Gene CLK_a (S.moellendorffii)

CLK_a

Species: S.moellendorffii
Alias: CLK_a
External Links:
Annotation:

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
CLK_a.AA Protein None 433 None Fasta, JSON
CLK_a.NA RNA None 1302 None Fasta, JSON
CLK_a.kin_dom Protein Kinase Domain None 330 None Fasta, JSON

Protein domain

Protein domains of CLK_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CLK_a.AA CLK 102-431 43 2.7e-172 521.52 In-house 1-350 (350) Show / Hide 
Range on Protein: 102-431
Range on HMM: 1-350/350
Sequence Identity: 43% (155 aa)

YKIIGKMGEGTFGRVLECWDRDT-QEYVAIKLIRNVQKYRDAAMIEID-VLNELARY-DRNGSRR--CVQLKRWFDF-RNHICMVFEKLGPSLYDFLRKN
|.|. . ||||||.|.||||.     |||.| |||| |||.|| .||. ..  ..   | |. ..  |...  |||.  .|||.|||..| |.|||...|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

E------YRPYAIDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSP------DHVKVPDFKGLYQRSGPGRCYVRVPRTSEIKLIDFGSAT---FN
       |.|| || .|....||.|.|  .||. |.|||||||||..|..        .|  . | . ..|    |.....   .|..|||||||   | 
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKINKKSNNCVCHYWHVKNTHICVIDFGSATKIRFD

SHYHCSVISTRHYRAPEVILGLGWSYSCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIG-PLPAHMIEKAD--RRAEKYF-KNKVELNWPEGAVS
  .|  ..|||||||||||||||||. ||.|||||||.|| .| ||||||.|.||||||||| | |.| .|| . .  .  .||| .|..  .| . . .
HEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDW-HNSDG

RESVRAVRKLPRLRNMILQHVDQYPNVLLDLLQGLLRYEPTERLSAKQALSHPFF
| . . .  | ...    .  .|    | ||.. .| |.|. |...|.||.||||
RYVMENCKPLKQYMDCKDPEHRQ----LFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase CLK_a.AA CMGC 102-431 20 1.3e-104 344.76 In-house 1-513 (513) Show / Hide 
Range on Protein: 102-431
Range on HMM: 1-513/513
Sequence Identity: 20% (109 aa)

YKIIGKMGEGTFGRVLECWD--------------RDTQEYVAIKLIRNVQKYRDAAM-------------IEIDVLNELARYDRNGS-----------RR
|.||.| ||||.| | .|.|              ..|.|.|||| |.|.. | . |               ||  | .| ... .             . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-CVQLKRWFDFRN-----------------HICMVFEKLGPSLYDFLRKNE--YRP------------------------YAIDLVREFGRQLLESVA--
 .|.|. .| ..|                 |...||| .. .||.....|   |..                        . | ..| . .|.|....  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YMHDLT--LIHTDLKPENILLVSPDHV-------KVPDFKGLYQRSGPGRCYVRVPRTSE----------IKLIDFGSAT-FNSH---------------
|.|      ||.||||||||. .   .       .                        |          .|..|||.|. ...|               
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKS------------------------EDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNV

--------YHCSVISTRHYRAPEVILGLG----------WSYSCDIWSIGCILVELCSG--------STLFQTHEN-----------LEHLAMMERIIGP
         . . ..||.|||||..|| .          .....|.||.|||. |.  |         .||..| .           ...|... ...|.
NKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGT

LPAHMIEKADRRA------EKYFKNKVELN-----------------WPEGAVSRESV---RAVRKLPRLRNMILQHVD---------------------
 . .||.|.. |       |. . |...|                  |.|.|    .       .. . ..|..  | .                     
PT-WMIQKGK-RHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKS

----------QYPNVLLDLLQGLLRYEPTERLSAKQALSHPFF
          . .  ..|||...|.|.|..|..|.|||.||.|
HKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase CLK_a.AA S_TKc 102-431 23 1.2e-80 275.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 102-431
Range on HMM: 1-231/231
Sequence Identity: 23% (81 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNELARYDRNGSRRCVQLKRWFDFRNHICMVFEKLGP---SLYDFLRKNEYR
|.|. | |.|.||.|  |....|...|||| |.      . .. ||..| .       .    |.|. .|.  .|..||.| ..    .|.|...|. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

P----YAIDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPDHVKVPDFKGLYQRSGPGRCYVRVPRTSEIKLIDFGSATFNSHYHCSVISTRHYR
.    .    .| . .|... ..|.|..  || ||||||||| .                             .||..|||.|..      ... |..|.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------------------------HIKICDFGLARQL----TTFCGTPWYM

APEVILGLGWSY-SCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIGPLPAHMIEKADRRAEKYFKNKVELNWPEGAVSRESVRAVRKLPRLRNMI
||||.   |... .||.||.|||| |...| ..|.      ...|| ..||                                                 
APEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------------------

LQHVDQYPNVLLDLLQGLLRYEPTERLSAKQALS-------HPFF
       .  ..|.....|...|..|..| .||        ||.|
-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CLK_a.AA Pkinase 102-431 23 1.3e-72 252.35 Pfam 1-293 (293) Show / Hide 
Range on Protein: 102-431
Range on HMM: 1-293/293
Sequence Identity: 23% (83 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMI-----EIDVLNELARYDRNGSRRCVQLKRWFDFRNHICMVFEKLGP-----SLYDF
|.|..| |.|.||.| .| ...|.. ||.| |. . .  .  ..     || ....| .     .   |.|..||  ..||.||.| ..      .|.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N-----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LRKNEYRPY--AIDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPDHVKVPDFKGLYQRSGPGRCYVRVPRTSEIKLIDFGSA----TFNSHYHC
..  .....    . .. . .|.|. ..|.|.   || ||||||||... .|..                         .|..|||.|    . |..   
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-----------------------CVKICDFGLAKQFDY-NNS-MT

SVISTRHYRAPEVIL-GLGWSYSCDIWSIGCILVELCSGSTLFQTH----ENLEHLAMMERIIGPLPAHMIEKADRRA---EKYFKNKVELNWPEGAVSR
..  |..|.|||||. | ......|.||.|||| |...| ..|. |    . .....|..|| || .   ... ...     .. . .            
TFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H------------

ESVRAVRKLPRLRNMILQHVDQYPNVLLDLLQGLLRYEPTERLSAKQALSHPFF
                .. ..  .  ..|.. ..|.. |..|..|.|.| ||.|
--------------F-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CLK_a.AA DYRK 102-247 42 1.3e-55 191.09 In-house 1-151 (320) Show / Hide 
Range on Protein: 102-247
Range on HMM: 1-151/320
Sequence Identity: 42% (64 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNELARYDRNGSRRCVQLKRWFDFRNHICMVFEKLGPSLYDFLRKNEYRPY-
|.|..  | |.|| |  |||. |.|.||||.||| ... . |.|||  |  | . |.. . .||.... | .||| |.||| |  .||.||..|  ... 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

AIDLVREFGRQLLESVAYMHDL-TLIHTDLKPENILLVSP---DHVKVPDF
 . ||| |..|.|..  ..| .  .|| |||||||.|..|     .|| ||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDF
Kinase CLK_a.AA DYRK2 102-247 39 1.3e-49 159.36 In-house 1-148 (318) Show / Hide 
Range on Protein: 102-247
Range on HMM: 1-148/318
Sequence Identity: 39% (59 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNELARYDRNGSRRCVQLKRWFDFRNHICMVFEKLGPSLYDFLRKNEYRPYA
| |   .| | || |..| |  |...||||.||| ...   | .|| .| .. | |....  || ..  | ||||.|..|| |. .||....||..  ..
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

IDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPDH--VKVPDF
  ||| |....|..    |   .|| ||||||||| ..    .|| ||
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDF
Kinase CLK_a.AA Ciliate-E2 102-431 16 1.6e-46 157.7 In-house 1-365 (365) Show / Hide 
Range on Protein: 102-431
Range on HMM: 1-365/365
Sequence Identity: 16% (76 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIK---------------------LIRNVQKYRDAAMIEIDVLNELARYD-----------RNGSRRCVQLKR
||.| | |.|.|| | .| .. .|. .|||                     . .. ..   . . ||....|.   .           .. .   .... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

WFD--FRNHICMVFEKL-GPSLYDFLRKN----------EYRPYAIDLVREFGRQLLE---------------SVAYMHDLT-LIHTDLKPENILLVSPD
.|    .|.| .|.| . | .|.|....|          .  .. .  .... .|.|.                . |.|     || |.||||||.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

HVKVPDFKGLYQRSGPGRCYVRVPRTSEIKLIDFGSATFNS----------------------------------HYHCSVISTRHYRAPEVILGLG---
                            ||.|||| .....                                  . . ... | .| |||.. | .   
----------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDN

------WSYSCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIGPLPAHMIEKADRRAEKYFKNKVELNWPEGAVSRESVRAVRKLPRLRNMILQHV
      ..|.|||||.|.|| |...| . |                                                               . |.|  
QQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------------------------------------------------------QQQIKQCK

DQYPNVL----------------------LDLLQG----LLRYEPTERLS-AKQALSHPFF
 ..|.                         ||..     .| ..| .|.. ..|.| ||.|
IDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CLK_a.AA DYRK 264-431 33 7e-43 148.79 In-house 140-320 (320) Show / Hide 
Range on Protein: 264-431
Range on HMM: 140-320/320
Sequence Identity: 33% (61 aa)

P-RTSEIKLIDFGSATFNSHYHCSV-ISTRHYRAPEVILGLGWSYSCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIGPLPAHMIEKA-DRRAEK
|   |.||.|||||..| .. ...  |  |.|||||||||.  .|. |.|| ||||.||  |  ||.   . . ||..  ..|. | .||.|.  ||..|
PRNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHK

YFKN---KVELNWPEGAV----------SRESVRAVRKLPRLRNMILQHVDQYPNVLLDLLQGLLRYEPTERLSAKQALSHPFF
.|..    .  .|... .           ...   .|..|  || .  |  .    ..|.....| ..|..|....||| ||.|
FFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase CLK_a.AA DYRK1 102-239 43 9.5e-40 137.04 In-house 1-140 (321) Show / Hide 
Range on Protein: 102-239
Range on HMM: 1-140/321
Sequence Identity: 43% (61 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNELARYDRNGSRRCVQLKRWFDFRNHICMVFEKLGPSLYDFLRKNEYRPYA
|.|.  .| | || |   .|. .|||||||.|.| . . . | ||| .|  . . |..   . |.||| | ||||.|.||| |   ||| ||  ..|  .
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

IDLVREFGRQLLESVAYMH--DLTLIHTDLKPENILLVSP
. |.| | .|.. .. .|   .| .|| |||||||||. |
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNP
Kinase CLK_a.AA HIPK 102-247 39 2.6e-39 121.14 In-house 1-149 (329) Show / Hide 
Range on Protein: 102-247
Range on HMM: 1-149/329
Sequence Identity: 39% (59 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNELARYDRNGSRRCVQLKRWFDFRNHICMVFEKLGPSLYDFLRKNEYRPYA
| ..  .| |||| |  || | |.| ||||...|   |     ||. .|. |   . .     |     |. .||.|.||| |   ||||...|.. |  
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

IDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPDH----VKVPDF
.  .|    | |   . . .| ||| |||||||.|| | .    ||| ||
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDF
Kinase CLK_a.AA YAK 102-240 35 5.2e-34 112.67 In-house 1-143 (347) Show / Hide 
Range on Protein: 102-240
Range on HMM: 1-143/347
Sequence Identity: 35% (51 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNEL-ARYDRNGSR---RCVQLKRWFDFRNHICMVFEKLGPSLYDFLRKNEY
|..    | |||| |  |   || | .|.| | | | |   |  || .|  |  . | |.     . . .   | ..|| |.||| |  .||..|  | .
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

RPYAIDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPD
.   . |.| .  | |..     .  .|| |||||||.|  |.
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPN
Kinase CLK_a.AA DYRK2 267-431 27 1.6e-30 96.19 In-house 141-318 (318) Show / Hide 
Range on Protein: 267-431
Range on HMM: 141-318/318
Sequence Identity: 27% (50 aa)

SEIKLIDFGSATFNSHYHCSV-ISTRHYRAPEVILGLGWSYSCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIGPLPAHMIEKA----DRRAEKY
| ||.||||| .|   |.  . | .| |||||||||.  . . |.|| |||..|| .|  ||      . .|.|  ..|  |.......     .|.. .
SGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYF

FK----------NKVELNWPEGAVSRESVRAVRKLPRLR--NMILQHVDQYPNVLLDLLQGLLRYEPTERLSAKQALSHPFF
|.          .  . . ... ...   .  |. |  .  ...|.  ....  ..| ..  .  .|.||....||| ||..
FNSHCFEWYCTFMTDHSMEIPKHYKNR--HGKRRPPGSKSWKSVLKGCEDEN--FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase CLK_a.AA DyrkP 268-365 42 2e-24 76.77 In-house 146-242 (323) Show / Hide 
Range on Protein: 268-365
Range on HMM: 146-242/323
Sequence Identity: 42% (42 aa)

EIKLIDFGSATFNSHYHCSVISTRHYRAPEVILGLGWSYSCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIGPLPAHMIEKADRRAEKYFKNK
..|.|||||. |      | .  | |||||||.|  . |  |.||.|||| ||  |  |||  .    || .  ||||.|  |. .  |  . .| .|
QVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQNDNIQGLLARVIGIIGPFPEWMM-QEGRLVQNFFTRK
Kinase CLK_a.AA PRP4 102-235 32 2.6e-24 85.91 In-house 1-138 (320) Show / Hide 
Range on Protein: 102-235
Range on HMM: 1-138/320
Sequence Identity: 32% (45 aa)

YKIIGKMGEGTFGRVLECWDRD-TQEYVAIKLIRNVQKYRDAAMIEIDVLNELARY--DRNGSRRCVQLKRWFDFRNHICMVFEKLGPSLYDFLRKN-EY
|...|. |.| |. |  | | . ..| |||| |||    ..  . |. .|  |     |.|    ||...| | .|.|.|.||| .  .| . | |    
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

RPYAIDLVREFGRQLLESVAYMHDLTLIHTDLKPENIL
    .. || . .||.     .  .  .| |.|| |||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNIL
Kinase CLK_a.AA DYRK1 264-370 38 9.4e-22 72.78 In-house 140-245 (321) Show / Hide 
Range on Protein: 264-370
Range on HMM: 140-245/321
Sequence Identity: 38% (41 aa)

PRTSEIKLIDFGSATFNSHYHCSVISTRHYRAPEVILGLGWSYSCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIGPLPAHMIEKADRRAEKYFK
|. | ||.|||||.    .     |  | ||.|||.||. .. . |.||.||||||.  |  ||   . .. .  .  ..|  |.|||..|  .|.|||.
PKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAP-KAHKYFE

NKVELNW
 . .  |
KDPDNTW
Kinase CLK_a.AA DyrkP 102-247 30 5.6e-18 55.16 In-house 1-152 (323) Show / Hide 
Range on Protein: 102-247
Range on HMM: 1-152/323
Sequence Identity: 30% (47 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNELARYDRNGSRRCVQLKRWFDFRNHICMVFEKLGPSLYDFL---RKNEYR
|.|.  .|   | . . | |. |   . .|.| | . | | .. || .|  .        .  ..   .|  . |. .. | |   ||.|    | ||  
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

PY-AIDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPD--HVKVPDF
.|  .  .     |.| .. |.| | ||| ||||||||. |    .||. ||
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDF
Kinase CLK_a.AA HIPK 269-431 25 4.5e-16 46.65 In-house 144-329 (329) Show / Hide 
Range on Protein: 269-431
Range on HMM: 144-329/329
Sequence Identity: 25% (47 aa)

IKLIDFGSATFNSHYHCSV-ISTRHYRAPEVILGLGWSYSCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIGPLPAHMIEKADRRAEKYF---KN
.| ||||||   |.  |.  .  |.|||||.||||    . |.|| ||.. ||  |  |.   .. .    ..   . ||.  . .| ......|   |.
VKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGWPLYPGADEYDQIRYICQTQH-LPHEHLLHAACKKHRFFDRDKQ

KVELNWPEGAVSRESVRAVRKLPRLRNMILQHVDQYPNVLL--------------------DLLQGLLRYEPTERLSAKQALSHPFF
     |.   .      .  |. ..| .|. ..|  |.| .                    ..|  ..  .. .|..  .|| ||| 
SKFRPWRLKHIEEHEQQTSVKSKEARKYIFNCLDDMPEVNMLVDPERQDYRVEKIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase CLK_a.AA YAK 268-320 47 5.9e-16 50.32 In-house 146-198 (347) Show / Hide 
Range on Protein: 268-320
Range on HMM: 146-198/347
Sequence Identity: 47% (25 aa)

EIKLIDFGSATFNSHYHCSVISTRHYRAPEVILGLGWSYSCDIWSIGCILVEL
|||.|||||.          |  ||||.||.|..   . | | || |||..||
EIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL
Kinase CLK_a.AA PRP4 269-327 46 7.3e-11 36.06 In-house 146-205 (320) Show / Hide 
Range on Protein: 269-327
Range on HMM: 146-205/320
Sequence Identity: 46% (29 aa)

IKLIDFGSATFNSHYHCSVIS----TRHYRAPEVILGLGWSYSCDIWSIGCILVELCSGSTLF
.|..|||||   || | . |      | |||||.|.|    |. |.||.|| | ||  |  .|
LKMCDFGSA---SHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMF
Kinase CLK_a.AA YAK 403-431 37 2.9e-09 27.22 In-house 319-347 (347) Show / Hide 
Range on Protein: 403-431
Range on HMM: 319-347/347
Sequence Identity: 37% (11 aa)

VLLDLLQGLLRYEPTERLSAKQALSHPFF
...|.. .||  .| || .. ||  ||| 
CFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase CLK_a.AA TyrKc 102-431 14 6.1e-08 -94.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 102-431
Range on HMM: 1-280/280
Sequence Identity: 14% (54 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNELARYDRN--GSRRCVQLKRWFDFR-------NHICMVFE--KLGPSLYD
 . . | ||| ||.| ..  .   . ||.| ...          . | ..|.    .        |.|                ...|.|  ..| .| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG-DLKD

FLRKNEYRPYAIDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPDHVKVPDFKGLYQRSGPGRCYVRVPRTSEIKLIDFGSATFNSHY-HC----
.|||.. .    .   .|  |  .  .| |.  .|| ||   |.|. ..                             .|  ||| . .  .. ..    
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------------------------TVKISDFGLSRDIYDDDQQGESK

SVISTR---HYR--------APEVILGLGWSYSCDIWSIGCILVELCS-------G-----STLFQTHENLEHLAMMERIIGPLPAHMIEKADRRAEKYF
......   . .        |||.|     .   |.|| |  . |...       |      . .. .|....  .|..   ..   |            
DYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-----------

KNKVELNWPEGAVSRESVRAVRKLPRLRNMILQHVDQYPNVLLDLLQGLLRYEPTERLSAKQALSHPFF
                                      |  . .. .   ...| .| . ..   | .|
----------------------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CLK_a.AA DyrkP 403-431 37 9e-06 14.32 In-house 295-323 (323) Show / Hide 
Range on Protein: 403-431
Range on HMM: 295-323/323
Sequence Identity: 37% (11 aa)

VLLDLLQGLLRYEPTERLSAKQALSHPFF
. .|  . .|  . | | .|| ||.||.|
MFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase CLK_a.AA PRP4 406-431 42 1.2e-05 16.7 In-house 295-320 (320) Show / Hide 
Range on Protein: 406-431
Range on HMM: 295-320/320
Sequence Identity: 42% (11 aa)

DLLQGLLRYEPTERLSAKQALSHPFF
||| ..|   |  | .  .|| |||.
DLLDKCLMLDPKKRITCNEALKHPFI
Kinase CLK_a.AA DYRK1 406-431 42 1.4e-05 15.05 In-house 296-321 (321) Show / Hide 
Range on Protein: 406-431
Range on HMM: 296-321/321
Sequence Identity: 42% (11 aa)

DLLQGLLRYEPTERLSAKQALSHPFF
||.. .|.|.| .|..  .|| |.||
DLIKRMLQYDPKQRITPYYALQHSFF