Gene CDKB_a-2 (S.moellendorffii)

CDKB_a-2

Species: S.moellendorffii
Alias: CDKB_a-2
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDKB

Sequence

Name Sequence Type Origin Length Description Download
CDKB_a-2.AA Protein None 303 None Fasta, JSON
CDKB_a-2.NA RNA None 912 None Fasta, JSON
CDKB_a-2.kin_dom Protein Kinase Domain None 292 None Fasta, JSON

Protein domain

Protein domains of CDKB_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDKB_a-2.AA CDC2 4-295 54 1.1e-176 547.98 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-295
Range on HMM: 1-301/301
Sequence Identity: 54% (169 aa)

YVKLEKVGEGTYGKVYKARDKNTGRLVALKKTRLDMQDEG--VPSTALREVALLHMLSQSLYVVRLLSVEHIDKGGKPLLYLVFEYLDTDLKKYMD-FTN
| |.||.||||||.|||..|. |...||||| ||. .|||  |||||.||  .|  | .   .|.|  | |.       ||.|||||| |||||||    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-----NKLYMVFEYLDMDLKKYMDMSIP

RRKPFGMDHFRTIKHLMYQLCKGVSHCHSHGVMHRDLKPQNLLVDQDKGLLKIADLGLGRAFTVPLKSYT--HEIVTLWYRAPEILLGASHYSVPVDMWS
 .|..  .   ..| .|||...||..||....|||||||||.|.| .|| .|||| ||.|||..|.. ||  ||.|||||||||||||...||.||||||
KNKHMPPQ---LVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWS

VGCIFGEL---AKRSPLFPGDSELQQLLHIFRLLGTPSEEVWPGVTKLRDWHE-YPKWSPQKLELVIPG---------LDQQGLDLLQQMLIYDPAKRIS
.|||| |.   . . |||.||||  ||  ||| ||||.|. |||||.| |. . .|.| ||.|. ..|          ||..|.|||.|||.|||.||||
IGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRIS

AKAALQHSYF
||.|||| ||
AKEALQHPYF
Kinase CDKB_a-2.AA CDK 4-295 49 9.3e-163 524.69 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-295
Range on HMM: 1-284/284
Sequence Identity: 49% (160 aa)

YVKLEKVGEGTYGKVYKARDKNTG-----RLVALKKTRLDMQ-----DEGVPSTALREVALLHMLSQSLYVVRLLSVEHIDKGG-------KPLLYLVFE
| ||||.||||||.|||||||.||     ..||||| |.. .     .||.|.||.||..||  |    ..|.|. | | ..         .  ||.|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

YLDTDLKKYMDFTNRRKPFGMDHFRTIKHLMYQLCKGVSHCHSHGVMHRDLKPQNLLVDQDKGL-----LKIADLGLGRAFTV------PLKSYTHEIVT
|.|.|||||||               ||..|.|| .|...|||...|||||||||.|.. ..|      ||||| || ||| .      |.. ||||.||
YMDHDLKKYMD---------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILIN-NNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVT

LWYRAPEILLGASHYS--VPVDMWSVGCIFGELAK---RSPLFPGDSELQQLLHIFRLLGTPSEEVWPGVTKLRDWHEYPKWSPQKLELVIPGLDQQGLD
|||||||.|||..|||   |.|||||||||.|..    | ||||||||. || .|||..|||.|..||||||| |.                       |
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------D

LLQQMLIYDPAKRISAKAALQHSYF
||..|| |||.|||||..|||| ||
LLNKMLCYDPKKRISAEQALQHPYF
Kinase CDKB_a-2.AA CDK5 4-295 53 1.3e-153 489.08 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-295
Range on HMM: 1-287/287
Sequence Identity: 53% (160 aa)

YVKLEKVGEGTYGKVYKARDKNTGRLVALKKTRLDMQDEGVPSTALREVALLHMLSQSLYVVRLLSVEHIDKGGKPLLYLVFEYLDTDLKKYMDFTNRRK
| |.||.|||||| |||||.|.|. .||||. |||  ||||||||.||..||  | .   .|||  | | .|     | ||||..| |||||||  |   
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKEL-KHKNIVRLHDVIHSEK----KLTLVFEFCDQDLKKYMDSCNG--

PFGMDHFRTIKHLMYQLCKGVSHCHSHGVMHRDLKPQNLLVDQDKGLLKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEILLGASHYSVPVDMWSVGCIF
  .||  ..|| .|||| ||.. ||.| |.||||||||||. . .| || || || ||| .| . |.||.||||||.| .|.|. ||| ..||||.||||
--EMDM-HIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINK-NGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIF

GELA-KRSPLFPGDSELQQLLHIFRLLGTPSEEVWPGVTKLRDWH----EYPKWSPQK-LELVIPGLDQQGLDLLQQMLIYDPAKRISAKAALQHSYF
 |.|    ||||| ..  ||  ||...|||.|. ||..||| |.     .||.. ... .. ..|.||..|.||||.||...|..||||||||.| ||
AEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDKB_a-2.AA CMGC 4-295 27 1.2e-144 478.74 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-295
Range on HMM: 1-513/513
Sequence Identity: 27% (143 aa)

YVKLEKVGEGTYGKVYKARD--------------KNTGRLVALKKTRLDMQDE----------GVPSTALREVALLHMLS---------------QSLY-
| ...|.||||||.|||.||              ..|...||.|| ...  .|          |.|..||||. .| .|.               .    
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVRLLSVEHIDKGGKP-------------LLYLVFEYLDTDLKKYMDFTN------RRKPFGMDH-----FRT----IKHLM------YQLCKGVS--HC
.|.|. . . ..  ..              |||||||.|.||..|.. ..      |..|.   |      |     ||..|      ||...|.   .|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSHG--VMHRDLKPQNLLVDQDK-------------------GLLKIADLGLGRAFTVP---------------------LKSYTHEIVTLWYRAPEILL
|||.  ..||||||.|.|.....                   | |||.| || |.. ..                     .. |||..||.|||||||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GASHYS---------VPVDMWSVGCIFGELAKR--------SPLFPGDSE-----------LQQLLHIFRLLGTPS---------------EEVWPGVTK
|..||.          |.|||||||||.|.  .         |||||.||           . || .||..||||.               || ||...|
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LRDWHE---------------------------YPKWSPQKLELVIPG-----------------------------------LDQQGLDLLQQMLIYDP
| ...                            .|.| |.... ..|.                                   .|.|..|||..||.|||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

AKRISAKAALQHSYF
.|||.|. |||| ||
DKRITAEQALQHPYF
Kinase CDKB_a-2.AA CDK4 4-295 45 8.20000000001e-106 357.84 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-295
Range on HMM: 1-290/290
Sequence Identity: 45% (135 aa)

YVKLEKVGEGTYGKVYKARDKNTGRLVALKKTRLDMQDE--GVPSTALREVALLHMLSQSLY--VVRLLSV-EHIDKGG-KPLLYLVFEYLDTDLKKYMD
|...  .||| ||.||.|||  ||. ||||. |  ...|  |.|   .||....  | |.    .|.|..| . .| .. . .. .|||  | ||. |.|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

FTNRRKPF-GMDHFRTIKHLMYQLCKGVSHCHSHGVMHRDLKPQNLLVDQDKGLLKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEILLGASHYSVPVDM
    . |  ||    ||||.| ||  ||   ||| . ||||||||.||  | | .|.|| || | .    .  |  .|||||||||.|| .| |  ||||
----KCPPPGMPP-CTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSD-GHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLL-QSYYNTPVDM

WSVGCIFGELAKRSPLFPGDSELQQLLHIFRLLGTPSEEVWPGVTKLRDWHEYPKWSPQKLELVIPGLDQQGLDLLQQMLIYDPAKRISAKAALQHSYF
||||||| |. .| |||.| ||  ||  || . |.| |. ||    |  |  .|  .|.... . | ...||.||||.|| |...||.|| ..|||.||
WSVGCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSL-PWDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDKB_a-2.AA PCTAIRE 4-295 46 1.1e-105 357.43 In-house 1-291 (291) Show / Hide 
Range on Protein: 4-295
Range on HMM: 1-291/291
Sequence Identity: 46% (140 aa)

YVKLEKVGEGTYGKVYKARDKNTGRLVALKKTRLDMQDEGVPSTALREVALLHMLSQSLYVVRLLSVEHIDKGGKPLLYLVFEYLDTDLKKYMDFTNRRK
|.||.| |||||  ||| | | |. |||||  ||. . || | || ||| ||  | .   .| |  . | ..     | |||||.| |||.|||      
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDL-KHANIVTLHDIIHTHH----QLTLVFEYMDMDLKQYMDDCGN--

PFGMDHFRTIKHLMYQLCKGVSHCHSHGVMHRDLKPQNLLVDQDKGLLKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEILLGASHYSVPVDMWSVGCIF
  .|.    .| ...||  |   ||   ..||||||||||..  .| || || || ||  || | | ||.|||||| |..|.| . || ..||| |||||
--IMN-MHNVKLFLFQLLRGLAYCHRRKILHRDLKPQNLLIN-ERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIF

GELAKRSPLFPGDS------ELQQLLHIFRLLGTPSEEVWPGVTKLRDWHEY--PKWSPQKLELVIPGLD---QQGLDLLQQMLIYDPAKRISAKAALQH
 |..   |||||           ||  |||.||||.|. ||||. . ..  |  |.. .| |  . | ||   .|. |||...| | . .|.|| .|..|
YEMCTGRPLFPGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKH

SYF
.||
PYF
Kinase CDKB_a-2.AA PFTAIRE 4-295 44 2.4e-104 352.99 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-295
Range on HMM: 1-287/287
Sequence Identity: 44% (133 aa)

YVKLEKVGEGTYGKVYKARDKNTGRLVALKKTRLDMQDEGVPSTALREVALLHMLSQSLYVVRLLSVEHIDKGGKPLLYLVFEYLDTDLKKYMDFTNRRK
|.|||| |||.| .|||.. . ....||||  ||. |.||.| || ||. ||  |  .  .| |  . | ..    .| .||||..|||..|||    . 
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQ-QEEGTPFTAIREASLLKNLKHA-NIVCLHDIIHTKE----TLTFVFEYVHTDLCQYMD----KH

PFGMDHFRTIKHLMYQLCKGVSHCHSHGVMHRDLKPQNLLVDQDKGLLKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEILLGASHYSVPVDMWSVGCIF
| ||.. . ..  ..||  | | ||   |.||||||||||.  ..| || || || ||  || . | ||.|||||| | .|||.  ||  .||| |||||
PGGMHP-NNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLI-SHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIF

GELAKRSPLFPGD-SELQQLLHIFRLLGTPSEEVWPGVTKLRDWHEYPKW----SPQKLELVIPGLD--QQGLDLLQQMLIYDPAKRISAKAALQHSYF
 |. .  |.|||    . ||  ||..|||| |. ||||..|  .. .       .|.||. ..| ..   .. ||...|| . | .|.||..|.|| ||
VEMMWGQPAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDKB_a-2.AA CDK7 113-295 44 3.5e-96 256.61 In-house 104-288 (288) Show / Hide 
Range on Protein: 113-295
Range on HMM: 104-288/288
Sequence Identity: 44% (83 aa)

IKHLMYQLCKGVSHCHSHGVMHRDLKPQNLLVDQDKGLLKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEILLGASHYSVPVDMWSVGCIFGELAKRSPL
||  | .. .|. .|| . . |||||| |||.... | ||||| || |..  | . ||| .|| |||||| | || || . |||||||||| ||  | | 
IKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNEN-GQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPY

FPGDSELQQLLHIFRLLGTPSEEVWPGVTKLRDWHEYPKWSP---QKLELVIPGLDQQGLDLLQQMLIYDPAKRISAKAALQHSYF
.||||.. ||  ||. ||||.|| ||..... |  .  .. .     |. .     .  |||.. |.  .| ||...  .|.. ||
LPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDKB_a-2.AA S_TKc 4-295 30 5.9e-94 319.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-295
Range on HMM: 1-231/231
Sequence Identity: 30% (92 aa)

YVKLEKVGEGTYGKVYKARDKNTGRLVALKKTRLDMQDEGVPSTALREVALLHMLSQSLYVVRLLSVEHIDKGGKPLLYLVFEYLDT---DLKKYMDFTN
| .|.|.|.|..|||||.|.|.|||.||.|. .          ...||...|..  .  ..|.|. | .        ||.|.||.|.   ||..|..  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRG

RRKPFGMDHFRTIKHLMYQLCKGVSHCHSHGVMHRDLKPQNLLVDQDKGLLKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEILLGASHYSV-PVDMWSV
|...    .  .....|||.|... .|||||..||||||.|.|.|.    .||.| || | .       |. ..|.||.|||.|    .|.  ..|.||.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GCIFGELAKRSPLFPGDSELQQLLHIFRLLGTPSEEVWPGVTKLRDWHEYPKWSPQKLELVIPGLDQQGLDLLQQMLIYDPAKRISAKAALQ-------H
|||. |.. . |.||      |.  .|...|                                  .....|.....| .||.||..|  |||       |
GCILYEMLCGYPPFP------QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

SYF
 .|
PWF
Kinase CDKB_a-2.AA Pkinase 4-295 31 1.3e-93 322.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-295
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

YVKLEKVGEGTYGKVYKARDKNTGRLVALKKTRLDMQDEGVPSTALR--EVALLHMLSQSLYVVRLLSVEHIDKGGKPLLYLVFEYLDTDLKKYMDFT--
|....|.|.|..|.|||...|.||..||.|. ... ...... |..|  |......| .. ..|||. . .     |. .|.|.||.. .|.  ||    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED----KDHIYMVMEYCEGGLY-VMDLFDY

---NRRKPF--GMDHFRTIKHLMYQLCKGVSHCHSHGVMHRDLKPQNLLVDQDKGL---LKIADLGLGRAF-TVPLKSYTHEIVTLWYRAPEILLGASHY
    |...|   ...   .|. |||...|. .|||.|..||||||.|.|.|..  .   .||.| || . | . .   .|.  .|.||.|||...|...|
ISTWRHGCFYFSEWE---CKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY

SVPVDMWSVGCIFGELAKRSPLFPGD----SELQQLLHIFRLLGTPSEEVWPGVTKLRDWHEYPKWSPQKLELVIPGLDQQGLDLLQQMLIYDPAKRISA
. .|||||.|||. |.. . |.|||.    . . |.  |.| .|.| .. ||     .. . .. | .. .... . ... ..|..  .| .||.||..|
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA

KAALQHSYF
. .||| .|
EQILQHPWF
Kinase CDKB_a-2.AA CRK7 4-295 34 1.3e-90 307.37 In-house 1-343 (343) Show / Hide 
Range on Protein: 4-295
Range on HMM: 1-343/343
Sequence Identity: 34% (121 aa)

YVKLEKVGEGTYGKVYKARDKNTGRLVALKKTRLDMQ---DEGVPSTALREVALLHMLSQSLYVVRLLSVEHIDK-------GGKPLLYLVFEYLDTDLK
| ... .||||||.||||..|.|| .||||| |.|      || | || ||. .|  |     .|.|  .  .||         |   |.|||| | || 
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQ-NIVNLKEI-VTDKQDASEFKKHKGSFYMVFEYMDHDLM

KYMDFTNR-RKPFGMDHFRTIKHLMYQLCKGVSHCHSHGVMHRDLKPQNLLVDQDKGLLKIADLGLGRAFTVPL--KSYTHEIVTLWYRAPEILLGASHY
  ..  .   . |  ..   .|..| ||  |.  ||  ...|||.|  |.|..  .| .||||.|| | .      . ||  ..|||||.|| |||. .|
GLLE--SKEMHHFSHQQ---CKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMN-NQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERY

--------------------------------------SVPVDMWSVGCIFGELAKRSPLFPGDSELQQLLHIFRLLGTPSEEVWPGVTKLRDWHEY-PK
                                         .||||.|||.|||. . |.|.|  |..||  |... |.|  ..|| |.||  |.   ||
TEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPK

W--SPQKLELVIP-----GLDQQGLDLLQQMLIYDPAKRISAKAALQHSYF
       .| ..       .... |||| .|| .|| ||..|. .||| .|
RQYNRRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDKB_a-2.AA PITSLRE 82-295 47 2.7e-89 302.99 In-house 79-295 (295) Show / Hide 
Range on Protein: 82-295
Range on HMM: 79-295/295
Sequence Identity: 47% (106 aa)

YLVFEYLDTDLKKYMDFTN-RRKPFGMDHFRTIKHLMYQLCKGVSHCHSHGVMHRDLKPQNLLVDQDKGLLKIADLGLGRAFTVPLKSYTHEIVTLWYRA
|.|.||.. |||  |.  . |..||       || || || .||.| |.. .||||||  |||    || |||.| ||.| .  |.|.||  .|||||||
YMVMEYVEHDLKSLMENMKRRNQPFKPGE---IKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLY-SHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRA

PEILLGASHYSVPVDMWSVGCIFGELAKRSPLFPGDSELQQLLHIFRLLGTPSEEVWPGVTKLRDWHEYP---KWSPQKLELVIP---GLDQQGLDLLQQ
||.|||.  || |||||||||||.|.    |||.|.||. |.  || ..|||.|  |||.|.|  |       .  .  |   .|    . ..|.|||.|
PELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQ

MLIYDPAKRISAKAALQHSYF
|| |.|..||.| .||.| .|
MLTYNPKNRITASDALKHPWF
Kinase CDKB_a-2.AA CDK7 4-92 35 4.8e-24 60.54 In-house 1-88 (288) Show / Hide 
Range on Protein: 4-92
Range on HMM: 1-88/288
Sequence Identity: 35% (33 aa)

YVKLEKVGEGTYGKVYKARDKNTGRLVALKKTR-LDMQDE---GVPSTALREVALLHMLSQSLYVVRLLSVEHIDKGGKPLLYLVFEYLDTDL
| |....|||... ||||.|..||. || || . |  ..|   |.  ||.||. .|  ..    |. |. .     . |  ..|||...|.||
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHD-NVIGLIDI----FMHKSNIQLVFDFMDWDL
Kinase CDKB_a-2.AA PITSLRE 4-55 43 8.1e-20 68.97 In-house 1-55 (295) Show / Hide 
Range on Protein: 4-55
Range on HMM: 1-55/295
Sequence Identity: 43% (24 aa)

YVKLEKVGEGTYGKVYKARDKNTGRLVALKKTRLD--MQDEGVPSTALREVA-LL
...| ...||||| ||.|.|| |.. ||||.. ..     || | |.|||.  .|
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMIL
Kinase CDKB_a-2.AA TyrKc 4-295 19 4.2e-11 -43.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-295
Range on HMM: 1-280/280
Sequence Identity: 19% (63 aa)

YVKLEKVGEGTYGKVYKARDKNTGRLVALKKTRLDMQDEGVPSTALREVALLHML-SQSLYVVRLLSVEHIDKGGK---PLLYLVFEYLDT-DLKKYMDF
 ....| ||| .|.|||.. |   . || |. . |          .||  ....|  .   .|||. |   ...     . |..|.|| .  |||.|   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

TNRRKPFGMDHFRTIKHLMYQLCKGVSHCHSHGVMHRDLKPQNLLVDQDKGLLKIADLGLGRAFTVP------LKSYT-----HEI--VTLWYRAPEILL
. ..        ..  . ..| ..| .. ||... ||||   | ||. ..   ||.| || |. .         . |.     ..   . .   ||| . 
HRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

GASHYSVPVDMWSVGCI------FGELAKRSPLF--PGDSELQQLLHIFRLLGTPSEEVWPGVTKLRDWHEYPKWSPQKLELVIPGLDQQGLDLLQQMLI
  . ..   | || |        .|.     . .    ..|. ...   . .  | .   | .                     ..  .   .. .|   
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-------------------FVCCPDEMYQIMKQCWH

YDPAKRISAKAALQHSYF
.||..| . ..   |..|
EDPEDRPTFSEI--HECF
Kinase CDKB_a-2.AA Pkinase_Tyr 4-158 29 1.1e-05 19.94 Pfam 1-157 (270) Show / Hide 
Range on Protein: 4-158
Range on HMM: 1-157/270
Sequence Identity: 29% (50 aa)

YVKLEKVGEGTYGKVYKARDK----NTGRLVALKKTRLDMQDEGVPSTA------LREVALLHMLSQSLYVVRLLSVEHIDKGGKP-LLYLVFEYLDT-D
 ....| ||| .|.|||.. |    ||.  || |. .     ||  . .      .||..... | .   .|||. |    . |.|  .|.|.||    |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT--DQGEPNQIYIVMEYMPHGD

LKKYMDFT-NRRKPFGMDHFRTIKHLMYQLCKGVSHCHSHGVMHRDLKPQNLLVDQDKGLLKIADLGL
|..|     . ..|. | .   . .  .| .|| .. .|..  ||||   | ||. ..   ||.| ||
LLDYLRKHREDKQPLTMKD---LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGL