|.||. |.   ...       . |..|.|.|.  || .|. . |..   ..
KLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LC

EVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNLNNSVVIKLIDFSRVCFASAG----------------SCENMGNVYYRAPELLLGGEKYI
     |.. || .  .. |||..||||    |.|...|.      ..|  ||    .   .                ..  |  .   ||| .    ...
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGK

YGREIDIWAAGCIFLELLT--GFPFGD---------------DDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNPSNLLQSRLG
.  . |.|. |    |..|  . |  .               ..|. .|  . |    .                                     .   
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS------------------------------------FVCC

DSPAYDLLRKMLCLNPRERITAKEALESDYF
 .  |.. ..    .| .| | .|    ..|
PDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CDC2-S2_k.AA CRK7 210-243 32 5.6e-11 33.9 In-house 180-249 (343) Show / Hide 
Range on Protein: 210-243
Range on HMM: 180-249/343
Sequence Identity: 32% (23 aa)

YRAPELLLGGEKY-----------------------IY-------------GREIDIWAAGCIFLELLTG
||.|||||| |.|                       ||             | |||.|  |||. ||.|.
YRPPELLLGEERYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTK
Kinase CDC2-S2_k.AA RCK 209-260 44 9.3e-10 26.84 In-house 178-221 (298) Show / Hide 
Range on Protein: 209-260
Range on HMM: 178-221/298
Sequence Identity: 44% (23 aa)

YYRAPELLLGGEKYIYGREIDIWAAGCIFLELLTGFPFGDDDGNFPPNSELD
.|||||.||   .| .   .|||| |||. || . .|       || .||.|
WYRAPECLLRCTYYNS--PMDIWAVGCIMYELYMLRPL------FPGSSEID
Kinase CDC2-S2_k.AA RCK 312-337 50 1.3e-09 26.4 In-house 273-298 (298) Show / Hide 
Range on Protein: 312-337
Range on HMM: 273-298/298
Sequence Identity: 50% (13 aa)

DLLRKMLCLNPRERITAKEALESDYF
.|..|||. .| .||||..||.  ||
ELMEKMLQWDPQKRITAQQALQHPYF
Kinase CDC2-S2_k.AA PITSLRE 92-177 28 4.1e-09 29.52 In-house 55-142 (295) Show / Hide 
Range on Protein: 92-177
Range on HMM: 55-142/295
Sequence Identity: 28% (25 aa)

LRACQHKNIIHLHSKLV--TEQGLFMVFELMDEDLFSYIWDVREREGKIPEVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHN
|.| || ||. .   ..  .    .||.| .. || | .   ..|. .  .  . . | | | . .. |..  .||| | || |..|.
LMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHK
Kinase CDC2-S2_k.AA CAMKL 312-337 38 7.8e-08 20.93 In-house 272-297 (297) Show / Hide 
Range on Protein: 312-337
Range on HMM: 272-297/297
Sequence Identity: 38% (10 aa)

DLLRKMLCLNPRERITAKEALESDYF
||.||||  || .|.|... ..   .
DLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase CDC2-S2_k.AA Pkinase_Tyr 51-178 26 1.7e-07 26.04 Pfam 7-148 (270) Show / Hide 
Range on Protein: 51-178
Range on HMM: 7-148/270
Sequence Identity: 26% (38 aa)

LGQGTDGVVRLARNR----VTGAMVAVKKL--SSKHDA---ADMMWECATLRAC-QHKNIIHLHSKLV-TEQG--LFMVFELMDE-DLFSYIWDVREREG
||.|  |.|.... .     |.  ||||.|  .. |..   .|.| | ....   .|.||. |.   .  ..   ...|.|.|   || .|  . || ..
LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ

KIPEVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNK
...     ..  || ..... .||..||||.   |.|...|.
PLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN
Kinase CDC2-S2_k.AA CAMKL 210-234 42 8.7e-05 11.04 In-house 199-223 (297) Show / Hide 
Range on Protein: 210-234
Range on HMM: 199-223/297
Sequence Identity: 42% (11 aa)

YRAPELLLGG-EKYIYGREIDIWAAG
| |||...|. ..| .|...|||..|
YMAPEIFQGNNKPY-DGPKVDIWSCG